- Tytuł:
- CAFs secreted exosomes promote metastasis and chemotherapy resistance by enhancing cell stemness and epithelial-mesenchymal transition in colorectal cancer.
- Autorzy:
- Źródło:
- Molecular cancer [Mol Cancer] 2019 May 07; Vol. 18 (1), pp. 91. Date of Electronic Publication: 2019 May 07.
- Typ publikacji:
- Journal Article; Research Support, Non-U.S. Gov't
- MeSH Terms:
-
Drug Resistance, Neoplasm*
Cancer-Associated Fibroblasts/*metabolismColorectal Neoplasms /*pathology
Exosomes/*genetics
Liver Neoplasms/*secondary
MicroRNAs/*genetics
Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Apoptosis Regulatory Proteins/genetics ; Apoptosis Regulatory Proteins/metabolism ; Cell Line, Tumor ;Colorectal Neoplasms /genetics ;Colorectal Neoplasms /metabolism ; Epithelial-Mesenchymal Transition ; Exosomes/metabolism ; F-Box-WD Repeat-Containing Protein 7/genetics ; F-Box-WD Repeat-Containing Protein 7/metabolism ; Gene Expression Regulation, Neoplastic ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Mice ; Neoplasm Transplantation ; Up-Regulation ; Wnt Signaling Pathway
Czasopismo naukowe