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Tytuł :
Potential Dual Role of Activating Transcription Factor 3 in Colorectal Cancer.
Autorzy :
Jiang X; Department of Nutrition and Food Science, College of Agriculture and Natural Resources, University of Maryland, College Park, MD, U.S.A.
Kim KJ; Department of Nutrition and Food Science, College of Agriculture and Natural Resources, University of Maryland, College Park, MD, U.S.A.
Ha T; Department of Nutrition and Food Science, College of Agriculture and Natural Resources, University of Maryland, College Park, MD, U.S.A.
Lee SH; Department of Nutrition and Food Science, College of Agriculture and Natural Resources, University of Maryland, College Park, MD, U.S.A. .
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Źródło :
Anticancer research [Anticancer Res] 2016 Feb; Vol. 36 (2), pp. 509-16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Cell Movement*
Gene Expression Regulation, Neoplastic*
Activating Transcription Factor 3/*metabolism
Colorectal Neoplasms/*metabolism
Colorectal Neoplasms/*pathology
Proto-Oncogene Proteins c-bcl-2/*metabolism
Activating Transcription Factor 3/genetics ; Blotting, Western ; Cell Cycle ; Cell Proliferation ; Colorectal Neoplasms/genetics ; Epithelial-Mesenchymal Transition ; Humans ; Immunoenzyme Techniques ; Promoter Regions, Genetic/genetics ; Proto-Oncogene Proteins c-bcl-2/genetics ; RNA, Messenger/genetics ; Real-Time Polymerase Chain Reaction ; Reverse Transcriptase Polymerase Chain Reaction ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
TCF4 Is a Molecular Target of Resveratrol in the Prevention of Colorectal Cancer.
Autorzy :
Jeong JB; Department of Nutrition and Food Science, College of Agriculture and Natural Resources, University of Maryland, College Park, MD 20742, USA. .
Lee J; Department of Nutrition and Food Science, College of Agriculture and Natural Resources, University of Maryland, College Park, MD 20742, USA. .
Lee SH; Department of Nutrition and Food Science, College of Agriculture and Natural Resources, University of Maryland, College Park, MD 20742, USA. .
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2015 May 07; Vol. 16 (5), pp. 10411-25. Date of Electronic Publication: 2015 May 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/*metabolism
Colorectal Neoplasms/*metabolism
Stilbenes/*pharmacology
Transcription Factors/*metabolism
Apoptosis/drug effects ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/genetics ; Caco-2 Cells ; Down-Regulation ; Humans ; MAP Kinase Signaling System ; Resveratrol ; Transcription Factor 4 ; Transcription Factors/genetics ; p38 Mitogen-Activated Protein Kinases/metabolism
Czasopismo naukowe
Tytuł :
Synergistic anticancer activity of capsaicin and 3,3'-diindolylmethane in human colorectal cancer.
Autorzy :
Clark R; Department of Nutrition and Food Science, College of Agriculture and Natural Resources, University of Maryland, College Park, Maryland 20742, United States.
Lee J; Department of Nutrition and Food Science, College of Agriculture and Natural Resources, University of Maryland, College Park, Maryland 20742, United States.
Lee SH; Department of Nutrition and Food Science, College of Agriculture and Natural Resources, University of Maryland, College Park, Maryland 20742, United States.
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Źródło :
Journal of agricultural and food chemistry [J Agric Food Chem] 2015 May 06; Vol. 63 (17), pp. 4297-304. Date of Electronic Publication: 2015 Apr 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Capsaicin/*pharmacology
Colorectal Neoplasms/*drug therapy
Indoles/*pharmacology
Apoptosis/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/physiopathology ; Drug Synergism ; Humans ; NF-kappa B/genetics ; NF-kappa B/metabolism ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism
Czasopismo naukowe
Tytuł :
Hepatectomy vs radiofrequency ablation for colorectal liver metastasis: a propensity score analysis.
Autorzy :
Lee H; Huisong Lee, Jin Seok Heo, Yong Beom Cho, Seong Hyeon Yun, Hee Cheol Kim, Woo Yong Lee, Seong Ho Choi, Dong Wook Choi, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, South Korea.
Heo JS; Huisong Lee, Jin Seok Heo, Yong Beom Cho, Seong Hyeon Yun, Hee Cheol Kim, Woo Yong Lee, Seong Ho Choi, Dong Wook Choi, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, South Korea.
Cho YB; Huisong Lee, Jin Seok Heo, Yong Beom Cho, Seong Hyeon Yun, Hee Cheol Kim, Woo Yong Lee, Seong Ho Choi, Dong Wook Choi, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, South Korea.
Yun SH; Huisong Lee, Jin Seok Heo, Yong Beom Cho, Seong Hyeon Yun, Hee Cheol Kim, Woo Yong Lee, Seong Ho Choi, Dong Wook Choi, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, South Korea.
Kim HC; Huisong Lee, Jin Seok Heo, Yong Beom Cho, Seong Hyeon Yun, Hee Cheol Kim, Woo Yong Lee, Seong Ho Choi, Dong Wook Choi, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, South Korea.
Lee WY; Huisong Lee, Jin Seok Heo, Yong Beom Cho, Seong Hyeon Yun, Hee Cheol Kim, Woo Yong Lee, Seong Ho Choi, Dong Wook Choi, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, South Korea.
Choi SH; Huisong Lee, Jin Seok Heo, Yong Beom Cho, Seong Hyeon Yun, Hee Cheol Kim, Woo Yong Lee, Seong Ho Choi, Dong Wook Choi, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, South Korea.
Choi DW; Huisong Lee, Jin Seok Heo, Yong Beom Cho, Seong Hyeon Yun, Hee Cheol Kim, Woo Yong Lee, Seong Ho Choi, Dong Wook Choi, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, South Korea.
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Źródło :
World journal of gastroenterology [World J Gastroenterol] 2015 Mar 21; Vol. 21 (11), pp. 3300-7.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Catheter Ablation*/adverse effects
Catheter Ablation*/mortality
Hepatectomy*/adverse effects
Hepatectomy*/mortality
Colorectal Neoplasms/*pathology
Liver Neoplasms/*secondary
Liver Neoplasms/*surgery
Metastasectomy/*methods
Adult ; Aged ; Chi-Square Distribution ; Colorectal Neoplasms/mortality ; Female ; Humans ; Kaplan-Meier Estimate ; Liver Neoplasms/mortality ; Logistic Models ; Male ; Metastasectomy/adverse effects ; Metastasectomy/mortality ; Middle Aged ; Multivariate Analysis ; Neoplasm Recurrence, Local ; Patient Selection ; Propensity Score ; Proportional Hazards Models ; Risk Factors ; Time Factors ; Treatment Outcome ; Tumor Burden
Czasopismo naukowe
Tytuł :
Repeat hepatic resection in patients with colorectal liver metastases.
Autorzy :
Lee H; Huisong Lee, Seong Ho Choi, Yong Beom Cho, Seong Hyeon Yun, Hee Cheol Kim, Woo Yong Lee, Jin Seok Heo, Dong Wook Choi, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, South Korea.
Choi SH; Huisong Lee, Seong Ho Choi, Yong Beom Cho, Seong Hyeon Yun, Hee Cheol Kim, Woo Yong Lee, Jin Seok Heo, Dong Wook Choi, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, South Korea.
Cho YB; Huisong Lee, Seong Ho Choi, Yong Beom Cho, Seong Hyeon Yun, Hee Cheol Kim, Woo Yong Lee, Jin Seok Heo, Dong Wook Choi, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, South Korea.
Yun SH; Huisong Lee, Seong Ho Choi, Yong Beom Cho, Seong Hyeon Yun, Hee Cheol Kim, Woo Yong Lee, Jin Seok Heo, Dong Wook Choi, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, South Korea.
Kim HC; Huisong Lee, Seong Ho Choi, Yong Beom Cho, Seong Hyeon Yun, Hee Cheol Kim, Woo Yong Lee, Jin Seok Heo, Dong Wook Choi, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, South Korea.
Lee WY; Huisong Lee, Seong Ho Choi, Yong Beom Cho, Seong Hyeon Yun, Hee Cheol Kim, Woo Yong Lee, Jin Seok Heo, Dong Wook Choi, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, South Korea.
Heo JS; Huisong Lee, Seong Ho Choi, Yong Beom Cho, Seong Hyeon Yun, Hee Cheol Kim, Woo Yong Lee, Jin Seok Heo, Dong Wook Choi, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, South Korea.
Choi DW; Huisong Lee, Seong Ho Choi, Yong Beom Cho, Seong Hyeon Yun, Hee Cheol Kim, Woo Yong Lee, Jin Seok Heo, Dong Wook Choi, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, South Korea.
Jung KU; Huisong Lee, Seong Ho Choi, Yong Beom Cho, Seong Hyeon Yun, Hee Cheol Kim, Woo Yong Lee, Jin Seok Heo, Dong Wook Choi, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, South Korea.
Chun HK; Huisong Lee, Seong Ho Choi, Yong Beom Cho, Seong Hyeon Yun, Hee Cheol Kim, Woo Yong Lee, Jin Seok Heo, Dong Wook Choi, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, South Korea.
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Źródło :
World journal of gastroenterology [World J Gastroenterol] 2015 Feb 21; Vol. 21 (7), pp. 2124-30.
Typ publikacji :
Journal Article
MeSH Terms :
Hepatectomy*/adverse effects
Hepatectomy*/mortality
Colorectal Neoplasms/*pathology
Liver Neoplasms/*secondary
Liver Neoplasms/*surgery
Adult ; Aged ; Aged, 80 and over ; Catheter Ablation/adverse effects ; Chi-Square Distribution ; Colorectal Neoplasms/mortality ; Disease-Free Survival ; Female ; Humans ; Kaplan-Meier Estimate ; Liver Neoplasms/mortality ; Male ; Middle Aged ; Multivariate Analysis ; Neoplasm Recurrence, Local ; Proportional Hazards Models ; Reoperation ; Retrospective Studies ; Risk Factors ; Time Factors ; Treatment Outcome
Czasopismo naukowe
Tytuł :
The involvement of endoplasmic reticulum stress in the suppression of colorectal tumorigenesis by tolfenamic acid.
Autorzy :
Zhang X; College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996-4542. Phone: 865-974-8216; Fax: 865-974-5616; ; Qingwang Li, College of Animal Science and Technology, Northwest A&F University, 22 Xinong Road, Yangling, Shaanxi 712100, People's Republic of China. .
Lee SH
Min KW
McEntee MF
Jeong JB
Li Q
Baek SJ
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Źródło :
Cancer prevention research (Philadelphia, Pa.) [Cancer Prev Res (Phila)] 2013 Dec; Vol. 6 (12), pp. 1337-47. Date of Electronic Publication: 2013 Oct 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenomatous Polyposis Coli Protein/*physiology
Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
Cell Transformation, Neoplastic/*drug effects
Colonic Polyps/*drug therapy
Colorectal Neoplasms/*drug therapy
Endoplasmic Reticulum Stress/*drug effects
ortho-Aminobenzoates/*pharmacology
Activating Transcription Factor 4/genetics ; Activating Transcription Factor 4/metabolism ; Animals ; Blotting, Western ; Cell Transformation, Neoplastic/metabolism ; Cell Transformation, Neoplastic/pathology ; Colonic Polyps/metabolism ; Colonic Polyps/pathology ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Cyclin D1/genetics ; Cyclin D1/metabolism ; Humans ; Immunoprecipitation ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Phosphorylation/drug effects ; Protein-Serine-Threonine Kinases/genetics ; Protein-Serine-Threonine Kinases/metabolism ; RNA, Messenger/genetics ; Real-Time Polymerase Chain Reaction ; Reverse Transcriptase Polymerase Chain Reaction ; Signal Transduction ; Tumor Cells, Cultured ; Unfolded Protein Response/drug effects ; eIF-2 Kinase/genetics ; eIF-2 Kinase/metabolism
Czasopismo naukowe
Tytuł :
Reactive oxygen species mediate tolfenamic acid-induced apoptosis in human colorectal cancer cells.
Autorzy :
Jeong JB; Department of Nutrition and Food Science, College of Agriculture and Natural Resources, University of Maryland, College Park, MD 20742, USA.
Choi J
Baek SJ
Lee SH
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Źródło :
Archives of biochemistry and biophysics [Arch Biochem Biophys] 2013 Sep 15; Vol. 537 (2), pp. 168-75. Date of Electronic Publication: 2013 Jul 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Damage*
Apoptosis/*drug effects
Colorectal Neoplasms/*genetics
Colorectal Neoplasms/*metabolism
Reactive Oxygen Species/*metabolism
Signal Transduction/*drug effects
Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Colorectal Neoplasms/pathology ; Humans ; ortho-Aminobenzoates
Czasopismo naukowe
Tytuł :
Patchouli alcohol, an essential oil of Pogostemon cablin, exhibits anti-tumorigenic activity in human colorectal cancer cells.
Autorzy :
Jeong JB; Department of Nutrition and Food Science, University of Maryland, College Park, MD 20742, USA.
Choi J
Lou Z
Jiang X
Lee SH
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Źródło :
International immunopharmacology [Int Immunopharmacol] 2013 Jun; Vol. 16 (2), pp. 184-90. Date of Electronic Publication: 2013 Apr 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Lamiaceae*
Antineoplastic Agents/*pharmacology
Colorectal Neoplasms/*metabolism
Histone Deacetylase Inhibitors/*pharmacology
Sesquiterpenes/*pharmacology
Apoptosis/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cells, Cultured ; Colorectal Neoplasms/drug therapy ; Cyclin D1/metabolism ; Cyclin-Dependent Kinase 4/metabolism ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Histone Deacetylase 2/antagonists & inhibitors ; Histone Deacetylase 2/metabolism ; Histone Deacetylases/metabolism ; Human Umbilical Vein Endothelial Cells/drug effects ; Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; NF-kappa B/metabolism ; Proto-Oncogene Proteins c-myc/metabolism
Czasopismo naukowe
Tytuł :
3,3'-diindolylmethane induces activating transcription factor 3 (ATF3) via ATF4 in human colorectal cancer cells.
Autorzy :
Lee SH; Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996-4542, USA.
Min KW
Zhang X
Baek SJ
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Źródło :
The Journal of nutritional biochemistry [J Nutr Biochem] 2013 Apr; Vol. 24 (4), pp. 664-71. Date of Electronic Publication: 2012 Jul 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Activating Transcription Factor 3/*biosynthesis
Activating Transcription Factor 4/*metabolism
Colorectal Neoplasms/*metabolism
Indoles/*pharmacology
Activating Transcription Factor 3/genetics ; Cell Line, Tumor ; Colorectal Neoplasms/pathology ; Humans ; Promoter Regions, Genetic ; Regulatory Sequences, Nucleic Acid
Czasopismo naukowe
Tytuł :
Protocatechualdehyde possesses anti-cancer activity through downregulating cyclin D1 and HDAC2 in human colorectal cancer cells.
Autorzy :
Jeong JB; Department of Nutrition and Food Science, University of Maryland, College Park, MD 20742, USA.
Lee SH
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2013 Jan 04; Vol. 430 (1), pp. 381-6. Date of Electronic Publication: 2012 Nov 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Benzaldehydes/*pharmacology
Catechols/*pharmacology
Colorectal Neoplasms/*metabolism
Cyclin D1/*antagonists & inhibitors
Histone Deacetylase 2/*antagonists & inhibitors
Histone Deacetylase Inhibitors/*pharmacology
Apoptosis/drug effects ; Down-Regulation ; HCT116 Cells ; Humans
Czasopismo naukowe
Tytuł :
Damnacanthal, a noni component, exhibits antitumorigenic activity in human colorectal cancer cells.
Autorzy :
Nualsanit T; Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996-4542, USA.
Rojanapanthu P
Gritsanapan W
Lee SH
Lawson D
Baek SJ
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Źródło :
The Journal of nutritional biochemistry [J Nutr Biochem] 2012 Aug; Vol. 23 (8), pp. 915-23. Date of Electronic Publication: 2011 Aug 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Anthraquinones/*pharmacology
Anticarcinogenic Agents/*pharmacology
Colorectal Neoplasms/*metabolism
Morinda/*chemistry
CCAAT-Enhancer-Binding Proteins/genetics ; CCAAT-Enhancer-Binding Proteins/metabolism ; Cell Line, Tumor ; Cell Proliferation ; Colorectal Neoplasms/drug therapy ; Growth Differentiation Factor 15/genetics ; Growth Differentiation Factor 15/metabolism ; HCT116 Cells ; Humans
Czasopismo naukowe
Tytuł :
Resveratrol-induced apoptosis is mediated by early growth response-1, Krüppel-like factor 4, and activating transcription factor 3.
Autorzy :
Whitlock NC; Laboratory of Environmental Carcinogenesis, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennesse 37996, USA.
Bahn JH
Lee SH
Eling TE
Baek SJ
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Źródło :
Cancer prevention research (Philadelphia, Pa.) [Cancer Prev Res (Phila)] 2011 Jan; Vol. 4 (1), pp. 116-27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Activating Transcription Factor 3/*metabolism
Anticarcinogenic Agents/*therapeutic use
Apoptosis/*drug effects
Colorectal Neoplasms/*drug therapy
Early Growth Response Protein 1/*genetics
Kruppel-Like Transcription Factors/*genetics
Stilbenes/*therapeutic use
Base Sequence ; Binding Sites ; Blotting, Western ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Chromatin Immunoprecipitation ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Early Growth Response Protein 1/metabolism ; Electrophoretic Mobility Shift Assay ; Humans ; Immunoenzyme Techniques ; Immunoprecipitation ; Kruppel-Like Transcription Factors/metabolism ; Luciferases/metabolism ; Molecular Sequence Data ; Phosphorylation/drug effects ; Promoter Regions, Genetic/genetics ; Protein Binding ; RNA, Messenger/genetics ; Resveratrol ; Reverse Transcriptase Polymerase Chain Reaction ; Signal Transduction ; Transcriptional Activation
Czasopismo naukowe
Tytuł :
Molecular targets of apigenin in colorectal cancer cells: involvement of p21, NAG-1 and p53.
Autorzy :
Zhong Y; Department of Pathobiology, The University of Tennessee, Knoxville, TN 37996, United States.
Krisanapun C
Lee SH
Nualsanit T
Sams C
Peungvicha P
Baek SJ
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Źródło :
European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2010 Dec; Vol. 46 (18), pp. 3365-74. Date of Electronic Publication: 2010 Aug 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Apigenin/*pharmacology
Colorectal Neoplasms/*therapy
Cyclin-Dependent Kinase Inhibitor p21/*metabolism
Growth Differentiation Factor 15/*metabolism
Tumor Suppressor Protein p53/*metabolism
Animals ; Apoptosis ; Cell Proliferation ; Colorectal Neoplasms/etiology ; Enzyme Inhibitors/pharmacology ; Humans ; Mice ; Phosphorylation/drug effects ; Phosphotransferases/antagonists & inhibitors ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Induction of cell growth arrest by atmospheric non-thermal plasma in colorectal cancer cells.
Autorzy :
Kim CH; Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA.
Bahn JH
Lee SH
Kim GY
Jun SI
Lee K
Baek SJ
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Źródło :
Journal of biotechnology [J Biotechnol] 2010 Dec; Vol. 150 (4), pp. 530-8. Date of Electronic Publication: 2010 Oct 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Proliferation*
Colorectal Neoplasms/*therapy
Plasma Gases/*therapeutic use
Signal Transduction/*physiology
Blotting, Western ; Cell Line, Tumor ; Cell Movement/physiology ; Flow Cytometry ; Humans ; In Situ Nick-End Labeling ; Indoles ; Phosphorylation ; beta Catenin/metabolism
Czasopismo naukowe
Tytuł :
NSAID-activated gene-1 as a molecular target for capsaicin-induced apoptosis through a novel molecular mechanism involving GSK3beta, C/EBPbeta and ATF3.
Autorzy :
Lee SH; Laboratory of Environmental Carcinogenesis, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA.
Krisanapun C
Baek SJ
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Źródło :
Carcinogenesis [Carcinogenesis] 2010 Apr; Vol. 31 (4), pp. 719-28. Date of Electronic Publication: 2010 Jan 28.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Activating Transcription Factor 3/*physiology
Apoptosis/*drug effects
CCAAT-Enhancer-Binding Protein-beta/*physiology
Capsaicin/*pharmacology
Colorectal Neoplasms/*drug therapy
Glycogen Synthase Kinase 3/*physiology
Growth Differentiation Factor 15/*genetics
Colorectal Neoplasms/pathology ; Glycogen Synthase Kinase 3 beta ; Growth Differentiation Factor 15/physiology ; HCT116 Cells ; HT29 Cells ; Humans ; Phosphorylation ; Promoter Regions, Genetic ; Protein Kinase C/physiology ; Receptors, Retinoic Acid/physiology ; Retinoic Acid Receptor alpha ; Signal Transduction
Czasopismo naukowe
Tytuł :
A reciprocal relationship exists between non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) and cyclooxygenase-2.
Autorzy :
Iguchi G; Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T.W. Alexander Drive, RTP, NC 27709, USA.
Chrysovergis K
Lee SH
Baek SJ
Langenbach R
Eling TE
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Źródło :
Cancer letters [Cancer Lett] 2009 Sep 18; Vol. 282 (2), pp. 152-8. Date of Electronic Publication: 2009 Apr 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural
MeSH Terms :
Colorectal Neoplasms/*etiology
Cyclooxygenase 2/*genetics
Growth Differentiation Factor 15/*genetics
Animals ; Celecoxib ; Dinoprostone/pharmacology ; Gene Expression Regulation/drug effects ; Humans ; Intestinal Polyps/metabolism ; Mice ; Mice, Inbred C57BL ; Pyrazoles/pharmacology ; Sulfonamides/pharmacology
Czasopismo naukowe
Tytuł :
ESE-1/EGR-1 pathway plays a role in tolfenamic acid-induced apoptosis in colorectal cancer cells.
Autorzy :
Lee SH; Laboratory of Environmental Carcinogenesis, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996-4542, USA.
Bahn JH
Choi CK
Whitlock NC
English AE
Safe S
Baek SJ
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Źródło :
Molecular cancer therapeutics [Mol Cancer Ther] 2008 Dec; Vol. 7 (12), pp. 3739-50.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Colorectal Neoplasms/*metabolism
DNA-Binding Proteins/*physiology
Early Growth Response Protein 1/*physiology
Proto-Oncogene Proteins/*physiology
Transcription Factors/*physiology
ortho-Aminobenzoates/*pharmacology
Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Antineoplastic Agents/pharmacology ; Apoptosis ; Binding Sites ; Cell Line, Tumor ; Cell Proliferation ; DNA-Binding Proteins/metabolism ; Early Growth Response Protein 1/metabolism ; Humans ; Models, Biological ; Proto-Oncogene Proteins/metabolism ; Proto-Oncogene Proteins c-ets ; RNA, Small Interfering/metabolism ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
A green tea component suppresses posttranslational expression of basic fibroblast growth factor in colorectal cancer.
Autorzy :
Sukhthankar M; Laboratory of Environmental Carcinogenesis, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee 37996, USA.
Yamaguchi K
Lee SH
McEntee MF
Eling TE
Hara Y
Baek SJ
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Źródło :
Gastroenterology [Gastroenterology] 2008 Jun; Vol. 134 (7), pp. 1972-80. Date of Electronic Publication: 2008 Mar 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Camellia sinensis*/chemistry
Antineoplastic Agents, Phytogenic/*pharmacology
Catechin/*analogs & derivatives
Colorectal Neoplasms/*drug therapy
Fibroblast Growth Factor 2/*metabolism
Protein Processing, Post-Translational/*drug effects
Acetylcysteine/analogs & derivatives ; Acetylcysteine/pharmacology ; Adenomatous Polyposis Coli/genetics ; Adenomatous Polyposis Coli/metabolism ; Adenomatous Polyposis Coli/prevention & control ; Animals ; Antineoplastic Agents, Phytogenic/isolation & purification ; Antineoplastic Agents, Phytogenic/therapeutic use ; Catechin/isolation & purification ; Catechin/pharmacology ; Catechin/therapeutic use ; Cell Transformation, Neoplastic/drug effects ; Cell Transformation, Neoplastic/metabolism ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/prevention & control ; Cycloheximide/pharmacology ; Cysteine Proteinase Inhibitors/pharmacology ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Down-Regulation ; Fibroblast Growth Factor 2/genetics ; Genes, APC ; HCT116 Cells ; HT29 Cells ; Humans ; Mice ; Proteasome Endopeptidase Complex/metabolism ; Proteasome Inhibitors ; Protein Synthesis Inhibitors/pharmacology ; Time Factors ; Transfection
Czasopismo naukowe
Tytuł :
Multiple mechanisms are involved in 6-gingerol-induced cell growth arrest and apoptosis in human colorectal cancer cells.
Autorzy :
Lee SH; The Laboratory of Environmental Carcinogenesis, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee 37996-4542, USA.
Cekanova M
Baek SJ
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Źródło :
Molecular carcinogenesis [Mol Carcinog] 2008 Mar; Vol. 47 (3), pp. 197-208.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Cell Proliferation/*drug effects
Colorectal Neoplasms/*drug therapy
Fatty Alcohols/*pharmacology
Anti-Inflammatory Agents, Non-Steroidal/metabolism ; Caco-2 Cells ; Catechols ; Cell Line, Tumor ; Colorectal Neoplasms/pathology ; Cyclin D1/metabolism ; Dose-Response Relationship, Drug ; G1 Phase/drug effects ; HT29 Cells ; Humans ; Luciferases/metabolism ; Plasmids ; S Phase/drug effects ; Statistics as Topic ; Transfection ; beta Catenin/metabolism
Czasopismo naukowe
Tytuł :
A novel peroxisome proliferator-activated receptor gamma ligand, MCC-555, induces apoptosis via posttranscriptional regulation of NAG-1 in colorectal cancer cells.
Autorzy :
Yamaguchi K; Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA.
Lee SH
Eling TE
Baek SJ
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Źródło :
Molecular cancer therapeutics [Mol Cancer Ther] 2006 May; Vol. 5 (5), pp. 1352-61.
Typ publikacji :
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*/drug effects
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Colorectal Neoplasms/*metabolism
Cytokines/*genetics
PPAR gamma/*metabolism
Thiazoles/*pharmacology
3' Untranslated Regions/genetics ; 3' Untranslated Regions/metabolism ; Base Sequence ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/genetics ; Cytokines/metabolism ; Growth Differentiation Factor 15 ; HCT116 Cells ; Humans ; Ligands ; Molecular Sequence Data ; RNA, Messenger/metabolism ; Thiazolidinediones ; Tumor Cells, Cultured ; Up-Regulation/drug effects
Czasopismo naukowe

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