Autor: "Kratschmar DV" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: The ratio of ursodeoxycholyltaurine to 7-oxolithocholyltaurine serves as a biomarker of decreased 11β-hydroxysteroid dehydrogenase 1 activity in mouse.
Autorzy:: Weingartner M; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.
Stücheli S; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.
Kratschmar DV; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.
Birk J; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.
Klusonova P; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.
Chapman KE; Queen's Medical Research Institute, University/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
Lavery GG; Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.
Odermatt A; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.; Pokaż więcej
Źródło:: British journal of pharmacology [Br J Pharmacol] 2021 Aug; Vol. 178 (16), pp. 3309-3326. Date of Electronic Publication: 2021 Feb 04.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: 11-beta-Hydroxysteroid Dehydrogenase Type 1*/genetics
Glucocorticoids*
Animals ; Bile Acids and Salts ; Biomarkers ; Mice ; Mice, Knockout

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Skocz do pozycji: 2.

Tytuł:: Ca mobilization-dependent reduction of the endoplasmic reticulum lumen is due to influx of cytosolic glutathione.
Autorzy:: Lizák B; Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary. .
Birk J; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056, Basel, Switzerland.
Zana M; Department of Physiology, Faculty of Medicine, Semmelweis University, Budapest, Hungary.; 'Momentum' Peroxidase Enzyme Research Group of the Semmelweis University and the Hungarian Academy of Sciences, Budapest, Hungary.
Kosztyi G; Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary.
Kratschmar DV; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056, Basel, Switzerland.
Odermatt A; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056, Basel, Switzerland.
Zimmermann R; Medical Biochemistry and Molecular Biology, Saarland University, 66421, Homburg, Germany.
Geiszt M; Department of Physiology, Faculty of Medicine, Semmelweis University, Budapest, Hungary.; 'Momentum' Peroxidase Enzyme Research Group of the Semmelweis University and the Hungarian Academy of Sciences, Budapest, Hungary.
Appenzeller-Herzog C; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056, Basel, Switzerland. .; University Medical Library, University of Basel, Spiegelgasse 5, 4051, Basel, Switzerland. .
Bánhegyi G; Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary.; Pokaż więcej
Źródło:: BMC biology [BMC Biol] 2020 Feb 26; Vol. 18 (1), pp. 19. Date of Electronic Publication: 2020 Feb 26.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Calcium/*metabolism
Cytosol/*metabolism
Endoplasmic Reticulum/*metabolism
Glutathione/*metabolism
Calreticulin/metabolism ; Humans ; Protein Binding

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Skocz do pozycji: 3.

Tytuł:: Deletion of the serine protease CAP2/Tmprss4 leads to dysregulated renal water handling upon dietary potassium depletion.
Autorzy:: Keppner A; Department of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland.; Department of Medicine/Physiology, University of Fribourg, Fribourg, Switzerland.; National Center of Competence in Research Kidney Control of Homeostasis (NCCR Kidney.CH), University of Lausanne, Lausanne, Switzerland.
Maric D; Department of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland.; Department of Medicine/Physiology, University of Fribourg, Fribourg, Switzerland.; National Center of Competence in Research Kidney Control of Homeostasis (NCCR Kidney.CH), University of Lausanne, Lausanne, Switzerland.
Sergi C; Department of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland.
Ansermet C; Department of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland.
De Bellis D; Department of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland.; Electron Microscopy Facility, University of Lausanne, Lausanne, Switzerland.; Department of Plant Molecular Biology, University of Lausanne, Lausanne, Switzerland.
Kratschmar DV; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.; National Center of Competence in Research Kidney Control of Homeostasis (NCCR Kidney.CH), University of Lausanne, Lausanne, Switzerland.
Canonica J; Department of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland.; National Center of Competence in Research Kidney Control of Homeostasis (NCCR Kidney.CH), University of Lausanne, Lausanne, Switzerland.; Ophthalmic Hospital Jules Gonin, University of Lausanne, Lausanne, Switzerland.
Klusonova P; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.; National Center of Competence in Research Kidney Control of Homeostasis (NCCR Kidney.CH), University of Lausanne, Lausanne, Switzerland.
Fenton RA; Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Odermatt A; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.; National Center of Competence in Research Kidney Control of Homeostasis (NCCR Kidney.CH), University of Lausanne, Lausanne, Switzerland.
Crambert G; INSERM, Paris, France.
Hoogewijs D; Department of Medicine/Physiology, University of Fribourg, Fribourg, Switzerland.; National Center of Competence in Research Kidney Control of Homeostasis (NCCR Kidney.CH), University of Lausanne, Lausanne, Switzerland.
Hummler E; Department of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland. .; National Center of Competence in Research Kidney Control of Homeostasis (NCCR Kidney.CH), University of Lausanne, Lausanne, Switzerland. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2019 Dec 20; Vol. 9 (1), pp. 19540. Date of Electronic Publication: 2019 Dec 20.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: 11-beta-Hydroxysteroid Dehydrogenase Type 2/*metabolism
Adaptor Proteins, Signal Transducing/*metabolism
Aquaporin 2/*metabolism
11-beta-Hydroxysteroid Dehydrogenase Type 2/genetics ; Adaptor Proteins, Signal Transducing/genetics ; Animals ; Blotting, Western ; Electrophoresis, Polyacrylamide Gel ; Enzyme-Linked Immunosorbent Assay ; Kidney/metabolism ; Male ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mice ; Potassium, Dietary/metabolism ; Receptors, Glucocorticoid/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Serine Endopeptidases/genetics ; Serine Endopeptidases/metabolism ; Solute Carrier Family 12, Member 1/metabolism

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Skocz do pozycji: 4.

Tytuł:: Absence of hexose-6-phosphate dehydrogenase results in reduced overall glucose consumption but does not prevent 11β-hydroxysteroid dehydrogenase-1-dependent glucocorticoid activation.
Autorzy:: Marbet P; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Switzerland.
Klusonova P; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Switzerland.
Birk J; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Switzerland.
Kratschmar DV; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Switzerland.
Odermatt A; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Switzerland.; Pokaż więcej
Źródło:: The FEBS journal [FEBS J] 2018 Nov; Vol. 285 (21), pp. 3993-4004. Date of Electronic Publication: 2018 Sep 06.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Macrophage Activation*
11-beta-Hydroxysteroid Dehydrogenases/*metabolism
Carbohydrate Dehydrogenases/*physiology
Glucocorticoids/*metabolism
Glucose/*metabolism
11-beta-Hydroxysteroid Dehydrogenases/genetics ; Animals ; Cells, Cultured ; Endoplasmic Reticulum/metabolism ; Energy Metabolism ; Female ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; NADP/metabolism ; Oxidation-Reduction

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Skocz do pozycji: 5.

Tytuł:: Novel 11β-hydroxysteroid dehydrogenase 1 inhibitors reduce cortisol levels in keratinocytes and improve dermal collagen content in human ex vivo skin after exposure to cortisone and UV.
Autorzy:: Boudon SM; DSM Nutritional Products Ltd., Kaiseraugst, Switzerland.
Vuorinen A; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.
Geotti-Bianchini P; DSM Nutritional Products Ltd., Kaiseraugst, Switzerland.
Wandeler E; DSM Nutritional Products Ltd., Kaiseraugst, Switzerland.
Kratschmar DV; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.
Heidl M; DSM Nutritional Products Ltd., Kaiseraugst, Switzerland.
Campiche R; DSM Nutritional Products Ltd., Kaiseraugst, Switzerland.
Jackson E; DSM Nutritional Products Ltd., Kaiseraugst, Switzerland.
Odermatt A; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2017 Feb 02; Vol. 12 (2), pp. e0171079. Date of Electronic Publication: 2017 Feb 02 (Print Publication: 2017).
Typ publikacji:: Journal Article
MeSH Terms:: 11-beta-Hydroxysteroid Dehydrogenase Type 1/*antagonists & inhibitors
Collagen/*metabolism
Hydrocortisone/*metabolism
Keratinocytes/*drug effects
Keratinocytes/*metabolism
Skin/*drug effects
Skin/*metabolism
Amides/chemical synthesis ; Amides/chemistry ; Amides/pharmacology ; Cortisone/adverse effects ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; HEK293 Cells ; Humans ; In Vitro Techniques ; Skin/radiation effects ; Skin Aging/drug effects ; Skin Aging/physiology ; Skin Aging/radiation effects ; Ultraviolet Rays/adverse effects

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Skocz do pozycji: 6.

Tytuł:: Acute Effects of Lysergic Acid Diethylamide on Circulating Steroid Levels in Healthy Subjects.
Autorzy:: Strajhar P; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.
Schmid Y; Division of Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Clinical Research, University Hospital Basel, Basel, Switzerland.
Liakoni E; Division of Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Clinical Research, University Hospital Basel, Basel, Switzerland.
Dolder PC; Division of Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Clinical Research, University Hospital Basel, Basel, Switzerland.; Laboratory Medicine, University Hospital Basel, Basel, Switzerland.
Rentsch KM; Laboratory Medicine, University Hospital Basel, Basel, Switzerland.
Kratschmar DV; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.
Odermatt A; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.
Liechti ME; Division of Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Clinical Research, University Hospital Basel, Basel, Switzerland.; Pokaż więcej
Źródło:: Journal of neuroendocrinology [J Neuroendocrinol] 2016 Mar; Vol. 28 (3), pp. 12374.
Typ publikacji:: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:: Adrenal Cortex Hormones/*blood
Gonadal Steroid Hormones/*blood
Hallucinogens/*pharmacology
Lysergic Acid Diethylamide/*pharmacology
Adult ; Corticosterone/analogs & derivatives ; Corticosterone/blood ; Cross-Over Studies ; Dehydroepiandrosterone/blood ; Double-Blind Method ; Female ; Healthy Volunteers ; Humans ; Hydrocortisone/blood ; Male ; Middle Aged