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Tytuł :
Innate, non-cytolytic CD8+ T cell-mediated suppression of HIV replication by MHC-independent inhibition of virus transcription.
Autorzy :
Zanoni M; Division of Microbiology and Immunology, Yerkes National Primate Research Center, and Emory Vaccine Center Emory University, Atlanta, Georgia, United States of America.
Palesch D; Division of Microbiology and Immunology, Yerkes National Primate Research Center, and Emory Vaccine Center Emory University, Atlanta, Georgia, United States of America.
Pinacchio C; Division of Microbiology and Immunology, Yerkes National Primate Research Center, and Emory Vaccine Center Emory University, Atlanta, Georgia, United States of America.
Statzu M; Division of Microbiology and Immunology, Yerkes National Primate Research Center, and Emory Vaccine Center Emory University, Atlanta, Georgia, United States of America.
Tharp GK; Division of Microbiology and Immunology, Yerkes National Primate Research Center, and Emory Vaccine Center Emory University, Atlanta, Georgia, United States of America.
Paiardini M; Division of Microbiology and Immunology, Yerkes National Primate Research Center, and Emory Vaccine Center Emory University, Atlanta, Georgia, United States of America.
Chahroudi A; Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, United States of America.
Bosinger SE; Division of Microbiology and Immunology, Yerkes National Primate Research Center, and Emory Vaccine Center Emory University, Atlanta, Georgia, United States of America.
Yoon J; Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, United States of America.
Cox B; Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, United States of America.
Silvestri G; Division of Microbiology and Immunology, Yerkes National Primate Research Center, and Emory Vaccine Center Emory University, Atlanta, Georgia, United States of America.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America.
Kulpa DA; Division of Microbiology and Immunology, Yerkes National Primate Research Center, and Emory Vaccine Center Emory University, Atlanta, Georgia, United States of America.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Sep 17; Vol. 16 (9), pp. e1008821. Date of Electronic Publication: 2020 Sep 17 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunity, Innate*
CD8-Positive T-Lymphocytes/*immunology
HIV-1/*physiology
Histocompatibility Antigens Class I/*immunology
Transcription, Genetic/*immunology
Virus Replication/*immunology
Animals ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/pathology ; Cell Proliferation ; Humans ; Macaca
Czasopismo naukowe
Tytuł :
Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8 cells.
Autorzy :
McBrien JB; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
Mavigner M; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Franchitti L; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
Smith SA; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
White E; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
Tharp GK; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
Walum H; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
Busman-Sahay K; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR, USA.
Aguilera-Sandoval CR; International Center for the Advancement of Translational Science, Division of Infectious Diseases, Center for AIDS Research, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Thayer WO; International Center for the Advancement of Translational Science, Division of Infectious Diseases, Center for AIDS Research, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Spagnuolo RA; International Center for the Advancement of Translational Science, Division of Infectious Diseases, Center for AIDS Research, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Kovarova M; International Center for the Advancement of Translational Science, Division of Infectious Diseases, Center for AIDS Research, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Wahl A; International Center for the Advancement of Translational Science, Division of Infectious Diseases, Center for AIDS Research, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Cervasi B; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
Margolis DM; International Center for the Advancement of Translational Science, Division of Infectious Diseases, Center for AIDS Research, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; University of North Carolina HIV Cure Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Vanderford TH; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
Carnathan DG; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
Paiardini M; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Lifson JD; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Lee JH; NantKwest, Culver City, CA, USA.
Safrit JT; NantKwest, Culver City, CA, USA.
Bosinger SE; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Estes JD; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR, USA.; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA.
Derdeyn CA; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Garcia JV; International Center for the Advancement of Translational Science, Division of Infectious Diseases, Center for AIDS Research, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Kulpa DA; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Chahroudi A; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.; Emory + Children's Center for Childhood Infections and Vaccines, Atlanta, GA, USA.
Silvestri G; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA. .; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA. .
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Źródło :
Nature [Nature] 2020 Feb; Vol. 578 (7793), pp. 154-159. Date of Electronic Publication: 2020 Jan 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Virus Replication*/immunology
CD8-Positive T-Lymphocytes/*immunology
Interleukin-15/*agonists
Simian Immunodeficiency Virus/*physiology
Animals ; CD4-Positive T-Lymphocytes/virology ; HIV Infections/immunology ; HIV Infections/virology ; Humans ; Interleukin-15/immunology ; Lymphocyte Depletion ; Macaca mulatta ; Mice ; Simian Acquired Immunodeficiency Syndrome/immunology ; Simian Acquired Immunodeficiency Syndrome/virology ; Virus Latency
Czasopismo naukowe
Tytuł :
Author Correction: Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8 cells.
Autorzy :
McBrien JB; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
Mavigner M; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Franchitti L; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
Smith SA; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
White E; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
Tharp GK; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
Walum H; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
Busman-Sahay K; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR, USA.
Aguilera-Sandoval CR; International Center for the Advancement of Translational Science, Division of Infectious Diseases, Center for AIDS Research, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Thayer WO; International Center for the Advancement of Translational Science, Division of Infectious Diseases, Center for AIDS Research, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Spagnuolo RA; International Center for the Advancement of Translational Science, Division of Infectious Diseases, Center for AIDS Research, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Kovarova M; International Center for the Advancement of Translational Science, Division of Infectious Diseases, Center for AIDS Research, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Wahl A; International Center for the Advancement of Translational Science, Division of Infectious Diseases, Center for AIDS Research, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Cervasi B; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
Margolis DM; International Center for the Advancement of Translational Science, Division of Infectious Diseases, Center for AIDS Research, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; University of North Carolina HIV Cure Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Vanderford TH; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
Carnathan DG; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
Paiardini M; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Lifson JD; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Lee JH; NantKwest, Culver City, CA, USA.
Safrit JT; NantKwest, Culver City, CA, USA.
Bosinger SE; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Estes JD; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR, USA.; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA.
Derdeyn CA; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Garcia JV; International Center for the Advancement of Translational Science, Division of Infectious Diseases, Center for AIDS Research, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Kulpa DA; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Chahroudi A; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.; Emory + Children's Center for Childhood Infections and Vaccines, Atlanta, GA, USA.
Silvestri G; Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA. .; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA. .
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Źródło :
Nature [Nature] 2020 Feb; Vol. 578 (7796), pp. E21.
Typ publikacji :
Published Erratum
Tytuł :
Differentiation into an Effector Memory Phenotype Potentiates HIV-1 Latency Reversal in CD4 T Cells.
Autorzy :
Kulpa DA; Department of Pediatrics, Emory University, Atlanta, Georgia, USA deanna.kulpa@emory.edu .
Talla A; Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.
Brehm JH; ViiV Healthcare, Research Triangle Park, North Carolina, USA.
Ribeiro SP; Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.
Yuan S; Janssen Pharmaceuticals, Springhouse, Pennsylvania, USA.
Bebin-Blackwell AG; University of Georgia, Athens, Georgia, USA.
Miller M; Infectious Disease, Merck & Co., Inc., West Point, Pennsylvania, USA.
Barnard R; Infectious Disease, Merck & Co., Inc., West Point, Pennsylvania, USA.
Deeks SG; Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
Hazuda D; Infectious Disease, Merck & Co., Inc., West Point, Pennsylvania, USA.
Chomont N; Centre de Recherche du CHUM, Montréal, Quebec, Canada.; Université de Montréal, Department of Microbiology, Infectiology, and Immunology, Montréal, Quebec, Canada.
Sékaly RP; Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA deanna.kulpa@emory.edu .
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Źródło :
Journal of virology [J Virol] 2019 Nov 26; Vol. 93 (24). Date of Electronic Publication: 2019 Nov 26 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Differentiation*
Phenotype*
CD4-Positive T-Lymphocytes/*virology
HIV Infections/*virology
HIV-1/*physiology
Virus Latency/*physiology
DNA, Viral/genetics ; Gene Expression ; Humans ; Immunologic Memory/physiology ; T-Lymphocyte Subsets/virology
Czasopismo naukowe
Tytuł :
Effector memory differentiation increases detection of replication-competent HIV-l in resting CD4+ T cells from virally suppressed individuals.
Autorzy :
Wonderlich ER; Southern Research, Frederick, Maryland, United States of America.
Subramanian K; Southern Research, Frederick, Maryland, United States of America.
Cox B; Department of Pediatrics, Emory University, Atlanta, Georgia, United States of America.
Wiegand A; HIV DRP, NCI at Frederick, NIH, Frederick, Maryland, United States of America.
Lackman-Smith C; Southern Research, Frederick, Maryland, United States of America.
Bale MJ; HIV DRP, NCI at Frederick, NIH, Frederick, Maryland, United States of America.
Stone M; Vitalant Research Institute, San Francisco, California, United States of America.; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, United States of America.
Hoh R; University of California, San Francisco (UCSF), San Francisco, California, United States of America.
Kearney MF; HIV DRP, NCI at Frederick, NIH, Frederick, Maryland, United States of America.
Maldarelli F; HIV DRP, NCI at Frederick, NIH, Frederick, Maryland, United States of America.
Deeks SG; University of California, San Francisco (UCSF), San Francisco, California, United States of America.
Busch MP; Vitalant Research Institute, San Francisco, California, United States of America.; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, United States of America.
Ptak RG; Southern Research, Frederick, Maryland, United States of America.
Kulpa DA; Department of Pediatrics, Emory University, Atlanta, Georgia, United States of America.
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Źródło :
PLoS pathogens [PLoS Pathog] 2019 Oct 14; Vol. 15 (10), pp. e1008074. Date of Electronic Publication: 2019 Oct 14 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
CD4-Positive T-Lymphocytes/*virology
HIV-1/*immunology
HIV-1/*physiology
Immunologic Memory/*immunology
Virus Latency/*immunology
Aged ; Anti-Retroviral Agents/therapeutic use ; CD4-Positive T-Lymphocytes/immunology ; Cell Differentiation ; Cell Proliferation ; Cells, Cultured ; HIV Infections/immunology ; HIV-1/growth & development ; Humans ; Male ; Middle Aged ; Proviruses/growth & development ; Viral Load/drug effects ; Virus Latency/drug effects ; Virus Replication/drug effects
Czasopismo naukowe
Tytuł :
Assessing intra-lab precision and inter-lab repeatability of outgrowth assays of HIV-1 latent reservoir size.
Autorzy :
Rosenbloom DIS; Department of Systems Biology, Columbia University College of Physicians and Surgeons, New York, New York, United States of America.; Department of Biomedical Informatics, Columbia University College of Physicians and Surgeons, New York, New York, United States of America.
Bacchetti P; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, United States of America.
Stone M; Blood Systems Research Institute, San Francisco, California, United States of America.
Deng X; Blood Systems Research Institute, San Francisco, California, United States of America.
Bosch RJ; Center for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, United States of America.
Richman DD; University of California San Diego, La Jolla, California, United States of America.; Veterans Affairs San Diego Healthcare System, San Diego, California, United States of America.
Siliciano JD; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Mellors JW; Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.
Deeks SG; Division of HIV, Infectious Diseases and Global Medicine, University of California San Francisco, San Francisco, California, United States of America.
Ptak RG; Southern Research, Frederick, Maryland, United States of America.
Hoh R; Division of HIV, Infectious Diseases and Global Medicine, University of California San Francisco, San Francisco, California, United States of America.
Keating SM; Blood Systems Research Institute, San Francisco, California, United States of America.; Division of HIV, Infectious Diseases and Global Medicine, University of California San Francisco, San Francisco, California, United States of America.
Dimapasoc M; Blood Systems Research Institute, San Francisco, California, United States of America.
Massanella M; University of California San Diego, La Jolla, California, United States of America.
Lai J; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Sobolewski MD; Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.
Kulpa DA; Southern Research, Frederick, Maryland, United States of America.; Department of Pediatrics, Emory University, Atlanta, Georgia, United States of America.
Busch MP; Blood Systems Research Institute, San Francisco, California, United States of America.; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, United States of America.
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Corporate Authors :
Reservoir Assay Validation and Evaluation Network (RAVEN) Study Group
Źródło :
PLoS computational biology [PLoS Comput Biol] 2019 Apr 12; Vol. 15 (4), pp. e1006849. Date of Electronic Publication: 2019 Apr 12 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
HIV-1*/physiology
Virus Latency*
HIV Infections/*virology
Viral Load/*methods
Anti-HIV Agents/therapeutic use ; Bayes Theorem ; CD4-Positive T-Lymphocytes/virology ; Computational Biology ; Computer Simulation ; HIV Infections/drug therapy ; Humans ; Leukocytes, Mononuclear/virology ; Likelihood Functions ; Markov Chains ; Monte Carlo Method ; Reproducibility of Results ; Viral Load/statistics & numerical data ; Virus Replication
Czasopismo naukowe
Tytuł :
Novel mechanisms to inhibit HIV reservoir seeding using Jak inhibitors.
Autorzy :
Gavegnano C; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University, Atlanta, GA, United States of America.
Brehm JH; Case Western Reserve University, Dept. of Pathology, Cleveland, OH, United States of America.
Dupuy FP; Research Institute of the MUHC, Montréal, QC, Canada.
Talla A; Case Western Reserve University, Dept. of Pathology, Cleveland, OH, United States of America.
Ribeiro SP; Case Western Reserve University, Dept. of Pathology, Cleveland, OH, United States of America.
Kulpa DA; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University, Atlanta, GA, United States of America.
Cameron C; Case Western Reserve University, Dept. of Pathology, Cleveland, OH, United States of America.
Santos S; Unconditional Love, Melbourne, FL, United States of America.
Hurwitz SJ; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University, Atlanta, GA, United States of America.
Marconi VC; Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, United States of America.
Routy JP; Chronic Viral Illnesses Service Research Institute, Division of Hematology, McGill University Health Centre, Montréal, QC, Canada.
Sabbagh L; Université de Montréal, Department of Microbiology, Infectiology, and Immunology, Montreal, QC, Canada.
Schinazi RF; Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University, Atlanta, GA, United States of America.
Sékaly RP; Case Western Reserve University, Dept. of Pathology, Cleveland, OH, United States of America.
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Źródło :
PLoS pathogens [PLoS Pathog] 2017 Dec 21; Vol. 13 (12), pp. e1006740. Date of Electronic Publication: 2017 Dec 21 (Print Publication: 2017).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-HIV Agents/*pharmacology
CD4-Positive T-Lymphocytes/*virology
HIV Infections/*virology
Janus Kinase Inhibitors/*pharmacology
Virus Latency/*drug effects
CD4-Positive T-Lymphocytes/drug effects ; Cells, Cultured ; HIV-1/drug effects ; HIV-1/physiology ; Humans ; Piperidines/pharmacology ; Pyrazoles/pharmacology ; Pyrimidines/pharmacology ; Pyrroles/pharmacology ; Virus Replication/drug effects
Czasopismo naukowe
Tytuł :
A Novel Assay to Measure the Magnitude of the Inducible Viral Reservoir in HIV-infected Individuals.
Autorzy :
Procopio FA; Vaccine and Gene Therapy Institute Florida, Port St. Lucie, FL, USA.
Fromentin R; Vaccine and Gene Therapy Institute Florida, Port St. Lucie, FL, USA.
Kulpa DA; Vaccine and Gene Therapy Institute Florida, Port St. Lucie, FL, USA.
Brehm JH; Vaccine and Gene Therapy Institute Florida, Port St. Lucie, FL, USA.
Bebin AG; Vaccine and Gene Therapy Institute Florida, Port St. Lucie, FL, USA.
Strain MC; University of California San Diego, La Jolla, California and Veterans Affairs San Diego Healthcare System, San Diego, CA, USA.
Richman DD; University of California San Diego, La Jolla, California and Veterans Affairs San Diego Healthcare System, San Diego, CA, USA.
O'Doherty U; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Palmer S; Centre for Virus Research, Westmead Millennium Institute, Westmead, Australia ; Sydney Medical School, University of Sydney, Sydney, Australia.
Hecht FM; Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
Hoh R; Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
Barnard RJ; Infectious Disease, Merck Research Laboratories, West Point, PA, USA.
Miller MD; Infectious Disease, Merck Research Laboratories, West Point, PA, USA.
Hazuda DJ; Infectious Disease, Merck Research Laboratories, West Point, PA, USA.
Deeks SG; Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
Sékaly RP; Vaccine and Gene Therapy Institute Florida, Port St. Lucie, FL, USA.
Chomont N; Vaccine and Gene Therapy Institute Florida, Port St. Lucie, FL, USA.
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Źródło :
EBioMedicine [EBioMedicine] 2015 Jun 27; Vol. 2 (8), pp. 874-83. Date of Electronic Publication: 2015 Jun 27 (Print Publication: 2015).
Typ publikacji :
Journal Article
MeSH Terms :
Virus Latency*
CD4-Positive T-Lymphocytes/*virology
HIV Infections/*blood
HIV-1/*physiology
RNA, Viral/*blood
Adult ; Anti-Retroviral Agents/administration & dosage ; DNA, Viral/blood ; Female ; HIV Infections/drug therapy ; Humans ; Male ; Middle Aged
Czasopismo naukowe
Tytuł :
HIV persistence in the setting of antiretroviral therapy: when, where and how does HIV hide?
Autorzy :
Kulpa DA; Vaccine and Gene Therapy Institute Florida, Port St Lucie, Florida, USA.
Chomont N; Department of Microbiology, Infectiology and Immunology, Université de Montréal, Faculty of Medicine, and Centre de Recherche du CHUM, Montréal, Quebec, Canada.
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Źródło :
Journal of virus eradication [J Virus Erad] 2015 Apr; Vol. 1 (2), pp. 59-66.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
PD-1 coinhibitory signals: the link between pathogenesis and protection.
Autorzy :
Kulpa DA; Division of Infectious Diseases, Vaccine and Gene Therapy Institute-Florida (VGTI-FL), Port Saint Lucie, FL, United States.
Lawani M
Cooper A
Peretz Y
Ahlers J
Sékaly RP
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Źródło :
Seminars in immunology [Semin Immunol] 2013 Oct 31; Vol. 25 (3), pp. 219-27. Date of Electronic Publication: 2013 Mar 31.
Typ publikacji :
Journal Article; Review
MeSH Terms :
HIV Infections/*immunology
Programmed Cell Death 1 Receptor/*metabolism
Systems Biology/*methods
T-Lymphocyte Subsets/*immunology
T-Lymphocytes/*immunology
Animals ; Biomarkers/metabolism ; HIV Infections/therapy ; Humans ; Immune Evasion ; Immunologic Memory ; Lymphocyte Activation ; Molecular Targeted Therapy ; Programmed Cell Death 1 Receptor/immunology ; Signal Transduction ; T-Lymphocyte Subsets/virology ; T-Lymphocytes/virology ; Transcriptome
Czasopismo naukowe
Tytuł :
Adaptor protein 1 promotes cross-presentation through the same tyrosine signal in major histocompatibility complex class I as that targeted by HIV-1.
Autorzy :
Kulpa DA; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Del Cid N
Peterson KA
Collins KL
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Źródło :
Journal of virology [J Virol] 2013 Jul; Vol. 87 (14), pp. 8085-98. Date of Electronic Publication: 2013 May 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptor Protein Complex 1/*metabolism
Antigen-Presenting Cells/*immunology
Cross-Priming/*immunology
HIV-1/*metabolism
Histocompatibility Antigens Class I/*metabolism
Tyrosine/*metabolism
Adaptor Protein Complex 1/immunology ; Amino Acid Sequence ; Animals ; Blotting, Western ; DNA Primers/genetics ; Enzyme-Linked Immunosorbent Assay ; Flow Cytometry ; Genetic Vectors/genetics ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Histocompatibility Antigens Class I/genetics ; Humans ; Immunoprecipitation ; Lentivirus ; Mice ; Mice, Inbred C57BL ; Microscopy, Confocal ; Molecular Sequence Data ; Tyrosine/genetics ; nef Gene Products, Human Immunodeficiency Virus/metabolism
Czasopismo naukowe
Tytuł :
ADP ribosylation factor 1 activity is required to recruit AP-1 to the major histocompatibility complex class I (MHC-I) cytoplasmic tail and disrupt MHC-I trafficking in HIV-1-infected primary T cells.
Autorzy :
Wonderlich ER; Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Leonard JA
Kulpa DA
Leopold KE
Norman JM
Collins KL
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Źródło :
Journal of virology [J Virol] 2011 Dec; Vol. 85 (23), pp. 12216-26. Date of Electronic Publication: 2011 Sep 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
ADP-Ribosylation Factor 1/*metabolism
ADP-Ribosylation Factors/*metabolism
HIV Infections/*virology
HLA-A2 Antigen/*metabolism
T-Lymphocytes/*metabolism
T-Lymphocytes/*virology
Transcription Factor AP-1/*metabolism
ADP-Ribosylation Factor 1/antagonists & inhibitors ; ADP-Ribosylation Factor 1/genetics ; ADP-Ribosylation Factors/antagonists & inhibitors ; ADP-Ribosylation Factors/genetics ; Antigen Presentation ; Blotting, Western ; Cells, Cultured ; Cytoplasm/metabolism ; Enzyme-Linked Immunosorbent Assay ; Fluorescent Antibody Technique ; Genetic Vectors ; HIV Infections/genetics ; HIV Infections/immunology ; HIV-1/genetics ; HIV-1/pathogenicity ; HLA-A2 Antigen/genetics ; Humans ; Immunoprecipitation ; Protein Binding ; Protein Transport ; T-Lymphocytes/immunology ; Transcription Factor AP-1/genetics ; nef Gene Products, Human Immunodeficiency Virus/genetics ; nef Gene Products, Human Immunodeficiency Virus/metabolism
Czasopismo naukowe
Tytuł :
The emerging role of HLA-C in HIV-1 infection.
Autorzy :
Kulpa DA; Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA. />Collins KL
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Źródło :
Immunology [Immunology] 2011 Oct; Vol. 134 (2), pp. 116-22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
HIV Infections/*immunology
HIV-1/*immunology
HLA-C Antigens/*immunology
Amino Acid Sequence ; Disease Progression ; HIV Infections/genetics ; HLA-C Antigens/genetics ; Humans ; Killer Cells, Natural/immunology ; MicroRNAs/immunology ; Molecular Sequence Data ; T-Lymphocytes, Cytotoxic/immunology ; nef Gene Products, Human Immunodeficiency Virus/immunology
Czasopismo naukowe
Tytuł :
Characterization of LINE-1 ribonucleoprotein particles.
Autorzy :
Doucet AJ; Institut de Génétique Humaine, CNRS, UPR 1142, Montpellier, France. />Hulme AE
Sahinovic E
Kulpa DA
Moldovan JB
Kopera HC
Athanikar JN
Hasnaoui M
Bucheton A
Moran JV
Gilbert N
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Źródło :
PLoS genetics [PLoS Genet] 2010 Oct 07; Vol. 6 (10). Date of Electronic Publication: 2010 Oct 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Long Interspersed Nucleotide Elements/*genetics
Open Reading Frames/*genetics
Ribonucleoproteins/*genetics
Binding Sites/genetics ; Blotting, Western ; Cell Line, Tumor ; Cytoplasm/metabolism ; Gene Expression ; HEK293 Cells ; HeLa Cells ; Humans ; In Situ Hybridization, Fluorescence ; Mutagenesis, Insertional ; Mutation ; Plasmids/genetics ; RNA/metabolism ; RNA-Directed DNA Polymerase/genetics ; RNA-Directed DNA Polymerase/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Ribonucleoproteins/metabolism ; Transfection
Czasopismo naukowe

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