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    Wyświetlanie 1-12 z 12
    Tytuł:
    Growth differentiation factor 15 ameliorates nonalcoholic steatohepatitis and related metabolic disorders in mice.
    Autorzy:
    Kim KH; Severance Biomedical Research Institute, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea. .
    Kim SH; Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, South Korea.
    Han DH; Department of Surgery, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.
    Jo YS; Department of Internal Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.
    Lee YH; Department of Internal Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.
    Lee MS; Severance Biomedical Research Institute, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea. .; Department of Internal Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea. .
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    Źródło:
    Scientific reports [Sci Rep] 2018 May 01; Vol. 8 (1), pp. 6789. Date of Electronic Publication: 2018 May 01.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Choline Deficiency/*genetics
    Endoplasmic Reticulum Stress/*genetics
    Growth Differentiation Factor 15/*genetics
    Hepatic Stellate Cells/*metabolism
    Liver/*metabolism
    Liver Cirrhosis/*genetics
    Non-alcoholic Fatty Liver Disease/*genetics
    Actins/genetics ; Actins/metabolism ; Animals ; Choline Deficiency/metabolism ; Choline Deficiency/pathology ; Collagen Type I/genetics ; Collagen Type I/metabolism ; Collagen Type I, alpha 1 Chain ; Diet/adverse effects ; Disease Models, Animal ; Gene Expression Regulation ; Growth Differentiation Factor 15/deficiency ; Hepatic Stellate Cells/pathology ; Humans ; Liver/pathology ; Liver Cirrhosis/etiology ; Liver Cirrhosis/metabolism ; Liver Cirrhosis/pathology ; Male ; Methionine/deficiency ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Non-alcoholic Fatty Liver Disease/etiology ; Non-alcoholic Fatty Liver Disease/metabolism ; Non-alcoholic Fatty Liver Disease/pathology ; Osteopontin/genetics ; Osteopontin/metabolism ; Primary Cell Culture ; Signal Transduction ; Tissue Inhibitor of Metalloproteinase-1/genetics ; Tissue Inhibitor of Metalloproteinase-1/metabolism ; Transcription Factor CHOP/genetics ; Transcription Factor CHOP/metabolism ; Transforming Growth Factor beta1/genetics ; Transforming Growth Factor beta1/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Muscle-specific deletion of signal transducer and activator of transcription 5 augments lipid accumulation in skeletal muscle and liver of mice in response to high-fat diet.
    Autorzy:
    Baik M; Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, College of Agriculture and Life Sciences, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 151-921, Republic of Korea. .; Institute of Green Bio Science Technology, Gangwon-do, Pyeungchang-gun, 232-916, Republic of Korea. .
    Lee MS; Bioneer Corporation, 8-11 Munpyengseoro, Daedeok-gu, Daejeon, 306-220, Republic of Korea.
    Kang HJ; Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, College of Agriculture and Life Sciences, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 151-921, Republic of Korea.
    Park SJ; Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, College of Agriculture and Life Sciences, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 151-921, Republic of Korea.
    Piao MY; Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, College of Agriculture and Life Sciences, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 151-921, Republic of Korea.
    Nguyen TH; Department of Molecular Biotechnology, Chonnam National University, Gwangju, 500-757, Republic of Korea.
    Hennighausen L; Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
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    Źródło:
    European journal of nutrition [Eur J Nutr] 2017 Mar; Vol. 56 (2), pp. 569-579. Date of Electronic Publication: 2015 Nov 18.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Diet, High-Fat*
    Lipid Metabolism/*physiology
    Liver/*metabolism
    Muscle, Skeletal/*metabolism
    STAT5 Transcription Factor/*deficiency
    STAT5 Transcription Factor/*physiology
    Animals ; CD36 Antigens/genetics ; Glucose/metabolism ; Lipoprotein Lipase/genetics ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; RNA, Messenger/analysis ; Receptors, LDL/genetics ; Signal Transduction/physiology ; Up-Regulation/physiology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Hepatoprotective Effect of Cuscuta campestris Yunck. Whole Plant on Carbon Tetrachloride Induced Chronic Liver Injury in Mice.
    Autorzy:
    Peng WH; Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Biopharmaceutical and Food Sciences, China Medical University, 91 Hsueh-Shih Road, Taichung 40402, Taiwan. .
    Chen YW; Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Biopharmaceutical and Food Sciences, China Medical University, 91 Hsueh-Shih Road, Taichung 40402, Taiwan. .
    Lee MS; Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Biopharmaceutical and Food Sciences, China Medical University, 91 Hsueh-Shih Road, Taichung 40402, Taiwan. .
    Chang WT; Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Biopharmaceutical and Food Sciences, China Medical University, 91 Hsueh-Shih Road, Taichung 40402, Taiwan. .
    Tsai JC; Department of Health and Nutrition Biotechnology, College of Health Science, Asia University, 500 Liufeng Rd., Wufeng, Taichung 41354, Taiwan. .
    Lin YC; Department of Optometry, Jen-Teh Junior College of Medicine, Nursing and Management, 79-9 Sha-Luen Hu Xi-Zhou Li Hou-Loung Town, Miaoli 356, Taiwan. .
    Lin MK; Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Biopharmaceutical and Food Sciences, China Medical University, 91 Hsueh-Shih Road, Taichung 40402, Taiwan. .; Graduate Institute of Biotechnology, National Chung Hsing University, 145 Xingda Rd., South Dist., Taichung 402, Taiwan. .
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    Źródło:
    International journal of molecular sciences [Int J Mol Sci] 2016 Dec 07; Vol. 17 (12). Date of Electronic Publication: 2016 Dec 07.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Antioxidants/*therapeutic use
    Cuscuta/*chemistry
    Liver/*drug effects
    Liver/*metabolism
    Plant Extracts/*pharmacology
    Alanine Transaminase/blood ; Animals ; Antioxidants/chemistry ; Aspartate Aminotransferases/blood ; Carbon Tetrachloride Poisoning ; Catalase/metabolism ; Glutathione/metabolism ; Glutathione Peroxidase/metabolism ; Lipid Peroxidation/drug effects ; Liver/injuries ; Male ; Malondialdehyde/metabolism ; Mice ; Oxidative Stress/drug effects ; Plant Extracts/chemistry ; Seeds/chemistry ; Superoxide Dismutase/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Melatonin pretreatment enhances the therapeutic effects of exogenous mitochondria against hepatic ischemia-reperfusion injury in rats through suppression of mitochondrial permeability transition.
    Autorzy:
    Chen HH; Division of Colorectal Surgery, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
    Chen YT; Division of Urology, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
    Yang CC; Division of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
    Chen KH; Department of Anesthesiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
    Sung PH; Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
    Chiang HJ; Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
    Chen CH; Divisions of General Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
    Chua S; Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
    Chung SY; Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
    Chen YL; Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
    Huang TH; Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
    Kao GS; Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
    Chen SY; Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
    Lee MS; Department of Orthopedics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
    Yip HK; Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.; Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.; Center for Shockwave Medicine and Tissue Engineering, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan.; Department of Nursing, Asia University, Taichung, Taiwan.
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    Źródło:
    Journal of pineal research [J Pineal Res] 2016 Aug; Vol. 61 (1), pp. 52-68. Date of Electronic Publication: 2016 Apr 07.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Liver/*metabolism
    Liver Diseases/*prevention & control
    Melatonin/*pharmacology
    Mitochondria, Liver/*metabolism
    Mitochondrial Membrane Transport Proteins/*metabolism
    Reperfusion Injury/*prevention & control
    Animals ; Apoptosis/drug effects ; Gene Expression Regulation/drug effects ; Liver/pathology ; Liver Diseases/metabolism ; Liver Diseases/pathology ; Male ; Mitochondria, Liver/pathology ; Mitochondrial Permeability Transition Pore ; Oxidative Stress/drug effects ; Rats ; Rats, Sprague-Dawley ; Reperfusion Injury/metabolism ; Reperfusion Injury/pathology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Gallic acid ameliorated impaired glucose and lipid homeostasis in high fat diet-induced NAFLD mice.
    Autorzy:
    Chao J; Institute of Pharmacology, College of Medicine, National Yang-Ming University, Taipei, Taiwan.
    Huo TI; Institute of Pharmacology, College of Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Oncology and Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
    Cheng HY; Department of Nursing, Chung Jen College of Nursing, Health Sciences and Management, Chia-Yi, Taiwan.
    Tsai JC; Department of Health and Nutrition Biotechnology, College of Health Science, Asia University, Taichung, Taiwan; Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli, Taiwan.
    Liao JW; Graduate Institute of Veterinary Pathology, National Chung Hsing University, Taichung, Taiwan.
    Lee MS; Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung, Taiwan.
    Qin XM; Modern Research Center for Traditional Chinese Medicine of Shanxi University, Taiyuan, China.
    Hsieh MT; Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung, Taiwan.
    Pao LH; Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan; School of Pharmacy, National Defense Medical Center, Taipei, Taiwan.
    Peng WH; Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung, Taiwan.
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    Źródło:
    PloS one [PLoS One] 2014 Jun 11; Vol. 9 (2), pp. e96969. Date of Electronic Publication: 2014 Jun 11 (Print Publication: 2014).
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Gallic Acid/*therapeutic use
    Glucose/*metabolism
    Lipid Metabolism/*drug effects
    Liver/*pathology
    Non-alcoholic Fatty Liver Disease/*drug therapy
    Non-alcoholic Fatty Liver Disease/*metabolism
    Animals ; Diet, High-Fat/adverse effects ; Homeostasis/drug effects ; Hypercholesterolemia/complications ; Hypercholesterolemia/prevention & control ; Insulin Resistance ; Liver/metabolism ; Male ; Metabolomics ; Mice ; Mice, Inbred C57BL ; Non-alcoholic Fatty Liver Disease/complications ; Non-alcoholic Fatty Liver Disease/pathology ; Obesity/complications ; Obesity/prevention & control
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Ginsenoside Rg3 reduces lipid accumulation with AMP-Activated Protein Kinase (AMPK) activation in HepG2 cells.
    Autorzy:
    Lee S; Department of Nutritional Science and Food Management, Ewha Womans University, Seoul 120-750, Korea.
    Lee MS; Department of Nutritional Science and Food Management, Ewha Womans University, Seoul 120-750, Korea.
    Kim CT; Food Bio-Nano Research Group, Korea Food Research Institute, Seongnam, Gyeonggi 463-746, Korea.
    Kim IH; Department of Food and Nutrition, College of Health Sciences, Korea University, Seoul 136-703, Korea.
    Kim Y; Department of Nutritional Science and Food Management, Ewha Womans University, Seoul 120-750, Korea.
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    Źródło:
    International journal of molecular sciences [Int J Mol Sci] 2012; Vol. 13 (5), pp. 5729-5739. Date of Electronic Publication: 2012 May 11.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    AMP-Activated Protein Kinases/*metabolism
    Enzyme Activation/*drug effects
    Ginsenosides/*pharmacology
    Lipid Metabolism/*drug effects
    Liver/*drug effects
    Liver/*metabolism
    Ginsenosides/chemistry ; Hep G2 Cells ; Humans ; Panax/chemistry
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Regular exercise is associated with a reduction in the risk of NAFLD and decreased liver enzymes in individuals with NAFLD independent of obesity in Korean adults.
    Autorzy:
    Bae JC; Division of Endocrinology and Metabolism, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
    Suh S
    Park SE
    Rhee EJ
    Park CY
    Oh KW
    Park SW
    Kim SW
    Hur KY
    Kim JH
    Lee MS
    Lee MK
    Kim KW
    Lee WY
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    Źródło:
    PloS one [PLoS One] 2012; Vol. 7 (10), pp. e46819. Date of Electronic Publication: 2012 Oct 22.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Exercise/*physiology
    Fatty Liver/*enzymology
    Fatty Liver/*physiopathology
    Liver/*enzymology
    Obesity/*enzymology
    Obesity/*physiopathology
    Adult ; Alanine Transaminase/metabolism ; Aspartate Aminotransferases/metabolism ; Body Mass Index ; Cross-Sectional Studies ; Fatty Liver/blood ; Female ; Humans ; Male ; Middle Aged ; Non-alcoholic Fatty Liver Disease ; Obesity/blood
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-12 z 12

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