Autor: "Lian WW" - OpacWWW

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Tytuł:: Design, synthesis and biological evaluation of honokiol derivatives as influenza neuraminidase inhibitors.
Autorzy:: Lin D; College of Chemistry and Chemical Engineering, Hunan University , Changsha 410082 , China.
Yi YJ; College of Chemistry and Chemical Engineering, Hunan University , Changsha 410082 , China.
Xiao MW; College of Chemistry and Chemical Engineering, Hunan University , Changsha 410082 , China.
Chen J; College of Chemistry and Chemical Engineering, Hunan University , Changsha 410082 , China.
Ye J; College of Chemistry and Chemical Engineering, Hunan University , Changsha 410082 , China.
Hu AX; College of Chemistry and Chemical Engineering, Hunan University , Changsha 410082 , China.
Lian WW; Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.
Liu AL; Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.
Du GH; Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.; Pokaż więcej
Źródło:: Journal of Asian natural products research [J Asian Nat Prod Res] 2019 Nov; Vol. 21 (11), pp. 1052-1067. Date of Electronic Publication: 2018 Dec 26.
Typ publikacji:: Journal Article
MeSH Terms:: Antiviral Agents*
Influenza, Human*
Biphenyl Compounds ; Drug Design ; Humans ; Lignans ; Molecular Structure ; Neuraminidase

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Tytuł:: Drug Discovery of Host CLK1 Inhibitors for Influenza Treatment.
Autorzy:: Zu M; Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. .; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China. .
Li C; Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. .
Fang JS; Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. .
Lian WW; Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. .
Liu AL; Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. .; Beijing Key Laboratory of Drug Target Research and New Drug Screening, Beijing 100050, China. .; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing 100050, China. .
Zheng LS; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China. .
Du GH; Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. .; Beijing Key Laboratory of Drug Target Research and New Drug Screening, Beijing 100050, China. .; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing 100050, China. .; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2015 Nov 02; Vol. 20 (11), pp. 19735-47. Date of Electronic Publication: 2015 Nov 02.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Drug Discovery*
Antiviral Agents/*pharmacology
Influenza A virus/*physiology
Influenza, Human/*metabolism
Influenza, Human/*virology
Protein Kinase Inhibitors/*pharmacology
Protein Serine-Threonine Kinases/*antagonists & inhibitors
Protein-Tyrosine Kinases/*antagonists & inhibitors
Animals ; Antiviral Agents/chemistry ; Antiviral Agents/therapeutic use ; Cell Line ; Cytopathogenic Effect, Viral/drug effects ; Drug Evaluation, Preclinical/methods ; Gene Order ; Genetic Vectors/genetics ; Humans ; Influenza, Human/drug therapy ; Inhibitory Concentration 50 ; Ligands ; Models, Molecular ; Protein Binding ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/therapeutic use ; Protein Serine-Threonine Kinases/chemistry ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/isolation & purification ; Protein Serine-Threonine Kinases/metabolism ; Protein-Tyrosine Kinases/chemistry ; Protein-Tyrosine Kinases/genetics ; Protein-Tyrosine Kinases/isolation & purification ; Protein-Tyrosine Kinases/metabolism ; Recombinant Proteins/genetics ; Recombinant Proteins/isolation & purification ; Recombinant Proteins/metabolism ; Virus Replication/drug effects

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Tytuł:: In vitro antiviral effects and 3D QSAR study of resveratrol derivatives as potent inhibitors of influenza H1N1 neuraminidase.
Autorzy:: Li C; Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China.
Fang JS
Lian WW
Pang XC
Liu AL
Du GH; Pokaż więcej
Źródło:: Chemical biology & drug design [Chem Biol Drug Des] 2015 Apr; Vol. 85 (4), pp. 427-38. Date of Electronic Publication: 2014 Sep 29.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Antiviral Agents/*chemistry
Antiviral Agents/*pharmacology
Influenza A Virus, H1N1 Subtype/*drug effects
Influenza A Virus, H1N1 Subtype/*enzymology
Neuraminidase/*antagonists & inhibitors
Stilbenes/*chemistry
Stilbenes/*pharmacology
Animals ; Cell Line ; Dogs ; Drug Design ; Humans ; Influenza, Human/drug therapy ; Influenza, Human/virology ; Molecular Docking Simulation ; Orthomyxoviridae Infections/drug therapy ; Orthomyxoviridae Infections/virology ; Quantitative Structure-Activity Relationship ; Resveratrol

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