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Wyszukujesz frazę ""Leukotriene B4"" wg kryterium: Temat


Tytuł :
Leukotriene B 4 and Its Receptor in Experimental Autoimmune Uveitis and in Human Retinal Tissues: Clinical Severity and LTB 4 Dependence of Retinal Th17 Cells.
Autorzy :
Eskandarpour M; UCL Institute of Ophthalmology, University College London, London, United Kingdom. Electronic address: .
Chen YH; UCL Institute of Ophthalmology, University College London, London, United Kingdom; Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Nunn MA; Akari Therapeutics plc, London, United Kingdom.
Coupland SE; Liverpool Clinical Laboratories, Liverpool University Hospitals NHS Foundation Trust, Liverpool, United Kingdom.
Weston-Davies W; Akari Therapeutics plc, London, United Kingdom.
Calder VL; UCL Institute of Ophthalmology, University College London, London, United Kingdom.
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Źródło :
The American journal of pathology [Am J Pathol] 2021 Feb; Vol. 191 (2), pp. 320-334. Date of Electronic Publication: 2020 Nov 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Leukotriene B4/*metabolism
Receptors, Leukotriene B4/*metabolism
Retina/*metabolism
Uveitis/*immunology
Uveitis/*metabolism
Animals ; Biological Products/pharmacology ; Complement C5a/antagonists & inhibitors ; Complement C5a/metabolism ; Disease Models, Animal ; Female ; Humans ; Leukotriene B4/antagonists & inhibitors ; Mice ; Mice, Inbred C57BL ; Receptors, Leukotriene B4/antagonists & inhibitors ; Retina/immunology ; Th17 Cells/immunology
Czasopismo naukowe
Tytuł :
[A Research on Drug Discovery for Intracerebral Hemorrhage Focusing on Leukotriene B 4 and Its Receptor].
Autorzy :
Hijioka M; Laboratory of Pharmacology and Neurobiology, College of Pharmaceutical Sciences, Ritsumeikan University.
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Źródło :
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan [Yakugaku Zasshi] 2020; Vol. 140 (11), pp. 1323-1327.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Discovery*
Leukotriene B4*/metabolism
Molecular Targeted Therapy*
Cerebral Hemorrhage/*drug therapy
Cerebral Hemorrhage/*genetics
Phenylpropionates/*administration & dosage
Phenylpropionates/*pharmacology
Receptors, Leukotriene B4/*antagonists & inhibitors
Administration, Oral ; Animals ; Brain/metabolism ; Cell Movement ; Cerebral Hemorrhage/etiology ; Cerebral Hemorrhage/pathology ; Disease Models, Animal ; HL-60 Cells ; Humans ; Mice ; Microglia/metabolism ; Neutrophil Infiltration/drug effects ; Receptors, Leukotriene B4/metabolism ; Thrombin/physiology
Czasopismo naukowe
Tytuł :
Leukotriene B 4 receptors as therapeutic targets for ophthalmic diseases.
Autorzy :
Hirakata T; Department of Ophthalmology, Juntendo University Graduate School of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo, Japan; Department of Biochemistry, Juntendo University Graduate School of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo, Japan.
Matsuda A; Department of Ophthalmology, Juntendo University Graduate School of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo, Japan.
Yokomizo T; Department of Biochemistry, Juntendo University Graduate School of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo, Japan. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular and cell biology of lipids [Biochim Biophys Acta Mol Cell Biol Lipids] 2020 Sep; Vol. 1865 (9), pp. 158756. Date of Electronic Publication: 2020 Jun 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Eye Diseases/*metabolism
Receptors, Leukotriene B4/*metabolism
Animals ; Eye/metabolism ; Humans ; Inflammation/metabolism ; Leukotriene B4/metabolism
Czasopismo naukowe
Tytuł :
Leukotriene B 4 receptor 1 exacerbates inflammation following myocardial infarction.
Autorzy :
Horii Y; Department of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Nakaya M; Department of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.; AMED-PRIME, Japan Agency for Medical Research and Development, Tokyo, Japan.
Ohara H; Department of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Nishihara H; Department of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Watari K; Department of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Nagasaka A; Department of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Nakaya T; Department of Pathology, Jichi Medical University, Tochigi, Japan.
Sugiura Y; Department of Biochemistry, Keio University School of Medicine, Tokyo, Japan.
Okuno T; Department of Biochemistry, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Koga T; Department of Biochemistry, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Tanaka A; Department of Pathology, Jichi Medical University, Tochigi, Japan.
Yokomizo T; Department of Biochemistry, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Kurose H; Department of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2020 Jun; Vol. 34 (6), pp. 8749-8763. Date of Electronic Publication: 2020 May 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Inflammation/*metabolism
Myocardial Infarction/*metabolism
Receptors, Leukotriene B4/*metabolism
Animals ; Disease Models, Animal ; Leukotriene B4/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Signal Transduction/physiology
Czasopismo naukowe
Tytuł :
LTB4-induced anti-apoptosis and infiltration of neutrophils in rheumatoid arthritis.
Autorzy :
Li KX; Department of Physiology, College of Medicine, Nanchang University, Nanchang, Jiangxi, China.
Zheng LX; Department of Physiology, College of Medicine, Nanchang University, Nanchang, Jiangxi, China.
Guo HQ; Department of Physiology, College of Medicine, Nanchang University, Nanchang, Jiangxi, China.
Hong FF; Department of Experimental Teaching Center, Nanchang University, Nanchang, Jiangxi, China. .
Yang SL; Department of Physiology, College of Medicine, Nanchang University, Nanchang, Jiangxi, China. .
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Źródło :
Clinical and experimental rheumatology [Clin Exp Rheumatol] 2020 May-Jun; Vol. 38 (3), pp. 543-551. Date of Electronic Publication: 2020 Feb 14.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Arthritis, Rheumatoid/*immunology
Leukotriene B4/*immunology
Neutrophils/*immunology
Apoptosis ; Arthritis, Rheumatoid/pathology ; Humans ; Receptors, Leukotriene B4 ; Signal Transduction
Czasopismo naukowe
Tytuł :
Pain and bone damage in rheumatoid arthritis: role of leukotriene B4.
Autorzy :
Zheng LX; Department of Physiology, College of Medicine, Nanchang University, China.
Li KX; Department of Physiology, College of Medicine, Nanchang University, China.
Hong FF; Department of Experimental Teaching Center, Nanchang University, China.
Yang SL; Department of Physiology, College of Medicine, Nanchang University, China. .
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Źródło :
Clinical and experimental rheumatology [Clin Exp Rheumatol] 2019 Sep-Oct; Vol. 37 (5), pp. 872-878. Date of Electronic Publication: 2019 Mar 27.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Arthritis, Rheumatoid*/immunology
Arthritis, Rheumatoid*/metabolism
Arthritis, Rheumatoid*/therapy
Leukotriene B4*/metabolism
Leukotriene B4*/physiology
Bone and Bones/*metabolism
Pain/*metabolism
Receptors, Leukotriene B4/*metabolism
Humans ; Molecular Targeted Therapy ; Signal Transduction
Czasopismo naukowe
Tytuł :
First Structure-Activity Relationship Study of Potent BLT2 Agonists as Potential Wound-Healing Promoters.
Autorzy :
Hernandez-Olmos V; Branch for Translational Medicine and Pharmacology TMP, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.
Heering J; Branch for Translational Medicine and Pharmacology TMP, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.
Planz V; Institute of Pharmaceutical Technology and Buchmann Institute for Molecular Life Sciences, Goethe University, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany.
Liu T; Branch for Translational Medicine and Pharmacology TMP, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.
Kaps A; Branch for Translational Medicine and Pharmacology TMP, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.
Rajkumar R; Branch for Translational Medicine and Pharmacology TMP, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.
Gramzow M; Branch for Translational Medicine and Pharmacology TMP, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.
Kaiser A; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.
Schubert-Zsilavecz M; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.
Parnham MJ; Branch for Translational Medicine and Pharmacology TMP, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.
Windbergs M; Institute of Pharmaceutical Technology and Buchmann Institute for Molecular Life Sciences, Goethe University, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany.
Steinhilber D; Branch for Translational Medicine and Pharmacology TMP, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.
Proschak E; Branch for Translational Medicine and Pharmacology TMP, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Oct 22; Vol. 63 (20), pp. 11548-11572. Date of Electronic Publication: 2020 Oct 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Development/*methods
Keratinocytes/*drug effects
Receptors, Leukotriene B4/*agonists
Wound Healing/*drug effects
Animals ; CHO Cells ; Cell Survival/drug effects ; Cricetulus ; HaCaT Cells ; Hep G2 Cells ; Humans ; Keratinocytes/metabolism ; Molecular Structure ; Receptors, Leukotriene B4/genetics ; Structure-Activity Relationship ; Wound Healing/physiology
Czasopismo naukowe
Tytuł :
Mediatory role of BLT2 in the proliferation of KRAS mutant colorectal cancer cells.
Autorzy :
Park J; School of Life Sciences and Biotechnology, Korea University, Seoul 136-701, Republic of Korea.
Jang JH; School of Life Sciences and Biotechnology, Korea University, Seoul 136-701, Republic of Korea.
Kim JH; School of Life Sciences and Biotechnology, Korea University, Seoul 136-701, Republic of Korea. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2019 Mar; Vol. 1866 (3), pp. 329-336. Date of Electronic Publication: 2018 Dec 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Colorectal Neoplasms/*metabolism
Proto-Oncogene Proteins p21(ras)/*metabolism
Receptors, Leukotriene B4/*metabolism
Animals ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Female ; Humans ; Hydroxyeicosatetraenoic Acids/pharmacology ; Leukotriene B4/pharmacology ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins p21(ras)/genetics ; Receptors, Leukotriene B4/antagonists & inhibitors ; Receptors, Leukotriene B4/genetics ; Signal Transduction ; Tetrazoles/pharmacology ; Up-Regulation ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
BLT1 signaling in epithelial cells mediates allergic sensitization via promotion of IL-33 production.
Autorzy :
Xiong Y; Department of Immunology and Basic Research Institute for Aging and Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Cui X; Department of Immunology and Basic Research Institute for Aging and Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Li W; Department of Immunology and Basic Research Institute for Aging and Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Lv J; Department of Immunology and Basic Research Institute for Aging and Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Du L; Department of Integrative Medicine and Neurobiology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Mi W; Department of Integrative Medicine and Neurobiology, School of Basic Medical Sciences, Fudan University, Shanghai, China.; State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Fudan University, Shanghai, China.
Li H; Department of Otolaryngology, Head and Neck Surgery, Eye, Nose and Throat Hospital, Fudan University, Shanghai, China.
Chen Z; Department of Respiratory Diseases, Children's Hospital of Soochow University, Suzhou, China.
Leng Q; CAS Key Laboratory of Molecular Virology & Immunology, Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.
Zhou H; Department of Immunology, Nanjing Medical University, Nanjing, China.
He R; Department of Immunology and Basic Research Institute for Aging and Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, China.; State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Fudan University, Shanghai, China.
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Źródło :
Allergy [Allergy] 2019 Mar; Vol. 74 (3), pp. 495-506. Date of Electronic Publication: 2018 Dec 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Signal Transduction*
Epithelial Cells/*metabolism
Hypersensitivity/*immunology
Hypersensitivity/*metabolism
Interleukin-33/*biosynthesis
Receptors, Leukotriene B4/*metabolism
Allergens/immunology ; Animals ; Cytokines/metabolism ; Hypersensitivity/genetics ; Immunization ; Interleukin-33/genetics ; Leukotriene B4/metabolism ; Lymphocyte Activation/immunology ; Lymphocytes/immunology ; Lymphocytes/metabolism ; Mice ; Papain/immunology ; Proto-Oncogene Proteins c-akt/metabolism ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism
Czasopismo naukowe
Tytuł :
Comparative Modeling and Evaluation of Leukotriene B4 Receptors for Selective Drug Discovery Towards the Treatment of Inflammatory Diseases.
Autorzy :
Ibrahim MAA; Computational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minia, 61519, Egypt. .
Hassan AMA; Computational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minia, 61519, Egypt.
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Źródło :
The protein journal [Protein J] 2018 Dec; Vol. 37 (6), pp. 518-530.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Discovery*
Molecular Dynamics Simulation*
Receptors, Leukotriene B4*/antagonists & inhibitors
Receptors, Leukotriene B4*/chemistry
Anti-Inflammatory Agents/*chemistry
Leukotriene B4/*chemistry
Anti-Inflammatory Agents/therapeutic use ; Drug Evaluation ; Humans ; Inflammation/drug therapy
Czasopismo naukowe
Tytuł :
BLT1 in dendritic cells promotes Th1/Th17 differentiation and its deficiency ameliorates TNBS-induced colitis.
Autorzy :
Zhou J; Putuo District People's Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
Lai W; Putuo District People's Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
Yang W; Putuo District People's Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
Pan J; Tongji Hospital of Tongji University branch, Tongji University, Shanghai, 200092, China.
Shen H; Tongji Hospital of Tongji University branch, Tongji University, Shanghai, 200092, China.
Cai Y; Putuo District People's Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
Yang C; Putuo District People's Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
Ma N; Putuo District People's Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
Zhang Y; Putuo District People's Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
Zhang R; Putuo District People's Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
Xie X; Putuo District People's Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.; CAS Key Laboratory of Receptor Research, National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Dong Z; Institute for Immunology and School of Medicine, Tsinghua University, Beijing, 100086, China.
Gao Y; Putuo District People's Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China. .
Du C; Putuo District People's Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China. .
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Źródło :
Cellular & molecular immunology [Cell Mol Immunol] 2018 Dec; Vol. 15 (12), pp. 1047-1056. Date of Electronic Publication: 2018 Apr 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Colitis/*immunology
Colon/*immunology
Dendritic Cells/*immunology
Inflammatory Bowel Diseases/*immunology
Receptors, Leukotriene B4/*metabolism
Th1 Cells/*immunology
Th17 Cells/*immunology
Animals ; Cell Differentiation ; Cells, Cultured ; Colitis/chemically induced ; Cytokines/metabolism ; Disease Models, Animal ; Humans ; Inflammation Mediators/metabolism ; Leukotriene B4/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Receptors, Leukotriene B4/genetics ; Signal Transduction ; Trinitrobenzenesulfonic Acid
Czasopismo naukowe
Tytuł :
Leukotriene B 4 Receptor Type 2 Accelerates the Healing of Intestinal Lesions by Promoting Epithelial Cell Proliferation.
Autorzy :
Matsumoto Y; Division of Pathological Sciences, Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Kyoto, Japan (Yui.M, Yuk.M., K.N., K.A., K.M., S.K.); Laboratory of Pharmacology and Pharmacotherapy, College of Pharmaceutical Sciences, Ritsumeikan University, Shiga, Japan (K.A.); and Department of Biochemistry, Juntendo University Graduate School of Medicine, Tokyo, Japan (K.S., T.Y.).
Matsuya Y; Division of Pathological Sciences, Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Kyoto, Japan (Yui.M, Yuk.M., K.N., K.A., K.M., S.K.); Laboratory of Pharmacology and Pharmacotherapy, College of Pharmaceutical Sciences, Ritsumeikan University, Shiga, Japan (K.A.); and Department of Biochemistry, Juntendo University Graduate School of Medicine, Tokyo, Japan (K.S., T.Y.).
Nagai K; Division of Pathological Sciences, Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Kyoto, Japan (Yui.M, Yuk.M., K.N., K.A., K.M., S.K.); Laboratory of Pharmacology and Pharmacotherapy, College of Pharmaceutical Sciences, Ritsumeikan University, Shiga, Japan (K.A.); and Department of Biochemistry, Juntendo University Graduate School of Medicine, Tokyo, Japan (K.S., T.Y.).
Amagase K; Division of Pathological Sciences, Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Kyoto, Japan (Yui.M, Yuk.M., K.N., K.A., K.M., S.K.); Laboratory of Pharmacology and Pharmacotherapy, College of Pharmaceutical Sciences, Ritsumeikan University, Shiga, Japan (K.A.); and Department of Biochemistry, Juntendo University Graduate School of Medicine, Tokyo, Japan (K.S., T.Y.).
Saeki K; Division of Pathological Sciences, Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Kyoto, Japan (Yui.M, Yuk.M., K.N., K.A., K.M., S.K.); Laboratory of Pharmacology and Pharmacotherapy, College of Pharmaceutical Sciences, Ritsumeikan University, Shiga, Japan (K.A.); and Department of Biochemistry, Juntendo University Graduate School of Medicine, Tokyo, Japan (K.S., T.Y.).
Matsumoto K; Division of Pathological Sciences, Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Kyoto, Japan (Yui.M, Yuk.M., K.N., K.A., K.M., S.K.); Laboratory of Pharmacology and Pharmacotherapy, College of Pharmaceutical Sciences, Ritsumeikan University, Shiga, Japan (K.A.); and Department of Biochemistry, Juntendo University Graduate School of Medicine, Tokyo, Japan (K.S., T.Y.).
Yokomizo T; Division of Pathological Sciences, Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Kyoto, Japan (Yui.M, Yuk.M., K.N., K.A., K.M., S.K.); Laboratory of Pharmacology and Pharmacotherapy, College of Pharmaceutical Sciences, Ritsumeikan University, Shiga, Japan (K.A.); and Department of Biochemistry, Juntendo University Graduate School of Medicine, Tokyo, Japan (K.S., T.Y.).
Kato S; Division of Pathological Sciences, Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Kyoto, Japan (Yui.M, Yuk.M., K.N., K.A., K.M., S.K.); Laboratory of Pharmacology and Pharmacotherapy, College of Pharmaceutical Sciences, Ritsumeikan University, Shiga, Japan (K.A.); and Department of Biochemistry, Juntendo University Graduate School of Medicine, Tokyo, Japan (K.S., T.Y.) .
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Źródło :
The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2020 Apr; Vol. 373 (1), pp. 1-9. Date of Electronic Publication: 2020 Jan 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Proliferation/*physiology
Colitis/*metabolism
Intestinal Mucosa/*metabolism
Receptors, Leukotriene B4/*metabolism
Animals ; Cell Proliferation/drug effects ; Cells, Cultured ; Colitis/chemically induced ; Colitis/pathology ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; Indomethacin/toxicity ; Intestinal Mucosa/drug effects ; Intestinal Mucosa/pathology ; Leukotriene Antagonists/pharmacology ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Receptors, Leukotriene B4/antagonists & inhibitors ; Receptors, Leukotriene B4/deficiency ; Tetrazoles/pharmacology
Czasopismo naukowe
Tytuł :
Structure of the agonist 12-HHT in its BLT2 receptor-bound state.
Autorzy :
Giusti F; Laboratoire de Biologie Physico-Chimique des Protéines Membranaires, UMR 7099, CNRS/Université de Paris, Institut de Biologie Physico-Chimique (FRC 550), 13 rue Pierre et Marie Curie, F-75005, Paris, France.; Institut de Chimie Séparative de Marcoule, ICSM UMR 5257, Site de Marcoule, Bâtiment 426, BP 17171, F-30207, Bagnols sur Cèze Cedex, France.
Casiraghi M; Laboratoire de Biologie Physico-Chimique des Protéines Membranaires, UMR 7099, CNRS/Université de Paris, Institut de Biologie Physico-Chimique (FRC 550), 13 rue Pierre et Marie Curie, F-75005, Paris, France.; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 279 Campus Drive, 94305, Stanford California, USA.
Point E; Laboratoire de Biologie Physico-Chimique des Protéines Membranaires, UMR 7099, CNRS/Université de Paris, Institut de Biologie Physico-Chimique (FRC 550), 13 rue Pierre et Marie Curie, F-75005, Paris, France.
Damian M; Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS, Université Montpellier, ENSCM, , 15 av. Charles Flahault, 34093, Montpellier, France.
Rieger J; Institut Parisien de Chimie Moléculaire, Sorbonne Université, CNRS, UMR 8232, Equipe Chimie des Polymères, 4 place Jussieu, 75252, Paris Cedex, 05, France.
Bon CL; Laboratoire de Biologie Physico-Chimique des Protéines Membranaires, UMR 7099, CNRS/Université de Paris, Institut de Biologie Physico-Chimique (FRC 550), 13 rue Pierre et Marie Curie, F-75005, Paris, France.
Pozza A; Laboratoire de Biologie Physico-Chimique des Protéines Membranaires, UMR 7099, CNRS/Université de Paris, Institut de Biologie Physico-Chimique (FRC 550), 13 rue Pierre et Marie Curie, F-75005, Paris, France.
Moncoq K; Laboratoire de Biologie Physico-Chimique des Protéines Membranaires, UMR 7099, CNRS/Université de Paris, Institut de Biologie Physico-Chimique (FRC 550), 13 rue Pierre et Marie Curie, F-75005, Paris, France.
Banères JL; Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS, Université Montpellier, ENSCM, , 15 av. Charles Flahault, 34093, Montpellier, France.
Catoire LJ; Laboratoire de Biologie Physico-Chimique des Protéines Membranaires, UMR 7099, CNRS/Université de Paris, Institut de Biologie Physico-Chimique (FRC 550), 13 rue Pierre et Marie Curie, F-75005, Paris, France. .
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Źródło :
Scientific reports [Sci Rep] 2020 Feb 14; Vol. 10 (1), pp. 2630. Date of Electronic Publication: 2020 Feb 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Fatty Acids, Unsaturated/*chemistry
Fatty Acids, Unsaturated/*pharmacology
Receptors, Leukotriene B4/*agonists
Receptors, Leukotriene B4/*metabolism
Humans ; Ligands ; Molecular Conformation ; Molecular Docking Simulation ; Nuclear Magnetic Resonance, Biomolecular ; Protein Binding ; Receptors, Leukotriene B4/chemistry
Czasopismo naukowe
Tytuł :
Leukotriene B4 receptor BLT1 signaling is critical for neutrophil apoptosis and resolution of experimental Lyme arthritis.
Autorzy :
Hilliard KA; Department of Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA.
Blaho VA; Immunity and Pathogenesis Program, Sanford Burnham Prebys Medical Discovery Institute, San Diego, CA, USA.
Jackson CD; Department of Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA.
Brown CR; Department of Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2020 Feb; Vol. 34 (2), pp. 2840-2852. Date of Electronic Publication: 2019 Dec 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Signal Transduction*
Borrelia burgdorferi/*metabolism
Lyme Disease/*metabolism
Neutrophils/*metabolism
Receptors, Leukotriene B4/*metabolism
Animals ; Disease Models, Animal ; Lyme Disease/genetics ; Lyme Disease/pathology ; Mice ; Mice, Knockout ; Neutrophils/pathology ; Receptors, Leukotriene B4/genetics
Czasopismo naukowe
Tytuł :
Excessive localized leukotriene B4 levels dictate poor skin host defense in diabetic mice.
Autorzy :
Brandt SL; Department of Medicine, Division of Infectious Diseases.; Indiana University School of Medicine, Department of Microbiology & Immunology, Indiana University, Indianapolis, Indiana, USA.
Wang S; Indiana University School of Medicine, Department of Microbiology & Immunology, Indiana University, Indianapolis, Indiana, USA.
Dejani NN; Indiana University School of Medicine, Department of Microbiology & Immunology, Indiana University, Indianapolis, Indiana, USA.
Klopfenstein N; Department of Medicine, Division of Infectious Diseases.; Department of Pathology, Microbiology, and Immunology, and.
Winfree S; Indiana Center for Biological Microscopy, Indianapolis, Indiana, USA.
Filgueiras L; Indiana University School of Medicine, Department of Microbiology & Immunology, Indiana University, Indianapolis, Indiana, USA.
McCarthy BP; Indiana Institute for Biomedical Imaging Sciences, Department of Radiology, Indianapolis, Indiana, USA.
Territo PR; Indiana Institute for Biomedical Imaging Sciences, Department of Radiology, Indianapolis, Indiana, USA.
Serezani CH; Department of Medicine, Division of Infectious Diseases.; Department of Pathology, Microbiology, and Immunology, and.; Vanderbilt Institute of Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Indiana University School of Medicine, Department of Microbiology & Immunology, Indiana University, Indianapolis, Indiana, USA.
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Źródło :
JCI insight [JCI Insight] 2018 Sep 06; Vol. 3 (17). Date of Electronic Publication: 2018 Sep 06 (Print Publication: 2018).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Diabetes Mellitus, Experimental/*metabolism
Leukotriene B4/*metabolism
Skin/*immunology
Skin/*metabolism
Staphylococcal Skin Infections/*immunology
Abscess/immunology ; Abscess/pathology ; Animals ; Bacterial Load ; Cell Movement ; Chemokines/metabolism ; Cytokines/metabolism ; Female ; Inflammation ; Leukotriene B4/genetics ; Leukotriene B4/immunology ; Macrophages/immunology ; Male ; Methicillin-Resistant Staphylococcus aureus/pathogenicity ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Neutrophils/immunology ; Receptors, Leukotriene B4/drug effects ; Receptors, Leukotriene B4/genetics ; Receptors, Leukotriene B4/metabolism ; Signal Transduction ; Skin/pathology ; Staphylococcal Skin Infections/pathology
Czasopismo naukowe
Tytuł :
Macrophage-derived LTB4 promotes abscess formation and clearance of Staphylococcus aureus skin infection in mice.
Autorzy :
Brandt SL; Indiana University School of Medicine, Department of Microbiology & Immunology, Indianapolis, Indiana, United States of America.; Vanderbilt University Medical Center, Department of Medicine, Division of Infectious Disease, Nashville, Tennessee, United States of America.
Klopfenstein N; Vanderbilt University Medical Center, Department of Medicine, Division of Infectious Disease, Nashville, Tennessee, United States of America.; Vanderbilt University Medical Center, Department of Pathology, Microbiology and Immunology, Nashville, Tennessee, United States of America.
Wang S; Indiana University School of Medicine, Department of Microbiology & Immunology, Indianapolis, Indiana, United States of America.
Winfree S; Indiana Center for Biological Microscopy, Indianapolis, Indiana, United States of America.
McCarthy BP; Indiana Institute for Biomedical Imaging Sciences, Department of Radiology, Indianapolis, Indiana, United States of America.
Territo PR; Indiana Institute for Biomedical Imaging Sciences, Department of Radiology, Indianapolis, Indiana, United States of America.
Miller L; Johns Hopkins University School of Medicine, Department of Dermatology, Baltimore, Maryland, United States of America.
Serezani CH; Indiana University School of Medicine, Department of Microbiology & Immunology, Indianapolis, Indiana, United States of America.; Vanderbilt University Medical Center, Department of Medicine, Division of Infectious Disease, Nashville, Tennessee, United States of America.; Vanderbilt University Medical Center, Department of Pathology, Microbiology and Immunology, Nashville, Tennessee, United States of America.; Vanderbilt Institute of Infection, Immunology and Inflammation, Nashville, Tennessee, United States of America.
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Źródło :
PLoS pathogens [PLoS Pathog] 2018 Aug 13; Vol. 14 (8), pp. e1007244. Date of Electronic Publication: 2018 Aug 13 (Print Publication: 2018).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Methicillin-Resistant Staphylococcus aureus*/growth & development
Methicillin-Resistant Staphylococcus aureus*/immunology
Abscess/*immunology
Bacterial Load/*immunology
Leukotriene B4/*physiology
Macrophages/*metabolism
Staphylococcal Skin Infections/*immunology
Abscess/genetics ; Abscess/microbiology ; Abscess/pathology ; Animals ; Arachidonate 5-Lipoxygenase/genetics ; Bacterial Load/genetics ; Cells, Cultured ; Female ; Leukotriene B4/metabolism ; Macrophages/immunology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Receptors, Leukotriene B4/genetics ; Staphylococcal Skin Infections/genetics ; Staphylococcal Skin Infections/pathology
Czasopismo naukowe
Tytuł :
Substance P-regulated leukotriene B4 production promotes acute pancreatitis-associated lung injury through neutrophil reverse migration.
Autorzy :
Li B; Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Pancreatic Disease, Institute of Pancreatic Disease, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Han X; Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Pancreatic Disease, Institute of Pancreatic Disease, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ye X; Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Pancreatic Disease, Institute of Pancreatic Disease, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ni J; Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Pancreatic Disease, Institute of Pancreatic Disease, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wu J; Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Pancreatic Disease, Institute of Pancreatic Disease, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Dai J; Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Pancreatic Disease, Institute of Pancreatic Disease, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wu Z; Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Pancreatic Disease, Institute of Pancreatic Disease, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chen C; Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Pancreatic Disease, Institute of Pancreatic Disease, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wan R; Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Pancreatic Disease, Institute of Pancreatic Disease, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wang X; Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Pancreatic Disease, Institute of Pancreatic Disease, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Hu G; Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory of Pancreatic Disease, Institute of Pancreatic Disease, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: .
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Źródło :
International immunopharmacology [Int Immunopharmacol] 2018 Apr; Vol. 57, pp. 147-156. Date of Electronic Publication: 2018 Feb 24.
Typ publikacji :
Journal Article
MeSH Terms :
Acinar Cells/*physiology
Acute Lung Injury/*metabolism
Leukotriene B4/*metabolism
Neutrophils/*physiology
Pancreatitis, Acute Necrotizing/*metabolism
Substance P/*metabolism
Acute Lung Injury/chemically induced ; Acute Lung Injury/complications ; Animals ; Benzoates/pharmacology ; Cells, Cultured ; Ceruletide ; Disease Models, Animal ; Humans ; MAP Kinase Signaling System ; Male ; Mice ; Mice, Inbred BALB C ; Pancreatitis, Acute Necrotizing/chemically induced ; Pancreatitis, Acute Necrotizing/complications ; Protein Kinase C/metabolism ; Receptors, Leukotriene B4/antagonists & inhibitors ; Receptors, Leukotriene B4/metabolism ; Receptors, Neurokinin-1/metabolism ; Transendothelial and Transepithelial Migration
Czasopismo naukowe
Tytuł :
20-Hydroxy- and 20-carboxy-leukotriene (LT) B 4 downregulate LTB 4 -mediated responses of human neutrophils and eosinophils.
Autorzy :
Archambault AS; Centre de recherche de l'Institut universitaire de cardiologie et pneumologie de Québec-Université Laval, Département de médecine, Faculté de médecine, Université Laval, Québec City, QC, G1V 4G5, Canada.
Poirier S; Centre de recherche de l'Institut universitaire de cardiologie et pneumologie de Québec-Université Laval, Département de médecine, Faculté de médecine, Université Laval, Québec City, QC, G1V 4G5, Canada.; Département de chimie et de biochimie, Université de Moncton, Moncton, NB, E1A 3E9, Canada.
Lefebvre JS; Centre de recherche de l'Institut universitaire de cardiologie et pneumologie de Québec-Université Laval, Département de médecine, Faculté de médecine, Université Laval, Québec City, QC, G1V 4G5, Canada.
Robichaud PP; Département de chimie et de biochimie, Université de Moncton, Moncton, NB, E1A 3E9, Canada.
Larose MC; Centre de recherche de l'Institut universitaire de cardiologie et pneumologie de Québec-Université Laval, Département de médecine, Faculté de médecine, Université Laval, Québec City, QC, G1V 4G5, Canada.
Turcotte C; Centre de recherche de l'Institut universitaire de cardiologie et pneumologie de Québec-Université Laval, Département de médecine, Faculté de médecine, Université Laval, Québec City, QC, G1V 4G5, Canada.
Martin C; Centre de recherche de l'Institut universitaire de cardiologie et pneumologie de Québec-Université Laval, Département de médecine, Faculté de médecine, Université Laval, Québec City, QC, G1V 4G5, Canada.
Provost V; Centre de recherche de l'Institut universitaire de cardiologie et pneumologie de Québec-Université Laval, Département de médecine, Faculté de médecine, Université Laval, Québec City, QC, G1V 4G5, Canada.
Boudreau LH; Département de chimie et de biochimie, Université de Moncton, Moncton, NB, E1A 3E9, Canada.
McDonald PP; Centre de recherche du CHUS et Faculté de Médecine, Université de Sherbrooke, Sherbrooke, QC, J1H 5N4, Canada.
Laviolette M; Centre de recherche de l'Institut universitaire de cardiologie et pneumologie de Québec-Université Laval, Département de médecine, Faculté de médecine, Université Laval, Québec City, QC, G1V 4G5, Canada.
Surette ME; Département de chimie et de biochimie, Université de Moncton, Moncton, NB, E1A 3E9, Canada.
Flamand N; Centre de recherche de l'Institut universitaire de cardiologie et pneumologie de Québec-Université Laval, Département de médecine, Faculté de médecine, Université Laval, Québec City, QC, G1V 4G5, Canada.
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Źródło :
Journal of leukocyte biology [J Leukoc Biol] 2019 Jun; Vol. 105 (6), pp. 1131-1142. Date of Electronic Publication: 2019 Jan 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Eosinophils/*immunology
Leukotriene B4/*immunology
Neutrophils/*immunology
Receptors, Leukotriene B4/*immunology
Arachidonic Acids/pharmacology ; Benzopyrans/pharmacology ; Carboxylic Acids/pharmacology ; Eicosapentaenoic Acid/analogs & derivatives ; Eicosapentaenoic Acid/pharmacology ; Eosinophils/cytology ; Humans ; Leukotriene B4/pharmacology ; Neutrophils/cytology ; Receptors, Leukotriene B4/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
New isoflavone glucosides in yabumame (Amphicarpaea bracteata (L.) Fernald subsp. edgeworthii (Benth.) H.Ohashi var. japonica (Oliv.) H.Ohashi) and their effect on leukotriene B 4 production in mast cells.
Autorzy :
Yang L; Department of Biotechnology and Environmental Chemistry, Kitami Institute of Technology, 165 Koencho, Kitami, Hokkaido, 090-8507, Japan.; Jinan Fruit Research Institute, All China Federation of Supply and Marketing Cooperatives, 16001 East Road Jingshi, Jinan, 250220, Shandong, China.
Kirikoshi J; Department of Biotechnology and Environmental Chemistry, Kitami Institute of Technology, 165 Koencho, Kitami, Hokkaido, 090-8507, Japan.
Sato D; Department of Biotechnology and Environmental Chemistry, Kitami Institute of Technology, 165 Koencho, Kitami, Hokkaido, 090-8507, Japan.
Takasugi M; Department of Life Science, Kyushu Sangyo University, 2-3-1 Matsukadai, Higashi-ku, Fukuoka, 813-8503, Japan.
Hishida A; National Institutes of Biomedical Innovation, Health and Nutrition, 108-4 Ohashi, Nayoro, Hokkaido, 096-0065, Japan.
Hayashi S; National Institutes of Biomedical Innovation, Health and Nutrition, 108-4 Ohashi, Nayoro, Hokkaido, 096-0065, Japan.
Kawahara N; National Institutes of Biomedical Innovation, Health and Nutrition, 108-4 Ohashi, Nayoro, Hokkaido, 096-0065, Japan.
Mizukami M; Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Hokkaido University of Science, Maeda 7-15-4-1, Teine, Sapporo, Hokkaido, 006-8585, Japan.
Wu M; Jinan Fruit Research Institute, All China Federation of Supply and Marketing Cooperatives, 16001 East Road Jingshi, Jinan, 250220, Shandong, China.
Yamagishi T; Department of Biotechnology and Environmental Chemistry, Kitami Institute of Technology, 165 Koencho, Kitami, Hokkaido, 090-8507, Japan.
Arai H; Department of Biotechnology and Environmental Chemistry, Kitami Institute of Technology, 165 Koencho, Kitami, Hokkaido, 090-8507, Japan. .
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Źródło :
Journal of natural medicines [J Nat Med] 2021 Jan; Vol. 75 (1), pp. 28-36. Date of Electronic Publication: 2020 Aug 16.
Typ publikacji :
Journal Article
MeSH Terms :
Fabaceae/*chemistry
Isoflavones/*chemistry
Leukotriene B4/*metabolism
Mast Cells/*metabolism
Glucosides/chemistry
Czasopismo naukowe
Tytuł :
Therapeutic potential of BLT1 antagonist for COPD: involvement of inducing autophagy and ameliorating inflammation.
Autorzy :
Zhang L; Department of Respiratory and Critical Care Medicine, Shanghai Institute of Respiratory Disease, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.; Institute of Respiratory Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Huang J; Department of Respiratory and Critical Care Medicine, Shanghai Institute of Respiratory Disease, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.; Institute of Respiratory Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Dong R; Department of Respiratory Medicine, Tongji Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.
Feng Y; Department of Respiratory and Critical Care Medicine, Shanghai Institute of Respiratory Disease, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.; Institute of Respiratory Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Zhou M; Department of Respiratory and Critical Care Medicine, Shanghai Institute of Respiratory Disease, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.; Institute of Respiratory Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
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Źródło :
Drug design, development and therapy [Drug Des Devel Ther] 2019 Sep 04; Vol. 13, pp. 3105-3116. Date of Electronic Publication: 2019 Sep 04 (Print Publication: 2019).
Typ publikacji :
Journal Article
MeSH Terms :
Autophagy/*drug effects
Inflammation/*drug therapy
Leukotriene B4/*pharmacology
Pulmonary Disease, Chronic Obstructive/*drug therapy
Receptors, Leukotriene B4/*antagonists & inhibitors
Animals ; Cells, Cultured ; Cigarette Smoking ; Inflammation/chemically induced ; Inflammation/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Pulmonary Disease, Chronic Obstructive/chemically induced ; Pulmonary Disease, Chronic Obstructive/metabolism ; RAW 264.7 Cells ; Receptors, Leukotriene B4/metabolism
Czasopismo naukowe

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