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Wyszukujesz frazę ""LACTATE dehydrogenase"" wg kryterium: Temat


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Tytuł :
Screening of lactate dehydrogenase inhibitor from bioactive compounds in natural products by electrophoretically mediated microanalysis.
Autorzy :
Li W; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, and Wuhan University School of Pharmaceutical Sciences, Wuhan, 430071, China; State Key Laboratory of Transducer Technology, Chinese Academy of Sciences, Beijing 10080, China.
Cui X; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, and Wuhan University School of Pharmaceutical Sciences, Wuhan, 430071, China.
Chen Z; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, and Wuhan University School of Pharmaceutical Sciences, Wuhan, 430071, China; State Key Laboratory of Transducer Technology, Chinese Academy of Sciences, Beijing 10080, China. Electronic address: .
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Źródło :
Journal of chromatography. A [J Chromatogr A] 2021 Oct 25; Vol. 1656, pp. 462554. Date of Electronic Publication: 2021 Sep 15.
Typ publikacji :
Journal Article
MeSH Terms :
Biological Products*
L-Lactate Dehydrogenase*
Electrophoresis, Capillary ; Lactic Acid ; Molecular Docking Simulation
Czasopismo naukowe
Tytuł :
p107 mediated mitochondrial function controls muscle stem cell proliferative fates.
Autorzy :
Bhattacharya D; Stem Cell Research Group, York University, Toronto, ON, M3J 1P3, Canada.; Molecular, Cellular and Integrative Physiology, Faculty of Health, York University, Toronto, ON, M3J 1P3, Canada.
Shah V; Stem Cell Research Group, York University, Toronto, ON, M3J 1P3, Canada.; Department of Biology, York University, Toronto, ON, M3J 1P3, Canada.
Oresajo O; Stem Cell Research Group, York University, Toronto, ON, M3J 1P3, Canada.; Molecular, Cellular and Integrative Physiology, Faculty of Health, York University, Toronto, ON, M3J 1P3, Canada.
Scimè A; Stem Cell Research Group, York University, Toronto, ON, M3J 1P3, Canada. .; Molecular, Cellular and Integrative Physiology, Faculty of Health, York University, Toronto, ON, M3J 1P3, Canada. .; Department of Biology, York University, Toronto, ON, M3J 1P3, Canada. .
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Źródło :
Nature communications [Nat Commun] 2021 Oct 13; Vol. 12 (1), pp. 5977. Date of Electronic Publication: 2021 Oct 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Lactate Dehydrogenase 5/*genetics
Mitochondria/*genetics
Muscle, Skeletal/*metabolism
Myoblasts/*metabolism
Retinoblastoma-Like Protein p107/*genetics
Stem Cells/*metabolism
Adenosine Triphosphate/biosynthesis ; Animals ; Cell Cycle/genetics ; Cell Line ; Cell Proliferation ; DNA, Mitochondrial/genetics ; DNA, Mitochondrial/metabolism ; Electron Transport Chain Complex Proteins/genetics ; Electron Transport Chain Complex Proteins/metabolism ; Gene Expression Regulation ; Glycolysis ; Humans ; Lactate Dehydrogenase 5/antagonists & inhibitors ; Lactate Dehydrogenase 5/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mitochondria/metabolism ; Muscle, Skeletal/cytology ; Myoblasts/cytology ; Oxidative Phosphorylation ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Retinoblastoma-Like Protein p107/metabolism ; Sirtuin 1/genetics ; Sirtuin 1/metabolism ; Stem Cells/cytology ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Red and white muscle proportions and enzyme activities in mesopelagic sharks.
Autorzy :
Pinte N; Marine biology laboratory, Earth and Life Institute, Université catholique de Louvain, 3 place Croix du Sud, Kellner building, 1348 Louvain-la-Neuve, Belgium.
Coubris C; Marine biology laboratory, Earth and Life Institute, Université catholique de Louvain, 3 place Croix du Sud, Kellner building, 1348 Louvain-la-Neuve, Belgium.
Jones E; National Institute of Water and Atmospheric Research (NIWA), 41 Market Pl, Auckland 1010, New Zealand.
Mallefet J; Marine biology laboratory, Earth and Life Institute, Université catholique de Louvain, 3 place Croix du Sud, Kellner building, 1348 Louvain-la-Neuve, Belgium. Electronic address: .
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Źródło :
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology [Comp Biochem Physiol B Biochem Mol Biol] 2021 Oct-Dec; Vol. 256, pp. 110649. Date of Electronic Publication: 2021 Jul 21.
Typ publikacji :
Journal Article
MeSH Terms :
Citrate (si)-Synthase/*metabolism
Fish Proteins/*metabolism
L-Lactate Dehydrogenase/*metabolism
Malate Dehydrogenase/*metabolism
Muscle, Skeletal/*metabolism
Sharks/*metabolism
Animals ; Citrate (si)-Synthase/genetics ; Fish Proteins/genetics ; L-Lactate Dehydrogenase/genetics ; Malate Dehydrogenase/genetics ; Muscle, Skeletal/growth & development ; Sharks/genetics ; Sharks/growth & development ; Swimming
Czasopismo naukowe
Tytuł :
LDHA is enriched in human islet alpha cells and upregulated in type 2 diabetes.
Autorzy :
Sanchez PKM; Centre for Biomolecular Interactions Bremen, University of Bremen, Bremen, Germany.
Khazaei M; Centre for Biomolecular Interactions Bremen, University of Bremen, Bremen, Germany.
Gatineau E; Pole of Endocrinology, Diabetes, and Nutrition (EDIN), Institute of Experimental and Clinical Research (IREC), Université Catholique de Louvain (UCLouvain), 1200, Brussels, Belgium.
Geravandi S; Centre for Biomolecular Interactions Bremen, University of Bremen, Bremen, Germany.
Lupse B; Centre for Biomolecular Interactions Bremen, University of Bremen, Bremen, Germany.
Liu H; Centre for Biomolecular Interactions Bremen, University of Bremen, Bremen, Germany.
Dringen R; Centre for Biomolecular Interactions Bremen, University of Bremen, Bremen, Germany.
Wojtusciszyn A; Department of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital, Lausanne, Switzerland.
Gilon P; Pole of Endocrinology, Diabetes, and Nutrition (EDIN), Institute of Experimental and Clinical Research (IREC), Université Catholique de Louvain (UCLouvain), 1200, Brussels, Belgium.
Maedler K; Centre for Biomolecular Interactions Bremen, University of Bremen, Bremen, Germany. Electronic address: .
Ardestani A; Centre for Biomolecular Interactions Bremen, University of Bremen, Bremen, Germany; Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Sep 03; Vol. 568, pp. 158-166. Date of Electronic Publication: 2021 Jul 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Diabetes Mellitus, Type 2/*genetics
Glucagon-Secreting Cells/*metabolism
L-Lactate Dehydrogenase/*genetics
Cells, Cultured ; Diabetes Mellitus, Type 2/metabolism ; Glucagon-Secreting Cells/cytology ; Glucose/metabolism ; Humans ; Insulin Secretion ; L-Lactate Dehydrogenase/analysis ; L-Lactate Dehydrogenase/metabolism ; RNA, Messenger/analysis ; RNA, Messenger/genetics ; Up-Regulation
Czasopismo naukowe
Tytuł :
The Warburg effect as a therapeutic target for bladder cancers and intratumoral heterogeneity in associated molecular targets.
Autorzy :
Burns JE; Leeds Institute of Medical Research, St. James' University Hospital, University of Leeds, Leeds, UK.
Hurst CD; Leeds Institute of Medical Research, St. James' University Hospital, University of Leeds, Leeds, UK.
Knowles MA; Leeds Institute of Medical Research, St. James' University Hospital, University of Leeds, Leeds, UK.
Phillips RM; School of Applied Sciences, University of Huddersfield, Huddersfield, UK.
Allison SJ; Leeds Institute of Medical Research, St. James' University Hospital, University of Leeds, Leeds, UK.; School of Applied Sciences, University of Huddersfield, Huddersfield, UK.
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Źródło :
Cancer science [Cancer Sci] 2021 Sep; Vol. 112 (9), pp. 3822-3834. Date of Electronic Publication: 2021 Jul 12.
Typ publikacji :
Journal Article
MeSH Terms :
Transcriptome*
Warburg Effect, Oncologic*/drug effects
L-Lactate Dehydrogenase/*metabolism
Lactic Acid/*biosynthesis
Urinary Bladder Neoplasms/*genetics
Urinary Bladder Neoplasms/*metabolism
Apoptosis/genetics ; Cell Line, Tumor ; Epithelial-Mesenchymal Transition/genetics ; Gene Knockdown Techniques ; Humans ; Isoenzymes/genetics ; Isoenzymes/metabolism ; L-Lactate Dehydrogenase/genetics ; Molecular Targeted Therapy/methods ; Neoplasm Staging ; RNA Interference ; Sirtuin 1/genetics ; Sirtuin 1/metabolism ; Transfection ; Urinary Bladder Neoplasms/drug therapy ; Urinary Bladder Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Lactate Dehydrogenase Variation in a Patient with History of Giant Cell Tumor.
Autorzy :
Pierre CC; Department of Pathology, University of Virginia School of Medicine, Charlottesville, VA.
Wiencek JR; Department of Pathology, University of Virginia School of Medicine, Charlottesville, VA.
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Źródło :
The journal of applied laboratory medicine [J Appl Lab Med] 2021 Sep 01; Vol. 6 (5), pp. 1355-1359.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Giant Cell Tumors*
L-Lactate Dehydrogenase*/genetics
Humans
Czasopismo naukowe
Tytuł :
LDH-A negatively regulates dMMR in colorectal cancer.
Autorzy :
Zhang Y; Department of Medical Oncology, Huai'an Hospital Affiliated with Xuzhou Medical University, Huai'an, China.
Li J; Department of Medical Oncology, Huai'an Hospital Affiliated with Xuzhou Medical University, Huai'an, China.
Wang B; Department of Anesthesiology, Huai'an Hospital of Traditional Chinese Medicine, Huai'an, China.
Chen T; Department of Medical Oncology, Huai'an Hospital Affiliated with Xuzhou Medical University, Huai'an, China.
Chen Y; Department of Medical Oncology, Huai'an Hospital Affiliated with Xuzhou Medical University, Huai'an, China.
Ma W; Department of Medical Oncology, Huai'an Hospital Affiliated with Xuzhou Medical University, Huai'an, China.
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Źródło :
Cancer science [Cancer Sci] 2021 Aug; Vol. 112 (8), pp. 3050-3063. Date of Electronic Publication: 2021 Jul 04.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Mismatch Repair*
Colorectal Neoplasms/*pathology
L-Lactate Dehydrogenase/*metabolism
Lung Neoplasms/*pathology
Lung Neoplasms/*secondary
Cell Line, Tumor ; Cell Proliferation ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Female ; Gene Expression Regulation, Neoplastic ; HCT116 Cells ; Humans ; L-Lactate Dehydrogenase/genetics ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Male ; Middle Aged ; Neoplasm Transplantation ; Prognosis ; Survival Analysis
Czasopismo naukowe
Tytuł :
Excess exogenous pyruvate inhibits lactate dehydrogenase activity in live cells in an MCT1-dependent manner.
Autorzy :
Rao Y; Department of Cancer System Imaging, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.
Gammon ST; Department of Cancer System Imaging, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.
Sutton MN; Department of Cancer System Imaging, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.
Zacharias NM; Department of Urology, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.
Bhattacharya P; Department of Cancer System Imaging, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.
Piwnica-Worms D; Department of Cancer System Imaging, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2021 Jul; Vol. 297 (1), pp. 100775. Date of Electronic Publication: 2021 May 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
L-Lactate Dehydrogenase/*antagonists & inhibitors
Monocarboxylic Acid Transporters/*metabolism
Pyruvic Acid/*pharmacology
Symporters/*metabolism
Acids/metabolism ; Buffers ; Carbon Isotopes ; Cell Extracts ; Cell Line, Tumor ; Cell Membrane/drug effects ; Cell Membrane/metabolism ; Extracellular Space/chemistry ; Glycolysis/drug effects ; Humans ; Inhibitory Concentration 50 ; Kinetics ; L-Lactate Dehydrogenase/metabolism ; Lactic Acid/biosynthesis ; Substrate Specificity/drug effects
Czasopismo naukowe
Tytuł :
Preparation, stability and commutability of candidate reference materials for lactate dehydrogenase (LDH).
Autorzy :
Guo Q; National Center for Clinical Laboratories, Beijing Engineering Research Center of Laboratory Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, PR China; Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, PR China.
Zhu Z; National Center for Clinical Laboratories, Beijing Engineering Research Center of Laboratory Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, PR China; Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, PR China.
Wang J; National Center for Clinical Laboratories, Beijing Engineering Research Center of Laboratory Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, PR China.
Huang W; The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing 100730, PR China.
Zhang C; National Center for Clinical Laboratories, Beijing Engineering Research Center of Laboratory Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, PR China.
Zeng J; National Center for Clinical Laboratories, Beijing Engineering Research Center of Laboratory Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, PR China.
Zhao H; National Center for Clinical Laboratories, Beijing Engineering Research Center of Laboratory Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, PR China.
Qi T; National Center for Clinical Laboratories, Beijing Engineering Research Center of Laboratory Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, PR China; Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, PR China.
Zhou W; National Center for Clinical Laboratories, Beijing Engineering Research Center of Laboratory Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, PR China.
Zhang T; National Center for Clinical Laboratories, Beijing Engineering Research Center of Laboratory Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, PR China; Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, PR China.
Zhang C; National Center for Clinical Laboratories, Beijing Engineering Research Center of Laboratory Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, PR China; Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, PR China. Electronic address: .
Xiao F; The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing 100730, PR China; Clinical Biobank, Beijing Hospital, National Center of Gerontology, Beijing 100730, PR China. Electronic address: .
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Źródło :
Clinical biochemistry [Clin Biochem] 2021 May; Vol. 91, pp. 45-51. Date of Electronic Publication: 2021 Feb 20.
Typ publikacji :
Journal Article
MeSH Terms :
L-Lactate Dehydrogenase*/chemistry
L-Lactate Dehydrogenase*/standards
Lactate Dehydrogenases*/chemistry
Lactate Dehydrogenases*/standards
Clinical Enzyme Tests/*standards
Humans ; Recombinant Proteins/chemistry ; Recombinant Proteins/standards ; Reference Standards
Czasopismo naukowe
Tytuł :
Analysis of relative bacterial activity and lactate dehydrogenase gene expression of caries-associated bacteria in a site-specific natural biofilm: an ex vivo study.
Autorzy :
Walther C; Department of Prosthetic Dentistry, Center for Dental and Oral Medicine, University Medical Center, Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany. .
Zumbülte S; Division of Oral Microbiology and Immunology, Department of Operative Dentistry, Periodontology, and Preventive Dentistry, RWTH Aachen University, Aachen, Germany.
Faerber CM; Department of Operative Dentistry, Periodontology, and Preventive Dentistry, RWTH Aachen University, Aachen, Germany.
Wierichs RJ; Department of Restorative, Preventive and Pediatric Dentistry, zmk bern, University of Bern, Bern, Switzerland.
Meyer-Lueckel H; Department of Restorative, Preventive and Pediatric Dentistry, zmk bern, University of Bern, Bern, Switzerland.
Conrads G; Division of Oral Microbiology and Immunology, Department of Operative Dentistry, Periodontology, and Preventive Dentistry, RWTH Aachen University, Aachen, Germany.
Henne K; Division of Oral Microbiology and Immunology, Department of Operative Dentistry, Periodontology, and Preventive Dentistry, RWTH Aachen University, Aachen, Germany.
Esteves-Oliveira M; Department of Operative Dentistry, Periodontology, and Preventive Dentistry, RWTH Aachen University, Aachen, Germany.; Department of Cariology, Endodontology and Periodontology, University of Leipzig, Leipzig, Germany.
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Źródło :
Clinical oral investigations [Clin Oral Investig] 2021 Jun; Vol. 25 (6), pp. 3669-3679. Date of Electronic Publication: 2020 Nov 23.
Typ publikacji :
Journal Article
MeSH Terms :
Dental Caries*
L-Lactate Dehydrogenase*/genetics
Bacteria/genetics ; Biofilms ; Dental Caries Susceptibility ; Gene Expression ; Humans ; RNA, Ribosomal, 16S/genetics ; Streptococcus mutans/genetics
Czasopismo naukowe
Tytuł :
Optimization of ether and aniline based inhibitors of lactate dehydrogenase.
Autorzy :
Christov PP; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37232, United States.
Kim K; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37232, United States.
Jana S; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37232, United States.
Romaine IM; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37232, United States.
Rai G; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, United States.
Mott BT; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, United States.
Allweil AA; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37232, United States.
Lamers A; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37232, United States.
Brimacombe KR; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, United States.
Urban DJ; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, United States.
Lee TD; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, United States.
Hu X; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, United States.
Lukacs CM; Beryllium Discovery Corp, 7869 Day Rd West, Bainbridge Island, WA 98110, United States.
Davies DR; Beryllium Discovery Corp, 7869 Day Rd West, Bainbridge Island, WA 98110, United States.
Jadhav A; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, United States.
Hall MD; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, United States.
Green N; Beryllium Discovery Corp, 7869 Day Rd West, Bainbridge Island, WA 98110, United States.
Moore WJ; NExT Program Support, Applied/Developmental Research Directorate, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, United States.
Stott GM; NExT Program Support, Applied/Developmental Research Directorate, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, United States.
Flint AJ; NExT Program Support, Applied/Developmental Research Directorate, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, United States.
Maloney DJ; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, United States.
Sulikowski GA; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37232, United States.
Waterson AG; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN 37232, United States. Electronic address: .
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2021 Jun 01; Vol. 41, pp. 127974. Date of Electronic Publication: 2021 Mar 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Drug Design*
Aniline Compounds/*pharmacology
Antineoplastic Agents/*pharmacology
Ethers/*pharmacology
L-Lactate Dehydrogenase/*antagonists & inhibitors
L-Lactate Dehydrogenase/*metabolism
Aniline Compounds/chemistry ; Antineoplastic Agents/chemistry ; Cell Line, Tumor ; Ethers/chemistry ; Humans ; L-Lactate Dehydrogenase/chemistry
Czasopismo naukowe
Tytuł :
Rational engineering of the Plasmodium falciparuml-lactate dehydrogenase loop involved in catalytic proton transfer to improve chiral 2-hydroxybutyric acid production.
Autorzy :
Tian L; The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu Province 214122, China.
Zhou J; The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu Province 214122, China.
Lv Q; The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu Province 214122, China.
Liu F; The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu Province 214122, China.
Yang T; The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu Province 214122, China.
Zhang X; The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu Province 214122, China.
Xu M; The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu Province 214122, China. Electronic address: .
Rao Z; The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu Province 214122, China. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 May 15; Vol. 179, pp. 71-79. Date of Electronic Publication: 2021 Feb 22.
Typ publikacji :
Journal Article
MeSH Terms :
Hydroxybutyrates/*chemical synthesis
L-Lactate Dehydrogenase/*chemistry
Plasmodium falciparum/*enzymology
Protozoan Proteins/*chemistry
Catalysis ; Hydroxybutyrates/chemistry ; L-Lactate Dehydrogenase/genetics ; Plasmodium falciparum/genetics ; Protein Engineering ; Protein Structure, Secondary ; Protozoan Proteins/genetics
Czasopismo naukowe
Tytuł :
Designed β-Hairpins Inhibit LDH5 Oligomerization and Enzymatic Activity.
Autorzy :
Nadal-Bufi F; School of Biomedical Sciences, Translational Research Institute, Queensland University of Technology, Brisbane, Queensland 4102, Australia.
Mason JM; Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, United Kingdom.
Chan LY; Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, Queensland 4072, Australia.
Craik DJ; Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, Queensland 4072, Australia.
Kaas Q; Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, Queensland 4072, Australia.
Troeira Henriques S; School of Biomedical Sciences, Translational Research Institute, Queensland University of Technology, Brisbane, Queensland 4102, Australia.; Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, Queensland 4072, Australia.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Apr 08; Vol. 64 (7), pp. 3767-3779. Date of Electronic Publication: 2021 Mar 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Enzyme Inhibitors/*pharmacology
Lactate Dehydrogenase 5/*antagonists & inhibitors
Peptides/*pharmacology
Protein Multimerization/*drug effects
Binding Sites ; Blood/metabolism ; Cell Line, Tumor ; Enzyme Inhibitors/metabolism ; Humans ; Lactate Dehydrogenase 5/chemistry ; Lactate Dehydrogenase 5/metabolism ; Male ; Molecular Dynamics Simulation ; Peptides/metabolism ; Protein Binding ; Protein Conformation, beta-Strand ; Protein Stability
Czasopismo naukowe
Tytuł :
LDH isoenzyme 5 is an index of early onset muscle soreness during prolonged running.
Autorzy :
Tokinoya K; Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan.; Japan Society for the Promotion of Science, Tokyo, Japan.
Ishikura K; Prefectural Education Center, Sojo University, Kumamoto, Japan.
Yoshida Y; Laboratory of Laboratory/Sports Medicine, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.; Department of Medical Technology, Faculty of Health Sciences, Tsukuba International University, Tsuchiura, Japan.
Ra SG; Faculty of Sports and Health Science, Fukuoka University, Fukuoka, Japan.
Sugasawa T; Laboratory of Laboratory/Sports Medicine, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Aoyagi A; Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan.
Nabekura Y; Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, Japan.
Takekoshi K; Laboratory of Laboratory/Sports Medicine, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Ohmori H; Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, Japan - .
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Źródło :
The Journal of sports medicine and physical fitness [J Sports Med Phys Fitness] 2020 Jul; Vol. 60 (7), pp. 1020-1026. Date of Electronic Publication: 2020 Apr 06.
Typ publikacji :
Journal Article
MeSH Terms :
Lactate Dehydrogenase 5/*blood
Myalgia/*diagnosis
Myalgia/*enzymology
Physical Endurance/*physiology
Running/*injuries
Aspartate Aminotransferases/blood ; Biomarkers/blood ; Creatine Kinase/blood ; Humans ; Inflammation/blood ; Isoenzymes/blood ; L-Lactate Dehydrogenase/blood ; Leukocyte Count ; Lower Extremity/physiopathology ; Male ; Neutrophils ; Oxidative Stress ; Running/physiology ; Young Adult
Czasopismo naukowe
Tytuł :
Novel circular RNA circSLIT2 facilitates the aerobic glycolysis of pancreatic ductal adenocarcinoma via miR-510-5p/c-Myc/LDHA axis.
Autorzy :
Guan H; Department of Health Management, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Luo W; Department of Stomatology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Liu Y; Department of Health Management, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China. .
Li M; Department of Hepatobiliary Surgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China. .
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Źródło :
Cell death & disease [Cell Death Dis] 2021 Jun 24; Vol. 12 (7), pp. 645. Date of Electronic Publication: 2021 Jun 24.
Typ publikacji :
Journal Article
MeSH Terms :
Glycolysis*
Carcinoma, Pancreatic Ductal/*enzymology
L-Lactate Dehydrogenase/*metabolism
MicroRNAs/*metabolism
Pancreatic Neoplasms/*enzymology
Proto-Oncogene Proteins c-myc/*metabolism
RNA, Circular/*metabolism
Aged ; Animals ; Apoptosis ; Carcinoma, Pancreatic Ductal/genetics ; Carcinoma, Pancreatic Ductal/pathology ; Cell Line, Tumor ; Cell Proliferation ; Female ; Gene Expression Regulation, Enzymologic ; Gene Expression Regulation, Neoplastic ; Humans ; L-Lactate Dehydrogenase/genetics ; Male ; Mice, Inbred BALB C ; Mice, Nude ; MicroRNAs/genetics ; Middle Aged ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/pathology ; Proto-Oncogene Proteins c-myc/genetics ; RNA, Circular/genetics ; Signal Transduction ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Lactate Dehydrogenase Prior to Transarterial Hepatic Chemoperfusion Predicts Survival and Time to Progression in Patients with Uveal Melanoma Liver Metastases.
Autorzy :
Ludwig J; Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Germany.
Haubold J; Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Germany.
Heusner TA; Clinic for Diagnostic and Interventional Radiology/Neuroradiology, Sankt-Elisabeth-Hospital Gütersloh, Gütersloh, Germany.
Bauer S; West German Cancer Center, University Hospital Essen, Germany.
Siveke JT; German Consortium for Translational Cancer Research (DKTK), partner location University Hospital Essen, University Hospital Essen, Germany.
Richly H; West German Cancer Center, University Hospital Essen, Germany.
Wetter A; Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Germany.
Umutlu L; Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Germany.
Theysohn JM; Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Germany.
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Transliterated Title :
Laktatdehydrogenase vor transarterieller hepatischer Chemoperfusion prognostiziert das Überleben und den Tumorprogress bei Patienten mit Lebermetastasen bei Aderhautmelanom.
Źródło :
RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin [Rofo] 2021 Jun; Vol. 193 (6), pp. 683-691. Date of Electronic Publication: 2020 Dec 21.
Typ publikacji :
Journal Article
MeSH Terms :
L-Lactate Dehydrogenase*/blood
Liver Neoplasms*/diagnostic imaging
Liver Neoplasms*/drug therapy
Liver Neoplasms*/secondary
Melanoma*/pathology
Uveal Neoplasms*/pathology
Female ; Humans ; Male ; Middle Aged ; Prognosis ; Retrospective Studies ; Treatment Outcome
SCR Disease Name :
Uveal melanoma
Czasopismo naukowe
Tytuł :
H19 promotes aerobic glycolysis, proliferation, and immune escape of gastric cancer cells through the microRNA-519d-3p/lactate dehydrogenase A axis.
Autorzy :
Sun L; Jiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China.; Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Li J; Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Yan W; Center for Systems Biology, Department of Bioinformatics, School of Biology and Basic Medical Sciences, Soochow University, Suzhou, China.
Yao Z; Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Wang R; Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, China.; Jiangsu Key Laboratory of Clinical Immunology, Soochow University, Suzhou, China.; Jiangsu Key Laboratory of Gastrointestinal Tumor Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Zhou X; Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.
Wu H; Jiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Zhang G; Jiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China.; Jiangsu Key Laboratory of Clinical Immunology, Soochow University, Suzhou, China.
Shi T; Jiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China.; Jiangsu Key Laboratory of Clinical Immunology, Soochow University, Suzhou, China.; Jiangsu Key Laboratory of Gastrointestinal Tumor Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Chen W; Jiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China.; Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, China.
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Źródło :
Cancer science [Cancer Sci] 2021 Jun; Vol. 112 (6), pp. 2245-2259. Date of Electronic Publication: 2021 Apr 07.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Proliferation*
Tumor Escape*
Warburg Effect, Oncologic*
L-Lactate Dehydrogenase/*metabolism
MicroRNAs/*metabolism
RNA, Long Noncoding/*metabolism
Stomach Neoplasms/*pathology
Animals ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Humans ; L-Lactate Dehydrogenase/genetics ; Mice ; MicroRNAs/genetics ; RNA, Long Noncoding/genetics ; Stomach Neoplasms/genetics ; Stomach Neoplasms/immunology ; Stomach Neoplasms/metabolism
Czasopismo naukowe
Tytuł :
Use of a Design of Experiments (DoE) Approach to Optimize Large-Scale Freeze-Thaw Process of Biologics.
Autorzy :
Minatovicz B; Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut, 06269, USA.
Bogner R; Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut, 06269, USA.
Chaudhuri B; Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut, 06269, USA. .; Department of Chemical & Biomolecular Engineering, University of Connecticut, 69 N. Eagleville Road, Storrs, Connecticut, 06269, USA. .
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Źródło :
AAPS PharmSciTech [AAPS PharmSciTech] 2021 May 12; Vol. 22 (4), pp. 153. Date of Electronic Publication: 2021 May 12.
Typ publikacji :
Journal Article
MeSH Terms :
Freezing*
Biological Products/*chemical synthesis
Chemistry, Pharmaceutical/*methods
L-Lactate Dehydrogenase/*chemical synthesis
Animals ; Biological Products/metabolism ; L-Lactate Dehydrogenase/metabolism ; Rabbits ; Research Design
Czasopismo naukowe
Tytuł :
Streptococcus pneumoniae Binds to Host Lactate Dehydrogenase via PspA and PspC To Enhance Virulence.
Autorzy :
Park SS; Department of Microbiology, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
Gonzalez-Juarbe N; Infectious Diseases and Genomic Medicine Group, J Craig Venter Institute, Rockville, Maryland, USA.
Martínez E; Department of Microbiology, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
Hale JY; Department of Microbiology, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
Lin YH; Infectious Diseases and Genomic Medicine Group, J Craig Venter Institute, Rockville, Maryland, USA.
Huffines JT; Department of Microbiology, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
Kruckow KL; Department of Microbiology, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
Briles DE; Department of Microbiology, The University of Alabama at Birmingham, Birmingham, Alabama, USA .
Orihuela CJ; Department of Microbiology, The University of Alabama at Birmingham, Birmingham, Alabama, USA .
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Źródło :
MBio [mBio] 2021 May 04; Vol. 12 (3). Date of Electronic Publication: 2021 May 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Host-Pathogen Interactions*
Bacterial Proteins/*metabolism
Heat-Shock Proteins/*metabolism
L-Lactate Dehydrogenase/*metabolism
Streptococcus pneumoniae/*metabolism
Streptococcus pneumoniae/*pathogenicity
A549 Cells ; Animals ; Bacterial Proteins/genetics ; Female ; Heat-Shock Proteins/genetics ; Humans ; L-Lactate Dehydrogenase/genetics ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Pneumococcal Infections/microbiology ; Protein Binding ; Streptococcus pneumoniae/genetics ; THP-1 Cells ; Virulence ; Virulence Factors
Czasopismo naukowe
Tytuł :
Pyridine Nucleotide-Linked Lactate Dehydrogenase of Tetrahymena: Evidence for D- and L-Enzymes in the Mitochondria.
Autorzy :
Stearns FM; Department of Biological Chemistry, Hahnemann Medical College, 230 North Broad Street, Philadelphia, Pennsylvania, 19102, USA.
Eichel HJ; Department of Biological Chemistry, Hahnemann Medical College, 230 North Broad Street, Philadelphia, Pennsylvania, 19102, USA.
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Źródło :
The Journal of eukaryotic microbiology [J Eukaryot Microbiol] 2021 May; Vol. 68 (3), pp. e12851. Date of Electronic Publication: 2021 Apr 15.
Typ publikacji :
Journal Article
MeSH Terms :
L-Lactate Dehydrogenase*/metabolism
Tetrahymena*/genetics
Tetrahymena*/metabolism
Lactate Dehydrogenases/metabolism ; Mitochondria/metabolism ; Nucleotides ; Oxidation-Reduction ; Pyridines
Czasopismo naukowe

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