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Tytuł:
Recombinant ferritins for multimodal nanomedicine.
Autorzy:
Li Y; College of Life Science, Yangtze University, Jingzhou, China.
Gao H; College of Life Science, Yangtze University, Jingzhou, China.
Nepovimova E; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Králové, Czech Republic.
Wu Q; College of Life Science, Yangtze University, Jingzhou, China.; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Králové, Czech Republic.
Adam V; Department of Chemistry and Biochemistry, Mendel University in Brno, Brno, Czech Republic.
Kuca K; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Králové, Czech Republic.; Biomedical Research Center, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2023 Dec; Vol. 38 (1), pp. 2219868.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Ferritins*/chemistry
Ferritins*/metabolism
Nanoparticles*
Nanomedicine
Czasopismo naukowe
Tytuł:
Inhibitors of phosphoinositide 3-kinase (PI3K) and phosphoinositide 3-kinase-related protein kinase family (PIKK).
Autorzy:
Huang X; College of Life Science, Yangtze University, Jingzhou, China.
You L; College of Physical Education and Health, Chongqing College of International Business and Economics, Chongqing, China.
Nepovimova E; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Czech Republic.
Psotka M; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Czech Republic.; Biomedical Research Center, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.
Malinak D; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Czech Republic.; Biomedical Research Center, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.
Valko M; Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava, Bratislava, Slovakia.
Sivak L; Department of Chemistry and Biochemistry, Mendel University in Brno, Brno, Czech Republic.
Korabecny J; Biomedical Research Center, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.
Heger Z; Department of Chemistry and Biochemistry, Mendel University in Brno, Brno, Czech Republic.
Adam V; Department of Chemistry and Biochemistry, Mendel University in Brno, Brno, Czech Republic.
Wu Q; College of Life Science, Yangtze University, Jingzhou, China.; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Czech Republic.
Kuca K; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Czech Republic.; Biomedical Research Center, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2023 Dec; Vol. 38 (1), pp. 2237209.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Phosphatidylinositol 3-Kinase*/metabolism
Phosphatidylinositol 3-Kinase*/therapeutic use
Neoplasms*/drug therapy
Humans ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Phosphoinositide-3 Kinase Inhibitors/pharmacology ; TOR Serine-Threonine Kinases/metabolism ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use
Czasopismo naukowe
Tytuł:
Privileged multi-target directed propargyl-tacrines combining cholinesterase and monoamine oxidase inhibition activities.
Autorzy:
Chrienova Z; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
Nepovimova E; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
Andrys R; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
Dolezal R; Biomedical Research Centre and Department of Neurology, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.
Janockova J; Biomedical Research Centre and Department of Neurology, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.
Muckova L; Biomedical Research Centre and Department of Neurology, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic.
Fabova L; Department of Pharmaceutical Chemistry and Pharmaceutical Analysis, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech Republic.
Soukup O; Biomedical Research Centre and Department of Neurology, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.
Oleksak P; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
Valis M; Biomedical Research Centre and Department of Neurology, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.; Faculty of Medicine in Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech Republic.
Korabecny J; Biomedical Research Centre and Department of Neurology, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic.
Marco-Contelles J; Institute of General Organic Chemistry (CSIC), Laboratory of Medicinal Chemistry, Madrid, Spain.
Kuca K; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 2605-2620.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/drug therapy
Butyrylcholinesterase*/metabolism
Acetylcholinesterase/metabolism ; Amines ; Cholinesterase Inhibitors/pharmacology ; Cholinesterase Inhibitors/therapeutic use ; Drug Design ; Humans ; Ligands ; Monoamine Oxidase ; Monoamine Oxidase Inhibitors/pharmacology ; Oxidoreductases ; Structure-Activity Relationship ; Tacrine/therapeutic use
Czasopismo naukowe
Tytuł:
The role of mTOR in age-related diseases.
Autorzy:
Chrienova Z; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czechia.
Nepovimova E; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czechia.
Kuca K; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czechia.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 1679-1693.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Neoplasms/*metabolism
Neurodegenerative Diseases/*metabolism
TOR Serine-Threonine Kinases/*metabolism
Age Factors ; Animals ; Humans ; Signal Transduction
Czasopismo naukowe
Tytuł:
Selective inhibitors for JNK signalling: a potential targeted therapy in cancer.
Autorzy:
Wu Q; College of Life Science, Yangtze University, Jingzhou, China.; College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
Wu W; College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
Jacevic V; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.; National Poison Control Centre, Military Medical Academy, Belgrade, Serbia.; Medical Faculty of the Military Medical Academy, University of Defence, Belgrade, Serbia.
Franca TCC; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.; Laboratory of Molecular Modeling Applied to the Chemical and Biological Defense, Military Institute of Engineering, Rio de Janeiro, Brazil.
Wang X; National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, China.
Kuca K; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 574-583.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Antineoplastic Agents/*pharmacology
JNK Mitogen-Activated Protein Kinases/*antagonists & inhibitors
Neoplasms/*drug therapy
Protein Kinase Inhibitors/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Humans ; JNK Mitogen-Activated Protein Kinases/metabolism ; Neoplasms/metabolism ; Neoplasms/pathology ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł:
Synthesis, in vitro screening and molecular docking of isoquinolinium-5-carbaldoximes as acetylcholinesterase and butyrylcholinesterase reactivators.
Autorzy:
Malinak D; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.; Biomedical Research Centre, University Hospital in Hradec Kralove, Hradec Kralove, Czech Republic.
Dolezal R; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.; Biomedical Research Centre, University Hospital in Hradec Kralove, Hradec Kralove, Czech Republic.
Hepnarova V; Biomedical Research Centre, University Hospital in Hradec Kralove, Hradec Kralove, Czech Republic.; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic.
Hozova M; Biomedical Research Centre, University Hospital in Hradec Kralove, Hradec Kralove, Czech Republic.
Andrys R; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
Bzonek P; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic.
Racakova V; Faculty of Informatics and Management, Center for Basic and Applied Research, University of Hradec Kralove, Hradec Kralove, Czech Republic.
Korabecny J; Biomedical Research Centre, University Hospital in Hradec Kralove, Hradec Kralove, Czech Republic.; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic.
Gorecki L; Biomedical Research Centre, University Hospital in Hradec Kralove, Hradec Kralove, Czech Republic.
Mezeiova E; Biomedical Research Centre, University Hospital in Hradec Kralove, Hradec Kralove, Czech Republic.
Psotka M; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.; Biomedical Research Centre, University Hospital in Hradec Kralove, Hradec Kralove, Czech Republic.
Jun D; Biomedical Research Centre, University Hospital in Hradec Kralove, Hradec Kralove, Czech Republic.; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic.
Kuca K; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.; Biomedical Research Centre, University Hospital in Hradec Kralove, Hradec Kralove, Czech Republic.
Musilek K; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.; Biomedical Research Centre, University Hospital in Hradec Kralove, Hradec Kralove, Czech Republic.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 478-488.
Typ publikacji:
Journal Article
MeSH Terms:
Acetylcholinesterase/*drug effects
Butyrylcholinesterase/*drug effects
Cholinesterase Reactivators/*pharmacology
Isoquinolines/*chemical synthesis
Isoquinolines/*pharmacology
Cholinesterase Inhibitors/pharmacology ; Humans ; Isoquinolines/chemistry ; Molecular Docking Simulation
Czasopismo naukowe
Tytuł:
Molecular modeling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime, 4-PA, 2-PAM, and obidoxime with VX-inhibited human acetylcholinesterase: a near attack conformation approach.
Autorzy:
da Silva JAV; a Laboratory of Molecular Modeling Applied to the Chemical and Biological Defense (LMCBD), Department of Chemical Engineering , Military Institute of Engineering , Rio de Janeiro/RJ , Brazil.
Nepovimova E; b Faculty of Science, Department of Chemistry , University of Hradec Kralove , Hradec Kralove , Czech Republic.
Ramalho TC; b Faculty of Science, Department of Chemistry , University of Hradec Kralove , Hradec Kralove , Czech Republic.; c Laboratory of Molecular Modeling, Chemistry Department , Federal University of Lavras , Lavras , Brazil.
Kuca K; b Faculty of Science, Department of Chemistry , University of Hradec Kralove , Hradec Kralove , Czech Republic.
Celmar Costa França T; a Laboratory of Molecular Modeling Applied to the Chemical and Biological Defense (LMCBD), Department of Chemical Engineering , Military Institute of Engineering , Rio de Janeiro/RJ , Brazil.; b Faculty of Science, Department of Chemistry , University of Hradec Kralove , Hradec Kralove , Czech Republic.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2019 Dec; Vol. 34 (1), pp. 1018-1029.
Typ publikacji:
Journal Article
MeSH Terms:
Cholinesterase Inhibitors/*pharmacology
Obidoxime Chloride/*pharmacology
Organothiophosphorus Compounds/*pharmacology
Oximes/*pharmacology
Pralidoxime Compounds/*pharmacology
Pyridines/*pharmacology
Acetylcholinesterase/metabolism ; Cholinesterase Inhibitors/chemical synthesis ; Cholinesterase Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Humans ; Models, Molecular ; Molecular Structure ; Obidoxime Chloride/chemistry ; Organothiophosphorus Compounds/chemistry ; Oximes/chemistry ; Pralidoxime Compounds/chemistry ; Pyridines/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł:
In vitro investigating of anticancer activity of new 7-MEOTA-tacrine heterodimers.
Autorzy:
Janockova J; a Department of Biochemistry, Institute of Chemistry, Faculty of Science , P. J. Šafárik University , Kosice , Slovak Republic.; b Biomedical Research Center , University Hospital Hradec Kralove , Hradec Kralove , Czech Republic.
Korabecny J; b Biomedical Research Center , University Hospital Hradec Kralove , Hradec Kralove , Czech Republic.; c Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences , University of Defence , Hradec Kralove , Czech Republic.
Plsikova J; a Department of Biochemistry, Institute of Chemistry, Faculty of Science , P. J. Šafárik University , Kosice , Slovak Republic.; d Associated Tissue Bank, Faculty of Medicine , P.J. Šafárik University , Kosice , Slovak Republic.
Babkova K; b Biomedical Research Center , University Hospital Hradec Kralove , Hradec Kralove , Czech Republic.; c Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences , University of Defence , Hradec Kralove , Czech Republic.
Konkolova E; a Department of Biochemistry, Institute of Chemistry, Faculty of Science , P. J. Šafárik University , Kosice , Slovak Republic.
Kucerova D; e Department of Cellular Biology, Institute of Biology and Ecology, Faculty of Science , P. J. Šafárik University , Kosice , Slovak Republic.
Vargova J; e Department of Cellular Biology, Institute of Biology and Ecology, Faculty of Science , P. J. Šafárik University , Kosice , Slovak Republic.
Koval J; e Department of Cellular Biology, Institute of Biology and Ecology, Faculty of Science , P. J. Šafárik University , Kosice , Slovak Republic.
Jendzelovsky R; e Department of Cellular Biology, Institute of Biology and Ecology, Faculty of Science , P. J. Šafárik University , Kosice , Slovak Republic.
Fedorocko P; e Department of Cellular Biology, Institute of Biology and Ecology, Faculty of Science , P. J. Šafárik University , Kosice , Slovak Republic.
Kasparkova J; f Department of Biophysics, Faculty of Science , Palacke University , Olomouc , Czech Republic.
Brabec V; f Department of Biophysics, Faculty of Science , Palacke University , Olomouc , Czech Republic.
Rosocha J; d Associated Tissue Bank, Faculty of Medicine , P.J. Šafárik University , Kosice , Slovak Republic.
Soukup O; b Biomedical Research Center , University Hospital Hradec Kralove , Hradec Kralove , Czech Republic.; c Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences , University of Defence , Hradec Kralove , Czech Republic.
Hamulakova S; g Department of Organic Chemistry, Institute of Chemistry, Faculty of Science , P. J. Šafárik University , Kosice , Slovak Republic.
Kuca K; b Biomedical Research Center , University Hospital Hradec Kralove , Hradec Kralove , Czech Republic.
Kozurkova M; a Department of Biochemistry, Institute of Chemistry, Faculty of Science , P. J. Šafárik University , Kosice , Slovak Republic.; b Biomedical Research Center , University Hospital Hradec Kralove , Hradec Kralove , Czech Republic.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2019 Dec; Vol. 34 (1), pp. 877-897.
Typ publikacji:
Journal Article
MeSH Terms:
Acridines/*pharmacology
Antineoplastic Agents/*pharmacology
Tacrine/*pharmacology
Thiourea/*pharmacology
A549 Cells ; Acridines/chemical synthesis ; Acridines/chemistry ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Fibroblasts/drug effects ; HL-60 Cells ; Humans ; Structure-Activity Relationship ; Tacrine/chemistry ; Thiourea/chemistry
Czasopismo naukowe
Tytuł:
1-(Benzo[d]thiazol-2-yl)-3-phenylureas as dual inhibitors of casein kinase 1 and ABAD enzymes for treatment of neurodegenerative disorders.
Autorzy:
Benek O; a University of Hradec Kralove, Faculty of Science, Department of Chemistry , Hradec Kralove , Czech Republic.; b University Hospital in Hradec Kralove, Biomedical Research Center , Hradec Kralove , Czech Republic.; c National Institute of Mental Health , Klecany , Czech Republic.
Hroch L; b University Hospital in Hradec Kralove, Biomedical Research Center , Hradec Kralove , Czech Republic.
Aitken L; d University of St. Andrews, Medical and Biological Sciences Building, School of Biology , St. Andrews , UK.
Gunn-Moore F; d University of St. Andrews, Medical and Biological Sciences Building, School of Biology , St. Andrews , UK.
Vinklarova L; a University of Hradec Kralove, Faculty of Science, Department of Chemistry , Hradec Kralove , Czech Republic.; b University Hospital in Hradec Kralove, Biomedical Research Center , Hradec Kralove , Czech Republic.
Kuca K; a University of Hradec Kralove, Faculty of Science, Department of Chemistry , Hradec Kralove , Czech Republic.; b University Hospital in Hradec Kralove, Biomedical Research Center , Hradec Kralove , Czech Republic.
Perez DI; e Centro de Investigaciones Biologicas-CSIC , Madrid , Spain.
Perez C; f Instituto de Quimica Medica-CSIC , Madrid , Spain.
Martinez A; e Centro de Investigaciones Biologicas-CSIC , Madrid , Spain.
Fisar Z; g Charles University and General University Hospital in Prague, First Faculty of Medicine, Department of Psychiatry , Prague , Czech Republic.
Musilek K; a University of Hradec Kralove, Faculty of Science, Department of Chemistry , Hradec Kralove , Czech Republic.; b University Hospital in Hradec Kralove, Biomedical Research Center , Hradec Kralove , Czech Republic.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2018 Dec; Vol. 33 (1), pp. 665-670.
Typ publikacji:
Journal Article
MeSH Terms:
3-Hydroxyacyl CoA Dehydrogenases/*metabolism
Casein Kinase I/*antagonists & inhibitors
Enzyme Inhibitors/*pharmacology
Neurodegenerative Diseases/*drug therapy
Phenylurea Compounds/*pharmacology
Casein Kinase I/metabolism ; Dose-Response Relationship, Drug ; Enzyme Inhibitors/chemistry ; Humans ; Molecular Structure ; Neurodegenerative Diseases/metabolism ; Phenylurea Compounds/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł:
Profiling donepezil template into multipotent hybrids with antioxidant properties.
Autorzy:
Mezeiova E; a Biomedical Research Centre, University Hospital Hradec Kralove , Hradec Kralove , Czech Republic.; b National Institute of Mental Health , Klecany , Czech Republic.
Spilovska K; a Biomedical Research Centre, University Hospital Hradec Kralove , Hradec Kralove , Czech Republic.; b National Institute of Mental Health , Klecany , Czech Republic.; d Department of Chemistry , University of Hradec Kralove , Hradec Kralove , Czech Republic.
Nepovimova E; a Biomedical Research Centre, University Hospital Hradec Kralove , Hradec Kralove , Czech Republic.; c Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences , Hradec Kralove , Czech Republic.; d Department of Chemistry , University of Hradec Kralove , Hradec Kralove , Czech Republic.
Gorecki L; a Biomedical Research Centre, University Hospital Hradec Kralove , Hradec Kralove , Czech Republic.; c Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences , Hradec Kralove , Czech Republic.
Soukup O; a Biomedical Research Centre, University Hospital Hradec Kralove , Hradec Kralove , Czech Republic.; b National Institute of Mental Health , Klecany , Czech Republic.
Dolezal R; a Biomedical Research Centre, University Hospital Hradec Kralove , Hradec Kralove , Czech Republic.
Malinak D; a Biomedical Research Centre, University Hospital Hradec Kralove , Hradec Kralove , Czech Republic.; d Department of Chemistry , University of Hradec Kralove , Hradec Kralove , Czech Republic.
Janockova J; a Biomedical Research Centre, University Hospital Hradec Kralove , Hradec Kralove , Czech Republic.
Jun D; a Biomedical Research Centre, University Hospital Hradec Kralove , Hradec Kralove , Czech Republic.; c Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences , Hradec Kralove , Czech Republic.
Kuca K; a Biomedical Research Centre, University Hospital Hradec Kralove , Hradec Kralove , Czech Republic.; d Department of Chemistry , University of Hradec Kralove , Hradec Kralove , Czech Republic.
Korabecny J; a Biomedical Research Centre, University Hospital Hradec Kralove , Hradec Kralove , Czech Republic.; c Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences , Hradec Kralove , Czech Republic.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2018 Dec; Vol. 33 (1), pp. 583-606.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Acetylcholinesterase/*metabolism
Alzheimer Disease/*drug therapy
Antioxidants/*pharmacology
Cholinesterase Inhibitors/*pharmacology
Indans/*pharmacology
Piperidines/*pharmacology
Alzheimer Disease/metabolism ; Antioxidants/chemistry ; Cholinesterase Inhibitors/chemistry ; Donepezil ; Humans ; Indans/chemistry ; Molecular Structure ; Piperidines/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł:
Evaluation of the antioxidant activity of several naturally occurring coumarins and their synthesized analogues by "ferric reducing antioxidant power" assay.
Autorzy:
Rehakova Z; Department of Pharmaceutical Botany and Ecology, Faculty of Pharmacy .
Koleckar V
Jahodar L
Opletal L
Macakova K
Cahlikova L
Jun D
Kuca K
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2014 Feb; Vol. 29 (1), pp. 49-54. Date of Electronic Publication: 2013 Jan 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antioxidants/*pharmacology
Coumarins/*pharmacology
Ferric Compounds/*chemistry
Oxidation-Reduction
Czasopismo naukowe
Tytuł:
The preparation, in vitro screening and molecular docking of symmetrical bisquaternary cholinesterase inhibitors containing a but-(2E)-en-1,4-diyl connecting linkage.
Autorzy:
Musilek K; Department of Toxicology, University of Defence, Faculty of Military Health Sciences, Trebesska 1575, Hradec Kralove, Czech Republic. />Pavlikova R
Marek J
Komloova M
Holas O
Hrabinova M
Pohanka M
Dohnal V
Dolezal M
Gunn-Moore F
Kuca K
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2011 Apr; Vol. 26 (2), pp. 245-53.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cholinesterase Inhibitors/*chemical synthesis
Enzyme Activation/*drug effects
Binding Sites ; Catalytic Domain ; Cholinesterase Inhibitors/chemistry ; Cholinesterase Inhibitors/pharmacology ; Erythrocytes/enzymology ; Humans ; Inhibitory Concentration 50 ; Models, Molecular ; Molecular Structure ; Spectrometry, Mass, Electrospray Ionization ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł:
Changes of rat plasma total low molecular weight antioxidant level after tabun exposure and consequent treatment by acetylcholinesterase reactivators.
Autorzy:
Pohanka M; Centre of Advanced Studies, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic. />Karasova JZ
Musilek K
Kuca K
Jung YS
Kassa J
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2011 Feb; Vol. 26 (1), pp. 93-7. Date of Electronic Publication: 2010 Jun 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antidotes/*pharmacology
Cholinesterase Inhibitors/*toxicity
Cholinesterase Reactivators/*pharmacology
Organophosphates/*toxicity
Oxidative Stress/*drug effects
Oximes/*pharmacology
Acetylcholinesterase/blood ; Animals ; Antidotes/chemical synthesis ; Antioxidants/analysis ; Atropine/pharmacology ; Cholinesterase Reactivators/chemical synthesis ; Male ; Molecular Weight ; Oximes/chemical synthesis ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł:
A comparison of tabun-inhibited rat brain acetylcholinesterase reactivation by three oximes (HI-6, obidoxime, and K048) in vivo detected by biochemical and histochemical techniques.
Autorzy:
Bajgar J; Department of Toxicology, Faculty of Military Health Sciences, University of Defense, Trebesska, Hradec Kralove, Czech Republic. />Hajek P
Zdarova JK
Kassa J
Paseka A
Slizova D
Krs O
Kuca K
Jun D
Fusek J
Capek L
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2010 Dec; Vol. 25 (6), pp. 790-7.
Typ publikacji:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Brain/*drug effects
Cholinesterase Reactivators/*pharmacology
Obidoxime Chloride/*pharmacology
Organophosphates/*antagonists & inhibitors
Organophosphates/*toxicity
Oximes/*pharmacology
Pyridinium Compounds/*pharmacology
Acetylcholinesterase/metabolism ; Animals ; Atropine ; Brain/enzymology ; Brain/pathology ; Chemical Warfare Agents/toxicity ; Cholinesterase Inhibitors/administration & dosage ; Cholinesterase Inhibitors/toxicity ; Cholinesterase Reactivators/administration & dosage ; Cholinesterase Reactivators/therapeutic use ; Female ; Frontal Lobe/drug effects ; Frontal Lobe/enzymology ; Frontal Lobe/pathology ; GPI-Linked Proteins/metabolism ; Lethal Dose 50 ; Obidoxime Chloride/administration & dosage ; Obidoxime Chloride/therapeutic use ; Organ Specificity ; Organophosphates/administration & dosage ; Oximes/administration & dosage ; Oximes/therapeutic use ; Pyridinium Compounds/administration & dosage ; Pyridinium Compounds/therapeutic use ; Rats ; Rats, Wistar ; Reticular Formation/drug effects ; Reticular Formation/enzymology ; Reticular Formation/pathology
Czasopismo naukowe
Tytuł:
A comparison of reactivating and therapeutic efficacy of the oxime K203 and its fluorinated analog (KR-22836) with currently available oximes (obidoxime, trimedoxime, HI-6) against tabun in rats and mice.
Autorzy:
Kassa J; Department of Toxicology, Faculty of Military Health Sciences, Hradec Kralove, Czech Republic. />Karasova JZ
Caisberger F
Musilek K
Kuca K
Jung YS
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2010 Aug; Vol. 25 (4), pp. 480-4.
Typ publikacji:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antidotes/*pharmacology
Cholinesterase Reactivators/*pharmacology
Organophosphates/*toxicity
Oximes/*pharmacology
Pyridinium Compounds/*pharmacology
Animals ; Antidotes/therapeutic use ; Cholinesterase Inhibitors/toxicity ; Cholinesterase Reactivators/therapeutic use ; Mice ; Obidoxime Chloride/pharmacology ; Obidoxime Chloride/therapeutic use ; Oximes/therapeutic use ; Pyridinium Compounds/therapeutic use ; Rats ; Trimedoxime/pharmacology ; Trimedoxime/therapeutic use
Czasopismo naukowe
Tytuł:
In vivo experimental approach to treatment against tabun poisoning.
Autorzy:
Berend S; Institute for Medical Research and Occupational Health, Ksaverska c. 2, Zagreb, Croatia. />Katalinić M
Vrdoljak AL
Kovarik Z
Kuca K
Radić B
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2010 Aug; Vol. 25 (4), pp. 531-6.
Typ publikacji:
Comparative Study; Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Organophosphate Poisoning*
Atropine/*pharmacology
Cholinesterase Inhibitors/*poisoning
Oximes/*pharmacology
Protective Agents/*pharmacology
Animals ; Atropine/therapeutic use ; Butanes/pharmacology ; Butanes/therapeutic use ; Chemical Warfare Agents ; Mice ; Organophosphates ; Oximes/therapeutic use ; Protective Agents/therapeutic use ; Pyridinium Compounds/pharmacology ; Pyridinium Compounds/therapeutic use ; Survival Rate ; Treatment Outcome ; Trimedoxime/pharmacology ; Trimedoxime/therapeutic use
Czasopismo naukowe
Tytuł:
Oxime K027: novel low-toxic candidate for the universal reactivator of nerve agent- and pesticide-inhibited acetylcholinesterase.
Autorzy:
Kuca K; Center of Advanced Studies, Faculty of Military Health Sciences, University of Defense, Trebesska, Hradec Kralove, Czech Republic. />Musilek K
Jun D
Pohanka M
Ghosh KK
Hrabinova M
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2010 Aug; Vol. 25 (4), pp. 509-12.
Typ publikacji:
Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antidotes/*pharmacology
Cholinesterase Reactivators/*pharmacology
Oximes/*pharmacology
Pyridinium Compounds/*pharmacology
Chemical Warfare Agents/toxicity ; Cholinesterase Inhibitors/toxicity ; Oximes/therapeutic use ; Pesticides/toxicity ; Pyridinium Compounds/therapeutic use
Czasopismo naukowe
Tytuł:
Why acetylcholinesterase reactivators do not work in butyrylcholinesterase.
Autorzy:
Wiesner J; National Centre for Biomolecular Research, Faculty of Science, Masaryk University, Brno, Czech Republic.
Kríz Z
Kuca K
Jun D
Koca J
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2010 Jun; Vol. 25 (3), pp. 318-22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Acetylcholinesterase/*chemistry
Butyrylcholinesterase/*chemistry
Cholinesterase Reactivators/*chemistry
Animals ; Antidotes/chemistry ; Binding Sites ; Humans ; Mice ; Models, Molecular ; Organophosphate Poisoning ; Oximes/chemistry ; Oximes/therapeutic use ; Protein Conformation ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł:
New antioxidant flavonoid isolated from Leuzea carthamoides.
Autorzy:
Koleckar V; Department of Pharmaceutical Botany and Ecology, Faculty of Pharmacy, Charles University, Hradec Kralove, Czech Republic.
Opletal L
Macakova K
Jahodar L
Jun D
Kunes J
Kuca K
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2010 Feb; Vol. 25 (1), pp. 143-5.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antioxidants/*isolation & purification
Flavonoids/*isolation & purification
Leuzea/*chemistry
Antioxidants/chemistry ; Antioxidants/pharmacology ; Flavonoids/chemistry ; Flavonoids/pharmacology ; Magnetic Resonance Spectroscopy ; Spectrometry, Mass, Electrospray Ionization ; Spectrophotometry, Ultraviolet ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł:
A comparison of the reactivating and therapeutic efficacy of newly developed bispyridinium oximes (K250, K251) with commonly used oximes against tabun in rats and mice.
Autorzy:
Kassa J; Department of Toxicology, Faculty of Military Health Sciences, Hradec Kralove, Czech Republic. />Karasova J
Bajgar J
Kuca K
Musilek K
Kopelikova I
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2009 Aug; Vol. 24 (4), pp. 1040-4.
Typ publikacji:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antidotes/*pharmacology
Organophosphates/*toxicity
Oximes/*pharmacology
Pyridinium Compounds/*pharmacology
Animals ; Cholinesterase Inhibitors/toxicity ; Cholinesterase Reactivators/pharmacology ; Male ; Mice ; Obidoxime Chloride/pharmacology ; Oximes/chemistry ; Pyridinium Compounds/chemistry ; Rats ; Rats, Wistar ; Trimedoxime/pharmacology
Czasopismo naukowe

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