Autor: "Kroeger JL" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Off-target based drug repurposing opportunities for tivantinib in acute myeloid leukemia.
Autorzy:: Kuenzi BM; Department of Drug Discovery, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, 33612, United States.; Cancer Biology Ph.D. Program, University of South Florida, Tampa, Florida, 33620, United States.
Remsing Rix LL; Department of Drug Discovery, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, 33612, United States.
Kinose F; Department of Thoracic Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, 33612, United States.
Kroeger JL; Flow Cytometry Core, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, 33612, United States.
Lancet JE; Department of Hematologic Malignancies, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, 33612, United States.
Padron E; Department of Hematologic Malignancies, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, 33612, United States.
Rix U; Department of Drug Discovery, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, 33612, United States. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2019 Jan 24; Vol. 9 (1), pp. 606. Date of Electronic Publication: 2019 Jan 24.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Drug Repositioning*
Apoptosis/*drug effects
Pyrrolidinones/*pharmacology
Quinolines/*pharmacology
Bridged Bicyclo Compounds, Heterocyclic/pharmacology ; Bridged Bicyclo Compounds, Heterocyclic/therapeutic use ; Down-Regulation/drug effects ; Drug Synergism ; G2 Phase Cell Cycle Checkpoints/drug effects ; Glycogen Synthase Kinase 3/antagonists & inhibitors ; Glycogen Synthase Kinase 3/metabolism ; HL-60 Cells ; Humans ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/pathology ; Lithium Chloride/pharmacology ; Lithium Chloride/therapeutic use ; Myeloid Cell Leukemia Sequence 1 Protein/genetics ; Myeloid Cell Leukemia Sequence 1 Protein/metabolism ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Proto-Oncogene Proteins c-met/antagonists & inhibitors ; Proto-Oncogene Proteins c-met/metabolism ; Pyrrolidinones/therapeutic use ; Quinolines/therapeutic use ; Sulfonamides/pharmacology ; Sulfonamides/therapeutic use ; bcl-X Protein/genetics ; bcl-X Protein/metabolism

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