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Wyszukujesz frazę ""Lamin"" wg kryterium: Temat


Tytuł :
A lamin A/C variant causing striated muscle disease provides insights into filament organization.
Autorzy :
Kronenberg-Tenga R; Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.
Tatli M; Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.
Eibauer M; Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.
Wu W; Department of Medicine and Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Shin JY; Department of Medicine and Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Bonne G; Sorbonne Université, INSERM, Centre de Recherche en Myologie, Institut de Myologie, F-75651 Paris CEDEX 13, France.
Worman HJ; Department of Medicine and Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Medalia O; Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland .
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Źródło :
Journal of cell science [J Cell Sci] 2021 Mar 22; Vol. 134 (6). Date of Electronic Publication: 2021 Mar 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Lamin Type A*/genetics
Muscle, Striated*
Animals ; Cytoskeleton ; Lamin Type B/genetics ; Mice ; Mutation/genetics ; Nuclear Lamina
Czasopismo naukowe
Tytuł :
Nuclear envelope rupture and NET formation is driven by PKCα-mediated lamin B disassembly.
Autorzy :
Li Y; Corporal Michael J. Crescenz VAMC, Philadelphia, PA, USA.; Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Li M; Corporal Michael J. Crescenz VAMC, Philadelphia, PA, USA.; Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Rheumatology and Immunology, Tianjin Medical University General Hospital, Tianjin, China.
Weigel B; Cell Fate Engineering and Disease Modeling Group, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.; HITBR Hector Institute for Translational Brain Research GmbH, Heidelberg, Germany.; Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Mall M; Cell Fate Engineering and Disease Modeling Group, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.; HITBR Hector Institute for Translational Brain Research GmbH, Heidelberg, Germany.; Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Werth VP; Corporal Michael J. Crescenz VAMC, Philadelphia, PA, USA.; Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Liu ML; Corporal Michael J. Crescenz VAMC, Philadelphia, PA, USA.; Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
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Źródło :
EMBO reports [EMBO Rep] 2020 Aug 05; Vol. 21 (8), pp. e48779. Date of Electronic Publication: 2020 Jun 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Lamin Type B*/genetics
Lamin Type B*/metabolism
Nuclear Envelope*/metabolism
Animals ; Lamin Type A/genetics ; Lamin Type A/metabolism ; Mice ; Nuclear Lamina/metabolism ; Phosphorylation ; Protein Kinase C-alpha/genetics ; Protein Kinase C-alpha/metabolism
Czasopismo naukowe
Tytuł :
AIMP3 induces laminopathy and senescence of vascular smooth muscle cells by reducing lamin A expression and leads to vascular aging in vivo.
Autorzy :
Hwang BH; Cardiovascular Research Institute for Intractable Disease, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; Division of Cardiology, Department of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.
Kim E; Cardiovascular Research Institute for Intractable Disease, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Park EH; Cardiovascular Research Institute for Intractable Disease, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Kim CW; Cardiovascular Research Institute for Intractable Disease, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Lee KY; Cardiovascular Research Institute for Intractable Disease, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; Division of Cardiology, Department of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.
Kim JJ; Cardiovascular Research Institute for Intractable Disease, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; Division of Cardiology, Department of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.
Choo EH; Cardiovascular Research Institute for Intractable Disease, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; Division of Cardiology, Department of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.
Lim S; Cardiovascular Research Institute for Intractable Disease, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; Division of Cardiology, Department of Internal Medicine, Uijeongbu St. Mary's Hospital, The Catholic University of Korea, Gyeonggi-do, Republic of Korea.
Choi IJ; Cardiovascular Research Institute for Intractable Disease, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; Division of Cardiology, Department of Internal Medicine, Incheon St. Mary's Hospital, The Catholic University of Korea, Incheon, Republic of Korea.
Kim CJ; Cardiovascular Research Institute for Intractable Disease, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; Division of Cardiology, Department of Internal Medicine, Uijeongbu St. Mary's Hospital, The Catholic University of Korea, Gyeonggi-do, Republic of Korea.
Ihm SH; Cardiovascular Research Institute for Intractable Disease, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; Division of Cardiology, Department of Internal Medicine, Bucheon St. Mary's Hospital, The Catholic University of Korea, Gyeonggi-do, Republic of Korea.
Chang K; Cardiovascular Research Institute for Intractable Disease, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; Division of Cardiology, Department of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address: .
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Źródło :
Experimental gerontology [Exp Gerontol] 2021 Oct 01; Vol. 153, pp. 111483. Date of Electronic Publication: 2021 Jul 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Lamin Type A*/genetics
Laminopathies*
Aging ; Animals ; Cells, Cultured ; Cellular Senescence ; Mice ; Muscle, Smooth, Vascular ; Myocytes, Smooth Muscle
Czasopismo naukowe
Tytuł :
Compromised Biomechanical Properties, Cell-Cell Adhesion and Nanotubes Communication in Cardiac Fibroblasts Carrying the Lamin A/C D192G Mutation.
Autorzy :
Lachaize V; Department of Engineering and Architecture, University of Trieste, Via Valerio 10, 34127 Trieste, Italy.
Peña B; CU-Cardiovascular Institute, University of Colorado Anschutz Medical Campus, 12700 E. 19th Ave., Aurora, CO 80045, USA.; Consortium for Fibrosis Research & Translation, Anschutz Medical Campus, University of Colorado, 12700 E. 19th Ave., Aurora, CO 80045, USA.; Bioengineering Department, University of Colorado Denver Anschutz Medical Campus, Bioscience 2 1270 E. Montview Ave., Suite 100, Aurora, CO 80045, USA.
Ciubotaru C; Institute of Materials, National Research Council of Italy (CNR_IOM), Area Science Park Basovizza, 34149 Trieste, Italy.
Cojoc D; Institute of Materials, National Research Council of Italy (CNR_IOM), Area Science Park Basovizza, 34149 Trieste, Italy.
Chen SN; CU-Cardiovascular Institute, University of Colorado Anschutz Medical Campus, 12700 E. 19th Ave., Aurora, CO 80045, USA.
Taylor MRG; CU-Cardiovascular Institute, University of Colorado Anschutz Medical Campus, 12700 E. 19th Ave., Aurora, CO 80045, USA.
Mestroni L; CU-Cardiovascular Institute, University of Colorado Anschutz Medical Campus, 12700 E. 19th Ave., Aurora, CO 80045, USA.
Sbaizero O; Department of Engineering and Architecture, University of Trieste, Via Valerio 10, 34127 Trieste, Italy.; CU-Cardiovascular Institute, University of Colorado Anschutz Medical Campus, 12700 E. 19th Ave., Aurora, CO 80045, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 25; Vol. 22 (17). Date of Electronic Publication: 2021 Aug 25.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Adhesion*
Lamin Type A/*metabolism
Myofibroblasts/*metabolism
Actin Cytoskeleton/metabolism ; Animals ; Cells, Cultured ; Lamin Type A/genetics ; Microscopy, Atomic Force ; Mutation, Missense ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/physiology ; Myofibroblasts/physiology ; Nanotubes/chemistry ; Optical Tweezers ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Disrupting the LINC complex by AAV mediated gene transduction prevents progression of Lamin induced cardiomyopathy.
Autorzy :
Chai RJ; Skin Research Institute (SRIS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Werner H; Skin Research Institute (SRIS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Li PY; Cardiovascular Research Institute (CVRI), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Lee YL; Skin Research Institute (SRIS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Nyein KT; Skin Research Institute (SRIS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Solovei I; Department of Biology II, Ludwig Maximilians University Munich, Munich, Germany.
Luu TDA; Cardiovascular Research Institute (CVRI), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Sharma B; Skin Research Institute (SRIS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Navasankari R; Skin Research Institute (SRIS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Maric M; Skin Research Institute (SRIS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Sim LYE; Skin Research Institute (SRIS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Loh YJ; Skin Research Institute (SRIS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Aliwarga E; Cardiovascular Research Institute (CVRI), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Cheong JWL; Skin Research Institute (SRIS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Chojnowski A; Skin Research Institute (SRIS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Autio MI; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Haiyang Y; Muscle and Cardiac Biophysics Laboratory, Lee Kong Chien School of Medicine, Nanyang Technological University, Singapore, Singapore.
Boon Tan KK; Skin Research Institute (SRIS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Keng CT; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Ng SL; Cardiovascular Research Institute (CVRI), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Chew WL; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Ferenczi M; Muscle and Cardiac Biophysics Laboratory, Lee Kong Chien School of Medicine, Nanyang Technological University, Singapore, Singapore.
Burke B; Skin Research Institute (SRIS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
Foo RSY; Cardiovascular Research Institute (CVRI), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. .
Stewart CL; Skin Research Institute (SRIS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. .; Deptartment of Physiology, School of Medicine, NUS, Singapore, Singapore. .
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Źródło :
Nature communications [Nat Commun] 2021 Aug 05; Vol. 12 (1), pp. 4722. Date of Electronic Publication: 2021 Aug 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cardiomyopathy, Dilated/*genetics
Lamin Type A/*genetics
Lamin Type A/*metabolism
Microtubule-Associated Proteins/*genetics
Microtubule-Associated Proteins/*metabolism
Animals ; Cardiomyopathy, Dilated/pathology ; Cardiomyopathy, Dilated/physiopathology ; Dependovirus/genetics ; Female ; Humans ; Lamin Type A/deficiency ; Male ; Mice ; Mice, 129 Strain ; Mice, Inbred C57BL ; Mice, Knockout ; Microtubule-Associated Proteins/deficiency ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Transduction, Genetic
Czasopismo naukowe
Tytuł :
Multiple G-quadruplexes in the LMNA promoter regulate LMNA variant 6 transcription and promote colon cancer cell growth.
Autorzy :
Nishikawa T; Department of Pathophysiology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan; Department of Onco-cardiology, Osaka International Cancer Institute, Osaka, Japan.
Kuwano Y; Department of Pathophysiology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan. Electronic address: .
Nakata M; Student Lab, Tokushima University Faculty of Medicine, Tokushima, Japan.
Rokutan K; Department of Pathophysiology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
Nishida K; Department of Pathophysiology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
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Źródło :
Biochimica et biophysica acta. Gene regulatory mechanisms [Biochim Biophys Acta Gene Regul Mech] 2021 Oct; Vol. 1864 (10), pp. 194746. Date of Electronic Publication: 2021 Aug 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
G-Quadruplexes*
Gene Expression Regulation, Neoplastic*
Promoter Regions, Genetic*
Colonic Neoplasms/*genetics
Lamin Type A/*genetics
Cell Line, Tumor ; Cell Proliferation/genetics ; Colonic Neoplasms/metabolism ; Humans ; Lamin Type A/metabolism ; RNA Isoforms/genetics ; RNA Isoforms/metabolism ; RNA Splicing ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
[Analysis of a child with congenital muscular dystrophy due to a novel variant of the LMNA gene].
Autorzy :
Tang W; Department of Molecular Diagnostics, Sun Yat-sen Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong 510060, China. .
Wu R
Qiu K
Zhang X
He Z
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Źródło :
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics [Zhonghua Yi Xue Yi Chuan Xue Za Zhi] 2021 Sep 10; Vol. 38 (9), pp. 857-860.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Lamin Type A*/genetics
Muscular Dystrophies*/genetics
Gene Frequency ; Genomics ; Humans ; Infant ; Male ; Mutation ; Whole Exome Sequencing
Czasopismo naukowe
Tytuł :
Evidence of synergism among three genetic variants in a patient with LMNA-related lipodystrophy and amyotrophic lateral sclerosis leading to a remarkable nuclear phenotype.
Autorzy :
Volkening K; Molecular Medicine, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.; Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Farhan SMK; Analytic and Translational Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
Kao J; Molecular Medicine, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Leystra-Lantz C; Molecular Medicine, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Ang LC; Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.; Department of Pathology and Laboratory Medicine, London Health Sciences Centre-University Hospital, London, ON, Canada.
McIntyre A; Blackburn Cardiovascular Genetics Lab, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Wang J; Blackburn Cardiovascular Genetics Lab, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Hegele RA; Department of Pathology and Laboratory Medicine, London Health Sciences Centre-University Hospital, London, ON, Canada.; Blackburn Cardiovascular Genetics Lab, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.; Department of Biochemistry, Western University, London, ON, Canada.
Strong MJ; Molecular Medicine, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. .; Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. .
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Źródło :
Molecular and cellular biochemistry [Mol Cell Biochem] 2021 Jul; Vol. 476 (7), pp. 2633-2650. Date of Electronic Publication: 2021 Mar 04.
Typ publikacji :
Journal Article
MeSH Terms :
Amyotrophic Lateral Sclerosis*/genetics
Amyotrophic Lateral Sclerosis*/metabolism
Amyotrophic Lateral Sclerosis*/pathology
DNA Helicases*/genetics
DNA Helicases*/metabolism
Lamin Type A*/genetics
Lamin Type A*/metabolism
Lipodystrophy*/genetics
Lipodystrophy*/metabolism
Lipodystrophy*/pathology
Multifunctional Enzymes*/genetics
Multifunctional Enzymes*/metabolism
Mutation, Missense*
RNA Helicases*/genetics
RNA Helicases*/metabolism
RNA-Binding Protein FUS*/genetics
RNA-Binding Protein FUS*/metabolism
Amino Acid Substitution ; Family ; Female ; HEK293 Cells ; Humans ; Male
Czasopismo naukowe
Tytuł :
Spatial distribution of lamin A/C determines nuclear stiffness and stress-mediated deformation.
Autorzy :
Srivastava LK; Department of Bioengineering, McGill University, Montreal H3A 0E9.
Ju Z; Department of Anatomy and Cell Biology, McGill University, Montreal H3A 0C7, Canada.
Ghagre A; Department of Bioengineering, McGill University, Montreal H3A 0E9.
Ehrlicher AJ; Department of Bioengineering, McGill University, Montreal H3A 0E9.; Department of Anatomy and Cell Biology, McGill University, Montreal H3A 0C7, Canada.; Department of Biomedical Engineering, McGill University, Montreal H3A 2B4, Canada.; Department of Mechanical Engineering, McGill University, Montreal H3A 0C3.; Centre for Structural Biology, McGill University, Montreal H3G 0B1, Canada.; Goodman Cancer Research Centre, McGill University, Montreal H3A 1A3, Canada.
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Źródło :
Journal of cell science [J Cell Sci] 2021 May 15; Vol. 134 (10). Date of Electronic Publication: 2021 May 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Lamin Type A*/genetics
Lamin Type A*/metabolism
Mechanotransduction, Cellular*
Cell Nucleus/metabolism ; Humans ; Nuclear Envelope/metabolism
Czasopismo naukowe
Tytuł :
Nuclear Lamin A/C Expression Is a Key Determinant of Paclitaxel Sensitivity.
Autorzy :
Smith ER; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida, USA.
Leal J; Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Amaya C; Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Li B; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida, USA.
Xu XX; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida, USA.; Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, Florida, USA.
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Źródło :
Molecular and cellular biology [Mol Cell Biol] 2021 Jun 23; Vol. 41 (7), pp. e0064820. Date of Electronic Publication: 2021 Jun 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Lamin Type A/*drug effects
Microtubules/*drug effects
Ovarian Neoplasms/*drug therapy
Paclitaxel/*pharmacology
Animals ; Antimitotic Agents/pharmacology ; Apoptosis/drug effects ; Cell Line, Tumor ; Drug Resistance, Neoplasm/drug effects ; Female ; Humans ; Lamin Type A/metabolism ; Mice, Transgenic ; Microtubules/metabolism ; Mitosis/drug effects ; Ovarian Neoplasms/pathology ; Tubulin/drug effects ; Tubulin/metabolism
Czasopismo naukowe
Tytuł :
Declining lamin B1 expression mediates age-dependent decreases of hippocampal stem cell activity.
Autorzy :
Bin Imtiaz MK; Laboratory of Neural Plasticity, Faculties of Medicine and Science, Brain Research Institute, University of Zurich, 8057 Zurich, Switzerland.
Jaeger BN; Laboratory of Neural Plasticity, Faculties of Medicine and Science, Brain Research Institute, University of Zurich, 8057 Zurich, Switzerland.
Bottes S; Laboratory of Neural Plasticity, Faculties of Medicine and Science, Brain Research Institute, University of Zurich, 8057 Zurich, Switzerland.
Machado RAC; Laboratory of Neural Plasticity, Faculties of Medicine and Science, Brain Research Institute, University of Zurich, 8057 Zurich, Switzerland.
Vidmar M; Laboratory of Neural Plasticity, Faculties of Medicine and Science, Brain Research Institute, University of Zurich, 8057 Zurich, Switzerland.
Moore DL; Department of Neuroscience, University of Wisconsin-Madison, Madison, WI 53705, USA. Electronic address: .
Jessberger S; Laboratory of Neural Plasticity, Faculties of Medicine and Science, Brain Research Institute, University of Zurich, 8057 Zurich, Switzerland. Electronic address: .
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Źródło :
Cell stem cell [Cell Stem Cell] 2021 May 06; Vol. 28 (5), pp. 967-977.e8. Date of Electronic Publication: 2021 Feb 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aging*
Lamin Type B*
Neural Stem Cells*
Progeria*
Animals ; Hippocampus/cytology ; Mice ; Neurogenesis
Czasopismo naukowe
Tytuł :
Protein structural and mechanistic basis of progeroid laminopathies.
Autorzy :
Marcelot A; Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Uni Paris-Sud, Uni Paris-Saclay, Gif-sur-Yvette Cedex, France.
Worman HJ; Department of Medicine and Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Zinn-Justin S; Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Uni Paris-Sud, Uni Paris-Saclay, Gif-sur-Yvette Cedex, France.
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Źródło :
The FEBS journal [FEBS J] 2021 May; Vol. 288 (9), pp. 2757-2772. Date of Electronic Publication: 2020 Sep 03.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Lamin Type A/*genetics
Laminopathies/*genetics
Membrane Proteins/*genetics
Metalloendopeptidases/*genetics
Progeria/*genetics
Amino Acids/genetics ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Lamin Type A/ultrastructure ; Laminopathies/pathology ; Membrane Proteins/ultrastructure ; Metalloendopeptidases/ultrastructure ; Mutation, Missense/genetics ; Nuclear Proteins/genetics ; Nuclear Proteins/ultrastructure ; Progeria/pathology ; Protein Conformation
Czasopismo naukowe
Tytuł :
Active microrheology using pulsed optical tweezers to probe viscoelasticity of lamin A.
Autorzy :
Mukherjee C; Biophysics & Structural Genomics Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata-700064, West Bengal, India. , Anushaktinagar, Mumbai-400076, Maharashtra, India.
Kundu A; Department of Physical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, West Bengal, India. .
Dey R; Department of Physical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, West Bengal, India. .
Banerjee A; Department of Physical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, West Bengal, India. .
Sengupta K; Biophysics & Structural Genomics Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata-700064, West Bengal, India. , Anushaktinagar, Mumbai-400076, Maharashtra, India.
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Źródło :
Soft matter [Soft Matter] 2021 Jul 21; Vol. 17 (28), pp. 6787-6796.
Typ publikacji :
Journal Article
MeSH Terms :
Lamin Type A*/genetics
Optical Tweezers*
Animals ; Cell Nucleus ; Humans ; Intermediate Filaments ; Viscosity
Czasopismo naukowe
Tytuł :
Progerin mRNA expression is elevated in aged human dermis and impairs TGF-β/Smad signaling.
Autorzy :
Xiang Y; Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Qin Z; Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Guo C; Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
He T; Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Liu Y; Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Quan T; Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA. Electronic address: .
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Źródło :
Journal of dermatological science [J Dermatol Sci] 2021 Jul; Vol. 103 (1), pp. 49-52. Date of Electronic Publication: 2021 Apr 26.
Typ publikacji :
Comparative Study; Letter
MeSH Terms :
Dermis/*metabolism
Lamin Type A/*metabolism
Skin Aging/*genetics
Adult ; Age Factors ; Aged ; Aged, 80 and over ; Biopsy ; Cells, Cultured ; Fibroblasts ; Humans ; Lamin Type A/genetics ; Male ; Phosphorylation ; Primary Cell Culture ; Progeria/genetics ; Progeria/pathology ; RNA, Messenger/metabolism ; Signal Transduction/physiology ; Smad3 Protein/metabolism ; Transforming Growth Factor beta1/metabolism ; Young Adult
Raport
Tytuł :
The nucleoplasmic interactions among Lamin A/C-pRB-LAP2α-E2F1 are modulated by dexamethasone.
Autorzy :
Ricci A; Department of Biomolecular Sciences, University of Urbino 'Carlo Bo', Via A. Saffi 2, 61029, Urbino, Italy.
Orazi S; Department of Biomolecular Sciences, University of Urbino 'Carlo Bo', Via A. Saffi 2, 61029, Urbino, Italy.
Biancucci F; Department of Biomolecular Sciences, University of Urbino 'Carlo Bo', Via A. Saffi 2, 61029, Urbino, Italy.
Magnani M; Department of Biomolecular Sciences, University of Urbino 'Carlo Bo', Via A. Saffi 2, 61029, Urbino, Italy.
Menotta M; Department of Biomolecular Sciences, University of Urbino 'Carlo Bo', Via A. Saffi 2, 61029, Urbino, Italy. .
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Źródło :
Scientific reports [Sci Rep] 2021 May 12; Vol. 11 (1), pp. 10099. Date of Electronic Publication: 2021 May 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Ataxia Telangiectasia/*metabolism
DNA-Binding Proteins/*metabolism
Dexamethasone/*pharmacology
E2F1 Transcription Factor/*metabolism
Lamin Type A/*metabolism
Membrane Proteins/*metabolism
Nuclear Envelope/*metabolism
Salivary Proline-Rich Proteins/*metabolism
Ataxia Telangiectasia/drug therapy ; Ataxia Telangiectasia/genetics ; DNA-Binding Proteins/genetics ; E2F1 Transcription Factor/genetics ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Humans ; Lamin Type A/genetics ; Membrane Proteins/genetics ; Nuclear Envelope/drug effects ; Nuclear Envelope/genetics ; Protein Binding/drug effects ; Salivary Proline-Rich Proteins/genetics
Czasopismo naukowe
Tytuł :
Computational analyses reveal spatial relationships between nuclear pore complexes and specific lamins.
Autorzy :
Kittisopikul M; Department of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL.; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX.
Shimi T; Department of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL.; Cell Biology Center and World Research Hub Initiative, Institute of Innovative Research, Tokyo Institute of Technology, Yokohama, Japan.
Tatli M; Department of Biochemistry, University of Zurich, Zurich, Switzerland.
Tran JR; Department of Embryology, Carnegie Institution for Science, Baltimore, MD.
Zheng Y; Department of Embryology, Carnegie Institution for Science, Baltimore, MD.
Medalia O; Department of Biochemistry, University of Zurich, Zurich, Switzerland.
Jaqaman K; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX.; Lyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX.
Adam SA; Department of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Goldman RD; Department of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL.
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Źródło :
The Journal of cell biology [J Cell Biol] 2021 Apr 05; Vol. 220 (4).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Computer Simulation*
Embryo, Mammalian/*metabolism
Fibroblasts/*metabolism
Lamin Type A/*metabolism
Lamin Type B/*metabolism
Nuclear Pore/*metabolism
Animals ; Cell Line ; Embryo, Mammalian/ultrastructure ; Fibroblasts/ultrastructure ; Lamin Type A/genetics ; Lamin Type B/genetics ; Mice ; Mice, Knockout ; Nuclear Pore/genetics ; Nuclear Pore/ultrastructure ; Nuclear Pore Complex Proteins/genetics ; Nuclear Pore Complex Proteins/metabolism
Czasopismo naukowe
Tytuł :
Cell signaling pathways in autosomal-dominant leukodystrophy (ADLD): the intriguing role of the astrocytes.
Autorzy :
Ratti S; Cellular Signalling Laboratory, Department of Biomedical and NeuroMotor Sciences (DIBINEM), University of Bologna, Bologna, Italy.
Rusciano I; Cellular Signalling Laboratory, Department of Biomedical and NeuroMotor Sciences (DIBINEM), University of Bologna, Bologna, Italy.
Mongiorgi S; Cellular Signalling Laboratory, Department of Biomedical and NeuroMotor Sciences (DIBINEM), University of Bologna, Bologna, Italy.
Owusu Obeng E; Cellular Signalling Laboratory, Department of Biomedical and NeuroMotor Sciences (DIBINEM), University of Bologna, Bologna, Italy.
Cappellini A; Cellular Signalling Laboratory, Department of Biomedical and NeuroMotor Sciences (DIBINEM), University of Bologna, Bologna, Italy.
Teti G; Department of Biomedical and NeuroMotor Sciences (DIBINEM), University of Bologna, Via Irnerio 48, Bologna, Italy.
Falconi M; Department of Biomedical and NeuroMotor Sciences (DIBINEM), University of Bologna, Via Irnerio 48, Bologna, Italy.
Talozzi L; Functional MR Unit, Department of Biomedical and NeuroMotor Sciences (DIBINEM), University of Bologna, Bologna, Italy.
Capellari S; Department of Biomedical and NeuroMotor Sciences (DIBINEM), University of Bologna, Bologna, Italy.; IRCCS Istituto delle Scienze Neurologiche di Bologna, UOC NeuroMet, Bologna, Italy.
Bartoletti-Stella A; IRCCS Istituto delle Scienze Neurologiche di Bologna, UOC NeuroMet, Bologna, Italy.
Guaraldi P; IRCCS Istituto delle Scienze Neurologiche di Bologna, UOC NeuroMet, Bologna, Italy.
Cortelli P; Department of Biomedical and NeuroMotor Sciences (DIBINEM), University of Bologna, Bologna, Italy.; IRCCS Istituto delle Scienze Neurologiche di Bologna, UOC NeuroMet, Bologna, Italy.
Suh PG; Korea Brain Research Institute, Daegu, Republic of Korea.; School of Life Sciences, UNIST, Ulsan, Republic of Korea.
Cocco L; Cellular Signalling Laboratory, Department of Biomedical and NeuroMotor Sciences (DIBINEM), University of Bologna, Bologna, Italy. .
Manzoli L; Cellular Signalling Laboratory, Department of Biomedical and NeuroMotor Sciences (DIBINEM), University of Bologna, Bologna, Italy. .
Ramazzotti G; Cellular Signalling Laboratory, Department of Biomedical and NeuroMotor Sciences (DIBINEM), University of Bologna, Bologna, Italy.
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2021 Mar; Vol. 78 (6), pp. 2781-2795. Date of Electronic Publication: 2020 Oct 09.
Typ publikacji :
Journal Article
MeSH Terms :
Signal Transduction*
Astrocytes/*metabolism
Demyelinating Diseases/*pathology
Lamin Type B/*metabolism
Astrocytes/cytology ; Cell Nucleus/metabolism ; Cell Nucleus/ultrastructure ; Cells, Cultured ; Demyelinating Diseases/metabolism ; Down-Regulation/drug effects ; Fibroblasts/cytology ; Fibroblasts/metabolism ; Humans ; Hydrogen Peroxide/pharmacology ; Inflammation Mediators/metabolism ; Lamin Type B/genetics ; Leukemia Inhibitory Factor/metabolism ; Leukemia Inhibitory Factor/pharmacology ; Oligodendroglia/cytology ; Oligodendroglia/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphorylation ; Reactive Oxygen Species/metabolism ; Receptors, OSM-LIF/metabolism ; Up-Regulation/drug effects
Czasopismo naukowe
Tytuł :
Ventricular Tachycardia in a Patient With Dilated Cardiomyopathy Caused by a Novel Mutation of Lamin A/C Gene: Insights From Features on Electroanatomic Mapping, Catheter Ablation and Tissue Pathology.
Autorzy :
Bennett R; Department of Cardiology, Westmead Hospital, Sydney, NSW, Australia; Westmead Applied Research Centre, University of Sydney, Sydney, NSW, Australia.
Campbell T; Department of Cardiology, Westmead Hospital, Sydney, NSW, Australia; Westmead Applied Research Centre, University of Sydney, Sydney, NSW, Australia.
Eslick A; Department of Anaesthesia, Westmead Hospital, Sydney, NSW, Australia.
Pudipeddi A; Department of Anaesthesia, Westmead Hospital, Sydney, NSW, Australia.
Hing A; Department of Cardiothoracic Surgery, Westmead Hospital, Sydney, NSW, Australia.
Yeates L; Westmead Applied Research Centre, University of Sydney, Sydney, NSW, Australia; Centenary Institute, Sydney, NSW, Australia.
Hanna B; Department of Medical Genetics, Westmead Hospital, Sydney, NSW, Australia.
Kumar S; Department of Cardiology, Westmead Hospital, Sydney, NSW, Australia; Westmead Applied Research Centre, University of Sydney, Sydney, NSW, Australia. Electronic address: .
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Źródło :
Heart, lung & circulation [Heart Lung Circ] 2021 Feb; Vol. 30 (2), pp. 310-317. Date of Electronic Publication: 2020 Oct 05.
Typ publikacji :
Case Reports
MeSH Terms :
Mutation*
Cardiomyopathy, Dilated/*complications
Catheter Ablation/*methods
DNA/*genetics
Lamin Type A/*genetics
Tachycardia, Ventricular/*surgery
Cardiomyopathy, Dilated/genetics ; Cardiomyopathy, Dilated/surgery ; DNA Mutational Analysis ; Humans ; Lamin Type A/metabolism ; Male ; Middle Aged ; Tachycardia, Ventricular/etiology ; Tachycardia, Ventricular/genetics
Raport
Tytuł :
LMNA-NTRK1 rearranged mesenchymal tumor (lipofibromatosis-like neural tumor) mimicking pigmented dermatofibrosarcoma protuberans.
Autorzy :
Panse G; Department of Dermatology, Yale School of Medicine, New Haven, Connecticut, USA.; Department of Pathology, Yale School of Medicine, New Haven, Connecticut, USA.
Reisenbichler E; Department of Pathology, Yale School of Medicine, New Haven, Connecticut, USA.
Snuderl M; Department of Pathology, NYU Langone Medical Center, New York, New York, USA.
Wang WL; Department of Pathology and Translational Molecular Pathology, MD Anderson Cancer Center, Houston, Texas, USA.
Laskin W; Department of Pathology, Yale School of Medicine, New Haven, Connecticut, USA.
Jour G; Department of Pathology, NYU Langone Medical Center, New York, New York, USA.; Department of Dermatology, NYU Langone Medical Center, New York, New York, USA.
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Źródło :
Journal of cutaneous pathology [J Cutan Pathol] 2021 Feb; Vol. 48 (2), pp. 290-294. Date of Electronic Publication: 2020 Jul 06.
Typ publikacji :
Case Reports
MeSH Terms :
Dermatofibrosarcoma*/diagnosis
Dermatofibrosarcoma*/genetics
Dermatofibrosarcoma*/metabolism
Dermatofibrosarcoma*/pathology
Gene Rearrangement*
Lamin Type A*/genetics
Lamin Type A*/metabolism
Neoplasms, Nerve Tissue*/diagnosis
Neoplasms, Nerve Tissue*/genetics
Neoplasms, Nerve Tissue*/metabolism
Neoplasms, Nerve Tissue*/pathology
Oncogene Proteins, Fusion*/genetics
Oncogene Proteins, Fusion*/metabolism
Receptor, trkA*/genetics
Receptor, trkA*/metabolism
Skin Neoplasms*/diagnosis
Skin Neoplasms*/genetics
Skin Neoplasms*/metabolism
Skin Neoplasms*/pathology
Adult ; Diagnosis, Differential ; Female ; Humans
Raport
Tytuł :
Timing of pacemaker and ICD implantation in LMNA mutation carriers.
Autorzy :
Ollila LH; Heart and Lung Centre, Helsinki University Central Hospital, Helsinki, Finland .
Nikus K; Heart Centre, Tampere University Hospital, Tampere, Finland.; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Parikka H; Heart and Lung Centre, Helsinki University Central Hospital, Helsinki, Finland.
Weckström S; Heart and Lung Centre, Helsinki University Central Hospital, Helsinki, Finland.
Tiina H; Heart and Lung Centre, Helsinki University Central Hospital, Helsinki, Finland.; University of Helsinki, Helsinki, Finland.
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Źródło :
Open heart [Open Heart] 2021 Apr; Vol. 8 (1).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Defibrillators, Implantable*
Mutation*
Pacemaker, Artificial*
Arrhythmias, Cardiac/*therapy
DNA/*genetics
Lamin Type B/*genetics
Adult ; Arrhythmias, Cardiac/genetics ; Arrhythmias, Cardiac/metabolism ; DNA Mutational Analysis ; Female ; Follow-Up Studies ; Heart Conduction System ; Humans ; Lamin Type B/metabolism ; Male ; Middle Aged ; Registries ; Retrospective Studies ; Time Factors
Czasopismo naukowe

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