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Tytuł :
Effect of surgical intervention on circulating tumor cells in patients with squamous cell carcinoma of the head and neck using a negative enrichment technology.
Autorzy :
Jatana KR; Department of Pediatric Otolaryngology - Head and Neck Surgery, Nationwide Children's Hospital, Columbus, Ohio.; Department of Otolaryngology - Head and Neck Surgery, Wexner Medical Center at Ohio State University, Columbus, Ohio.
Balasubramanian P; William G. Lowrie Department of Chemical and Biomolecular Engineering, Ohio State University, Columbus, Ohio.
McMullen KP; Department of Otolaryngology - Head and Neck Surgery, Wexner Medical Center at Ohio State University, Columbus, Ohio.
Lang JC; Department of Otolaryngology - Head and Neck Surgery, Wexner Medical Center at Ohio State University, Columbus, Ohio.
Teknos TN; Department of Otolaryngology - Head and Neck Surgery, Wexner Medical Center at Ohio State University, Columbus, Ohio.
Chalmers JJ; William G. Lowrie Department of Chemical and Biomolecular Engineering, Ohio State University, Columbus, Ohio.
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Źródło :
Head & neck [Head Neck] 2016 Dec; Vol. 38 (12), pp. 1799-1803. Date of Electronic Publication: 2016 Jun 05.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Carcinoma, Squamous Cell/*blood
Carcinoma, Squamous Cell/*mortality
Carcinoma, Squamous Cell/*surgery
Head and Neck Neoplasms/*blood
Head and Neck Neoplasms/*surgery
Neoplastic Cells, Circulating/*pathology
Aged ; Aged, 80 and over ; Carcinoma, Squamous Cell/pathology ; Cohort Studies ; Disease-Free Survival ; Female ; Flow Cytometry ; Head and Neck Neoplasms/mortality ; Head and Neck Neoplasms/pathology ; Humans ; Male ; Middle Aged ; Prognosis ; Retrospective Studies ; Squamous Cell Carcinoma of Head and Neck ; Statistics, Nonparametric ; Survival Analysis
Czasopismo naukowe
Tytuł :
miR-124 Regulates the Epithelial-Restricted with Serine Box/Epidermal Growth Factor Receptor Signaling Axis in Head and Neck Squamous Cell Carcinoma.
Autorzy :
Zhang M; Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio. Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio.
Piao L; Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio. Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio.
Datta J; Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio. Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio.
Lang JC; Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio. Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio.
Xie X; Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio. Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio.
Teknos TN; Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio. Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio.
Mapp AK; Department of Chemistry, University of Michigan, Ann Arbor, Michigan.
Pan Q; Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio. Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio. .
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Źródło :
Molecular cancer therapeutics [Mol Cancer Ther] 2015 Oct; Vol. 14 (10), pp. 2313-20. Date of Electronic Publication: 2015 Jul 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinoma, Squamous Cell/*metabolism
DNA-Binding Proteins/*metabolism
ErbB Receptors/*metabolism
Head and Neck Neoplasms/*metabolism
MicroRNAs/*genetics
Proto-Oncogene Proteins c-ets/*metabolism
Transcription Factors/*metabolism
Afatinib ; Animals ; Antineoplastic Agents/pharmacology ; Base Sequence ; Carcinogenesis/genetics ; Carcinogenesis/metabolism ; Carcinoma, Squamous Cell/pathology ; Cell Line, Tumor ; Cell Proliferation ; Cell Survival ; DNA-Binding Proteins/genetics ; ErbB Receptors/genetics ; Gene Expression ; Gene Expression Regulation, Neoplastic ; Head and Neck Neoplasms/pathology ; Humans ; Lapatinib ; Mice, Nude ; Neoplasm Transplantation ; Proto-Oncogene Proteins c-ets/genetics ; Quinazolines/pharmacology ; RNA Interference ; Signal Transduction ; Transcription Factors/genetics ; Tumor Burden
Czasopismo naukowe
Tytuł :
Down regulation of RhoC by microRNA-138 results in de-activation of FAK, Src and Erk1/2 signaling pathway in head and neck squamous cell carcinoma.
Autorzy :
Islam M; Department of Otolaryngology-Head and Neck Surgery, The Ohio State University, Wexner Medical Center, Columbus, OH, USA; Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University, Wexner Medical Center, Columbus, OH, USA. Electronic address: .
Datta J; Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University, Wexner Medical Center, Columbus, OH, USA.
Lang JC; Department of Otolaryngology-Head and Neck Surgery, The Ohio State University, Wexner Medical Center, Columbus, OH, USA; Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University, Wexner Medical Center, Columbus, OH, USA.
Teknos TN; Department of Otolaryngology-Head and Neck Surgery, The Ohio State University, Wexner Medical Center, Columbus, OH, USA; Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University, Wexner Medical Center, Columbus, OH, USA.
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Źródło :
Oral oncology [Oral Oncol] 2014 May; Vol. 50 (5), pp. 448-56. Date of Electronic Publication: 2014 Feb 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Down-Regulation*
Signal Transduction*
Carcinoma, Squamous Cell/*metabolism
Head and Neck Neoplasms/*metabolism
MicroRNAs/*physiology
rho GTP-Binding Proteins/*metabolism
3' Untranslated Regions ; Carcinoma, Squamous Cell/enzymology ; Carcinoma, Squamous Cell/pathology ; Cell Line, Tumor ; Focal Adhesion Protein-Tyrosine Kinases/metabolism ; Head and Neck Neoplasms/enzymology ; Head and Neck Neoplasms/pathology ; Humans ; MAP Kinase Signaling System ; Proto-Oncogene Proteins pp60(c-src) ; rhoC GTP-Binding Protein
Czasopismo naukowe
Tytuł :
microRNA-107 functions as a candidate tumor-suppressor gene in head and neck squamous cell carcinoma by downregulation of protein kinase Cɛ.
Autorzy :
Datta J; Department of Otolaryngology-Head and Neck Surgery, The Ohio State University Medical Center, Columbus, OH 43210, USA.
Smith A
Lang JC
Islam M
Dutt D
Teknos TN
Pan Q
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Źródło :
Oncogene [Oncogene] 2012 Sep 06; Vol. 31 (36), pp. 4045-53. Date of Electronic Publication: 2011 Dec 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Genes, Tumor Suppressor*
Carcinoma, Squamous Cell/*genetics
Head and Neck Neoplasms/*genetics
MicroRNAs/*physiology
Protein Kinase C-epsilon/*genetics
Animals ; Base Sequence ; Carcinoma, Squamous Cell/enzymology ; Carcinoma, Squamous Cell/pathology ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Cell Transformation, Neoplastic ; Down-Regulation ; Head and Neck Neoplasms/enzymology ; Head and Neck Neoplasms/pathology ; Humans ; Mice ; Mice, Nude ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Neoplasm Invasiveness ; Neoplasm Transplantation ; Protein Kinase C-epsilon/metabolism ; Tumor Burden
Czasopismo naukowe
Tytuł :
YM155 reverses cisplatin resistance in head and neck cancer by decreasing cytoplasmic survivin levels.
Autorzy :
Kumar B; Department of Otolaryngology–Head and Neck Surgery, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA. />Yadav A
Lang JC
Cipolla MJ
Schmitt AC
Arradaza N
Teknos TN
Kumar P
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Źródło :
Molecular cancer therapeutics [Mol Cancer Ther] 2012 Sep; Vol. 11 (9), pp. 1988-98. Date of Electronic Publication: 2012 Jun 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Carcinoma, Squamous Cell/*drug therapy
Head and Neck Neoplasms/*drug therapy
Inhibitor of Apoptosis Proteins/*metabolism
Papillomavirus Infections/*drug therapy
Adult ; Aged ; Animals ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Carcinoma, Squamous Cell/metabolism ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/virology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cisplatin/administration & dosage ; Cytoplasm/metabolism ; Drug Synergism ; Female ; Head and Neck Neoplasms/metabolism ; Head and Neck Neoplasms/pathology ; Head and Neck Neoplasms/virology ; Human papillomavirus 16 ; Humans ; Imidazoles/administration & dosage ; Inhibitor of Apoptosis Proteins/antagonists & inhibitors ; Inhibitor of Apoptosis Proteins/genetics ; Inhibitory Concentration 50 ; Male ; Mice ; Mice, SCID ; Middle Aged ; Naphthoquinones/administration & dosage ; Neovascularization, Pathologic/prevention & control ; Papillomavirus Infections/metabolism ; Papillomavirus Infections/pathology ; Papillomavirus Infections/virology ; Statistics, Nonparametric ; Survivin ; Tissue Array Analysis ; Tumor Burden/drug effects ; Up-Regulation ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Multiparameter analysis, including EMT markers, on negatively enriched blood samples from patients with squamous cell carcinoma of the head and neck.
Autorzy :
Balasubramanian P; William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio, United States of America.
Lang JC
Jatana KR
Miller B
Ozer E
Old M
Schuller DE
Agrawal A
Teknos TN
Summers TA Jr
Lustberg MB
Zborowski M
Chalmers JJ
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Źródło :
PloS one [PLoS One] 2012; Vol. 7 (7), pp. e42048. Date of Electronic Publication: 2012 Jul 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Epithelial-Mesenchymal Transition*
Biomarkers, Tumor/*metabolism
Carcinoma, Squamous Cell/*blood
Carcinoma, Squamous Cell/*pathology
Head and Neck Neoplasms/*blood
Head and Neck Neoplasms/*pathology
Neoplastic Cells, Circulating/*pathology
Adult ; Aged ; Antigens, Neoplasm/metabolism ; Carcinoma, Squamous Cell/metabolism ; Cell Adhesion Molecules/metabolism ; Cell Line, Tumor ; Epithelial Cell Adhesion Molecule ; Female ; Head and Neck Neoplasms/metabolism ; Humans ; Leukocyte Common Antigens/metabolism ; Male ; Middle Aged
Czasopismo naukowe
Tytuł :
Gankyrin, a biomarker for epithelial carcinogenesis, is overexpressed in human oral cancer.
Autorzy :
Li J; Division of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, OH 43210, USA. />Knobloch TJ
Kresty LA
Zhang Z
Lang JC
Schuller DE
Weghorst CM
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Źródło :
Anticancer research [Anticancer Res] 2011 Sep; Vol. 31 (9), pp. 2683-92.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cell Transformation, Neoplastic*
Biomarkers, Tumor/*metabolism
Carcinoma, Squamous Cell/*metabolism
Mouth Neoplasms/*metabolism
Proteasome Endopeptidase Complex/*metabolism
Proto-Oncogene Proteins/*metabolism
Adult ; Aged ; Base Sequence ; Carcinoma, Squamous Cell/pathology ; DNA Primers ; Female ; Humans ; Male ; Middle Aged ; Mouth Neoplasms/pathology ; Proteasome Endopeptidase Complex/genetics ; Proto-Oncogene Proteins/genetics ; Reverse Transcriptase Polymerase Chain Reaction
Czasopismo naukowe
Tytuł :
Identification of circulating tumor cells: a prognostic marker in squamous cell carcinoma of the head and neck?
Autorzy :
Jatana KR
Lang JC
Chalmers JJ
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Źródło :
Future oncology (London, England) [Future Oncol] 2011 Apr; Vol. 7 (4), pp. 481-4.
Typ publikacji :
Editorial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Biomarkers, Tumor/*analysis
Carcinoma, Squamous Cell/*pathology
Head and Neck Neoplasms/*pathology
Neoplastic Cells, Circulating/*chemistry
Carcinoma, Squamous Cell/chemistry ; Head and Neck Neoplasms/chemistry ; Humans ; Prognosis
Raport
Tytuł :
Significance of circulating tumor cells in patients with squamous cell carcinoma of the head and neck: initial results.
Autorzy :
Jatana KR; Department of Otolaryngology-Head and Neck Surgery, The Ohio State University and Nationwide Children's Hospital, 555 S 18th St, Columbus, OH 43205, USA. />Balasubramanian P
Lang JC
Yang L
Jatana CA
White E
Agrawal A
Ozer E
Schuller DE
Teknos TN
Chalmers JJ
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Źródło :
Archives of otolaryngology--head & neck surgery [Arch Otolaryngol Head Neck Surg] 2010 Dec; Vol. 136 (12), pp. 1274-9.
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Carcinoma, Squamous Cell/*pathology
Head and Neck Neoplasms/*pathology
Neoplastic Cells, Circulating/*pathology
Carcinoma, Squamous Cell/blood ; Carcinoma, Squamous Cell/surgery ; Disease-Free Survival ; Female ; Follow-Up Studies ; Head and Neck Neoplasms/blood ; Head and Neck Neoplasms/surgery ; Humans ; Immunohistochemistry ; Immunomagnetic Separation/methods ; Keratins/blood ; Male ; Middle Aged ; Neoplasm Staging/methods ; Prognosis ; Prospective Studies
Czasopismo naukowe
Tytuł :
Genome-wide hypomethylation in head and neck cancer is more pronounced in HPV-negative tumors and is associated with genomic instability.
Autorzy :
Richards KL; Department of Genetics, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Zhang B
Baggerly KA
Colella S
Lang JC
Schuller DE
Krahe R
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Źródło :
PloS one [PLoS One] 2009; Vol. 4 (3), pp. e4941. Date of Electronic Publication: 2009 Mar 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
DNA Methylation*
Genome, Human*
Genomic Instability*
Carcinoma, Squamous Cell/*genetics
Head and Neck Neoplasms/*genetics
Papillomaviridae/*isolation & purification
Alu Elements ; Base Sequence ; Carcinoma, Squamous Cell/virology ; DNA Primers ; Head and Neck Neoplasms/virology ; Humans ; Long Interspersed Nucleotide Elements ; Loss of Heterozygosity
Czasopismo naukowe
Tytuł :
Molecular signatures of metastasis in head and neck cancer.
Autorzy :
Colella S; Department of Cancer Genetics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.
Richards KL
Bachinski LL
Baggerly KA
Tsavachidis S
Lang JC
Schuller DE
Krahe R
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Źródło :
Head & neck [Head Neck] 2008 Oct; Vol. 30 (10), pp. 1273-83.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Biopsy*
Carcinoma, Squamous Cell/*genetics
Carcinoma, Squamous Cell/*secondary
Head and Neck Neoplasms/*genetics
Head and Neck Neoplasms/*pathology
Frozen Sections ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; Lymphatic Metastasis ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
The effects of reactive species on the tumorigenic phenotype of human head and neck squamous cell carcinoma (HNSCC) cells.
Autorzy :
Bradburn JE; Integrated Biomedical Sciences Graduate Program, School of Biomedical Sciences, The Ohio State University College of Medicine, Columbus, OH 43210, USA.
Pei P
Kresty LA
Lang JC
Yates AJ
McCormick AP
Mallery SR
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Źródło :
Anticancer research [Anticancer Res] 2007 Nov-Dec; Vol. 27 (6B), pp. 3819-27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Carcinoma, Squamous Cell/*metabolism
Carcinoma, Squamous Cell/*pathology
Head and Neck Neoplasms/*metabolism
Head and Neck Neoplasms/*pathology
Reactive Nitrogen Species/*metabolism
Reactive Oxygen Species/*metabolism
Cell Line, Tumor ; Cell Survival/physiology ; ErbB Receptors/metabolism ; Humans ; I-kappa B Proteins/metabolism ; Interleukin-8/metabolism ; NF-kappa B/metabolism ; Oxidation-Reduction ; Vascular Endothelial Growth Factor A/metabolism
Czasopismo naukowe
Tytuł :
Tumor suppressor activity of CCAAT/enhancer binding protein alpha is epigenetically down-regulated in head and neck squamous cell carcinoma.
Autorzy :
Bennett KL; Department of Molecular Genetics, The Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, USA.
Hackanson B
Smith LT
Morrison CD
Lang JC
Schuller DE
Weber F
Eng C
Plass C
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Źródło :
Cancer research [Cancer Res] 2007 May 15; Vol. 67 (10), pp. 4657-64.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
CCAAT-Enhancer-Binding Protein-alpha/*genetics
Carcinoma, Squamous Cell/*genetics
Head and Neck Neoplasms/*genetics
Azacitidine/analogs & derivatives ; Azacitidine/pharmacology ; CCAAT-Enhancer-Binding Protein-alpha/biosynthesis ; Carcinoma, Squamous Cell/metabolism ; Carcinoma, Squamous Cell/pathology ; Cell Differentiation/genetics ; Cell Line, Tumor ; DNA Methylation ; Decitabine ; Down-Regulation ; Epigenesis, Genetic ; Gene Deletion ; Genes, Tumor Suppressor ; Head and Neck Neoplasms/metabolism ; Head and Neck Neoplasms/pathology ; Humans ; Loss of Heterozygosity ; Neoplasm Metastasis ; Transfection
Czasopismo naukowe
Tytuł :
Expression of the serine protease DESC1 correlates directly with normal keratinocyte differentiation and inversely with head and neck squamous cell carcinoma progression.
Autorzy :
Sedghizadeh PP; Department of Oral and Maxillofacial Surgery, Oral and Maxillofacial Pathology and Dental Anesthesiology, Ohio State University, College of Dentistry, 305 West 12th Avenue, 2196 Postle Hall, Columbus, OH 43218-2357, USA. />Mallery SR
Thompson SJ
Kresty L
Beck FM
Parkinson EK
Biancamano J
Lang JC
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Źródło :
Head & neck [Head Neck] 2006 May; Vol. 28 (5), pp. 432-40.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Carcinoma, Squamous Cell/*metabolism
Carcinoma, Squamous Cell/*pathology
Oropharyngeal Neoplasms/*metabolism
Oropharyngeal Neoplasms/*pathology
Precancerous Conditions/*metabolism
Serine Endopeptidases/*metabolism
Adult ; Aged ; Aged, 80 and over ; Case-Control Studies ; Cell Differentiation ; Female ; Humans ; Keratinocytes/cytology ; Male ; Middle Aged ; Precancerous Conditions/pathology ; RNA, Messenger/metabolism ; Respiratory Mucosa/metabolism ; Respiratory Mucosa/pathology ; Serine Endopeptidases/genetics
Czasopismo naukowe
Tytuł :
DNA copy number gains in head and neck squamous cell carcinoma.
Autorzy :
Lin M; Deparment of Otolaryngology and Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.
Smith LT
Smiraglia DJ
Kazhiyur-Mannar R
Lang JC
Schuller DE
Kornacker K
Wenger R
Plass C
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Źródło :
Oncogene [Oncogene] 2006 Mar 02; Vol. 25 (9), pp. 1424-33.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Gene Amplification*
Gene Dosage*
Carcinoma, Squamous Cell/*genetics
Head and Neck Neoplasms/*genetics
Chromosomes, Human, Pair 11 ; Chromosomes, Human, Pair 3 ; Humans ; Restriction Mapping
Czasopismo naukowe
Tytuł :
p16 gene alterations in locally advanced squamous cell carcinoma of the head and neck.
Autorzy :
Wang D; Division of Radiation Oncology, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA. />Grecula JC
Gahbauer RA
Schuller DE
Jatana KR
Biancamano JD
Lang JC
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Źródło :
Oncology reports [Oncol Rep] 2006 Mar; Vol. 15 (3), pp. 661-5.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Genes, p16*
Mutation*
Carcinoma, Squamous Cell/*pathology
Head and Neck Neoplasms/*pathology
Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/therapy ; Cisplatin/administration & dosage ; Combined Modality Therapy ; DNA Mutational Analysis ; Female ; Gene Expression Regulation, Neoplastic ; Head and Neck Neoplasms/genetics ; Head and Neck Neoplasms/therapy ; Humans ; Male ; Middle Aged ; Neoplasm Recurrence, Local ; Neoplasm Staging ; Paclitaxel/administration & dosage ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Differential targets of CpG island hypermethylation in primary and metastatic head and neck squamous cell carcinoma (HNSCC).
Autorzy :
Smiraglia DJ; Division of Human Cancer Genetics, Department of Molecular Virology, Immunology and Medical Genetics, and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA. />Smith LT
Lang JC
Rush LJ
Dai Z
Schuller DE
Plass C
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Źródło :
Journal of medical genetics [J Med Genet] 2003 Jan; Vol. 40 (1), pp. 25-33.
Typ publikacji :
Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
DNA Methylation*
Carcinoma, Squamous Cell/*genetics
Carcinoma, Squamous Cell/*secondary
CpG Islands/*genetics
Head and Neck Neoplasms/*genetics
Head and Neck Neoplasms/*pathology
Adult ; Aged ; Cloning, Molecular ; DNA Fingerprinting ; Female ; Genetic Markers/genetics ; Humans ; Laryngeal Neoplasms/genetics ; Laryngeal Neoplasms/pathology ; Lymphatic Metastasis/genetics ; Male ; Middle Aged ; Mouth Neoplasms/genetics ; Mouth Neoplasms/pathology ; Pharyngeal Neoplasms/genetics ; Pharyngeal Neoplasms/pathology ; Phenotype ; Restriction Mapping ; Sequence Analysis, DNA ; Sulfites/metabolism
Czasopismo naukowe
Tytuł :
Mutational status of overexpressed p16 in head and neck cancer: evidence for germline mutation of p16/p14ARF.
Autorzy :
Lang JC; Department of Otolaryngology and Comprehensive Cancer Center, The Ohio State University, 1248 James Cancer Hospital, and Solove Research Institute, Columbus, OH 43210, USA. lang. />Borchers J
Danahey D
Smith S
Stover DG
Agrawal A
Malone JP
Schuller DE
Weghorst CM
Holinga AJ
Lingam K
Patel CR
Esham B
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Źródło :
International journal of oncology [Int J Oncol] 2002 Aug; Vol. 21 (2), pp. 401-8.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Germ-Line Mutation*
Carcinoma, Squamous Cell/*genetics
Cyclin-Dependent Kinase Inhibitor p16/*genetics
Head and Neck Neoplasms/*genetics
Tumor Suppressor Protein p14ARF/*genetics
Cyclin-Dependent Kinase Inhibitor p16/metabolism ; DNA Primers/chemistry ; Gene Deletion ; Humans ; RNA, Messenger/metabolism ; RNA, Neoplasm/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Tumor Suppressor Protein p14ARF/metabolism ; Up-Regulation
Czasopismo naukowe
Tytuł :
Analysis of TGF-beta type I receptor for mutations and polymorphisms in head and neck cancers.
Autorzy :
Knobloch TJ; Division of Environmental Health Sciences, School of Public Health, College of Medicine and Public Health, The Ohio State University, Columbus, OH 43210, USA.
Lynch MA
Song H
DeGroff VL
Casto BC
Adams EM
Alam KY
Lang JC
Schuller DE
Weghorst CM
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Źródło :
Mutation research [Mutat Res] 2001 Aug 08; Vol. 479 (1-2), pp. 131-9.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Mutation*
Polymorphism, Genetic*
Activin Receptors, Type I/*genetics
Carcinoma, Squamous Cell/*genetics
Head and Neck Neoplasms/*genetics
Receptors, Transforming Growth Factor beta/*genetics
Alleles ; DNA Mutational Analysis ; Exons ; Gene Deletion ; Genetic Predisposition to Disease ; Genotype ; Heterozygote ; Homozygote ; Humans ; Introns ; Microsatellite Repeats ; Phenotype ; Polymerase Chain Reaction ; Polymorphism, Single-Stranded Conformational ; Protein-Serine-Threonine Kinases ; Receptor, Transforming Growth Factor-beta Type I
Czasopismo naukowe
Tytuł :
Somatic INK4a-ARF locus mutations: a significant mechanism of gene inactivation in squamous cell carcinomas of the head and neck.
Autorzy :
Poi MJ; Ohio State Biochemistry Program, The Ohio State University, Columbus, Ohio 43210, USA.
Yen T
Li J
Song H
Lang JC
Schuller DE
Pearl DK
Casto BC
Tsai MD
Weghorst CM
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Źródło :
Molecular carcinogenesis [Mol Carcinog] 2001 Jan; Vol. 30 (1), pp. 26-36.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Mutation*
Carcinoma, Squamous Cell/*genetics
Cyclin-Dependent Kinase Inhibitor p16/*genetics
Head and Neck Neoplasms/*genetics
Helminth Proteins/*genetics
Muscle Proteins/*genetics
Base Sequence ; DNA Primers ; Humans ; Mutagenesis, Site-Directed ; Nuclear Magnetic Resonance, Biomolecular ; Polymerase Chain Reaction ; Polymorphism, Single-Stranded Conformational
Czasopismo naukowe

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