- Tytuł:
- Inhibition of phosphorylated Ser473-Akt from translocating into the nucleus contributes to 2-cell arrest and defective zygotic genome activation in mouse preimplantation embryogenesis.
- Autorzy:
- Źródło:
- Development, growth & differentiation [Dev Growth Differ] 2016 Apr; Vol. 58 (3), pp. 280-92. Date of Electronic Publication: 2016 Mar 23.
- Typ publikacji:
- Journal Article; Research Support, Non-U.S. Gov't
- MeSH Terms:
-
Embryonic Development*
Blastocyst/*metabolism
Cell Nucleus/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
Zygote/*metabolism
Active Transport, Cell Nucleus/drug effects ; Animals ; Blastocyst/cytology ; Blastocyst/drug effects ; Chlorpropamide/analogs & derivatives ; Chlorpropamide/pharmacology ; Embryo Culture Techniques ; Eukaryotic Initiation Factor-1/genetics ; Female ; Gene Expression Regulation, Developmental/drug effects ; Genome/genetics ; Heterocyclic Compounds, 3-Ring/pharmacology ; Male ; Mice ; Microscopy, Fluorescence ; Phosphorylation/drug effects ; Proteins/genetics ; Proto-Oncogene Proteins c-akt/antagonists & inhibitors ; Reverse Transcriptase Polymerase Chain Reaction ; Serine/metabolism ; Zygote/cytology ; Zygote/drug effects
Czasopismo naukowe