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    Tytuł:
    Mediator kinase inhibition further activates super-enhancer-associated genes in AML.
    Autorzy:
    Pelish HE; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
    Liau BB; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
    Nitulescu II; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
    Tangpeerachaikul A; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
    Poss ZC; Department of Chemistry and Biochemistry, University of Colorado, Campus Box 596, Boulder, CO 80303, USA.
    Da Silva DH; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
    Caruso BT; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
    Arefolov A; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
    Fadeyi O; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
    Christie AL; Lurie Family Imaging Center, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
    Du K; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
    Banka D; Division of Hematology/Oncology, Children's Hospital, Boston, MA 02215, USA.
    Schneider EV; Proteros Biostructures GmbH, Bunsenstrasse 7a, D-82152 Martinsried, Germany.; Max-Planck-Institut für Biochemie, Am Kloperspitz 18, D-82152 Martinsried, Germany.
    Jestel A; Proteros Biostructures GmbH, Bunsenstrasse 7a, D-82152 Martinsried, Germany.
    Zou G; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
    Si C; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
    Ebmeier CC; Department of Chemistry and Biochemistry, University of Colorado, Campus Box 596, Boulder, CO 80303, USA.
    Bronson RT; Dana-Farber Cancer Institute, Boston, MA 02215, USA.
    Krivtsov AV; Cancer Biology and Genetics Program and Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
    Myers AG; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
    Kohl NE; Lurie Family Imaging Center, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
    Kung AL; Department of Pediatrics, Columbia University Medical Center, New York, NY 10032, USA.
    Armstrong SA; Cancer Biology and Genetics Program and Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
    Lemieux ME; Bioinfo, Plantagenet, Ontario K0B 1L0, Canada.
    Taatjes DJ; Department of Chemistry and Biochemistry, University of Colorado, Campus Box 596, Boulder, CO 80303, USA.
    Shair MD; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
    Pokaż więcej
    Źródło:
    Nature [Nature] 2015 Oct 08; Vol. 526 (7572), pp. 273-276. Date of Electronic Publication: 2015 Sep 28.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Cyclin-Dependent Kinase 8/*antagonists & inhibitors
    Cyclin-Dependent Kinases/*antagonists & inhibitors
    Enhancer Elements, Genetic/*genetics
    Gene Expression Regulation, Neoplastic/*genetics
    Genes, Neoplasm/*genetics
    Leukemia, Myeloid, Acute/*enzymology
    Leukemia, Myeloid, Acute/*genetics
    Animals ; Cell Cycle Proteins ; Cell Division/drug effects ; Cell Line, Tumor ; Cell Lineage/drug effects ; Cell Lineage/genetics ; Cyclin-Dependent Kinase 8/metabolism ; Cyclin-Dependent Kinases/metabolism ; Disease Progression ; Down-Regulation/drug effects ; Down-Regulation/genetics ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Genes, Tumor Suppressor/drug effects ; Heterocyclic Compounds, 4 or More Rings/pharmacology ; Humans ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/pathology ; Male ; Mice ; Mice, Inbred Strains ; Mice, SCID ; Nuclear Proteins/antagonists & inhibitors ; Polycyclic Compounds/pharmacology ; Transcription Factors/antagonists & inhibitors ; Transcription Factors/biosynthesis ; Transcription Factors/genetics ; Up-Regulation/drug effects ; Up-Regulation/genetics
    Czasopismo naukowe
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