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Wyszukujesz frazę ""LONG-QT"" wg kryterium: Temat


Tytuł:
Case report of a child with long QT syndrome type 14 caused by CALM1 gene mutation and literature review.
Autorzy:
Sun Q; Department of Cardiology, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou Hospital of Beijing Children's Hospital, Zhengzhou, China.
Xie Z; Henan Key Laboratory of Pediatric Inherited and Metabolic Diseases, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou Hospital of Beijing Children's Hospital, Zhengzhou, China.
Wang F; Department of Cardiology, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou Hospital of Beijing Children's Hospital, Zhengzhou, China.
Guo J; Beijing Key Laboratory for Genetics of Birth Defects, Beijing Pediatric Research Institute, MOE Key Laboratory of Major Diseases in Children, Capital Medical University, Center of Rare Diseases, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Yan X; Department of Cardiology, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou Hospital of Beijing Children's Hospital, Zhengzhou, China.
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Źródło:
Molecular genetics & genomic medicine [Mol Genet Genomic Med] 2024 Jan; Vol. 12 (1), pp. e2287. Date of Electronic Publication: 2023 Oct 31.
Typ publikacji:
Review; Case Reports; Journal Article
MeSH Terms:
Long QT Syndrome*/diagnosis
Long QT Syndrome*/genetics
Long QT Syndrome*/drug therapy
Child ; Female ; Humans ; Infant ; Syncope/genetics ; Syncope/diagnosis ; Electrocardiography/adverse effects ; Mutation ; Seizures
Czasopismo naukowe
Tytuł:
Takotsubo Cardiomyopathy Presenting with QT Prolongation and Torsade de Pointes in a Patient with Coronavirus Disease 2019.
Autorzy:
Kawanaka H; Department of Cardiovascular Medicine, Shizuoka Medical Center.
Ogano M; Department of Cardiovascular Medicine, Shizuoka Medical Center.
Hibako K; Department of Emergency Medicine, Shizuoka Medical Center.
Tanabe J; Department of Cardiovascular Medicine, Shizuoka Medical Center.
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Źródło:
Journal of Nippon Medical School = Nippon Ika Daigaku zasshi [J Nippon Med Sch] 2024 Mar 09; Vol. 91 (1), pp. 124-128. Date of Electronic Publication: 2023 Feb 21.
Typ publikacji:
Case Reports; Journal Article
MeSH Terms:
Torsades de Pointes*/diagnosis
Torsades de Pointes*/etiology
Torsades de Pointes*/therapy
Takotsubo Cardiomyopathy*/complications
Takotsubo Cardiomyopathy*/diagnosis
COVID-19*/complications
Long QT Syndrome*/complications
Long QT Syndrome*/diagnosis
Humans ; Female ; Middle Aged ; Electrocardiography
Czasopismo naukowe
Tytuł:
Primary Electrical Heart Disease-Principles of Pathophysiology and Genetics.
Autorzy:
Badura K; Department of Nephrocardiology, Medical University of Lodz, Ul. Zeromskiego 113, 90-549 Lodz, Poland.
Buławska D; Department of Nephrocardiology, Medical University of Lodz, Ul. Zeromskiego 113, 90-549 Lodz, Poland.
Dąbek B; Department of Nephrocardiology, Medical University of Lodz, Ul. Zeromskiego 113, 90-549 Lodz, Poland.
Witkowska A; Department of Nephrocardiology, Medical University of Lodz, Ul. Zeromskiego 113, 90-549 Lodz, Poland.
Lisińska W; Department of Nephrocardiology, Medical University of Lodz, Ul. Zeromskiego 113, 90-549 Lodz, Poland.
Radzioch E; Department of Nephrocardiology, Medical University of Lodz, Ul. Zeromskiego 113, 90-549 Lodz, Poland.
Skwira S; Department of Nephrocardiology, Medical University of Lodz, Ul. Zeromskiego 113, 90-549 Lodz, Poland.
Młynarska E; Department of Nephrocardiology, Medical University of Lodz, Ul. Zeromskiego 113, 90-549 Lodz, Poland.
Rysz J; Department of Nephrology, Hypertension and Family Medicine, Medical University of Lodz, Ul. Zeromskiego 113, 90-549 Lodz, Poland.
Franczyk B; Department of Nephrocardiology, Medical University of Lodz, Ul. Zeromskiego 113, 90-549 Lodz, Poland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 02; Vol. 25 (3). Date of Electronic Publication: 2024 Feb 02.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Channelopathies*/complications
Long QT Syndrome*
Humans ; Arrhythmias, Cardiac/diagnosis ; Death, Sudden, Cardiac/etiology ; Death, Sudden, Cardiac/prevention & control ; Ventricular Fibrillation
Czasopismo naukowe
Tytuł:
Modeling mutation-specific arrhythmogenic phenotypes in isogenic human iPSC-derived cardiac tissues.
Autorzy:
Maurissen TL; Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, 606-8507, Japan.; Roche Pharma Research and Early Development, Cardiovascular, Metabolism, Immunology, Infectious Diseases and Ophthalmology, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.
Kawatou M; Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, 606-8507, Japan.; Department of Cardiovascular Surgery, Kyoto University Graduate School of Medicine, Kyoto, 606-8507, Japan.
López-Dávila V; Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, 606-8507, Japan.; Gourmey, Paris, France.
Minatoya K; Department of Cardiovascular Surgery, Kyoto University Graduate School of Medicine, Kyoto, 606-8507, Japan.
Yamashita JK; Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, 606-8507, Japan. .; Department of Cellular and Tissue Communications, Graduate School of Medicine, University of Tokyo, Tokyo, Japan. .
Woltjen K; Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, 606-8507, Japan. .
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Źródło:
Scientific reports [Sci Rep] 2024 Jan 31; Vol. 14 (1), pp. 2586. Date of Electronic Publication: 2024 Jan 31.
Typ publikacji:
Journal Article
MeSH Terms:
Induced Pluripotent Stem Cells*/physiology
Long QT Syndrome*/genetics
Humans ; ERG1 Potassium Channel/genetics ; Arrhythmias, Cardiac/genetics ; Mutation ; Myocytes, Cardiac/physiology ; Phenotype ; Action Potentials/genetics
Czasopismo naukowe
Tytuł:
Identification and characterization of two novel KCNH2 mutations contributing to long QT syndrome.
Autorzy:
Owusu-Mensah A; Department of Electrical and Computer Engineering, Old Dominion University, Norfolk, Virginia, United States of America.
Treat J; Masonic Medical Research Laboratory, Utica, New York, United States of America.
Bernardi J; Masonic Medical Research Laboratory, Utica, New York, United States of America.
Pfeiffer R; Masonic Medical Research Laboratory, Utica, New York, United States of America.
Goodrow R; Masonic Medical Research Laboratory, Utica, New York, United States of America.
Tsevi B; Department of Engineering, Norfolk State University, Norfolk, Virginia, United States of America.
Lam V; Department of Electrical and Computer Engineering, Old Dominion University, Norfolk, Virginia, United States of America.
Audette M; Department of Computational Modeling and Simulation Engineering, Old Dominion University, Norfolk, Virginia, United States of America.
Cordeiro JM; Masonic Medical Research Laboratory, Utica, New York, United States of America.; ICON Laboratory Services Incorporation, Whitesboro, New York, United States of America.
Deo M; Department of Engineering, Norfolk State University, Norfolk, Virginia, United States of America.
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Źródło:
PloS one [PLoS One] 2024 Jan 05; Vol. 19 (1), pp. e0287206. Date of Electronic Publication: 2024 Jan 05 (Print Publication: 2024).
Typ publikacji:
Case Reports; Journal Article
MeSH Terms:
ERG1 Potassium Channel*/genetics
Long QT Syndrome*/genetics
Adolescent ; Female ; Humans ; Infant ; Action Potentials ; Computer Simulation ; Epithelial Cells ; Mutation
Czasopismo naukowe
Tytuł:
The "One-Step" approach for QT analysis increases the sensitivity of nonclinical QTc analysis.
Autorzy:
Leishman DJ; Eli Lilly and Company, Indianapolis, Indiana, USA.
Holdsworth DL; Charles River Laboratories, Mattawan, Michigan, USA.
Lauver DA; Michigan State University, East Lansing, Michigan, USA.
Bailie MB; Certara, Ann Arbor, Michigan, USA.
Roche BM; Charles River Laboratories, Mattawan, Michigan, USA.
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Źródło:
Clinical and translational science [Clin Transl Sci] 2023 Nov; Vol. 16 (11), pp. 2253-2264. Date of Electronic Publication: 2023 Sep 19.
Typ publikacji:
Journal Article
MeSH Terms:
Long QT Syndrome*/chemically induced
Long QT Syndrome*/diagnosis
Animals ; Moxifloxacin/adverse effects ; Heart ; Electrocardiography ; Heart Rate
Czasopismo naukowe
Tytuł:
Rapid changes of mRNA expressions of cardiac ion channels affected by Torsadogenic drugs influence susceptibility of rat hearts to arrhythmias induced by Beta-Adrenergic stimulation.
Autorzy:
Hadova K; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University Bratislava, Bratislava, Slovakia.
Kmecova J; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University Bratislava, Bratislava, Slovakia.; State Institute for Drug Control, Bratislava, Slovakia.
Ochodnicka-Mackovicova K; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University Bratislava, Bratislava, Slovakia.
Kralova E; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University Bratislava, Bratislava, Slovakia.
Doka G; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University Bratislava, Bratislava, Slovakia.
Bies Pivackova L; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University Bratislava, Bratislava, Slovakia.
Vavrinec P; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University Bratislava, Bratislava, Slovakia.
Stankovicova T; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University Bratislava, Bratislava, Slovakia.
Krenek P; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University Bratislava, Bratislava, Slovakia.
Klimas J; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University Bratislava, Bratislava, Slovakia.
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Źródło:
Pharmacology research & perspectives [Pharmacol Res Perspect] 2023 Oct; Vol. 11 (5), pp. e01134.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Adrenergic Agents*
Long QT Syndrome*/chemically induced
Long QT Syndrome*/genetics
Animals ; Rats ; Pharmaceutical Preparations ; Clarithromycin ; Furosemide ; Arrhythmias, Cardiac/chemically induced ; Calcium Channels ; RNA, Messenger ; DNA-Binding Proteins
Czasopismo naukowe
Tytuł:
Cardiac response to water activities in children with Long QT syndrome type 1.
Autorzy:
Lundström A; Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden.
Wiklund U; Department of Radiation Sciences, Radiation Physics, Biomedical Engineering, Umeå University, Umeå, Sweden.
Winbo A; Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden.; Department of Physiology, University of Auckland, Auckland, New Zealand.
Eliasson H; Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Karlsson M; Department of Radiation Sciences, Radiation Physics, Biomedical Engineering, Umeå University, Umeå, Sweden.
Rydberg A; Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden.
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Źródło:
PloS one [PLoS One] 2023 Dec 07; Vol. 18 (12), pp. e0295431. Date of Electronic Publication: 2023 Dec 07 (Print Publication: 2023).
Typ publikacji:
Journal Article
MeSH Terms:
Romano-Ward Syndrome*
Long QT Syndrome*
Adolescent ; Child ; Humans ; Cross-Sectional Studies ; Heart ; Autonomic Nervous System ; Electrocardiography ; Heart Rate/physiology
Czasopismo naukowe
Tytuł:
Effect of Tucatinib on Cardiac Repolarization in Healthy Volunteers.
Autorzy:
Topletz-Erickson AR; Clinical Pharmacology and Pharmacometrics, Seagen Inc., 21823 30th Drive SE, Bothell, WA, 98021, USA.
Mayor JG; Clinical Development, Seagen Inc., Bothell, WA, USA.
Liu HT; Global Safety Risk Management, Seagen Inc., Bothell, WA, USA.
Abdulrasool LI; Global Safety Risk Management, Seagen Inc., Bothell, WA, USA.
Endres CJ; Clinical Pharmacology and Pharmacometrics, Seagen Inc., 21823 30th Drive SE, Bothell, WA, 98021, USA. .
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Źródło:
Drugs in R&D [Drugs R D] 2023 Dec; Vol. 23 (4), pp. 411-419. Date of Electronic Publication: 2023 Sep 26.
Typ publikacji:
Randomized Controlled Trial; Clinical Trial, Phase I; Journal Article
MeSH Terms:
Electrocardiography*
Long QT Syndrome*
Humans ; Healthy Volunteers ; Cross-Over Studies ; Fluoroquinolones ; Dose-Response Relationship, Drug ; Double-Blind Method ; Heart Rate
Czasopismo naukowe
Tytuł:
Pharmacological Screening of Kv7.1 and Kv7.1/KCNE1 Activators as Potential Antiarrhythmic Drugs in the Zebrafish Heart.
Autorzy:
De la Cruz A; Department of Physiology and Biophysics, Miller School of Medicine, University of Miami, 1600 NW 10th Avenue, Miami, FL 33136, USA.
Wu X; Department of Physiology and Biophysics, Miller School of Medicine, University of Miami, 1600 NW 10th Avenue, Miami, FL 33136, USA.
Rainer QC; Department of Physiology and Biophysics, Miller School of Medicine, University of Miami, 1600 NW 10th Avenue, Miami, FL 33136, USA.
Hiniesto-Iñigo I; Department of Biomedical and Clinical Sciences, Linköping University, SE-581 85 Linköping, Sweden.
Perez ME; Department of Physiology and Biophysics, Miller School of Medicine, University of Miami, 1600 NW 10th Avenue, Miami, FL 33136, USA.
Edler I; Department of Physiology and Biophysics, Miller School of Medicine, University of Miami, 1600 NW 10th Avenue, Miami, FL 33136, USA.; Department of Biomedical and Clinical Sciences, Linköping University, SE-581 85 Linköping, Sweden.
Liin SI; Department of Biomedical and Clinical Sciences, Linköping University, SE-581 85 Linköping, Sweden.
Larsson HP; Department of Physiology and Biophysics, Miller School of Medicine, University of Miami, 1600 NW 10th Avenue, Miami, FL 33136, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jul 28; Vol. 24 (15). Date of Electronic Publication: 2023 Jul 28.
Typ publikacji:
Journal Article
MeSH Terms:
Long QT Syndrome*/drug therapy
Long QT Syndrome*/genetics
Potassium Channels, Voltage-Gated*/pharmacology
Animals ; Humans ; Anti-Arrhythmia Agents/pharmacology ; Zebrafish ; Heart ; Arrhythmias, Cardiac/drug therapy ; Arrhythmias, Cardiac/genetics ; Action Potentials
Czasopismo naukowe
Tytuł:
A Novel KCNH2 S981fs Mutation Identified by Whole-Exome Sequencing Is Associated with Type 2 Long QT Syndrome.
Autorzy:
Cheng YW; Cardiovascular Division, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Tao-Yuan 33305, Taiwan.
Wu CT; Cardiovascular Division, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Tao-Yuan 33305, Taiwan.
Chang CJ; Cardiovascular Division, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Tao-Yuan 33305, Taiwan.
Yeh YH; Cardiovascular Division, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Tao-Yuan 33305, Taiwan.
Chang GJ; Graduate Institute of Clinical Medical Sciences, Chang Gung University, Tao-Yuan 33305, Taiwan.
Tsai HY; Cardiovascular Division, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Tao-Yuan 33305, Taiwan.
Hsu LA; Cardiovascular Division, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Tao-Yuan 33305, Taiwan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Aug 13; Vol. 24 (16). Date of Electronic Publication: 2023 Aug 13.
Typ publikacji:
Journal Article
MeSH Terms:
Long QT Syndrome*/genetics
Humans ; Exome Sequencing ; Heart ; Cell Membrane ; Mutation ; ERG1 Potassium Channel/genetics
Czasopismo naukowe
Tytuł:
Dosage of the pseudoautosomal gene SLC25A6 is implicated in QTc interval duration.
Autorzy:
Skakkebæk A; Department of Clinical Genetics, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200, Aarhus N, Denmark. .; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark. .; Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark. .
Kjær-Sørensen K; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Matchkov VV; Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Christensen LL; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark.
Just J; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark.
Cömert C; Research Unit for Molecular Medicine, Department of Clinical Medicine, Aarhus University and Aarhus University Hospital, Aarhus, Denmark.
Andersen NH; Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark.
Oxvig C; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Gravholt CH; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Endocrinology and Internal Medicine and Medical Research Laboratories, Aarhus University Hospital, Aarhus, Denmark.
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Źródło:
Scientific reports [Sci Rep] 2023 Jul 26; Vol. 13 (1), pp. 12089. Date of Electronic Publication: 2023 Jul 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Klinefelter Syndrome*
Long QT Syndrome*/genetics
Turner Syndrome*
Animals ; Female ; Humans ; Male ; Adenosine Triphosphate ; Electrocardiography ; X Chromosome ; Zebrafish/genetics ; Adenine Nucleotide Translocator 3
Czasopismo naukowe
Tytuł:
Comparison of oral versus intravenous methadone on postoperative pain and opioid use after adult spinal deformity surgery: A retrospective, non-inferiority analysis.
Autorzy:
Esfahani K; Department of Anesthesiology, University of Virginia, Charlottesville, Virginia, United States of America.
Tennant W; Department of Anesthesiology, University of Virginia, Charlottesville, Virginia, United States of America.
Tsang S; Department of Anesthesiology, University of Virginia, Charlottesville, Virginia, United States of America.
Naik BI; Department of Anesthesiology, University of Virginia, Charlottesville, Virginia, United States of America.; Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia, United States of America.
Dunn LK; Department of Anesthesiology, University of Virginia, Charlottesville, Virginia, United States of America.; Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia, United States of America.
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Źródło:
PloS one [PLoS One] 2023 Jul 21; Vol. 18 (7), pp. e0288988. Date of Electronic Publication: 2023 Jul 21 (Print Publication: 2023).
Typ publikacji:
Journal Article
MeSH Terms:
Opioid-Related Disorders*/drug therapy
Long QT Syndrome*/drug therapy
Humans ; Adult ; Methadone/therapeutic use ; Analgesics, Opioid/adverse effects ; Retrospective Studies ; Cohort Studies ; Pain, Postoperative/drug therapy ; Pain, Postoperative/etiology ; Morphine
Czasopismo naukowe
Tytuł:
Feasibility of using KardiaMobile-L6 for QT interval monitoring during the early phase of the COVID-19 pandemic in critical care patients.
Autorzy:
Zaballos M; Department of Forensic Medicine, Psychiatry and Pathology, Complutense University, C/ Dr Esquerdo nº46, 28007, Madrid, Spain. .; Department of Anaesthesiology, Hospital General Universitario Gregorio Marañón, Madrid, Spain. .
Fernández I; Department of Anaesthesiology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Rodríguez L; Department of Anaesthesiology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Orozco S; Department of Anaesthesiology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
García A; Department of Anaesthesiology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Juncos M; Department of Anaesthesiology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Alvarez-Zaballos S; Department of Cardiology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Piñeiro P; Department of Anaesthesiology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Hortal J; Department of Anaesthesiology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.; Department of Pharmacology, Complutense University, Madrid, Spain.
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Źródło:
Scientific reports [Sci Rep] 2023 Jul 06; Vol. 13 (1), pp. 10985. Date of Electronic Publication: 2023 Jul 06.
Typ publikacji:
Journal Article; Observational Study; Research Support, Non-U.S. Gov't
MeSH Terms:
COVID-19*
Long QT Syndrome*/diagnosis
Humans ; Critical Care ; Critical Illness ; Electrocardiography/methods ; Feasibility Studies ; Pandemics ; Reproducibility of Results ; SARS-CoV-2
Czasopismo naukowe
Tytuł:
Relevance of KCNJ5 in Pathologies of Heart Disease.
Autorzy:
Meyer KM; Department of Surgery, Division of Cardiac Surgery, The Ohio State University, Columbus, OH 43210, USA.; The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA.
Malhotra N; Department of Surgery, Division of Cardiac Surgery, The Ohio State University, Columbus, OH 43210, USA.; The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA.
Kwak JS; Department of Surgery, Division of Cardiac Surgery, The Ohio State University, Columbus, OH 43210, USA.; The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA.
El Refaey M; Department of Surgery, Division of Cardiac Surgery, The Ohio State University, Columbus, OH 43210, USA.; The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jun 29; Vol. 24 (13). Date of Electronic Publication: 2023 Jun 29.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Hyperaldosteronism*
Long QT Syndrome*
Humans ; G Protein-Coupled Inwardly-Rectifying Potassium Channels/genetics ; Heart ; Sick Sinus Syndrome
Czasopismo naukowe
Tytuł:
Concentration QTc analysis of giredestrant: Overcoming QT/heart rate confounding in the presence of drug-induced heart rate changes.
Autorzy:
Brooks L; Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA.
Dolton M; Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA.
Langenhorst J; Pharmetheus AB, Uppsala, Sweden.
Yoshida K; Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA.
Lien YTK; Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA.
Malhi V; Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA.
Li C; Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA.
Perez-Moreno P; Product Development Oncology, Genentech, Inc., South San Francisco, California, USA.
Bond J; Product Development Oncology, Genentech, Inc., South San Francisco, California, USA.
Chen YC; Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA.
Yu J; Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA.
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Źródło:
Clinical and translational science [Clin Transl Sci] 2023 May; Vol. 16 (5), pp. 823-834. Date of Electronic Publication: 2023 Feb 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Fluoroquinolones*
Long QT Syndrome*/chemically induced
Long QT Syndrome*/diagnosis
Humans ; Moxifloxacin/adverse effects ; Heart Rate ; Receptors, Estrogen ; Double-Blind Method ; Dose-Response Relationship, Drug
Czasopismo naukowe
Tytuł:
A Common East Asian aldehyde dehydrogenase 2*2 variant promotes ventricular arrhythmia with chronic light-to-moderate alcohol use in mice.
Autorzy:
Lee AS; Department of Medicine, MacKay Medical College, New Taipei, Taiwan.; Division of Cardiovascular Medicine, China Medical University Hospital, Taichung, Taiwan.
Sung YL; Institute of Biomedical Engineering, College of Electrical and Computer Engineering, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.; Graduate Institute of Biomedical Optomechatronics, Taipei Medical University, Taipei, Taiwan.
Pan SH; Graduate Institute of Medical Genomics and Proteomics, College of Medicine, National Taiwan University, Taipei, Taiwan.; Genome and Systems Biology Degree Program, National Taiwan University and Academia Sinica, Taipei, Taiwan.; Doctoral Degree Program of Translational Medicine, National Taiwan University, Taipei, Taiwan.
Sung KT; Department of Medicine, MacKay Medical College, New Taipei, Taiwan.; Division of Cardiology, Departments of Internal Medicine, MacKay Memorial Hospital, Taipei, Taiwan.
Su CH; Department of Medicine, MacKay Medical College, New Taipei, Taiwan.; Division of Cardiology, Departments of Internal Medicine, MacKay Memorial Hospital, Taipei, Taiwan.
Ding SL; Department of Medical Research, MacKay Memorial Hospital, New Taipei, Taiwan.
Lu YJ; Department of Medical Research, MacKay Memorial Hospital, New Taipei, Taiwan.
Hsieh CL; Department of Medical Research, MacKay Memorial Hospital, New Taipei, Taiwan.
Chen YF; Department of Medicine, MacKay Medical College, New Taipei, Taiwan.
Liu CC; Department of Physiology Examination, MacKay Memorial Hospital, New Taipei, Taiwan.
Chen WY; Department of Medicine, MacKay Medical College, New Taipei, Taiwan.
Chen XR; Graduate Institute of Medical Genomics and Proteomics, College of Medicine, National Taiwan University, Taipei, Taiwan.
Chung FP; Heart Rhythm Center and Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.; Department of Medicine, National Yang Ming Chiao Tung University, School of Medicine, Taipei, Taiwan.
Wang SW; Department of Medicine, MacKay Medical College, New Taipei, Taiwan.; Institute of Biomedical Sciences, MacKay Medical College, New Taipei, Taiwan.
Chen CH; Department of Chemical and Systems Biology, Stanford University, School of Medicine, Stanford, CA, USA.
Mochly-Rosen D; Department of Chemical and Systems Biology, Stanford University, School of Medicine, Stanford, CA, USA.
Hung CL; Department of Medicine, MacKay Medical College, New Taipei, Taiwan. .; Division of Cardiology, Departments of Internal Medicine, MacKay Memorial Hospital, Taipei, Taiwan. .; Institute of Biomedical Sciences, MacKay Medical College, New Taipei, Taiwan. .
Yeh HI; Department of Medicine, MacKay Medical College, New Taipei, Taiwan. .; Division of Cardiology, Departments of Internal Medicine, MacKay Memorial Hospital, Taipei, Taiwan. .
Lin SF; Institute of Biomedical Engineering, College of Electrical and Computer Engineering, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.
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Źródło:
Communications biology [Commun Biol] 2023 Jun 06; Vol. 6 (1), pp. 610. Date of Electronic Publication: 2023 Jun 06.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Aldehyde Dehydrogenase, Mitochondrial*/genetics
Ethanol*/toxicity
Long QT Syndrome*/chemically induced
Animals ; Humans ; Mice ; Arrhythmias, Cardiac/genetics ; East Asian People ; Mice, Transgenic
Czasopismo naukowe
Tytuł:
Unraveling Structural Alerts in Marketed Drugs for Improving Adverse Outcome Pathway Framework of Drug-Induced QT Prolongation.
Autorzy:
Long W; College of Chemistry, Sichuan University, Chengdu 610064, China.
Li S; College of Chemistry, Sichuan University, Chengdu 610064, China.
He Y; College of Chemistry, Sichuan University, Chengdu 610064, China.
Lin J; College of Chemistry, Sichuan University, Chengdu 610064, China.
Li M; College of Chemistry, Sichuan University, Chengdu 610064, China.
Wen Z; College of Chemistry, Sichuan University, Chengdu 610064, China.; Medical Big Data Center, Sichuan University, Chengdu 610064, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Apr 05; Vol. 24 (7). Date of Electronic Publication: 2023 Apr 05.
Typ publikacji:
Journal Article
MeSH Terms:
Torsades de Pointes*/chemically induced
Long QT Syndrome*/chemically induced
Adverse Outcome Pathways*
Drug-Related Side Effects and Adverse Reactions*/etiology
Humans ; Ion Channels ; Heart ; Electrocardiography
Czasopismo naukowe
Tytuł:
Long QT begets long QT.
Autorzy:
Viskin S; Department of Cardiology, Tel Aviv Sourasky Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
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Źródło:
Journal of cardiovascular electrophysiology [J Cardiovasc Electrophysiol] 2023 Jan; Vol. 34 (1), pp. 177-179. Date of Electronic Publication: 2022 Nov 15.
Typ publikacji:
Editorial; Comment
MeSH Terms:
Torsades de Pointes*
Long QT Syndrome*/diagnosis
Long QT Syndrome*/genetics
Long QT Syndrome*/therapy
Humans ; Electrocardiography
Opinia redakcyjna
Tytuł:
Same family, same mutation, different ECG.
Autorzy:
Akbuğa K; Cardiology Department, Faculty of Medicine, TOBB ETU, Ankara, Turkey.
Karanfil M; Cardiology Clinic, Ankara City Hospital, Ankara, Turkey.
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Źródło:
Molecular genetics & genomic medicine [Mol Genet Genomic Med] 2023 Jan; Vol. 11 (1), pp. e2079. Date of Electronic Publication: 2022 Oct 28.
Typ publikacji:
Journal Article
MeSH Terms:
Electrocardiography*
Long QT Syndrome*/diagnosis
Long QT Syndrome*/genetics
Humans ; Genotype ; Arrhythmias, Cardiac ; Mutation
Czasopismo naukowe

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