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Tytuł:
A Novel Triple-Action Inhibitor Targeting B-Cell Receptor Signaling and BRD4 Demonstrates Preclinical Activity in Chronic Lymphocytic Leukemia.
Autorzy:
Smith AL; Eppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Eiken AP; Eppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Skupa SA; Eppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Moore DY; Eppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Umeta LT; Eppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Smith LM; Department of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Lyden ER; Department of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, NE 68198, USA.
D'Angelo CR; Division of Hematology and Oncology, Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Kallam A; Division of Hematology and Oncology, Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Vose JM; Division of Hematology and Oncology, Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Kutateladze TG; Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
El-Gamal D; Eppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Jun 16; Vol. 23 (12). Date of Electronic Publication: 2022 Jun 16.
Typ publikacji:
Journal Article
MeSH Terms:
Leukemia, Lymphocytic, Chronic, B-Cell*/pathology
Cell Cycle Proteins/pharmacology ; Humans ; Nuclear Proteins ; Phosphatidylinositol 3-Kinases ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Receptors, Antigen, B-Cell/metabolism ; Transcription Factors ; Tumor Microenvironment
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The ZZ domain of HERC2 is a receptor of arginylated substrates.
Autorzy:
Tencer AH; Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
Liu J; Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
Zhu J; Department of Translational Oncology, St. Marianna University Graduate School of Medicine, 2‑16‑1, Sugao, Miyamae‑ku, Kawasaki, 216‑8511, Japan.
Burkholder NT; Department of Biochemistry and Biophysics, The University of North Carolina School of Medicine, Chapel Hill, NC, 27599, USA.
Zhang Y; Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
Wu W; Department of Translational Oncology, St. Marianna University Graduate School of Medicine, 2‑16‑1, Sugao, Miyamae‑ku, Kawasaki, 216‑8511, Japan.
Strahl BD; Department of Biochemistry and Biophysics, The University of North Carolina School of Medicine, Chapel Hill, NC, 27599, USA.
Ohta T; Department of Translational Oncology, St. Marianna University Graduate School of Medicine, 2‑16‑1, Sugao, Miyamae‑ku, Kawasaki, 216‑8511, Japan.
Kutateladze TG; Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, 80045, USA. tatiana.kutateladze@cuanschutz.edu.
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Źródło:
Scientific reports [Sci Rep] 2022 Apr 11; Vol. 12 (1), pp. 6063. Date of Electronic Publication: 2022 Apr 11.
Typ publikacji:
Journal Article
MeSH Terms:
Ubiquitin*/metabolism
Ubiquitin-Protein Ligases*/metabolism
Binding Sites ; Humans ; Proteasome Endopeptidase Complex/metabolism ; Protein Domains
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
PI3K-α/mTOR/BRD4 inhibitor alone or in combination with other anti-virals blocks replication of SARS-CoV-2 and its variants of concern including Delta and Omicron.
Autorzy:
Acharya A; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Pathania AS; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Centre, Omaha, Nebraska, USA.
Pandey K; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Thurman M; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Vann KR; Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Kutateladze TG; Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Challagundala KB; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Centre, Omaha, Nebraska, USA.; The Child Health Research Institute, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Durden DL; Division of Pediatric Hematology-Oncology, Department of Pediatrics, Moores Cancer Center, UC San Diego School of Medicine, La Jolla, California, USA.; Levine Cancer Institute, Charlotte, North Carolina, USA.
Byrareddy SN; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, USA.; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Centre, Omaha, Nebraska, USA.; Department of Genetics, Cell Biology, and Anatomy, University of Nebraska Medical Centre, Omaha, Nebraska, USA.; Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden.
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Źródło:
Clinical and translational medicine [Clin Transl Med] 2022 Apr; Vol. 12 (4), pp. e806.
Typ publikacji:
Letter
MeSH Terms:
Phosphoinositide-3 Kinase Inhibitors*/pharmacology
SARS-CoV-2*/drug effects
COVID-19 Drug Treatment*
Antiviral Agents/pharmacology ; Cell Cycle Proteins/antagonists & inhibitors ; Humans ; Phosphatidylinositol 3-Kinases ; TOR Serine-Threonine Kinases/antagonists & inhibitors ; Transcription Factors/antagonists & inhibitors ; Virus Replication/drug effects
Opinia redakcyjna
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Characterization of nucleosome sediments for protein interaction studies by solid-state NMR spectroscopy.
Autorzy:
le Paige UB; Utrecht NMR Group, Bijvoet Centre for Biomolecular Research, Utrecht University, 3584 CH, Utrecht, the Netherlands.
Xiang S; Utrecht NMR Group, Bijvoet Centre for Biomolecular Research, Utrecht University, 3584 CH, Utrecht, the Netherlands.
Hendrix MMRM; Laboratory of Self-Organizing Soft Matter, Department of Chemical Engineering and Chemistry & Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, the Netherlands.
Zhang Y; Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Folkers GE; Utrecht NMR Group, Bijvoet Centre for Biomolecular Research, Utrecht University, 3584 CH, Utrecht, the Netherlands.
Weingarth M; Utrecht NMR Group, Bijvoet Centre for Biomolecular Research, Utrecht University, 3584 CH, Utrecht, the Netherlands.
Bonvin AMJJ; Utrecht NMR Group, Bijvoet Centre for Biomolecular Research, Utrecht University, 3584 CH, Utrecht, the Netherlands.
Kutateladze TG; Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Voets IK; Laboratory of Self-Organizing Soft Matter, Department of Chemical Engineering and Chemistry & Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, the Netherlands.
Baldus M; Utrecht NMR Group, Bijvoet Centre for Biomolecular Research, Utrecht University, 3584 CH, Utrecht, the Netherlands.
van Ingen H; Utrecht NMR Group, Bijvoet Centre for Biomolecular Research, Utrecht University, 3584 CH, Utrecht, the Netherlands.
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Źródło:
Magnetic resonance (Gottingen, Germany) [Magn Reson (Gott)] 2021; Vol. 2 (1), pp. 187-202. Date of Electronic Publication: 2021 Apr 21.
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Design of thienopyranone-based BET inhibitors that bind multiple synthetic lethality targets.
Autorzy:
Vann KR; Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, USA.
Pal D; Division of Pediatric Hematology and Oncology, Department of Pediatrics, Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.
Morales GA; SignalRx Pharmaceuticals, San Diego, CA, USA.
Burgoyne AM; Division of Hematology-Oncology, Department of Medicine, Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.
Durden DL; Division of Pediatric Hematology and Oncology, Department of Pediatrics, Moores Cancer Center, University of California San Diego, La Jolla, CA, USA. .; SignalRx Pharmaceuticals, San Diego, CA, USA. .
Kutateladze TG; Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, USA. tatiana.kutateladze@cuanschutz.edu.
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Źródło:
Scientific reports [Sci Rep] 2020 Jul 21; Vol. 10 (1), pp. 12027. Date of Electronic Publication: 2020 Jul 21.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
MeSH Terms:
Drug Design*
Synthetic Lethal Mutations*
Antineoplastic Agents/*chemistry
Antineoplastic Agents/*pharmacology
Proteins/*antagonists & inhibitors
Proteins/*metabolism
Animals ; Binding Sites ; Cell Line, Tumor ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Humans ; Mice ; Molecular Conformation ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Protein Binding ; Proteins/chemistry ; Spectrum Analysis ; Structure-Activity Relationship ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The ZZ domain as a new epigenetic reader and a degradation signal sensor.
Autorzy:
Zhang Y; a Department of Pharmacology , University of Colorado School of Medicine , Aurora , CO , USA.
Mi W; b Center for Epigenetics Van Andel Research Institute , Grand Rapids , MI , USA.
Xue Y; c Genetics and Epigenetics Graduate Program , The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences , Houston , TX , USA.
Shi X; b Center for Epigenetics Van Andel Research Institute , Grand Rapids , MI , USA.
Kutateladze TG; a Department of Pharmacology , University of Colorado School of Medicine , Aurora , CO , USA.
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Źródło:
Critical reviews in biochemistry and molecular biology [Crit Rev Biochem Mol Biol] 2019 Feb; Vol. 54 (1), pp. 1-10. Date of Electronic Publication: 2019 Jan 28.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Epigenesis, Genetic*
Zinc Fingers*
Acetylation ; Animals ; Autophagy ; Chromatin/genetics ; Chromatin/metabolism ; Histones/genetics ; Histones/metabolism ; Humans ; Protein Processing, Post-Translational
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Epigenetic countermarks in mitotic chromosome condensation.
Autorzy:
van Wely KH; a Department of Immunology and Oncology , Centro Nacional de Biotecnología/CSIC , Madrid , Spain.
Mora Gallardo C; a Department of Immunology and Oncology , Centro Nacional de Biotecnología/CSIC , Madrid , Spain.
Vann KR; b Department of Pharmacology , University of Colorado School of Medicine , Aurora , CO , USA.
Kutateladze TG; b Department of Pharmacology , University of Colorado School of Medicine , Aurora , CO , USA.
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Źródło:
Nucleus (Austin, Tex.) [Nucleus] 2017 Mar 04; Vol. 8 (2), pp. 144-149. Date of Electronic Publication: 2017 Jan 03.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Epigenesis, Genetic*
Chromosome Segregation/*genetics
Mitosis/*genetics
Chromatin/chemistry ; Chromatin/metabolism ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Perceiving the epigenetic landscape through histone readers.
Autorzy:
Musselman CA; Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Lalonde ME
Côté J
Kutateladze TG
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Źródło:
Nature structural & molecular biology [Nat Struct Mol Biol] 2012 Dec; Vol. 19 (12), pp. 1218-27.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Epigenesis, Genetic*
Histones/*chemistry
Acetylation ; DNA/chemistry ; DNA/genetics ; DNA Methylation ; DNA Repair ; DNA Replication ; Models, Molecular ; Phosphorylation ; Recombination, Genetic ; Transcription, Genetic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 30

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