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Wyświetlanie 1-12 z 12
Tytuł :
The European Medicines Agency Review of Crizanlizumab for the Prevention of Recurrent Vaso-Occlusive Crises in Patients With Sickle Cell Disease.
Autorzy :
Delgado J; Oncology & Haematology Office, European Medicines Agency, Amsterdam, The Netherlands.; Department of Haematology, Hospital Clinic, Barcelona, Spain.
Voltz C; Oncology & Haematology Office, European Medicines Agency, Amsterdam, The Netherlands.
Stain M; Bundesamt fur Sicherheit im Gesundheitswesen, Vienna, Austria.; Committe for Medicinal Products for Human Use, European Medicines Agency, Amsterdam, The Netherlands.
Lapveteläinen T; Committe for Medicinal Products for Human Use, European Medicines Agency, Amsterdam, The Netherlands.; Lääkealan turvallisuus- ja kehittämiskeskus, Fimea, Finland.
Urach S; Bundesamt fur Sicherheit im Gesundheitswesen, Vienna, Austria.
Lähteenvuo J; Committe for Medicinal Products for Human Use, European Medicines Agency, Amsterdam, The Netherlands.; Lääkealan turvallisuus- ja kehittämiskeskus, Fimea, Finland.
Penttilä K; Lääkealan turvallisuus- ja kehittämiskeskus, Fimea, Finland.
Gisselbrecht C; Hopital Saint Louis, Paris, France.
Enzmann H; Committe for Medicinal Products for Human Use, European Medicines Agency, Amsterdam, The Netherlands.; Bundesinstitut für Arzneimittel und Medizinprodukte, Bonn, Germany.
Pignatti F; Oncology & Haematology Office, European Medicines Agency, Amsterdam, The Netherlands.
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Źródło :
HemaSphere [Hemasphere] 2021 Jun 28; Vol. 5 (7), pp. e604. Date of Electronic Publication: 2021 Jun 28 (Print Publication: 2021).
Typ publikacji :
Journal Article; Review
Czasopismo naukowe
Tytuł :
EMA Review of Belantamab Mafodotin (Blenrep) for the Treatment of Adult Patients with Relapsed/Refractory Multiple Myeloma.
Autorzy :
Tzogani K; European Medicines Agency, Amsterdam, The Netherlands.
Penttilä K; Lääkealan turvallisuus- ja kehittämiskeskus, Fimea, Finland.; The Committee for Medicinal Products for Human Use (CHMP).
Lähteenvuo J; Lääkealan turvallisuus- ja kehittämiskeskus, Fimea, Finland.; The Committee for Medicinal Products for Human Use (CHMP).
Lapveteläinen T; Lääkealan turvallisuus- ja kehittämiskeskus, Fimea, Finland.; The Committee for Medicinal Products for Human Use (CHMP).
Lopez Anglada L; Agencia Española de Medicamentos y Productos Sanitarios, Madrid, Spain.; The Committee for Medicinal Products for Human Use (CHMP).
Prieto C; Agencia Española de Medicamentos y Productos Sanitarios, Madrid, Spain.; The Committee for Medicinal Products for Human Use (CHMP).
Garcia-Ochoa B; Agencia Española de Medicamentos y Productos Sanitarios, Madrid, Spain.; The Committee for Medicinal Products for Human Use (CHMP).
Enzmann H; Bundesinstitut für Arzneimittel und Medizinprodukte, Bonn, Germany.; The Committee for Medicinal Products for Human Use (CHMP).
Gisselbrecht C; Hospital Saint Louis, Paris, France.
Delgado J; European Medicines Agency, Amsterdam, The Netherlands.
Pignatti F; European Medicines Agency, Amsterdam, The Netherlands.
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Źródło :
The oncologist [Oncologist] 2021 Jan; Vol. 26 (1), pp. 70-76. Date of Electronic Publication: 2020 Nov 23.
Typ publikacji :
Journal Article; Multicenter Study; Randomized Controlled Trial
MeSH Terms :
Antineoplastic Agents, Immunological*/therapeutic use
Immunoconjugates*/therapeutic use
Multiple Myeloma*/drug therapy
Adult ; Antibodies, Monoclonal, Humanized/therapeutic use ; Humans
Czasopismo naukowe
Tytuł :
Susceptibility to Cardiac Arrhythmias and Sympathetic Nerve Growth in VEGF-B Overexpressing Myocardium.
Autorzy :
Lähteenvuo J; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Yliopistonranta 1E, 70211 Kuopio, Finland.
Hätinen OP; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Yliopistonranta 1E, 70211 Kuopio, Finland.
Kuivanen A; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Yliopistonranta 1E, 70211 Kuopio, Finland.
Huusko J; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Yliopistonranta 1E, 70211 Kuopio, Finland.
Paananen J; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Yliopistonranta 1E, 70211 Kuopio, Finland.
Lähteenvuo M; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Yliopistonranta 1E, 70211 Kuopio, Finland.
Nurro J; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Yliopistonranta 1E, 70211 Kuopio, Finland.
Hedman M; Heart Center, Kuopio University Hospital, Puijonlaaksontie 2, 70210 Kuopio, Finland.
Hartikainen J; Heart Center, Kuopio University Hospital, Puijonlaaksontie 2, 70210 Kuopio, Finland.
Laham-Karam N; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Yliopistonranta 1E, 70211 Kuopio, Finland.
Mäkinen P; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Yliopistonranta 1E, 70211 Kuopio, Finland.
Räsänen M; Wihuri Research Institute and Translational Cancer Medicine Program, Faculty of Medicine, University of Helsinki, Haartmaninkatu 8, 00290 Helsinki, Finland.
Alitalo K; Wihuri Research Institute and Translational Cancer Medicine Program, Faculty of Medicine, University of Helsinki, Haartmaninkatu 8, 00290 Helsinki, Finland.
Rosenzweig A; Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
Ylä-Herttuala S; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Yliopistonranta 1E, 70211 Kuopio, Finland; Heart Center, Kuopio University Hospital, Puijonlaaksontie 2, 70210 Kuopio, Finland. Electronic address: .
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Źródło :
Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2020 Jul 08; Vol. 28 (7), pp. 1731-1740. Date of Electronic Publication: 2020 Mar 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Up-Regulation*
Arrhythmias, Cardiac/*pathology
Myosin Heavy Chains/*genetics
Sympathetic Nervous System/*pathology
Vascular Endothelial Growth Factor B/*genetics
Animals ; Animals, Genetically Modified ; Arrhythmias, Cardiac/genetics ; Arrhythmias, Cardiac/metabolism ; Dependovirus/genetics ; Disease Notification ; Female ; Gene Knockout Techniques ; Genetic Therapy ; Genetic Vectors/administration & dosage ; Male ; Mice ; Promoter Regions, Genetic ; Recombinant Proteins/metabolism ; Swine ; Sympathetic Nervous System/metabolism ; Transduction, Genetic ; Vascular Endothelial Growth Factor B/adverse effects ; Vascular Endothelial Growth Factor B/metabolism
Czasopismo naukowe
Tytuł :
Beyond endothelial cells: Vascular endothelial growth factors in heart, vascular anomalies and placenta.
Autorzy :
Laakkonen JP; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland. Electronic address: .
Lähteenvuo J; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Jauhiainen S; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Heikura T; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Ylä-Herttuala S; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland; Science Service Center, Kuopio University Hospital, Kuopio, Finland; Gene Therapy Unit, Kuopio University Hospital, Kuopio, Finland.
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Źródło :
Vascular pharmacology [Vascul Pharmacol] 2019 Jan; Vol. 112, pp. 91-101. Date of Electronic Publication: 2018 Oct 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Arteriovenous Malformations/*metabolism
Endothelial Cells/*metabolism
Heart Diseases/*metabolism
Hemangioma/*metabolism
Myocardium/*metabolism
Placenta/*metabolism
Vascular Endothelial Growth Factor A/*metabolism
Animals ; Arteriovenous Malformations/genetics ; Arteriovenous Malformations/pathology ; Endothelial Cells/pathology ; Female ; Heart Diseases/pathology ; Hemangioma/genetics ; Hemangioma/pathology ; Humans ; Lymphangiogenesis ; Myocardium/pathology ; Neovascularization, Pathologic ; Neovascularization, Physiologic ; Paracrine Communication ; Placenta/pathology ; Pregnancy ; Signal Transduction ; Vascular Endothelial Growth Factor A/genetics
Czasopismo naukowe
Tytuł :
Advances and Challenges in Cardiovascular Gene Therapy.
Autorzy :
Lähteenvuo J; 1 A.I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland .
Ylä-Herttuala S; 1 A.I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland .; 2 Heart Center and Gene Therapy Unit, Kuopio University Hospital , Kuopio, Finland .
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Źródło :
Human gene therapy [Hum Gene Ther] 2017 Nov; Vol. 28 (11), pp. 1024-1032. Date of Electronic Publication: 2017 Aug 15.
Typ publikacji :
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms :
Cardiovascular Diseases/*therapy
Genetic Therapy/*trends
Genetic Vectors/*therapeutic use
Translational Medical Research/*trends
Cardiovascular Diseases/genetics ; Cardiovascular Diseases/pathology ; Cardiovascular System ; Genetic Vectors/genetics ; Humans ; Transgenes/genetics
Czasopismo naukowe
Tytuł :
AdVEGF-B186 and AdVEGF-DΔNΔC induce angiogenesis and increase perfusion in porcine myocardium.
Autorzy :
Nurro J; Department of Biotechnology and Molecular Medicine, A. I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland.
Halonen PJ; Department of Biotechnology and Molecular Medicine, A. I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland.
Kuivanen A; Department of Biotechnology and Molecular Medicine, A. I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland.
Tarkia M; Turku PET Centre, Turku University Hospital, Turku, Finland Department of Pharmacology, University of Helsinki, Helsinki, Finland.
Saraste A; Turku PET Centre, Turku University Hospital, Turku, Finland.
Honkonen K; Department of Biotechnology and Molecular Medicine, A. I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland.
Lähteenvuo J; Department of Biotechnology and Molecular Medicine, A. I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland.
Rissanen TT; Department of Biotechnology and Molecular Medicine, A. I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland Department of Internal Medicine, Central Hospital of North Karelia, Joensuu, Finland.
Knuuti J; Turku PET Centre, Turku University Hospital, Turku, Finland.
Ylä-Herttuala S; Department of Biotechnology and Molecular Medicine, A. I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland Science Service Center, Kuopio University Hospital, Kuopio, Finland Gene Therapy Unit, Kuopio University Hospital, Kuopio, Finland.
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Źródło :
Heart (British Cardiac Society) [Heart] 2016 Nov 01; Vol. 102 (21), pp. 1716-1720. Date of Electronic Publication: 2016 May 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Coronary Circulation*
Gene Transfer Techniques*/adverse effects
Genetic Vectors*
Neovascularization, Physiologic*
Adenoviridae/*genetics
Coronary Vessels/*metabolism
Myocardium/*metabolism
Vascular Endothelial Growth Factor B/*biosynthesis
Vascular Endothelial Growth Factor D/*biosynthesis
Animals ; Coronary Angiography ; Echocardiography ; Female ; Models, Animal ; Myocardial Perfusion Imaging/methods ; Positron-Emission Tomography ; Signal Transduction ; Sus scrofa ; Time Factors ; Up-Regulation ; Vascular Endothelial Growth Factor B/genetics ; Vascular Endothelial Growth Factor D/genetics
Czasopismo naukowe
Tytuł :
Effects of aging on angiogenesis.
Autorzy :
Lähteenvuo J; Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Rosenzweig A
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Źródło :
Circulation research [Circ Res] 2012 Apr 27; Vol. 110 (9), pp. 1252-64.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Aging*/metabolism
Neovascularization, Physiologic*
Cardiovascular Diseases/*etiology
Age Factors ; Angiogenic Proteins/metabolism ; Animals ; Cardiovascular Diseases/metabolism ; Cardiovascular Diseases/physiopathology ; Cardiovascular Diseases/therapy ; Cellular Senescence ; Cyclin-Dependent Kinase Inhibitor Proteins/metabolism ; Humans ; Nitric Oxide/metabolism ; Oxidative Stress ; Risk Factors ; Signal Transduction
Czasopismo naukowe
Tytuł :
Growth factor therapy and autologous lymph node transfer in lymphedema.
Autorzy :
Lähteenvuo M; Plastic Surgery, Turku University Central Hospital, Finland.
Honkonen K
Tervala T
Tammela T
Suominen E
Lähteenvuo J
Kholová I
Alitalo K
Ylä-Herttuala S
Saaristo A
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Źródło :
Circulation [Circulation] 2011 Feb 15; Vol. 123 (6), pp. 613-20. Date of Electronic Publication: 2011 Jan 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Therapy/*methods
Lymph Nodes/*transplantation
Lymphedema/*therapy
Vascular Endothelial Growth Factor C/*genetics
Vascular Endothelial Growth Factor D/*genetics
Adenoviruses, Human ; Animals ; Disease Models, Animal ; Genetic Vectors ; Lymphedema/pathology ; Lymphedema/surgery ; Seroma/therapy ; Swine ; beta-Galactosidase/genetics
Czasopismo naukowe
Tytuł :
Intravitreal adenoviral 15-lipoxygenase-1 gene transfer prevents vascular endothelial growth factor A-induced neovascularization in rabbit eyes.
Autorzy :
Viita H; Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Kuopio, FI-70211 Kuopio, Finland.
Kinnunen K
Eriksson E
Lähteenvuo J
Babu M
Kalesnykas G
Heikura T
Laidinen S
Takalo T
Ylä-Herttuala S
Pokaż więcej
Źródło :
Human gene therapy [Hum Gene Ther] 2009 Dec; Vol. 20 (12), pp. 1679-86.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Therapy*
Arachidonate 15-Lipoxygenase/*genetics
Diabetic Retinopathy/*therapy
Macular Degeneration/*therapy
Neovascularization, Pathologic/*prevention & control
Vascular Endothelial Growth Factor A/*antagonists & inhibitors
Adenoviridae/genetics ; Animals ; Genetic Vectors/genetics ; Humans ; Ligands ; Mice ; Neovascularization, Pathologic/genetics ; Optic Disk/blood supply ; Optic Disk/metabolism ; PPAR gamma/antagonists & inhibitors ; Rabbits ; Retinal Vessels/metabolism ; Retinal Vessels/pathology ; Vascular Endothelial Growth Factor A/genetics ; Vascular Endothelial Growth Factor Receptor-2
Czasopismo naukowe
    Wyświetlanie 1-12 z 12

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