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Wyświetlanie 1-20 z 60
Tytuł:
Z-Ajoene Inhibits Growth of Colon Cancer by Promotion of CK1α Dependent β-Catenin Phosphorylation.
Autorzy:
Li H; Research Institute of Pharmaceutical Sciences and College of Pharmacy, Sookmyung Women's University, Seoul 04310, Korea.
Jeong JH; Research Institute of Pharmaceutical Sciences and College of Pharmacy, Sookmyung Women's University, Seoul 04310, Korea.
Kwon SW; College of Pharmacy, Seoul National University, Seoul 08826, Korea.
Lee SK; College of Pharmacy, Seoul National University, Seoul 08826, Korea.
Lee HJ; School of Industrial Bio-Pharmaceutical Science, Semyung University, Jecheon 27136, Korea.
Ryu JH; Research Institute of Pharmaceutical Sciences and College of Pharmacy, Sookmyung Women's University, Seoul 04310, Korea.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2020 Feb 06; Vol. 25 (3). Date of Electronic Publication: 2020 Feb 06.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents/*pharmacology
Casein Kinase Ialpha/*metabolism
Cell Proliferation/*drug effects
Colonic Neoplasms/*drug therapy
Disulfides/*pharmacology
Phosphorylation/*drug effects
beta Catenin/*metabolism
Apoptosis/drug effects ; Cell Line ; Cell Line, Tumor ; Colonic Neoplasms/metabolism ; Cyclin D1/metabolism ; Garlic/chemistry ; HEK293 Cells ; Humans ; Sulfoxides ; Wnt Signaling Pathway/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The Antiproliferative Activity of Oxypeucedanin via Induction of G 2 /M Phase Cell Cycle Arrest and p53-Dependent MDM2/p21 Expression in Human Hepatoma Cells.
Autorzy:
Park SH; College of Pharmacy, Natural Products Research Institute, Seoul National University, 08826 Seoul, Korea.
Hong JY; College of Pharmacy, Natural Products Research Institute, Seoul National University, 08826 Seoul, Korea.
Park HJ; College of Pharmacy, Natural Products Research Institute, Seoul National University, 08826 Seoul, Korea.
Lee SK; College of Pharmacy, Natural Products Research Institute, Seoul National University, 08826 Seoul, Korea.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2020 Jan 23; Vol. 25 (3). Date of Electronic Publication: 2020 Jan 23.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents/*pharmacology
Carcinoma, Hepatocellular/*drug therapy
Furocoumarins/*pharmacology
G2 Phase Cell Cycle Checkpoints/*drug effects
Liver Neoplasms/*drug therapy
Proto-Oncogene Proteins c-mdm2/*metabolism
Tumor Suppressor Protein p53/*metabolism
Angelica/chemistry ; Antineoplastic Combined Chemotherapy Protocols ; CDC2 Protein Kinase/metabolism ; Carcinoma, Hepatocellular/metabolism ; Cell Proliferation/drug effects ; Checkpoint Kinase 1/metabolism ; Cyclin B1/metabolism ; Cyclin E/metabolism ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Deoxycytidine/analogs & derivatives ; Deoxycytidine/pharmacology ; Drug Synergism ; Hep G2 Cells ; Humans ; Liver Neoplasms/metabolism ; Signal Transduction/drug effects ; cdc25 Phosphatases/metabolism ; Gemcitabine
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Depsidomycins B and C: New Cyclic Peptides from a Ginseng Farm Soil-Derived Actinomycete.
Autorzy:
Kwon Y; Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea. .
Byun WS; Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea. sky_.
Kim BY; ChunLab, Inc., JW TOWER, Seocho-gu, Seoul 06725, Republic of Korea. .
Song MC; Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Republic of Korea. .
Bae M; Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea. .
Yoon YJ; Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Republic of Korea. .
Shin J; Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea. .
Lee SK; Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea. .
Oh DC; Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea. .
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2018 May 25; Vol. 23 (6). Date of Electronic Publication: 2018 May 25.
Typ publikacji:
Journal Article
MeSH Terms:
Soil Microbiology*
Antineoplastic Agents/*isolation & purification
Oligopeptides/*isolation & purification
Streptomyces/*chemistry
Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cell Survival/drug effects ; Epithelial Cells/drug effects ; Epithelial Cells/pathology ; Farms ; Humans ; Isothiocyanates/chemistry ; Leucine/chemistry ; Leucine/isolation & purification ; Oligopeptides/chemistry ; Oligopeptides/pharmacology ; Panax/growth & development ; Pyridazines/chemistry ; Pyridazines/isolation & purification ; Stereoisomerism ; Streptomyces/metabolism ; Threonine/chemistry ; Threonine/isolation & purification ; Valine/chemistry ; Valine/isolation & purification
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Anti-Tumor Activity of Yuanhuacine by Regulating AMPK/mTOR Signaling Pathway and Actin Cytoskeleton Organization in Non-Small Cell Lung Cancer Cells.
Autorzy:
Kang JI; College of Pharmacy, Seoul National University, Seoul, 151-742, Republic of Korea.
Hong JY; College of Pharmacy, Seoul National University, Seoul, 151-742, Republic of Korea.
Lee HJ; College of Pharmacy, Seoul National University, Seoul, 151-742, Republic of Korea.
Bae SY; College of Pharmacy, Seoul National University, Seoul, 151-742, Republic of Korea.
Jung C; College of Pharmacy, Seoul National University, Seoul, 151-742, Republic of Korea.
Park HJ; College of Pharmacy, Seoul National University, Seoul, 151-742, Republic of Korea.
Lee SK; College of Pharmacy, Seoul National University, Seoul, 151-742, Republic of Korea.
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Źródło:
PloS one [PLoS One] 2015 Dec 11; Vol. 10 (12), pp. e0144368. Date of Electronic Publication: 2015 Dec 11 (Print Publication: 2015).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
AMP-Activated Protein Kinases/*metabolism
Actin Cytoskeleton/*metabolism
Antineoplastic Agents/*pharmacology
Carcinoma, Non-Small-Cell Lung/*enzymology
Diterpenes/*pharmacology
Lung Neoplasms/*enzymology
Signal Transduction/*drug effects
TOR Serine-Threonine Kinases/*metabolism
Actin Cytoskeleton/drug effects ; Animals ; Biomarkers, Tumor/metabolism ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Female ; Gefitinib ; Humans ; Lung Neoplasms/pathology ; Mice, Inbred BALB C ; Mice, Nude ; Neoplasm Invasiveness ; Quinazolines/pharmacology ; Sirolimus/pharmacology ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Suppression of MAPK Signaling and Reversal of mTOR-Dependent MDR1-Associated Multidrug Resistance by 21α-Methylmelianodiol in Lung Cancer Cells.
Autorzy:
Aldonza MB; College of Pharmacy, Seoul National University, Seoul, Korea.
Hong JY; College of Pharmacy, Seoul National University, Seoul, Korea.
Bae SY; College of Pharmacy, Seoul National University, Seoul, Korea.
Song J; College of Pharmacy, Seoul National University, Seoul, Korea.
Kim WK; College of Pharmacy, Seoul National University, Seoul, Korea.
Oh J; College of Pharmacy, Seoul National University, Seoul, Korea.
Shin Y; College of Pharmacy, Seoul National University, Seoul, Korea.
Lee SH; College of Pharmacy, Yeungnam University, Gyeongbuk, Korea.
Lee SK; College of Pharmacy, Seoul National University, Seoul, Korea.
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Źródło:
PloS one [PLoS One] 2015 Jun 22; Vol. 10 (6), pp. e0127841. Date of Electronic Publication: 2015 Jun 22 (Print Publication: 2015).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents/*pharmacology
Carcinoma, Non-Small-Cell Lung/*drug therapy
Drug Resistance, Neoplasm/*drug effects
Lung Neoplasms/*drug therapy
Triterpenes/*pharmacology
AMP-Activated Protein Kinases/metabolism ; ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Drug Combinations ; Drug Resistance, Multiple/drug effects ; G1 Phase Cell Cycle Checkpoints/drug effects ; Humans ; MAP Kinase Signaling System/drug effects ; Membrane Potential, Mitochondrial/drug effects ; Neoplasm Invasiveness/pathology ; Paclitaxel/pharmacology ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; RNA Interference ; RNA, Small Interfering ; Reactive Oxygen Species/metabolism ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Synthesis and antitumor activity of fluorocyclopentenyl-pyrimidines.
Autorzy:
Jeong LS; College of Pharmacy, Ewha Womans University, Seoul, Korea. />Zhao LX
Choi WJ
Pal S
Park YH
Lee SK
Chun MW
Lee YB
Ahn CH
Moon HR
Pokaż więcej
Źródło:
Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids] 2007; Vol. 26 (6-7), pp. 713-6.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents/*chemical synthesis
Antineoplastic Agents/*pharmacology
Pyrimidines/*chemical synthesis
Pyrimidines/*pharmacology
Antineoplastic Agents/chemistry ; Cell Line, Tumor ; Drug Design ; Drug Screening Assays, Antitumor ; Humans ; Pyrimidines/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Design, synthesis, and anti-tumor activity of 4'-thionucleosides as potent and selective agonists at the human A3 adenosine receptor.
Autorzy:
Jeong LS; College of Pharmacy, Ewha Womans University, Seoul 120-750, Korea. />Lee HW
Kim HO
Jung JY
Gunaga P
Lee SK
Lee EJ
Chun MW
Gao ZG
Jacobson KA
Moon HR
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Źródło:
Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids] 2007; Vol. 26 (10-12), pp. 1565-8.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Adenosine A3 Receptor Agonists*
Adenosine/*analogs & derivatives
Antineoplastic Agents/*chemistry
Antineoplastic Agents/*pharmacology
Thionucleosides/*chemistry
Thionucleosides/*pharmacology
Adenosine/chemical synthesis ; Adenosine/chemistry ; Adenosine/pharmacology ; Antineoplastic Agents/chemical synthesis ; Drug Design ; HL-60 Cells ; Humans ; Thionucleosides/chemical synthesis ; Wnt Proteins/antagonists & inhibitors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Repurposing Synthetic Congeners of a Natural Product Aurone Unveils a Lead Antitumor Agent Inhibiting Folded P-Loop Conformation of MET Receptor Tyrosine Kinase.
Autorzy:
Hassan, Ahmed H. E.
Wang, Cai Yi
Lee, Cheol Jung
Jeon, Hye Rim
Choi, Yeonwoo
Moon, Suyeon
Lee, Chae Hyeon
Kim, Yeon Ju
Cho, Soo Bin
Mahmoud, Kazem
El-Sayed, Selwan M.
Lee, Sang Kook
Lee, Yong Sup
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Temat:
MET receptor
NATURAL products
ANTINEOPLASTIC agents
COLON cancer
CELL cycle
Źródło:
Pharmaceuticals (14248247); Nov2023, Vol. 16 Issue 11, p1597, 20p
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Antimetastatic Activity of Apoptolidin A by Upregulation of N-Myc Downstream-Regulated Gene 1 Expression in Human Colorectal Cancer Cells.
Autorzy:
Kyaw, Kay Zin
Park, Jiyoon
Oh, Seung Ho
Lee, Ji Yun
Bae, Eun Seo
Park, Hyen Joo
Oh, Dong-Chan
Lee, Sang Kook
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Temat:
COLORECTAL cancer
GENE expression
CANCER cells
CELL cycle
EPITHELIAL-mesenchymal transition
TUMOR suppressor genes
Źródło:
Pharmaceuticals (14248247); Apr2023, Vol. 16 Issue 4, p491, 14p
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 60

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