Senescent skeletal muscle fibroadipogenic progenitors recruit and promote M2 polarization of macrophages.
Autorzy:
Zhang X; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, USA.; Paul F. Glenn Center for Biology of Aging Research at Mayo Clinic, Rochester, Minnesota, USA. Ng YE; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA. Chini LCS; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA. Heeren AA; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA. White TA; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA. Li H; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, USA. Huang H; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, USA. Doolittle ML; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.; Division of Endocrinology, Mayo Clinic, Rochester, Minnesota, USA. Khosla S; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.; Division of Endocrinology, Mayo Clinic, Rochester, Minnesota, USA. LeBrasseurNK; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.; Paul F. Glenn Center for Biology of Aging Research at Mayo Clinic, Rochester, Minnesota, USA.; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, Minnesota, USA.
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Źródło:
Aging cell [Aging Cell] 2024 Mar; Vol. 23 (3), pp. e14069. Date of Electronic Publication: 2023 Dec 19.
Calorie restriction reduces biomarkers of cellular senescence in humans.
Autorzy:
Aversa Z; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, Minnesota, USA. White TA; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA. Heeren AA; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA. Hulshizer CA; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA. Saul D; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.; Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tübingen, BG Trauma Center Tübingen, Tübingen, Germany. Zhang X; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA. Molina AJA; Department of Medicine, University of California San Diego, La Jolla, California, USA. Redman LM; Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA. Martin CK; Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA. Racette SB; College of Health Solutions, Arizona State University, Phoenix, Arizona, USA.; Program in Physical Therapy, Washington University School of Medicine, St. Louis, Missouri, USA. Huffman KM; Duke Clinical Research Institute and Molecular Physiology Institute, School of Medicine, Durham, North Carolina, USA. Bhapkar M; Duke Clinical Research Institute and Molecular Physiology Institute, School of Medicine, Durham, North Carolina, USA. Khosla S; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.; Division of Endocrinology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA. Das SK; Energy Metabolism Team, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA. Fielding RA; Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA. Atkinson EJ; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA. LeBrasseurNK; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, Minnesota, USA.; Paul F. Glenn Center for the Biology of Aging at Mayo Clinic, Rochester, Minnesota, USA.
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Źródło:
Aging cell [Aging Cell] 2024 Feb; Vol. 23 (2), pp. e14038. Date of Electronic Publication: 2023 Nov 14.
Biomarkers of cellular senescence and risk of death in humans.
Autorzy:
St Sauver JL; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA. Weston SA; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA. Atkinson EJ; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA. Mc Gree ME; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA. Mielke MM; Department of Epidemiology and Prevention, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA. White TA; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA. Heeren AA; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA. Olson JE; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA. Rocca WA; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA.; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.; Women's Health Research Center, Mayo Clinic, Rochester, Minnesota, USA. Palmer AK; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.; Division of Hospital Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA. Cummings SR; Departments of Medicine, Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA.; Research Institute, California Pacific Medical Center, San Francisco, California, USA. Fielding RA; Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA. Bielinski SJ; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA. LeBrasseurNK; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.; Paul F. Glenn Center for the Biology of Aging Research, Mayo Clinic, Rochester, Minnesota, USA.; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, Minnesota, USA.
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Źródło:
Aging cell [Aging Cell] 2023 Dec; Vol. 22 (12), pp. e14006. Date of Electronic Publication: 2023 Oct 06.
Single-cell Mayo Map (scMayoMap): an easy-to-use tool for cell type annotation in single-cell RNA-sequencing data analysis.
Autorzy:
Yang L; Division of Computational Biology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, 55905, USA.; Center for Individualized Medicine, Mayo Clinic, Rochester, MN, 55905, USA. Ng YE; Robert and Arlene Kogod Center On Aging, Mayo Clinic, Rochester, MN, 55905, USA. Sun H; Department of Biochemistry and Microbiology, Rutgers University, New Brunswick, NJ, 08901, USA. Li Y; Department of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL, 32224, USA. Chini LCS; Robert and Arlene Kogod Center On Aging, Mayo Clinic, Rochester, MN, 55905, USA. LeBrasseurNK; Robert and Arlene Kogod Center On Aging, Mayo Clinic, Rochester, MN, 55905, USA. lebrasseur..; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, 55905, USA. lebrasseur.. Chen J; Division of Computational Biology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, 55905, USA. .; Center for Individualized Medicine, Mayo Clinic, Rochester, MN, 55905, USA. . Zhang X; Robert and Arlene Kogod Center On Aging, Mayo Clinic, Rochester, MN, 55905, USA. .; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, 55905, USA. .
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Źródło:
BMC biology [BMC Biol] 2023 Oct 20; Vol. 21 (1), pp. 223. Date of Electronic Publication: 2023 Oct 20.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
2023 Padua Days of Muscle and Mobility Medicine: post-meeting Book of Abstracts.
Autorzy:
Zampieri S; Department of Surgery, Oncology and Gastroenterology, Padua University Hospital, Padua, Italy; Department of Biomedical Sciences, University of Padua, Italy; CIR MYO - Interdepartmental Research Centre of Myology, University of Padua, Italy; Armando & Carmela Mioni-Carraro Foundation for Translational Myology, Padua, Italy; Ludwig Boltzmann Institute for Rehabilitation Research, Wien, Austria; Centre of Active Ageing, Sankt Poelten . . Bersch I; International FES Centre®, Swiss Paraplegic Centre, Nottwil. . Kern H; Ludwig Boltzmann Institute for Rehabilitation Research, Wien, Austria; Centre of Active Ageing, Sankt Poelten. . Sarabon N; University of Primorska, Faculty of Health Sciences, Izola, Slovenia; S2P, Science to Practice, Ltd., Laboratory for Motor Control and Motor Behaviour, Ljubljana, Slovenia; InnoRenew CoE, Izola. . Rosati R; Department of Biomedical Surgical and Dental Sciences, University of Milan, Milan. . LeBrasseurNK; Department of Physical Medicine and Rehabilitation, Robert and Arlene Kogod Center on Aging, Mayo Clinic, Minnesota. LeBrasseur.. Leeuwenburg C; Department of Aging and Geriatric Research, Institute on Aging, University of Florida, Gainesville, FL. . Carraro U; Department of Biomedical Sciences, University of Padua, Italy; CIR MYO - Interdepartmental Research Centre of Myology, University of Padua, Italy; Armando & Carmela Mioni-Carraro Foundation for Translational Myology, Padua. .
Biomarkers of cellular senescence in idiopathic pulmonary fibrosis.
Autorzy:
Aversa Z; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA. Atkinson EJ; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA. Carmona EM; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN, USA. White TA; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. Heeren AA; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. Jachim SK; Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN, USA. Zhang X; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. Cummings SR; Departments of Medicine, Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.; Research Institute, California Pacific Medical Center, San Francisco, CA, USA. Chiarella SE; Division of Allergic Diseases, Mayo Clinic, Rochester, MN, USA. Limper AH; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN, USA. LeBrasseurNK; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. lebrasseur..; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA. lebrasseur..
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Źródło:
Respiratory research [Respir Res] 2023 Apr 07; Vol. 24 (1), pp. 101. Date of Electronic Publication: 2023 Apr 07.
Targeted clearance of p21- but not p16-positive senescent cells prevents radiation-induced osteoporosis and increased marrow adiposity.
Autorzy:
Chandra A; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA. Lagnado AB; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA. Farr JN; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.; Division of Endocrinology, Mayo Clinic, Rochester, Minnesota, USA. Doolittle M; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.; Division of Endocrinology, Mayo Clinic, Rochester, Minnesota, USA. Tchkonia T; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA. Kirkland JL; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA. LeBrasseurNK; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, Minnesota, USA. Robbins PD; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA. Niedernhofer LJ; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA. Ikeno Y; Department of Pathology and Laboratory Medicine, University of Texas Health Science Center, San Antonio, Texas, USA. Passos JF; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA. Monroe DG; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.; Division of Endocrinology, Mayo Clinic, Rochester, Minnesota, USA. Pignolo RJ; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.; Division of Endocrinology, Mayo Clinic, Rochester, Minnesota, USA. Khosla S; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.; Division of Endocrinology, Mayo Clinic, Rochester, Minnesota, USA.
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Źródło:
Aging cell [Aging Cell] 2022 May; Vol. 21 (5), pp. e13602. Date of Electronic Publication: 2022 Apr 01.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
Novel small molecule inhibition of IKK/NF-κB activation reduces markers of senescence and improves healthspan in mouse models of aging.
Autorzy:
Zhang L; Department of Biochemistry, Molecular Biology and Biophysics, Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, Minnesota, USA. Zhao J; Department of Molecular Medicine, Scripps Research, Jupiter, Florida, USA. Mu X; Center for Regenerative Sports Medicine, Steadman Philippon Research Institute, Vail, Colorado, USA.; Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan, China. McGowan SJ; Department of Biochemistry, Molecular Biology and Biophysics, Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, Minnesota, USA. Angelini L; Department of Biochemistry, Molecular Biology and Biophysics, Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, Minnesota, USA. O'Kelly RD; Department of Biochemistry, Molecular Biology and Biophysics, Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, Minnesota, USA. Yousefzadeh MJ; Department of Biochemistry, Molecular Biology and Biophysics, Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, Minnesota, USA. Sakamoto A; Department of Physical Medicine and Rehabilitation and Robert and Arlene Kogod Center on Aging, Rochester, Minnesota, USA. Aversa Z; Department of Physical Medicine and Rehabilitation and Robert and Arlene Kogod Center on Aging, Rochester, Minnesota, USA. LeBrasseurNK; Department of Physical Medicine and Rehabilitation and Robert and Arlene Kogod Center on Aging, Rochester, Minnesota, USA. Suh Y; Department of Genetics and Development, Columbia University, New York, New York, USA. Huard J; Center for Regenerative Sports Medicine, Steadman Philippon Research Institute, Vail, Colorado, USA. Kamenecka TM; Department of Molecular Medicine, Scripps Research, Jupiter, Florida, USA. Niedernhofer LJ; Department of Biochemistry, Molecular Biology and Biophysics, Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, Minnesota, USA. Robbins PD; Department of Biochemistry, Molecular Biology and Biophysics, Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, Minnesota, USA.
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Źródło:
Aging cell [Aging Cell] 2021 Dec; Vol. 20 (12), pp. e13486. Date of Electronic Publication: 2021 Nov 03.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Senolytics reduce coronavirus-related mortality in old mice.
Autorzy:
Camell CD; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA. Yousefzadeh MJ; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA. Zhu Y; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA. Prata LGPL; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA. Huggins MA; Department of Laboratory Medicine and Pathology and Center of Immunology, University of Minnesota, Minneapolis, MN, USA. Pierson M; Department of Laboratory Medicine and Pathology and Center of Immunology, University of Minnesota, Minneapolis, MN, USA. Zhang L; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA. O'Kelly RD; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA. Pirtskhalava T; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA. Xun P; Department of Epidemiology and Biostatistics, School of Public Health, Indiana University-Bloomington, Bloomington, IN, USA. Ejima K; Department of Epidemiology and Biostatistics, School of Public Health, Indiana University-Bloomington, Bloomington, IN, USA. Xue A; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA. Tripathi U; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA. Espindola-Netto JM; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA. Giorgadze N; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA. Atkinson EJ; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.; Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA. Inman CL; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA. Johnson KO; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA. Cholensky SH; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA. Carlson TW; Masonic Cancer Center Comparative Pathology Shared Resource, University of Minnesota, St. Paul, MN, USA.; Department of Veterinary Population Medicine, University of Minnesota, St. Paul, MN, USA. LeBrasseurNK; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA. Khosla S; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.; Division of Endocrinology, Department of Medicine, Mayo Clinic, Rochester, MN, USA. O'Sullivan MG; Masonic Cancer Center Comparative Pathology Shared Resource, University of Minnesota, St. Paul, MN, USA.; Department of Veterinary Population Medicine, University of Minnesota, St. Paul, MN, USA. Allison DB; Department of Epidemiology and Biostatistics, School of Public Health, Indiana University-Bloomington, Bloomington, IN, USA. Jameson SC; Department of Laboratory Medicine and Pathology and Center of Immunology, University of Minnesota, Minneapolis, MN, USA. Meves A; Department of Dermatology, Mayo Clinic, Rochester, MN, USA. Li M; Department of Dermatology, Mayo Clinic, Rochester, MN, USA. Prakash YS; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA. Chiarella SE; Division of Allergic Diseases, Department of Medicine, Mayo Clinic, Rochester, MN, USA. Hamilton SE; Department of Laboratory Medicine and Pathology and Center of Immunology, University of Minnesota, Minneapolis, MN, USA. . Tchkonia T; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA. .; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA. Niedernhofer LJ; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA. . Kirkland JL; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA. .; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Division of General Internal Medicine, Department of Medicine, Mayo Clinic, Rochester, MN, USA. Robbins PD; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA. .
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Źródło:
Science (New York, N.Y.) [Science] 2021 Jul 16; Vol. 373 (6552). Date of Electronic Publication: 2021 Jun 08.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Exercise reduces circulating biomarkers of cellular senescence in humans.
Autorzy:
Englund DA; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA. Sakamoto AE; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA. Fritsche CM; Dan Abraham Healthy Living Center, Mayo Clinic, Rochester, MN, USA. Heeren AA; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA. Zhang X; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA. Kotajarvi BR; Center for Clinical and Translational Sciences, Mayo Clinic, Rochester, MN, USA. Lecy DR; Dan Abraham Healthy Living Center, Mayo Clinic, Rochester, MN, USA. Yousefzadeh MJ; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA. Schafer MJ; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA. White TA; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA. Atkinson EJ; Division of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA. LeBrasseurNK; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
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Źródło:
Aging cell [Aging Cell] 2021 Jul; Vol. 20 (7), pp. e13415. Date of Electronic Publication: 2021 Jun 08.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Whole-body senescent cell clearance alleviates age-related brain inflammation and cognitive impairment in mice.
Autorzy:
Ogrodnik M; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA. Evans SA; Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA. Fielder E; Biostatistics Consulting Center, School of Public Health-Bloomington, Indiana University, Bloomington, IN, USA. Victorelli S; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA. Kruger P; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA. Salmonowicz H; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA. Weigand BM; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA. Patel AD; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA. Pirtskhalava T; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA. Inman CL; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA. Johnson KO; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA. Dickinson SL; Biostatistics Consulting Center, School of Public Health-Bloomington, Indiana University, Bloomington, IN, USA. Rocha A; Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA. Schafer MJ; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA. Zhu Y; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA. Allison DB; Biostatistics Consulting Center, School of Public Health-Bloomington, Indiana University, Bloomington, IN, USA. von Zglinicki T; Faculty of Medical Sciences, Biosciences Institute, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK. LeBrasseurNK; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA. Tchkonia T; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA. Neretti N; Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA. Passos JF; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA. Kirkland JL; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA. Jurk D; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
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Źródło:
Aging cell [Aging Cell] 2021 Feb; Vol. 20 (2), pp. e13296. Date of Electronic Publication: 2021 Jan 20.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Effect of menopausal hormone therapy on proteins associated with senescence and inflammation.
Autorzy:
Faubion L; Department of Surgery, Mayo Clinic, Rochester, MN, USA. White TA; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA. Peterson BJ; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA. Geske JR; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA. LeBrasseurNK; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Specialized Center of Research Excellence on Sex Differences, Mayo Clinic, Rochester, MN, USA. Schafer MJ; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Specialized Center of Research Excellence on Sex Differences, Mayo Clinic, Rochester, MN, USA. Mielke MM; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.; Specialized Center of Research Excellence on Sex Differences, Mayo Clinic, Rochester, MN, USA.; Department of Neurology, Mayo Clinic, Rochester, MN, USA. Miller VM; Department of Surgery, Mayo Clinic, Rochester, MN, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.; Specialized Center of Research Excellence on Sex Differences, Mayo Clinic, Rochester, MN, USA.
Late-life time-restricted feeding and exercise differentially alter healthspan in obesity.
Autorzy:
Schafer MJ; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota.; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, Minnesota. Mazula DL; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota. Brown AK; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota. White TA; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota. Atkinson E; Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota. Pearsall VM; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota. Aversa Z; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota.; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, Minnesota. Verzosa GC; Department of Surgery, Mayo Clinic, Rochester, Minnesota. Smith LA; Department of Surgery, Mayo Clinic, Rochester, Minnesota. Matveyenko A; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota. Miller JD; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota.; Department of Surgery, Mayo Clinic, Rochester, Minnesota. LeBrasseurNK; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota.; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, Minnesota.
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Źródło:
Aging cell [Aging Cell] 2019 Aug; Vol. 18 (4), pp. e12966. Date of Electronic Publication: 2019 May 21.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Palmer AK; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota.; Medical Scientist Training Program, Mayo Clinic, Rochester, Minnesota.; Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota. Xu M; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota.; University of Connecticut Center on Aging, University of Connecticut Health, Farmington, Connecticut. Zhu Y; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota. Pirtskhalava T; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota. Weivoda MM; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota. Hachfeld CM; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota. Prata LG; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota. van Dijk TH; Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Verkade E; Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Casaclang-Verzosa G; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota. Johnson KO; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota. Cubro H; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota. Doornebal EJ; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota. Ogrodnik M; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota.; Institute for Ageing, Ageing Research Laboratories, Newcastle University, Newcastle upon Tyne, UK. Jurk D; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota.; Institute for Ageing, Ageing Research Laboratories, Newcastle University, Newcastle upon Tyne, UK. Jensen MD; Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota. Chini EN; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota.; Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota. Miller JD; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota.; Department of Surgery, Mayo Clinic, Rochester, Minnesota. Matveyenko A; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota. Stout MB; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota.; Department of Nutritional Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.; Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.; Harold Hamm Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma. Schafer MJ; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota. White TA; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota. Hickson LJ; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.; Division of Geriatric Medicine and Gerontology, Mayo Clinic, Rochester, Minnesota. Demaria M; Buck Institute for Research on Aging, Novato, California.; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Garovic V; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota. Grande J; Department of Pathology, Mayo Clinic, Rochester, Minnesota. Arriaga EA; Department of Chemistry, University of Minnesota, Minneapolis, Minnesota. Kuipers F; Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. von Zglinicki T; Institute for Ageing, Ageing Research Laboratories, Newcastle University, Newcastle upon Tyne, UK. LeBrasseurNK; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota.; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, Minnesota. Campisi J; Buck Institute for Research on Aging, Novato, California. Tchkonia T; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota. Kirkland JL; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota.; Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota.; Division of Geriatric Medicine and Gerontology, Mayo Clinic, Rochester, Minnesota.
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Źródło:
Aging cell [Aging Cell] 2019 Jun; Vol. 18 (3), pp. e12950. Date of Electronic Publication: 2019 Mar 25.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Circulating levels of monocyte chemoattractant protein-1 as a potential measure of biological age in mice and frailty in humans.
Autorzy:
Yousefzadeh MJ; Department of Molecular Medicine, Center on Aging, The Scripps Research Institute, Jupiter, FL, USA. Schafer MJ; Robert and Arlene Kogod Center on Aging, Mayo Clinic College of Medicine, Rochester, MN, USA.; Department of Physical Medicine and Rehabilitation, Mayo Clinic College of Medicine, Rochester, MN, USA. Noren Hooten N; Laboratory of Epidemiology and Population Science, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA. Atkinson EJ; Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, USA. Evans MK; Laboratory of Epidemiology and Population Science, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA. Baker DJ; Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA. Quarles EK; Department of Pathology, University of Washington, Seattle, WA, USA. Robbins PD; Department of Molecular Medicine, Center on Aging, The Scripps Research Institute, Jupiter, FL, USA. Ladiges WC; Department of Comparative Medicine, University of Washington, Seattle, WA, USA. LeBrasseurNK; Robert and Arlene Kogod Center on Aging, Mayo Clinic College of Medicine, Rochester, MN, USA.; Department of Physical Medicine and Rehabilitation, Mayo Clinic College of Medicine, Rochester, MN, USA. Niedernhofer LJ; Department of Molecular Medicine, Center on Aging, The Scripps Research Institute, Jupiter, FL, USA.
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Źródło:
Aging cell [Aging Cell] 2018 Apr; Vol. 17 (2). Date of Electronic Publication: 2017 Dec 31.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
Relationship between pre-transplant physical function and outcomes after kidney transplant.
Autorzy:
Lorenz EC; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.; William J von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN, USA. Cheville AL; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA. Amer H; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.; William J von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN, USA. Kotajarvi BR; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA. Stegall MD; William J von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN, USA.; Division of Transplantation Surgery, Mayo Clinic, Rochester, MN, USA. Petterson TM; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA. Kremers WK; William J von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN, USA.; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA. Cosio FG; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.; William J von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN, USA. LeBrasseurNK; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA.
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Źródło:
Clinical transplantation [Clin Transplant] 2017 May; Vol. 31 (5). Date of Electronic Publication: 2017 Apr 17.
Typ publikacji:
Journal Article; Observational Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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