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Tytuł :
Association of deposition of tau and amyloid-β proteins with structural connectivity changes in cognitively normal older adults and Alzheimer's disease spectrum patients.
Autorzy :
Shigemoto Y; Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, Tokyo, Japan.; Department of Radiology, National Center of Neurology and Psychiatry, Tokyo, Japan.
Sone D; Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, Tokyo, Japan.; Department of Psychiatry, National Center of Neurology and Psychiatry, Tokyo, Japan.
Maikusa N; Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, Tokyo, Japan.
Okamura N; Division of Pharmacology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan.; Department of Geriatric and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Furumoto S; Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan.
Kudo Y; Department of Geriatric and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Ogawa M; Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, Tokyo, Japan.
Takano H; Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, Tokyo, Japan.; Department of Psychiatry, National Center of Neurology and Psychiatry, Tokyo, Japan.
Yokoi Y; Department of Psychiatry, National Center of Neurology and Psychiatry, Tokyo, Japan.
Sakata M; Department of Psychiatry, National Center of Neurology and Psychiatry, Tokyo, Japan.
Tsukamoto T; Department of Neurology, National Center of Neurology and Psychiatry, Tokyo, Japan.
Kato K; Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, Tokyo, Japan.
Sato N; Department of Radiology, National Center of Neurology and Psychiatry, Tokyo, Japan.
Matsuda H; Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, Tokyo, Japan.
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Źródło :
Brain and behavior [Brain Behav] 2018 Dec; Vol. 8 (12), pp. e01145. Date of Electronic Publication: 2018 Oct 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease/*pathology
Amyloid beta-Peptides/*metabolism
Brain/*pathology
Cognition/*physiology
tau Proteins/*metabolism
Aged ; Alzheimer Disease/metabolism ; Brain/metabolism ; Cognitive Dysfunction/metabolism ; Cognitive Dysfunction/pathology ; Female ; Humans ; Male ; Neural Pathways/metabolism ; Neural Pathways/pathology ; Positron-Emission Tomography/methods ; White Matter/metabolism ; White Matter/pathology
Czasopismo naukowe
Tytuł :
Correlations of F-THK5351 PET with Postmortem Burden of Tau and Astrogliosis in Alzheimer Disease.
Autorzy :
Harada R; Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan .; Department of Gerontology and Geriatrics, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Ishiki A; Department of Gerontology and Geriatrics, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Kai H; Department of Neurological Science, Tohoku University School of Medicine, Sendai, Japan.
Sato N; Department of Pathology, Tohoku University School of Medicine, Sendai, Japan.
Furukawa K; Department of Gerontology and Geriatrics, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.; Division of Community Medicine, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Furumoto S; Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan.
Tago T; Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan; and.
Tomita N; Department of Gerontology and Geriatrics, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Watanuki S; Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan.
Hiraoka K; Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan.
Ishikawa Y; Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan.
Funaki Y; Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan.
Nakamura T; Division of Pharmacology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Yoshikawa T; Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan.
Iwata R; Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan.
Tashiro M; Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan.
Sasano H; Department of Pathology, Tohoku University School of Medicine, Sendai, Japan.
Kitamoto T; Department of Neurological Science, Tohoku University School of Medicine, Sendai, Japan.
Yanai K; Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan.; Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan.
Arai H; Department of Gerontology and Geriatrics, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Kudo Y; Department of Gerontology and Geriatrics, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Okamura N; Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan.; Division of Pharmacology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
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Źródło :
Journal of nuclear medicine : official publication, Society of Nuclear Medicine [J Nucl Med] 2018 Apr; Vol. 59 (4), pp. 671-674. Date of Electronic Publication: 2017 Sep 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aminopyridines*
Positron-Emission Tomography*
Quinolines*
Alzheimer Disease/*complications
Alzheimer Disease/*metabolism
Gliosis/*complications
Gliosis/*diagnostic imaging
tau Proteins/*metabolism
Aged, 80 and over ; Alzheimer Disease/diagnostic imaging ; Humans ; Male ; Postmortem Changes
Czasopismo naukowe
Tytuł :
Development of molecular imaging probe targeted at Alzheimer's disease pathology.
Autorzy :
Okamura N
Harada R
Furumoto S
Nakamura T
Yanai K
Kudo Y
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Źródło :
Nihon yakurigaku zasshi. Folia pharmacologica Japonica [Nihon Yakurigaku Zasshi] 2017; Vol. 150 (4), pp. 172-176.
Typ publikacji :
Journal Article
MeSH Terms :
Alzheimer Disease/*pathology
Molecular Probes/*analysis
Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/metabolism ; Humans ; Molecular Probes/chemistry ; Molecular Probes/metabolism ; Positron-Emission Tomography ; Protein Structure, Secondary
Czasopismo naukowe
Tytuł :
Dynamic PET Measures of Tau Accumulation in Cognitively Normal Older Adults and Alzheimer's Disease Patients Measured Using [18F] THK-5351.
Autorzy :
Lockhart SN; Helen Wills Neuroscience Institute, University of California, Berkeley, California, United States of America.
Baker SL; Helen Wills Neuroscience Institute, University of California, Berkeley, California, United States of America.; Center of Functional Imaging, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America.
Okamura N; Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan.
Furukawa K; Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Ishiki A; Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Furumoto S; Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan.
Tashiro M; Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan.
Yanai K; Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan.; Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan.
Arai H; Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Kudo Y; Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Harada R; Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Tomita N; Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Hiraoka K; Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan.
Watanuki S; Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan.
Jagust WJ; Helen Wills Neuroscience Institute, University of California, Berkeley, California, United States of America.; Center of Functional Imaging, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America.
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Źródło :
PloS one [PLoS One] 2016 Jun 29; Vol. 11 (6), pp. e0158460. Date of Electronic Publication: 2016 Jun 29 (Print Publication: 2016).
Typ publikacji :
Journal Article
MeSH Terms :
Positron-Emission Tomography*
Alzheimer Disease/*diagnostic imaging
Aminopyridines/*chemistry
Fluorine Radioisotopes/*chemistry
Quinolines/*chemistry
tau Proteins/*metabolism
Aged ; Biomarkers/metabolism ; Brain/metabolism ; Brain Mapping/methods ; Case-Control Studies ; Cognition ; Frontal Lobe/diagnostic imaging ; Humans ; Temporal Lobe/diagnostic imaging ; Time Factors
Czasopismo naukowe
Tytuł :
Structure-Activity Relationship of 2-Arylquinolines as PET Imaging Tracers for Tau Pathology in Alzheimer Disease.
Autorzy :
Tago T; Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan Department of Radiopharmaceutical Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Furumoto S; Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan Department of Radiopharmaceutical Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan .
Okamura N; Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan; and.
Harada R; Division of Neuro-Imaging, Institute of Development, Aging and Cancer, Sendai, Japan.
Adachi H; Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan Department of Radiopharmaceutical Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Ishikawa Y; Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan.
Yanai K; Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan; and.
Iwata R; Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan.
Kudo Y; Division of Neuro-Imaging, Institute of Development, Aging and Cancer, Sendai, Japan.
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Źródło :
Journal of nuclear medicine : official publication, Society of Nuclear Medicine [J Nucl Med] 2016 Apr; Vol. 57 (4), pp. 608-14. Date of Electronic Publication: 2015 Dec 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease/*diagnostic imaging
Quinolines/*chemical synthesis
Radiopharmaceuticals/*chemical synthesis
Tauopathies/*diagnostic imaging
Animals ; Autoradiography ; Brain/diagnostic imaging ; Female ; Fluorine Radioisotopes ; Humans ; Isotope Labeling ; Mice ; Positron-Emission Tomography ; Pregnancy ; Protein Binding ; Structure-Activity Relationship ; Tissue Distribution ; tau Proteins/metabolism
Czasopismo naukowe
Tytuł :
[The trend of developing new disease-modifying drugs in Alzheimer's disease].
Autorzy :
Arai H
Furukawa K
Tomita N
Ishiki A
Okamura N
Kudo Y
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Źródło :
Nihon rinsho. Japanese journal of clinical medicine [Nihon Rinsho] 2016 Mar; Vol. 74 (3), pp. 411-6.
Typ publikacji :
English Abstract; Journal Article
MeSH Terms :
Alzheimer Disease/*drug therapy
Aging ; Amyloid/antagonists & inhibitors ; Amyloid/metabolism ; Humans ; tau Proteins/metabolism
Czasopismo naukowe
Tytuł :
[Tau imaging].
Autorzy :
Kudo Y
Furumoto S
Harada R
Okamura N
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Źródło :
Nihon rinsho. Japanese journal of clinical medicine [Nihon Rinsho] 2016 Mar; Vol. 74 (3), pp. 404-9.
Typ publikacji :
English Abstract; Journal Article
MeSH Terms :
Alzheimer Disease/*diagnosis
tau Proteins/*analysis
Alzheimer Disease/metabolism ; Cognition ; Humans ; Positron-Emission Tomography ; Radiopharmaceuticals/chemistry ; tau Proteins/metabolism
Czasopismo naukowe
Tytuł :
18F-THK5351: A Novel PET Radiotracer for Imaging Neurofibrillary Pathology in Alzheimer Disease.
Autorzy :
Harada R; Division of Neuro-imaging, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Okamura N; Division of Neuro-imaging, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan Division of Cyclotron Nuclear Medicine, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan .
Furumoto S; Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan.
Furukawa K; Department of Geriatrics and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan; and.
Ishiki A; Department of Geriatrics and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan; and.
Tomita N; Department of Geriatrics and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan; and.
Tago T; Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan.
Hiraoka K; Division of Cyclotron Nuclear Medicine, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan.
Watanuki S; Division of Cyclotron Nuclear Medicine, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan.
Shidahara M; Division of Cyclotron Nuclear Medicine, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan Division of Medical Physics, Tohoku University School of Medicine, Sendai, Japan.
Miyake M; Division of Cyclotron Nuclear Medicine, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan.
Ishikawa Y; Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan.
Matsuda R; Division of Cyclotron Nuclear Medicine, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan.
Inami A; Division of Cyclotron Nuclear Medicine, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan.
Yoshikawa T; Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan.
Funaki Y; Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan.
Iwata R; Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan.
Tashiro M; Division of Cyclotron Nuclear Medicine, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan.
Yanai K; Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan.
Arai H; Department of Geriatrics and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan; and.
Kudo Y; Division of Neuro-imaging, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan.
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Źródło :
Journal of nuclear medicine : official publication, Society of Nuclear Medicine [J Nucl Med] 2016 Feb; Vol. 57 (2), pp. 208-14. Date of Electronic Publication: 2015 Nov 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Radiopharmaceuticals*/adverse effects
Radiopharmaceuticals*/chemical synthesis
Radiopharmaceuticals*/pharmacokinetics
Alzheimer Disease/*diagnostic imaging
Neurofibrillary Tangles/*diagnostic imaging
Positron-Emission Tomography/*methods
Alzheimer Disease/pathology ; Aminopyridines/adverse effects ; Aminopyridines/chemical synthesis ; Aminopyridines/pharmacokinetics ; Animals ; Autoradiography ; Biotransformation ; Brain/diagnostic imaging ; Brain/metabolism ; Hippocampus/metabolism ; Magnetic Resonance Imaging ; Mice ; Mice, Inbred ICR ; Neurofibrillary Tangles/pathology ; Quinolines/adverse effects ; Quinolines/chemical synthesis ; Quinolines/pharmacokinetics ; Radiation Dosage ; Tissue Distribution ; White Matter/diagnostic imaging ; White Matter/metabolism ; tau Proteins/metabolism
Czasopismo naukowe
Tytuł :
Characteristics of Tau and Its Ligands in PET Imaging.
Autorzy :
Harada R; Division of Neuro-imaging, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan. .
Okamura N; Division of Neuro-imaging, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan. .; Department of Pharmacology, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan. .
Furumoto S; Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, 6-3Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan. .
Tago T; Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, 6-3Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan. .
Yanai K; Department of Pharmacology, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan. .
Arai H; Department of Geriatrics and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan. .
Kudo Y; Division of Neuro-imaging, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan. .; Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, 6-3Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan. .
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Źródło :
Biomolecules [Biomolecules] 2016 Jan 06; Vol. 6 (1), pp. 7. Date of Electronic Publication: 2016 Jan 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Alzheimer Disease/*diagnostic imaging
Positron-Emission Tomography/*methods
Tauopathies/*diagnostic imaging
tau Proteins/*metabolism
Alzheimer Disease/metabolism ; Binding Sites ; Humans ; Ligands ; Protein Binding ; Protein Structure, Secondary ; Radiopharmaceuticals/metabolism ; Tauopathies/metabolism ; tau Proteins/chemistry
Czasopismo naukowe
Tytuł :
Longitudinal Assessment of Tau Pathology in Patients with Alzheimer's Disease Using [18F]THK-5117 Positron Emission Tomography.
Autorzy :
Ishiki A; Department of Geriatrics and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, Sendai city, Miyagi prefecture, Japan.
Okamura N; Department of Pharmacology, Tohoku University School of Medicine, Sendai city, Miyagi prefecture, Japan; Division of Neuro-imaging, Institute of Development, Aging and Cancer, Tohoku University, Sendai city, Miyagi prefecture, Japan.
Furukawa K; Department of Geriatrics and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, Sendai city, Miyagi prefecture, Japan.
Furumoto S; Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, Sendai city, Miyagi prefecture, Japan.
Harada R; Division of Neuro-imaging, Institute of Development, Aging and Cancer, Tohoku University, Sendai city, Miyagi prefecture, Japan.
Tomita N; Department of Geriatrics and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, Sendai city, Miyagi prefecture, Japan.
Hiraoka K; Division of Cyclotron Nuclear Medicine, Cyclotron and Radioisotope Center, Tohoku University, Sendai city, Miyagi prefecture, Japan.
Watanuki S; Division of Cyclotron Nuclear Medicine, Cyclotron and Radioisotope Center, Tohoku University, Sendai city, Miyagi prefecture, Japan.
Ishikawa Y; Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, Sendai city, Miyagi prefecture, Japan.
Tago T; Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, Sendai city, Miyagi prefecture, Japan.
Funaki Y; Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, Sendai city, Miyagi prefecture, Japan.
Iwata R; Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, Sendai city, Miyagi prefecture, Japan.
Tashiro M; Division of Cyclotron Nuclear Medicine, Cyclotron and Radioisotope Center, Tohoku University, Sendai city, Miyagi prefecture, Japan.
Yanai K; Department of Pharmacology, Tohoku University School of Medicine, Sendai city, Miyagi prefecture, Japan.
Kudo Y; Division of Neuro-imaging, Institute of Development, Aging and Cancer, Tohoku University, Sendai city, Miyagi prefecture, Japan; Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, Sendai city, Miyagi prefecture, Japan.
Arai H; Department of Geriatrics and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, Sendai city, Miyagi prefecture, Japan.
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Źródło :
PloS one [PLoS One] 2015 Oct 13; Vol. 10 (10), pp. e0140311. Date of Electronic Publication: 2015 Oct 13 (Print Publication: 2015).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aniline Compounds*
Positron-Emission Tomography*
Quinolines*
Alzheimer Disease/*diagnostic imaging
Alzheimer Disease/*pathology
tau Proteins/*metabolism
Aged ; Aged, 80 and over ; Case-Control Studies ; Demography ; Female ; Humans ; Longitudinal Studies ; Male
Czasopismo naukowe
Tytuł :
[(18)F]THK-5117 PET for assessing neurofibrillary pathology in Alzheimer's disease.
Autorzy :
Harada R; Division of Neuro-imaging, Institute of Development, Aging and Cancer, Tohoku University, Sendai, 980-8575, Japan.
Okamura N
Furumoto S
Furukawa K
Ishiki A
Tomita N
Hiraoka K
Watanuki S
Shidahara M
Miyake M
Ishikawa Y
Matsuda R
Inami A
Yoshikawa T
Tago T
Funaki Y
Iwata R
Tashiro M
Yanai K
Arai H
Kudo Y
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Źródło :
European journal of nuclear medicine and molecular imaging [Eur J Nucl Med Mol Imaging] 2015 Jun; Vol. 42 (7), pp. 1052-61. Date of Electronic Publication: 2015 Mar 20.
Typ publikacji :
Comparative Study; Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Positron-Emission Tomography*
Radiopharmaceuticals*
Alzheimer Disease/*diagnostic imaging
Aniline Compounds/*pharmacokinetics
Neurofibrils/*diagnostic imaging
Quinolines/*pharmacokinetics
Aged ; Aged, 80 and over ; Alzheimer Disease/pathology ; Aniline Compounds/pharmacology ; Benzothiazoles ; Case-Control Studies ; Cerebral Cortex/diagnostic imaging ; Cerebral Cortex/pathology ; Female ; Humans ; Male ; Neurofibrils/pathology ; Quinolines/pharmacology ; Thiazoles
Czasopismo naukowe
Tytuł :
Cortical laminar binding of PET amyloid and tau tracers in Alzheimer disease.
Autorzy :
Li Y; Center for Brain Health, New York University, New York, New York Shandong University, Shandong, China.
Tsui W; Center for Brain Health, New York University, New York, New York.
Rusinek H; Center for Brain Health, New York University, New York, New York.
Butler T; Center for Brain Health, New York University, New York, New York Cornell University, Ithaca, New York.
Mosconi L; Center for Brain Health, New York University, New York, New York.
Pirraglia E; Center for Brain Health, New York University, New York, New York.
Mozley D; Cornell University, Ithaca, New York.
Vallabhajosula S; Cornell University, Ithaca, New York.
Harada R; Institute of Development, Aging, and Cancer, Sendai, Japan.
Furumoto S; Cyclotron and Radioisotope Center, Sendai, Japan.
Furukawa K; Institute of Development, Aging, and Cancer, Sendai, Japan.
Arai H; Institute of Development, Aging, and Cancer, Sendai, Japan.
Kudo Y; Institute of Development, Aging, and Cancer, Sendai, Japan.
Okamura N; Institute of Development, Aging, and Cancer, Sendai, Japan Tohoku University School of Medicine, Sendai, Japan; and.
de Leon MJ; Center for Brain Health, New York University, New York, New York The Steven and Alexandra Cohen Veterans Center at NYU, New York, New York .
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Źródło :
Journal of nuclear medicine : official publication, Society of Nuclear Medicine [J Nucl Med] 2015 Feb; Vol. 56 (2), pp. 270-3. Date of Electronic Publication: 2015 Jan 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Positron-Emission Tomography*
Alzheimer Disease/*diagnostic imaging
Amyloid/*chemistry
Amyloid beta-Peptides/*chemistry
tau Proteins/*chemistry
Aged ; Aged, 80 and over ; Alzheimer Disease/diagnosis ; Biomarkers, Tumor/chemistry ; Carbon Radioisotopes/chemistry ; Cerebral Cortex/diagnostic imaging ; Disease Progression ; Female ; Fluorine Radioisotopes/chemistry ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neurofibrillary Tangles/diagnostic imaging
Czasopismo naukowe
Tytuł :
Pitfalls of voxel-based amyloid PET analyses for diagnosis of Alzheimer's disease: artifacts due to non-specific uptake in the white matter and the skull.
Autorzy :
Arai A; Department of Diagnostic Radiology, Tohoku University School of Medicine.
Kaneta T
Okamura N
Tashiro M
Iwata R
Takanami K
Fukuda H
Takahashi S
Yanai K
Kudo Y
Arai H
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Źródło :
The Tohoku journal of experimental medicine [Tohoku J Exp Med] 2014 Nov; Vol. 234 (3), pp. 175-81.
Typ publikacji :
Journal Article
MeSH Terms :
Amyloid*
Artifacts*
Positron-Emission Tomography*
Alzheimer Disease/*diagnostic imaging
Skull/*diagnostic imaging
White Matter/*diagnostic imaging
Aged ; Alzheimer Disease/pathology ; Benzoxazoles ; Cognitive Dysfunction/diagnostic imaging ; Dementia/diagnostic imaging ; Demography ; Female ; Humans ; Male ; Thiazoles ; White Matter/pathology
Czasopismo naukowe
Tytuł :
Tau PET imaging in Alzheimer's disease.
Autorzy :
Okamura N; Department of Pharmacology, Tohoku University School of Medicine, 2-1, Seiryo-machi, Aoba-ku, Sendai, 9808575, Japan, .
Harada R
Furumoto S
Arai H
Yanai K
Kudo Y
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Źródło :
Current neurology and neuroscience reports [Curr Neurol Neurosci Rep] 2014 Nov; Vol. 14 (11), pp. 500.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Radiopharmaceuticals*
Alzheimer Disease/*diagnostic imaging
Alzheimer Disease/*metabolism
Positron-Emission Tomography/*methods
tau Proteins/*metabolism
Humans ; Protein Binding/drug effects
Czasopismo naukowe
Tytuł :
Non-invasive assessment of Alzheimer's disease neurofibrillary pathology using 18F-THK5105 PET.
Autorzy :
Okamura N; 1 Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan .
Furumoto S; 2 Cyclotron and Radioisotope Centre, Tohoku University, Sendai, Japan.
Fodero-Tavoletti MT; 3 The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Australia4 Centre for PET, Austin Health, Melbourne, Australia.
Mulligan RS; 4 Centre for PET, Austin Health, Melbourne, Australia.
Harada R; 1 Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan.
Yates P; 4 Centre for PET, Austin Health, Melbourne, Australia.
Pejoska S; 4 Centre for PET, Austin Health, Melbourne, Australia.
Kudo Y; 5 Clinical Research, Innovation and Education Centre, Tohoku University Hospital, Sendai, Japan.
Masters CL; 3 The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Australia6 The Mental Health Research Institute, Melbourne, Australia.
Yanai K; 1 Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan2 Cyclotron and Radioisotope Centre, Tohoku University, Sendai, Japan.
Rowe CC; 4 Centre for PET, Austin Health, Melbourne, Australia.
Villemagne VL; 3 The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Australia4 Centre for PET, Austin Health, Melbourne, Australia.
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Źródło :
Brain : a journal of neurology [Brain] 2014 Jun; Vol. 137 (Pt 6), pp. 1762-71. Date of Electronic Publication: 2014 Mar 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aniline Compounds*
Positron-Emission Tomography*/methods
Quinolines*
Alzheimer Disease/*pathology
Neurofibrillary Tangles/*pathology
Plaque, Amyloid/*pathology
Aged ; Aged, 80 and over ; Alzheimer Disease/diagnostic imaging ; Amyloid beta-Peptides/metabolism ; Brain Mapping/methods ; Carbon Radioisotopes ; Female ; Humans ; Male ; Neurofibrillary Tangles/diagnostic imaging ; Radiopharmaceuticals ; Thiazoles
Czasopismo naukowe
Tytuł :
In vivo evaluation of a novel tau imaging tracer for Alzheimer's disease.
Autorzy :
Villemagne VL; Centre for PET, Austin Health, Melbourne, Australia, .
Furumoto S
Fodero-Tavoletti MT
Mulligan RS
Hodges J
Harada R
Yates P
Piguet O
Pejoska S
Doré V
Yanai K
Masters CL
Kudo Y
Rowe CC
Okamura N
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Źródło :
European journal of nuclear medicine and molecular imaging [Eur J Nucl Med Mol Imaging] 2014 May; Vol. 41 (5), pp. 816-26. Date of Electronic Publication: 2014 Feb 11.
Typ publikacji :
Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aniline Compounds*/pharmacokinetics
Quinolines*/pharmacokinetics
Radiopharmaceuticals*/pharmacokinetics
Alzheimer Disease/*diagnostic imaging
tau Proteins/*metabolism
Aged ; Aged, 80 and over ; Amyloid beta-Peptides/metabolism ; Brain/diagnostic imaging ; Case-Control Studies ; Female ; Frontotemporal Dementia/diagnostic imaging ; Humans ; Male ; Middle Aged ; Positron-Emission Tomography ; Protein Binding ; Thiazoles/pharmacokinetics ; Tissue Distribution
Czasopismo naukowe
Tytuł :
Analysis of early phase [11C]BF-227 PET, and its application for anatomical standardization of late-phase images for 3D-SSP analysis.
Autorzy :
Kaneta T; Department of Diagnostic Radiology, Tohoku University, 1-1 Seiryomachi, Aobaku, Sendai, 980-8574, Japan, .
Okamura N
Arai A
Takanami K
Furukawa K
Tashiro M
Furumoto S
Iwata R
Takahashi S
Arai H
Yanai K
Kudo Y
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Źródło :
Japanese journal of radiology [Jpn J Radiol] 2014 Mar; Vol. 32 (3), pp. 138-44. Date of Electronic Publication: 2014 Jan 10.
Typ publikacji :
Journal Article
MeSH Terms :
Benzoxazoles*
Thiazoles*
Alzheimer Disease/*diagnostic imaging
Cognitive Dysfunction/*diagnostic imaging
Imaging, Three-Dimensional/*methods
Positron-Emission Tomography/*methods
Aged ; Brain/diagnostic imaging ; Carbon Radioisotopes ; Female ; Fluorodeoxyglucose F18 ; Humans ; Male ; Radiopharmaceuticals ; Reproducibility of Results
Czasopismo naukowe
Tytuł :
Use of a benzimidazole derivative BF-188 in fluorescence multispectral imaging for selective visualization of tau protein fibrils in the Alzheimer's disease brain.
Autorzy :
Harada R; Department of Pharmacology, Tohoku University School of Medicine, 2-1, Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan.
Okamura N
Furumoto S
Yoshikawa T
Arai H
Yanai K
Kudo Y
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Źródło :
Molecular imaging and biology [Mol Imaging Biol] 2014 Feb; Vol. 16 (1), pp. 19-27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Benzimidazoles*/chemistry
Butadienes*/chemistry
Alzheimer Disease/*diagnosis
Alzheimer Disease/*metabolism
Amyloid/*metabolism
Diagnostic Imaging/*methods
tau Proteins/*analysis
Aged ; Aged, 80 and over ; Amyloid/analysis ; Amyloid beta-Peptides/metabolism ; Animals ; Blood-Brain Barrier/metabolism ; Brain/metabolism ; Brain/pathology ; Female ; Humans ; Lewy Bodies/pathology ; Male ; Mice ; Neurofibrillary Tangles/metabolism ; Neurofibrillary Tangles/pathology ; Permeability ; Phosphorylation ; Plaque, Amyloid/diagnosis ; Plaque, Amyloid/metabolism ; Plaque, Amyloid/pathology ; Spectrometry, Fluorescence ; tau Proteins/metabolism
Czasopismo naukowe
Tytuł :
Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls.
Autorzy :
Maruyama M; Molecular Imaging Center, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba, Chiba 263-8555, Japan.
Shimada H
Suhara T
Shinotoh H
Ji B
Maeda J
Zhang MR
Trojanowski JQ
Lee VM
Ono M
Masamoto K
Takano H
Sahara N
Iwata N
Okamura N
Furumoto S
Kudo Y
Chang Q
Saido TC
Takashima A
Lewis J
Jang MK
Aoki I
Ito H
Higuchi M
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Źródło :
Neuron [Neuron] 2013 Sep 18; Vol. 79 (6), pp. 1094-108.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease/*pathology
Brain/*pathology
Tauopathies/*pathology
tau Proteins/*metabolism
Age Factors ; Aged ; Alzheimer Disease/diagnostic imaging ; Aminopyridines/pharmacokinetics ; Amyloid beta-Peptides/metabolism ; Aniline Compounds ; Animals ; Autoradiography ; Benzothiazoles/chemistry ; Benzothiazoles/pharmacokinetics ; Brain/diagnostic imaging ; Brain/drug effects ; Brain Mapping ; Calcium-Binding Proteins ; Carbon Isotopes/pharmacokinetics ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Microfilament Proteins ; Middle Aged ; Mutation/genetics ; Positron-Emission Tomography ; Protein Structure, Secondary ; Tauopathies/diagnostic imaging ; Thiazoles ; tau Proteins/genetics
Czasopismo naukowe
Tytuł :
Novel 18F-labeled arylquinoline derivatives for noninvasive imaging of tau pathology in Alzheimer disease.
Autorzy :
Okamura N; Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan. />Furumoto S
Harada R
Tago T
Yoshikawa T
Fodero-Tavoletti M
Mulligan RS
Villemagne VL
Akatsu H
Yamamoto T
Arai H
Iwata R
Yanai K
Kudo Y
Pokaż więcej
Źródło :
Journal of nuclear medicine : official publication, Society of Nuclear Medicine [J Nucl Med] 2013 Aug; Vol. 54 (8), pp. 1420-7. Date of Electronic Publication: 2013 Jul 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Fluorine Radioisotopes*
Alzheimer Disease/*diagnostic imaging
Alzheimer Disease/*metabolism
Aniline Compounds/*chemistry
Quinolines/*chemistry
tau Proteins/*chemistry
tau Proteins/*metabolism
Aniline Compounds/pharmacokinetics ; Aniline Compounds/toxicity ; Animals ; Female ; Male ; Mice ; Positron-Emission Tomography ; Quinolines/pharmacokinetics ; Quinolines/toxicity ; Radiochemistry ; Rats ; Receptors, Neurotransmitter/metabolism
Czasopismo naukowe

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