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Tytuł :
NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.
Autorzy :
Marques JG; Department of Oncology and Children's Research Center, University Children's Hospital, Zurich, Switzerland.
Gryder BE; Oncogenomics Section, Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, United States.
Pavlovic B; Department of Oncology and Children's Research Center, University Children's Hospital, Zurich, Switzerland.
Chung Y; Department of Oncology and Children's Research Center, University Children's Hospital, Zurich, Switzerland.
Ngo QA; Department of Oncology and Children's Research Center, University Children's Hospital, Zurich, Switzerland.
Frommelt F; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.
Gstaiger M; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.
Song Y; Oncogenomics Section, Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, United States.
Benischke K; Department of Oncology and Children's Research Center, University Children's Hospital, Zurich, Switzerland.
Laubscher D; Department of Oncology and Children's Research Center, University Children's Hospital, Zurich, Switzerland.
Wachtel M; Department of Oncology and Children's Research Center, University Children's Hospital, Zurich, Switzerland.
Khan J; Oncogenomics Section, Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, United States.
Schäfer BW; Department of Oncology and Children's Research Center, University Children's Hospital, Zurich, Switzerland.
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Źródło :
ELife [Elife] 2020 Aug 03; Vol. 9. Date of Electronic Publication: 2020 Aug 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Czasopismo naukowe
Tytuł :
Aurora A Kinase Inhibition Destabilizes PAX3-FOXO1 and MYCN and Synergizes with Navitoclax to Induce Rhabdomyosarcoma Cell Death.
Autorzy :
Ommer J; Department of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
Selfe JL; Sarcoma Molecular Pathology Laboratory, The Institute of Cancer Research, London, United Kingdom.
Wachtel M; Department of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
O'Brien EM; Sarcoma Molecular Pathology Laboratory, The Institute of Cancer Research, London, United Kingdom.
Laubscher D; Department of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
Roemmele M; Department of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
Kasper S; Department of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
Delattre O; France INSERM U830, Équipe Labellisé LNCC, PSL Université, SIREDO Oncology Centre, Institut Curie, Paris, France.
Surdez D; France INSERM U830, Équipe Labellisé LNCC, PSL Université, SIREDO Oncology Centre, Institut Curie, Paris, France.
Petts G; Department of Diagnostic Paediatric Histopathology, Royal Manchester Children's Hospital, Manchester, United Kingdom.
Kelsey A; Department of Diagnostic Paediatric Histopathology, Royal Manchester Children's Hospital, Manchester, United Kingdom.
Shipley J; Sarcoma Molecular Pathology Laboratory, The Institute of Cancer Research, London, United Kingdom.
Schäfer BW; Department of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland. .
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Źródło :
Cancer research [Cancer Res] 2020 Feb 15; Vol. 80 (4), pp. 832-842. Date of Electronic Publication: 2019 Dec 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Aurora Kinase A/*metabolism
N-Myc Proto-Oncogene Protein/*metabolism
Oncogene Proteins, Fusion/*metabolism
Paired Box Transcription Factors/*metabolism
Rhabdomyosarcoma, Alveolar/*drug therapy
Aniline Compounds/pharmacology ; Aniline Compounds/therapeutic use ; Animals ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Apoptosis/drug effects ; Aurora Kinase A/antagonists & inhibitors ; Drug Synergism ; Gene Knockdown Techniques ; HEK293 Cells ; Humans ; Mice ; Mutagenesis, Site-Directed ; Oncogene Proteins, Fusion/genetics ; Paired Box Transcription Factors/genetics ; Phosphorylation/drug effects ; Primary Cell Culture ; Protein Stability/drug effects ; Proto-Oncogene Proteins c-bcl-2/metabolism ; RNA, Small Interfering/metabolism ; Rhabdomyosarcoma, Alveolar/genetics ; Rhabdomyosarcoma, Alveolar/pathology ; Sulfonamides/pharmacology ; Sulfonamides/therapeutic use ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
A Novel Simulation to Assess Residents' Utilization of a Medical Interpreter.
Autorzy :
Zdradzinski MJ; Resident Physician, Department of Emergency Medicine, Emory University School of Medicine.
Backster A; Assistant Professor, Department of Emergency Medicine, Emory University School of Medicine.
Heron S; Assistant Dean for Medical Education and Student Affairs, Emory University School of Medicine.
White M; Residency Program Director, Department of Emergency Medicine, Emory University School of Medicine.
Laubscher D; Standardized Patient Educator, Emory University School of Medicine.
Siegelman JN; Associate Residency Director, Department of Emergency Medicine, Emory University School of Medicine.
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Źródło :
MedEdPORTAL : the journal of teaching and learning resources [MedEdPORTAL] 2019 Nov 22; Vol. 15, pp. 10853. Date of Electronic Publication: 2019 Nov 22.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Ancillary Services, Hospital*/statistics & numerical data
Internship and Residency*
Patient Simulation*
Translating*
Emergency Medicine/*education
Clinical Competence ; Communication Barriers ; Cultural Competency ; Health Services Research ; Hispanic Americans ; Humans ; Manikins ; Patient Education as Topic/methods ; Professional-Patient Relations ; United States
Czasopismo naukowe
Tytuł :
Birt-Hogg-Dubé syndrome: novel FLCN frameshift deletion in daughter and father with renal cell carcinomas.
Autorzy :
Näf E; Department of Practice Development in Nursing, Solothurner Spitäler AG, Olten, Switzerland.
Laubscher D; Genetic Center of the Foundation for People with Rare Diseases, Schlieren-Zurich, Switzerland.
Hopfer H; Institute for Pathology, University Hospital, Basel, Switzerland.
Streit M; Department of Dermatology, Kantonsspital, Aarau, Switzerland.
Matyas G; Genetic Center of the Foundation for People with Rare Diseases, Schlieren-Zurich, Switzerland. .; Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland. .
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Źródło :
Familial cancer [Fam Cancer] 2016 Jan; Vol. 15 (1), pp. 127-32.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Birt-Hogg-Dube Syndrome/*genetics
Carcinoma, Renal Cell/*genetics
Genetic Predisposition to Disease/*genetics
Kidney Neoplasms/*genetics
Proto-Oncogene Proteins/*genetics
Tumor Suppressor Proteins/*genetics
Female ; Frameshift Mutation ; Humans ; Male ; Middle Aged ; Pedigree ; Reverse Transcriptase Polymerase Chain Reaction
Czasopismo naukowe

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