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Tytuł:
Relationship between polymorphisms and mutations at rs7125942 and rs3736228 of LRP5 gene and bone metabolism in postmenopausal women.
Autorzy:
Li J; Department of Endocrinology and Metabolism, The First Affiliated Hospital, Shihezi University, Shihezi, 832002, Xinjiang, China. .
Li Y; Department of Endocrinology and Metabolism, The First Affiliated Hospital, Shihezi University, Shihezi, 832002, Xinjiang, China.
Li S; Medical School of Shihezi University, Shihezi, 832002, China.
Lu Y; Medical School of Shihezi University, Shihezi, 832002, China.
Rai P; Ocaf Hospital, Karachi, Pakistan.
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Źródło:
Journal of orthopaedic surgery and research [J Orthop Surg Res] 2024 Feb 01; Vol. 19 (1), pp. 104. Date of Electronic Publication: 2024 Feb 01.
Typ publikacji:
Journal Article
MeSH Terms:
Low Density Lipoprotein Receptor-Related Protein-5*/genetics
Osteoporosis, Postmenopausal*/genetics
Humans ; Female ; Postmenopause/genetics ; Bone Density/genetics ; Polymorphism, Genetic ; Mutation
Czasopismo naukowe
Tytuł:
The endocytic receptor protein LRP-1 modulate P-glycoprotein mediated drug resistance in MCF-7 cells.
Autorzy:
Henry A; UMR-CNRS 7369 Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), UFR SEN, URCA, Reims cedex, France.
Mauperin M; UMR-CNRS 7369 Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), UFR SEN, URCA, Reims cedex, France.
Devy J; UMR-CNRS 7369 Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), UFR SEN, URCA, Reims cedex, France.
Dedieu S; UMR-CNRS 7369 Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), UFR SEN, URCA, Reims cedex, France.
Chazee L; UMR-CNRS 7369 Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), UFR SEN, URCA, Reims cedex, France.
Hachet C; UMR-CNRS 7369 Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), UFR SEN, URCA, Reims cedex, France.
Terryn C; Technical Platform for Cellular and Tissue Imaging (PICT), UFR Pharmacie, URCA, Reims, France.
Duca L; UMR-CNRS 7369 Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), UFR SEN, URCA, Reims cedex, France.
Martiny L; UMR-CNRS 7369 Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), UFR SEN, URCA, Reims cedex, France.
Devarenne-Charpentier E; UMR-CNRS 7369 Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), UFR SEN, URCA, Reims cedex, France.
Btaouri HE; UMR-CNRS 7369 Matrice Extracellulaire et Dynamique Cellulaire (MEDyC), UFR SEN, URCA, Reims cedex, France.
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Źródło:
PloS one [PLoS One] 2023 Sep 28; Vol. 18 (9), pp. e0285834. Date of Electronic Publication: 2023 Sep 28 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents*/pharmacology
ATP Binding Cassette Transporter, Subfamily B, Member 1*/metabolism
Drug Resistance, Neoplasm*
Low Density Lipoprotein Receptor-Related Protein-1*/metabolism
Humans ; Carrier Proteins/pharmacology ; Doxorubicin/pharmacology ; MCF-7 Cells
Czasopismo naukowe
Tytuł:
Novel Homozygous Nonsense Mutation in the LRP5 Gene in Two Siblings with Osteoporosis-pseudoglioma Syndrome
Autorzy:
Heidari A; Reference Laboratory of Qazvin Medical University, Iran Sana Medical Genetics Laboratory, Qazvin, Iran
Homaei A; Shahid Beheshti University of Medical Sciences, Department of General Surgery, Tehran, Iran
Saffari F; Qazvin University of Medical Sciences, Children Growth Research Center, Research Institute for Prevention of Non-Communicable Diseases, Department of Pediatric Endocrinology, Qazvin, Iran
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Źródło:
Journal of clinical research in pediatric endocrinology [J Clin Res Pediatr Endocrinol] 2023 Aug 23; Vol. 15 (3), pp. 318-323. Date of Electronic Publication: 2021 Dec 30.
Typ publikacji:
Case Reports; Journal Article
MeSH Terms:
Low Density Lipoprotein Receptor-Related Protein-5*/genetics
Osteoporosis*/genetics
Female ; Humans ; Male ; Codon, Nonsense ; Mutation ; Siblings
SCR Disease Name:
Osteoporosis-pseudoglioma syndrome
Czasopismo naukowe
Tytuł:
LRP1 Deficiency Promotes Mitostasis in Response to Oxidative Stress: Implications for Mitochondrial Targeting after Traumatic Brain Injury.
Autorzy:
Velmurugan GV; Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY 405036, USA.; Department of Neuroscience, University of Kentucky, Lexington, KY 40536, USA.
Hubbard WB; Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY 405036, USA.; Lexington Veterans' Affairs Healthcare System, Lexington, KY 40502, USA.; Department of Physiology, University of Kentucky, Lexington, KY 40536, USA.
Prajapati P; Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY 405036, USA.; Department of Neuroscience, University of Kentucky, Lexington, KY 40536, USA.; Lexington Veterans' Affairs Healthcare System, Lexington, KY 40502, USA.
Vekaria HJ; Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY 405036, USA.; Department of Neuroscience, University of Kentucky, Lexington, KY 40536, USA.; Lexington Veterans' Affairs Healthcare System, Lexington, KY 40502, USA.
Patel SP; Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY 405036, USA.; Department of Physiology, University of Kentucky, Lexington, KY 40536, USA.
Rabchevsky AG; Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY 405036, USA.; Department of Physiology, University of Kentucky, Lexington, KY 40536, USA.
Sullivan PG; Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY 405036, USA.; Department of Neuroscience, University of Kentucky, Lexington, KY 40536, USA.; Lexington Veterans' Affairs Healthcare System, Lexington, KY 40502, USA.
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Źródło:
Cells [Cells] 2023 May 22; Vol. 12 (10). Date of Electronic Publication: 2023 May 22.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Brain Injuries, Traumatic*/metabolism
Fibroblasts*/metabolism
Oxidative Stress*
Low Density Lipoprotein Receptor-Related Protein-1*/genetics
Animals ; Mice ; Brain/metabolism ; Mice, Transgenic ; Mitochondria/metabolism
Czasopismo naukowe
Tytuł:
LRP5-/6 gene polymorphisms and its association with risk of abnormal bone mass in postmenopausal women.
Autorzy:
Li J; The First Affiliated Hospital of Shihezi University, 107 North Second Road, Hongshan Sub-District, Shihezi City, 832000, Xinjiang Uygur Autonomous Region, People's Republic of China. .
Liu Z; The First Affiliated Hospital of Shihezi University, 107 North Second Road, Hongshan Sub-District, Shihezi City, 832000, Xinjiang Uygur Autonomous Region, People's Republic of China.
Ren Y; The First Affiliated Hospital of Shihezi University, 107 North Second Road, Hongshan Sub-District, Shihezi City, 832000, Xinjiang Uygur Autonomous Region, People's Republic of China.
Shao H; School of Medicine, Shihezi University, Shihezi, 832000, Xinjiang Uygur Autonomous Region, People's Republic of China.
Li S; School of Medicine, Shihezi University, Shihezi, 832000, Xinjiang Uygur Autonomous Region, People's Republic of China.
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Źródło:
Journal of orthopaedic surgery and research [J Orthop Surg Res] 2023 May 18; Vol. 18 (1), pp. 369. Date of Electronic Publication: 2023 May 18.
Typ publikacji:
Journal Article
MeSH Terms:
Bone Density*/genetics
Low Density Lipoprotein Receptor-Related Protein-5*/genetics
Female ; Humans ; Genotype ; Polymorphism, Single Nucleotide/genetics ; Postmenopause/genetics
Czasopismo naukowe
Tytuł:
Potential association of genetically predicted lipid and lipid-modifying drugs with rheumatoid arthritis: A Mendelian randomization study.
Autorzy:
Huang, Zhican (AUTHOR)
Cui, Ting (AUTHOR)
Yao, Jin (AUTHOR)
Wu, Yutong (AUTHOR)
Zhu, Jun (AUTHOR)
Yang, Xin (AUTHOR)
Cui, Li (AUTHOR)
Zhou, Haiyan (AUTHOR)
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Źródło:
PLoS ONE. 2/28/2024, Vol. 19 Issue 2, p1-16. 16p.
Czasopismo naukowe
Tytuł:
Unlocking the mysteries of VLDL: exploring its production, intracellular trafficking, and metabolism as therapeutic targets.
Autorzy:
Chen, Jingfei (AUTHOR)
Fang, Zhenfei (AUTHOR)
Luo, Qin (AUTHOR)
Wang, Xiao (AUTHOR)
Warda, Mohamad (AUTHOR)
Das, Avash (AUTHOR)
Oldoni, Federico (AUTHOR)
Luo, Fei (AUTHOR)
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Źródło:
Lipids in Health & Disease. 1/12/2024, Vol. 23 Issue 1, p1-11. 11p.
Czasopismo naukowe
Tytuł:
FUT2 inhibits the EMT and metastasis of colorectal cancer by increasing LRP1 fucosylation.
Autorzy:
He L; Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.; Endoscopy Center, Department of Gastroenterology, Shanghai East Hospital, Tongji University School of Medicine, 150 Jimo Road, Pudong New Area, Shanghai, China.
Guo Z; Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.; Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Wang W; Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Tian S; Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Lin R; Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. .
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Źródło:
Cell communication and signaling : CCS [Cell Commun Signal] 2023 Mar 27; Vol. 21 (1), pp. 63. Date of Electronic Publication: 2023 Mar 27.
Typ publikacji:
Video-Audio Media; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Colorectal Neoplasms*/pathology
Epithelial-Mesenchymal Transition*
Low Density Lipoprotein Receptor-Related Protein-1*/genetics
Fucosyltransferases*/genetics
Animals ; Mice ; Cell Line, Tumor ; Cell Movement ; Gene Expression Regulation, Neoplastic ; Mice, Nude ; Neoplasm Metastasis ; Galactoside 2-alpha-L-fucosyltransferase
Czasopismo naukowe
Tytuł:
Transplantation of the LRP1 subpopulation of human umbilical cord-derived mesenchymal stem cells improves ovarian function in mice with premature ovarian failure and aged mice.
Autorzy:
Shen J; Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
Wu L; Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China. 14_.
Shi X; Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Department of Orthopedics, Tongji Hospital, School of Life Science and Technology, Tongji University, Tongji, 200092, China.; Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
Chen G; Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
Liu T; Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
Xu F; Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
Xu X; Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
Kou X; Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.; Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
Zhao Y; Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.; Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
Wang H; Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.; Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
Wang C; Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Department of Orthopedics, Tongji Hospital, School of Life Science and Technology, Tongji University, Tongji, 200092, China.; Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
Gao S; Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China. .; Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China. .
Xu S; Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China. .
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Źródło:
Stem cell research & therapy [Stem Cell Res Ther] 2024 Mar 05; Vol. 15 (1), pp. 64. Date of Electronic Publication: 2024 Mar 05.
Typ publikacji:
Journal Article
MeSH Terms:
Primary Ovarian Insufficiency*/therapy
Mesenchymal Stem Cells*
Humans ; Female ; Animals ; Mice ; Aged ; Oocytes ; Stem Cells ; Low Density Lipoprotein Receptor-Related Protein-1/genetics
Czasopismo naukowe
Tytuł:
Angiotensin II type 2 receptor activation preserves megalin in the kidney and prevents proteinuria in high salt diet fed rats.
Autorzy:
Kulkarni K; Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Health 2, 4349 Martin Luther King Boulevard, Houston, TX, 77204-5037, USA.
Patel S; Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Health 2, 4349 Martin Luther King Boulevard, Houston, TX, 77204-5037, USA.
Ali R; Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Health 2, 4349 Martin Luther King Boulevard, Houston, TX, 77204-5037, USA.
Hussain T; Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Health 2, 4349 Martin Luther King Boulevard, Houston, TX, 77204-5037, USA. .
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Źródło:
Scientific reports [Sci Rep] 2023 Mar 15; Vol. 13 (1), pp. 4277. Date of Electronic Publication: 2023 Mar 15.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Low Density Lipoprotein Receptor-Related Protein-2*/metabolism
Proteinuria*/metabolism
Receptor, Angiotensin, Type 2*/metabolism
Animals ; Rats ; Diet ; Glycogen Synthase Kinase 3 beta/metabolism ; Kidney Glomerulus/pathology ; Obesity/metabolism ; Rats, Zucker ; Receptor, Angiotensin, Type 1/metabolism ; Sodium Chloride, Dietary/pharmacology
Czasopismo naukowe
Tytuł:
N -Glycosylation of LRP6 by B3GnT2 Promotes Wnt/β-Catenin Signalling.
Autorzy:
Xu R; Institute of Biological and Chemical Systems-Functional Molecular Systems (IBCS-FMS), Karlsruhe Institute of Technology (KIT), 76344 Eggenstein-Leopoldshafen, Germany.; Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Wang X; Institute of Biological and Chemical Systems-Functional Molecular Systems (IBCS-FMS), Karlsruhe Institute of Technology (KIT), 76344 Eggenstein-Leopoldshafen, Germany.; Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany.
Safi S; Institute of Biological and Chemical Systems-Functional Molecular Systems (IBCS-FMS), Karlsruhe Institute of Technology (KIT), 76344 Eggenstein-Leopoldshafen, Germany.
Braunegger N; Institute of Biological and Chemical Systems-Functional Molecular Systems (IBCS-FMS), Karlsruhe Institute of Technology (KIT), 76344 Eggenstein-Leopoldshafen, Germany.
Hipgrave Ederveen A; Center for Proteomics and Metabolomics, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.
Rottmann M; Institute of Biological and Chemical Systems-Functional Molecular Systems (IBCS-FMS), Karlsruhe Institute of Technology (KIT), 76344 Eggenstein-Leopoldshafen, Germany.
Wittbrodt J; COS-Centre for Organismal Studies, Department of Molecular Developmental Biology & Physiology, Heidelberg University, Im Neuenheimer Feld 230, 69120 Heidelberg, Germany.
Wuhrer M; Center for Proteomics and Metabolomics, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.
Wesslowski J; Institute of Biological and Chemical Systems-Functional Molecular Systems (IBCS-FMS), Karlsruhe Institute of Technology (KIT), 76344 Eggenstein-Leopoldshafen, Germany.
Davidson G; Institute of Biological and Chemical Systems-Functional Molecular Systems (IBCS-FMS), Karlsruhe Institute of Technology (KIT), 76344 Eggenstein-Leopoldshafen, Germany.
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Źródło:
Cells [Cells] 2023 Mar 10; Vol. 12 (6). Date of Electronic Publication: 2023 Mar 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
beta Catenin*/metabolism
Low Density Lipoprotein Receptor-Related Protein-6*/metabolism
Animals ; Humans ; Glycosylation ; Wnt Signaling Pathway ; Glycosyltransferases/metabolism ; N-Acetylglucosaminyltransferases/metabolism
Czasopismo naukowe
Tytuł:
LRP5 Regulates HIF-1α Stability via Interaction with PHD2 in Ischemic Myocardium.
Autorzy:
Ju S; Department of Biochemistry and Molecular Biology, Chosun University School of Medicine, Gwangju 61452, Korea.
Lim L; Cancer Mutation Research Center, Chosun University, Gwangju 61452, Korea.
Wi K; Department of Biochemistry and Molecular Biology, Chosun University School of Medicine, Gwangju 61452, Korea.
Park C; Department of Molecular & Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71103, USA.
Ki YJ; Department of Internal Medicine, Chosun University School of Medicine, Gwangju 61452, Korea.
Choi DH; Department of Internal Medicine, Chosun University School of Medicine, Gwangju 61452, Korea.
Song H; Department of Biochemistry and Molecular Biology, Chosun University School of Medicine, Gwangju 61452, Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 19; Vol. 22 (12). Date of Electronic Publication: 2021 Jun 19.
Typ publikacji:
Journal Article
MeSH Terms:
Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism
Hypoxia-Inducible Factor-Proline Dioxygenases/*metabolism
Low Density Lipoprotein Receptor-Related Protein-5/*metabolism
Myocardial Ischemia/*metabolism
Myocytes, Cardiac/*metabolism
Animals ; Animals, Newborn ; Gene Expression Regulation ; Hydroxylation ; Hypoxia/metabolism ; Low Density Lipoprotein Receptor-Related Protein-6/metabolism ; Primary Cell Culture ; Rats ; Wnt Signaling Pathway
Czasopismo naukowe
Tytuł:
LRP1 and RAGE Genes Transporting Amyloid and Tau Protein in the Hippocampal CA3 Area in an Ischemic Model of Alzheimer's Disease with 2-Year Survival.
Autorzy:
Pluta R; Department of Pathophysiology, Medical University of Lublin, 20-090 Lublin, Poland.
Kocki J; Department of Clinical Genetics, Medical University of Lublin, 20-080 Lublin, Poland.
Bogucki J; Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Lublin, 20-093 Lublin, Poland.
Bogucka-Kocka A; Department of Biology and Genetics, Medical University of Lublin, 20-093 Lublin, Poland.
Czuczwar SJ; Department of Pathophysiology, Medical University of Lublin, 20-090 Lublin, Poland.
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Źródło:
Cells [Cells] 2023 Dec 04; Vol. 12 (23). Date of Electronic Publication: 2023 Dec 04.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alzheimer Disease*/genetics
Alzheimer Disease*/metabolism
Brain Ischemia*/genetics
Brain Ischemia*/metabolism
Humans ; Amyloidogenic Proteins/metabolism ; Hippocampus/metabolism ; Ischemia/metabolism ; Low Density Lipoprotein Receptor-Related Protein-1/genetics ; Low Density Lipoprotein Receptor-Related Protein-1/metabolism ; tau Proteins/metabolism ; Protein Transport
Czasopismo naukowe
Tytuł:
Induced alternative splicing an opportunity to study PCSK9 protein isoforms at physiologically relevant concentrations.
Autorzy:
Cale, Jessica M. (AUTHOR)
Ham, Kristin A. (AUTHOR)
Li, Dunhui (AUTHOR)
McIntosh, Craig S. (AUTHOR)
Watts, Gerald F. (AUTHOR)
Wilton, Steve D. (AUTHOR)
Aung-Htut, May T. (AUTHOR)
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Źródło:
Scientific Reports. 11/13/2023, Vol. 13 Issue 1, p1-11. 11p.
Czasopismo naukowe
Tytuł:
Megalin Orchestrates FcRn Endocytosis and Trafficking.
Autorzy:
Dahlke E; Institute of Anatomy, Christian Albrechts-University Kiel, 24118 Kiel, Germany.
Anan Y; Institute of Anatomy, Christian Albrechts-University Kiel, 24118 Kiel, Germany.
Klie LM; Institute of Anatomy, Christian Albrechts-University Kiel, 24118 Kiel, Germany.
Hartkopf AE; Institute of Anatomy, Christian Albrechts-University Kiel, 24118 Kiel, Germany.
Theilig F; Institute of Anatomy, Christian Albrechts-University Kiel, 24118 Kiel, Germany.
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Źródło:
Cells [Cells] 2022 Dec 22; Vol. 12 (1). Date of Electronic Publication: 2022 Dec 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Endocytosis*
Low Density Lipoprotein Receptor-Related Protein-2*/metabolism
Albumins/metabolism ; Clathrin ; Ligands ; Protein Transport
Czasopismo naukowe
Tytuł:
MT1-MMP Expression Levels and Catalytic Functions Dictate LDL Receptor-Related Protein-1 Ligand Internalization Capacity in U87 Glioblastoma Cells.
Autorzy:
Pratt J; Laboratoire d'Oncologie Moléculaire, Centre de Recherche CERMO-FC, Département de Chimie, Université du Québec à Montréal, Montréal, QC H3C 3P8, Canada.
Haidara K; Laboratoire d'Oncologie Moléculaire, Centre de Recherche CERMO-FC, Département de Chimie, Université du Québec à Montréal, Montréal, QC H3C 3P8, Canada.
Annabi B; Laboratoire d'Oncologie Moléculaire, Centre de Recherche CERMO-FC, Département de Chimie, Université du Québec à Montréal, Montréal, QC H3C 3P8, Canada.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Nov 17; Vol. 23 (22). Date of Electronic Publication: 2022 Nov 17.
Typ publikacji:
Journal Article
MeSH Terms:
Brain Neoplasms*/drug therapy
Brain Neoplasms*/genetics
Brain Neoplasms*/pathology
Glioblastoma*/metabolism
Low Density Lipoprotein Receptor-Related Protein-1*/metabolism
Matrix Metalloproteinase 14*/genetics
Matrix Metalloproteinase 14*/metabolism
Humans ; Cell Line, Tumor ; Ligands ; Matrix Metalloproteinase Inhibitors/pharmacology
Czasopismo naukowe
Tytuł:
It is Good to Recycle: Bringing Megalin Back to the Membrane to Stop Proteinuria.
Autorzy:
Hall AM; Institute of Anatomy, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.; Department of Nephrology, University Hospital Zurich, Rämistrasse 100, 8091 Zurich, Switzerland.
Sakhi I; Institute of Anatomy, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.
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Źródło:
Function (Oxford, England) [Function (Oxf)] 2022 Nov 03; Vol. 3 (6), pp. zqac056. Date of Electronic Publication: 2022 Nov 03 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Comment
MeSH Terms:
Low Density Lipoprotein Receptor-Related Protein-2*/physiology
Opossums*
Mice ; Animals ; Kidney ; Proteinuria
Czasopismo naukowe
Tytuł:
Exosomes from Adipose Stem Cells Promote Diabetic Wound Healing through the eHSP90/LRP1/AKT Axis.
Autorzy:
Ren S; Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan 430022, China.; Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
Chen J; Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan 430022, China.
Guo J; Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan 430022, China.
Liu Y; Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan 430022, China.
Xiong H; Department of Emergency Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Jing B; Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Yang X; Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan 430022, China.
Li G; Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan 430022, China.
Kang Y; Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan 430022, China.
Wang C; Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan 430022, China.
Xu X; Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan 430022, China.
Liu Z; Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan 430022, China.
Zhang M; Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan 430022, China.
Xiang K; Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan 430022, China.
Li C; Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan 430022, China.
Li Q; Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan 430022, China.
Machens HG; Department of Plastic and Hand Surgery, Technical University of Munich, D-80333 Munich, Germany.
Chen Z; Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan 430022, China.
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Źródło:
Cells [Cells] 2022 Oct 14; Vol. 11 (20). Date of Electronic Publication: 2022 Oct 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Exosomes*/metabolism
Low Density Lipoprotein Receptor-Related Protein-1*/metabolism
Proto-Oncogene Proteins c-akt*/metabolism
Wound Healing*
Mesenchymal Stem Cells*/metabolism
Adipose Tissue*/metabolism
Diabetes Complications*/metabolism
HSP90 Heat-Shock Proteins*/metabolism
Humans ; Collagen/metabolism ; Endothelial Cells ; Lipoproteins, LDL/metabolism ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł:
TMAO Suppresses Megalin Expression and Albumin Uptake in Human Proximal Tubular Cells Via PI3K and ERK Signaling.
Autorzy:
Kapetanaki S; School of Medical Sciences, Örebro University, Campus USÖ, 701 82 Örebro, Sweden.; Nephrology Department, Karolinska University Hospital, 141 86 Huddinge, Sweden.
Kumawat AK; School of Medical Sciences, Örebro University, Campus USÖ, 701 82 Örebro, Sweden.; Cardiovascular Research Center, Faculty of Medicine and Health, Örebro University, 702 81 Örebro, Sweden.
Persson K; School of Medical Sciences, Örebro University, Campus USÖ, 701 82 Örebro, Sweden.; iRiSC-Inflammatory Response and Infection Susceptibility Center, Faculty of Medicine and Health, Örebro University, 702 81 Örebro, Sweden.
Demirel I; School of Medical Sciences, Örebro University, Campus USÖ, 701 82 Örebro, Sweden.; iRiSC-Inflammatory Response and Infection Susceptibility Center, Faculty of Medicine and Health, Örebro University, 702 81 Örebro, Sweden.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Aug 09; Vol. 23 (16). Date of Electronic Publication: 2022 Aug 09.
Typ publikacji:
Journal Article
MeSH Terms:
Low Density Lipoprotein Receptor-Related Protein-2*/genetics
Low Density Lipoprotein Receptor-Related Protein-2*/metabolism
Renal Insufficiency, Chronic*/metabolism
Albumins/metabolism ; Endocytosis ; Epithelial Cells/metabolism ; Humans ; Kidney Tubules, Proximal/metabolism ; MAP Kinase Signaling System ; Methylamines ; Phosphatidylinositol 3-Kinases/metabolism
Czasopismo naukowe
Tytuł:
Dietary supplementation of cystinotic mice by lysine inhibits the megalin pathway and decreases kidney cystine content.
Autorzy:
Rega LR; Nephrology Research Unit, Translational Pediatrics and Clinical Genetics Research Area, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Janssens V; Cell Biology Unit, de Duve Institute and Louvain University Medical School, Brussels, Belgium.
Graversen JH; Department of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Moestrup SK; Department of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Cairoli S; Division of Metabolic Diseases and Drug Biology, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Goffredo BM; Division of Metabolic Diseases and Drug Biology, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Nevo N; Laboratoire des Maladies Rénales Héréditaires, Inserm UMR 1163, Institut Imagine, Université Paris Cité, Paris, France.
Courtoy GE; Imaging Platform (2IP), Institut de Recherche Expérimentale et Clinique, Louvain University Medical School, Brussels, Belgium.
Jouret F; Groupe Interdisciplinaire de Génoprotéomique Appliquée (GIGA), Cardiovascular Sciences, University of Liège, Liège, Belgium.
Antignac C; Laboratoire des Maladies Rénales Héréditaires, Inserm UMR 1163, Institut Imagine, Université Paris Cité, Paris, France.
Emma F; Nephrology Research Unit, Translational Pediatrics and Clinical Genetics Research Area, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Pierreux CE; Cell Biology Unit, de Duve Institute and Louvain University Medical School, Brussels, Belgium. .
Courtoy PJ; Cell Biology Unit, de Duve Institute and Louvain University Medical School, Brussels, Belgium. .
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Źródło:
Scientific reports [Sci Rep] 2023 Oct 12; Vol. 13 (1), pp. 17276. Date of Electronic Publication: 2023 Oct 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cystine*/metabolism
Cystinosis*/metabolism
Adult ; Humans ; Animals ; Mice ; Lysine ; Low Density Lipoprotein Receptor-Related Protein-2 ; Kidney/metabolism ; Dietary Supplements
Czasopismo naukowe

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