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Tytuł:
Pb(II) coordination to the nonclassical zinc finger tristetraprolin: retained function with an altered fold.
Autorzy:
Stoltzfus AT; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD, 21201, USA.
Campbell CJ; Department of Pharmaceutical Sciences, Wayne State University, Detroit, MI, 48201, USA.
Worth MM; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD, 21201, USA.
Hom K; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD, 21201, USA.
Stemmler TL; Department of Pharmaceutical Sciences, Wayne State University, Detroit, MI, 48201, USA.
Michel SLJ; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD, 21201, USA. .
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Źródło:
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry [J Biol Inorg Chem] 2023 Feb; Vol. 28 (1), pp. 85-100. Date of Electronic Publication: 2022 Dec 07.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural
MeSH Terms:
Tristetraprolin*/genetics
Tristetraprolin*/chemistry
Tristetraprolin*/metabolism
Lead*
Animals ; Zinc Fingers ; RNA ; Cytokines ; Inflammation
Czasopismo naukowe
Tytuł:
Sodium Para-Aminosalicylic Acid Modulates Autophagy to Lessen Lead-Induced Neurodegeneration in Rat Cortex.
Autorzy:
Wang LL; Department of Toxicology, School of Public Health, Guangxi Medical University, 22 Shuang-Yong Rd., Nanning, 530021, Guangxi, China.; Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning, China.
Zhu XJ; Department of Toxicology, School of Public Health, Guangxi Medical University, 22 Shuang-Yong Rd., Nanning, 530021, Guangxi, China.; The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Fang YY; Department of Toxicology, School of Public Health, Guangxi Medical University, 22 Shuang-Yong Rd., Nanning, 530021, Guangxi, China.; Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning, China.
Li Y; Guangxi Zhuang Autonomous Region Institute for the Prevention and Treatment of Occupational Disease, Nanning, 530021, China.
Zhao YS; Department of Toxicology, School of Public Health, Guangxi Medical University, 22 Shuang-Yong Rd., Nanning, 530021, Guangxi, China.; Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning, China.
Gan CL; Department of Toxicology, School of Public Health, Guangxi Medical University, 22 Shuang-Yong Rd., Nanning, 530021, Guangxi, China.; Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning, China.
Luo JJ; Department of Toxicology, School of Public Health, Guangxi Medical University, 22 Shuang-Yong Rd., Nanning, 530021, Guangxi, China.; Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning, China.
Ou SY; Department of Toxicology, School of Public Health, Guangxi Medical University, 22 Shuang-Yong Rd., Nanning, 530021, Guangxi, China. .; Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning, China. .
Aschner M; Guangxi Zhuang Autonomous Region Institute for the Prevention and Treatment of Occupational Disease, Nanning, 530021, China.; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.
Jiang YM; Department of Toxicology, School of Public Health, Guangxi Medical University, 22 Shuang-Yong Rd., Nanning, 530021, Guangxi, China. .; Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning, China. .
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Źródło:
Neurotoxicity research [Neurotox Res] 2023 Feb; Vol. 41 (1), pp. 1-15. Date of Electronic Publication: 2023 Jan 04.
Typ publikacji:
Journal Article
MeSH Terms:
Aminosalicylic Acid*/pharmacology
Autophagy*/drug effects
Cerebral Cortex*/pathology
Animals ; Rats ; Beclin-1 ; Lead/toxicity ; Rats, Sprague-Dawley ; Sodium ; Neurodegenerative Diseases/chemically induced ; Neurodegenerative Diseases/pathology
Czasopismo naukowe
Tytuł:
Oral Exposure to Lead Acetate for 28 Days Reduces the Number of Neural Progenitor Cells but Increases the Number and Synaptic Plasticity of Newborn Granule Cells in Adult Hippocampal Neurogenesis of Young-Adult Rats.
Autorzy:
Maeda N; Laboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan.
Shimizu S; Laboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan.
Takahashi Y; Laboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan.; Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan.
Kubota R; Division of Environmental Chemistry, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-shi, Kawasaki-ku, Kanagawa, 210-9501, Japan.
Uomoto S; Laboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan.
Takesue K; Laboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan.
Takashima K; Laboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan.; Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan.
Okano H; Laboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan.; Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan.
Ojiro R; Laboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan.; Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan.
Ozawa S; Laboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan.; Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan.
Tang Q; Laboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan.; Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan.
Jin M; Laboratory of Veterinary Pathology, College of Veterinary Medicine, Southwest University, BeiBei District, No. 2 Tiansheng Road, Chongqing, 400715, People's Republic of China.
Ikarashi Y; Division of Environmental Chemistry, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-shi, Kawasaki-ku, Kanagawa, 210-9501, Japan.
Yoshida T; Laboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan.; Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan.
Shibutani M; Laboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan. .; Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan. .; Institute of Global Innovation Research, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan. .
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Źródło:
Neurotoxicity research [Neurotox Res] 2022 Dec; Vol. 40 (6), pp. 2203-2220. Date of Electronic Publication: 2022 Sep 13.
Typ publikacji:
Journal Article
MeSH Terms:
Neural Stem Cells*/metabolism
Prenatal Exposure Delayed Effects*/metabolism
Rats ; Animals ; Female ; Humans ; Brain-Derived Neurotrophic Factor/metabolism ; Lead ; Neuroinflammatory Diseases ; Rats, Sprague-Dawley ; Apoptosis ; Hippocampus/metabolism ; Neurogenesis/physiology ; Dentate Gyrus ; Neuronal Plasticity
Czasopismo naukowe
Tytuł:
Persistent Effects on Cardiorespiratory and Nervous Systems Induced by Long-Term Lead Exposure: Results from a Longitudinal Study.
Autorzy:
Shvachiy L; Centro Cardiovascular da Universidade de Lisboa, Faculdade de Medicina, Universidade de Lisboa, Av Prof Egas Moniz, 1649-028, Lisbon, Portugal.
Geraldes V; Centro Cardiovascular da Universidade de Lisboa, Faculdade de Medicina, Universidade de Lisboa, Av Prof Egas Moniz, 1649-028, Lisbon, Portugal. .
Amaro-Leal Â; Centro Cardiovascular da Universidade de Lisboa, Faculdade de Medicina, Universidade de Lisboa, Av Prof Egas Moniz, 1649-028, Lisbon, Portugal.
Rocha I; Centro Cardiovascular da Universidade de Lisboa, Faculdade de Medicina, Universidade de Lisboa, Av Prof Egas Moniz, 1649-028, Lisbon, Portugal.
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Źródło:
Neurotoxicity research [Neurotox Res] 2020 Apr; Vol. 37 (4), pp. 857-870. Date of Electronic Publication: 2020 Jan 29.
Typ publikacji:
Journal Article
MeSH Terms:
Heart Diseases/*chemically induced
Heart Diseases/*physiopathology
Lead/*toxicity
Lung Diseases/*chemically induced
Lung Diseases/*physiopathology
Neurodegenerative Diseases/*chemically induced
Neurodegenerative Diseases/*physiopathology
Animals ; Animals, Newborn ; Female ; Heart Diseases/pathology ; Hippocampus/drug effects ; Hippocampus/pathology ; Hippocampus/physiopathology ; Lead/administration & dosage ; Longitudinal Studies ; Lung Diseases/pathology ; Male ; Neurodegenerative Diseases/pathology ; Pregnancy ; Rats ; Rats, Wistar ; Time Factors
Czasopismo naukowe
Tytuł:
Assessment of the biological effect of metal ions and their complexes using Allium cepa and Artemia salina assays: a possible environmental implementation of biological inorganic chemistry.
Autorzy:
Tzima CS; Section of Inorganic and Analytical Chemistry, Department of Chemistry, University of Ioannina, 45110, Ioannina, Greece.
Banti CN; Section of Inorganic and Analytical Chemistry, Department of Chemistry, University of Ioannina, 45110, Ioannina, Greece. .
Hadjikakou SK; Section of Inorganic and Analytical Chemistry, Department of Chemistry, University of Ioannina, 45110, Ioannina, Greece. .; Institute of Materials Science and Computing, University Research Center of Ioannina (URCI), Ioannina, Greece. .
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Źródło:
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry [J Biol Inorg Chem] 2022 Oct; Vol. 27 (7), pp. 611-629. Date of Electronic Publication: 2022 Sep 23.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Mercury*/pharmacology
Metals, Heavy*/metabolism
Metals, Heavy*/toxicity
Animals ; Artemia/metabolism ; Cadmium/metabolism ; Chemistry, Bioinorganic ; Ecosystem ; Humans ; Ions/metabolism ; Lead ; Ligands ; Onions
Czasopismo naukowe
Tytuł:
Alpha-Lipoic Acid Attenuates Cadmium- and Lead-Induced Neurotoxicity by Inhibiting Both Endoplasmic-Reticulum Stress and Activation of Fas/FasL and Mitochondrial Apoptotic Pathways in Rat Cerebral Cortex.
Autorzy:
Yuan Y; College of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, Jiangsu, China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, 225009, Jiangsu, China.
Zhao SW; College of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, Jiangsu, China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, 225009, Jiangsu, China.
Wen SQ; College of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, Jiangsu, China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, 225009, Jiangsu, China.
Zhu QP; College of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, Jiangsu, China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, 225009, Jiangsu, China.
Wang L; College of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, Jiangsu, China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, 225009, Jiangsu, China.
Zou H; College of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, Jiangsu, China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, 225009, Jiangsu, China.
Gu JH; College of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, Jiangsu, China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, 225009, Jiangsu, China.
Liu XZ; College of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, Jiangsu, China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, 225009, Jiangsu, China.
Bian JC; College of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, Jiangsu, China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, 225009, Jiangsu, China.
Liu ZP; College of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, Jiangsu, China. .; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, 225009, Jiangsu, China. .
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Źródło:
Neurotoxicity research [Neurotox Res] 2021 Aug; Vol. 39 (4), pp. 1103-1115. Date of Electronic Publication: 2021 Mar 10.
Typ publikacji:
Journal Article
MeSH Terms:
Cadmium/*toxicity
Cerebral Cortex/*drug effects
Endoplasmic Reticulum Stress/*drug effects
Fas Ligand Protein/*antagonists & inhibitors
Lead/*toxicity
Thioctic Acid/*pharmacology
fas Receptor/*antagonists & inhibitors
Animals ; Antioxidants/pharmacology ; Apoptosis/drug effects ; Apoptosis/physiology ; Cerebral Cortex/metabolism ; Cerebral Cortex/ultrastructure ; Endoplasmic Reticulum Stress/physiology ; Fas Ligand Protein/metabolism ; Female ; Mitochondria/drug effects ; Mitochondria/metabolism ; Mitochondria/ultrastructure ; Rats ; Rats, Sprague-Dawley ; fas Receptor/metabolism
Czasopismo naukowe
Tytuł:
The curing performances of lead-contaminated soil conditioned with modified phosphorus β-hemihydrate gypsum cemented materials
Autorzy:
Xuquan Huang
Ruting Wang
Xiaorong Zhao
Mingming Jiang
Yunzhi Tan
Haojie Wang
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Temat:
Modified phosphogypsum
Lead contaminated soil
Leaching
Heavy metal
Solidification/stabilization
Environmental sciences
GE1-350
Źródło:
Discover Environment, Vol 2, Iss 1, Pp 1-11 (2024)
Opis pliku:
electronic resource
Relacje:
https://doaj.org/toc/2731-9431
Dostęp URL:
https://doaj.org/article/14fa44602c19428b81c7079437075b1f  Link otwiera się w nowym oknie
Czasopismo naukowe
Tytuł:
Protective Effect of Vitamin D3 Against Pb-Induced Neurotoxicity by Regulating the Nrf2 and NF-κB Pathways.
Autorzy:
Hoseinrad H; Department of Cell Biology and Anatomical Science, Faculty of Medicine, Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Shahrestanaki JK; Student Research Committee, Sabzevar University of Medical Sciences, Sabzevar, Iran.
Moosazadeh Moghaddam M; Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. .
Mousazadeh A; Faculty of Chemistry, Shahrood University of Technology, Shahrood, Iran.
Yadegari P; Student Research Committee, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Afsharzadeh N; Azad Islamic University, Damghan Branch, Damghan, Iran.
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Źródło:
Neurotoxicity research [Neurotox Res] 2021 Jun; Vol. 39 (3), pp. 687-696. Date of Electronic Publication: 2021 Jan 05.
Typ publikacji:
Journal Article
MeSH Terms:
Cholecalciferol/*pharmacology
Lead/*toxicity
NF-E2-Related Factor 2/*antagonists & inhibitors
NF-kappa B/*antagonists & inhibitors
Signal Transduction/*drug effects
Animals ; Anti-Inflammatory Agents/pharmacology ; Antioxidants/pharmacology ; Cerebral Cortex/drug effects ; Cerebral Cortex/metabolism ; Lipid Peroxidation/drug effects ; Lipid Peroxidation/physiology ; Male ; NF-E2-Related Factor 2/biosynthesis ; NF-kappa B/biosynthesis ; Oxidative Stress/drug effects ; Oxidative Stress/physiology ; Rats ; Rats, Wistar ; Reactive Oxygen Species/antagonists & inhibitors ; Reactive Oxygen Species/metabolism ; Signal Transduction/physiology
Czasopismo naukowe
Tytuł:
Evaluation of lead tolerance and biosorption characteristics of fungi from dumpsite soils
Autorzy:
Mobolaji Adenike Titilawo
Temitope Fasunloye Ajani
Suliyat Adeola Adedapo
Grace Oluwabusola Akinleye
Olafunke Esther Ogunlana
Deborah Aderibigbe
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Temat:
Dumpsite soils
Lead pollution
Aspergillus
Tolerance index
Biosorption capacity
FTIR
Environmental sciences
GE1-350
Źródło:
Discover Environment, Vol 1, Iss 1, Pp 1-13 (2023)
Opis pliku:
electronic resource
Relacje:
https://doaj.org/toc/2731-9431
Dostęp URL:
https://doaj.org/article/b4b0f12fb0f74f81819a56b99b278049  Link otwiera się w nowym oknie
Czasopismo naukowe
Tytuł:
Observation on structural and optical features of new nanostructured lead-free methylammonium zinc or cobalt iodide perovskites for solar cells applications
Autorzy:
Hager H. Zeenelabden
Ahmed Mourtada Elseman
Mostafa A. El-Aasser
Nasr Gad
Mohamed M. Rashad
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Temat:
Lead-free
Zinc
Cobalt
Halide perovskite
Nanocrystals
Science
Technology
Źródło:
SN Applied Sciences, Vol 5, Iss 12, Pp 1-11 (2023)
Opis pliku:
electronic resource
Relacje:
https://doaj.org/toc/2523-3963; https://doaj.org/toc/2523-3971
Dostęp URL:
https://doaj.org/article/4e9f776d3748441194ccfaee7909fadc  Link otwiera się w nowym oknie
Czasopismo naukowe
Tytuł:
Early-life Pb exposure as a potential risk factor for Alzheimer's disease: are there hazards for the Mexican population?
Autorzy:
Chin-Chan M; Faculty of Chemical and Biological Sciences, Autonomous University of Campeche, Campeche, Campeche, Mexico.; Leibniz Institute on Aging-Fritz Lipmann Institute, Jena, Germany.
Cobos-Puc L; Faculty of Chemical Sciences, Autonomous University of Coahuila, Saltillo, Coahuila, Mexico.
Alvarado-Cruz I; Therapeutic Radiology Department, School of Medicine, Yale University, Connecticut, USA.
Bayar M; Leibniz Institute on Aging-Fritz Lipmann Institute, Jena, Germany.
Ermolaeva M; Leibniz Institute on Aging-Fritz Lipmann Institute, Jena, Germany. .
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Źródło:
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry [J Biol Inorg Chem] 2019 Dec; Vol. 24 (8), pp. 1285-1303. Date of Electronic Publication: 2019 Nov 26.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Alzheimer Disease/*etiology
Child Development/*drug effects
Environmental Exposure/*adverse effects
Lead/*toxicity
Alzheimer Disease/genetics ; Amyloid beta-Peptides/drug effects ; Animals ; Child ; DNA/metabolism ; DNA Methylation/drug effects ; Environmental Pollutants/toxicity ; Epigenesis, Genetic/drug effects ; Humans ; Mexico ; Risk Factors ; tau Proteins/drug effects
Czasopismo naukowe

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