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Tytuł :
Induction of DR5-Dependent Apoptosis by PGA 2 through ATF4-CHOP Pathway.
Autorzy :
Park KM; Department of Biomedicine and Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.; Department of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Park JY; Department of Biomedicine and Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.; Department of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Pyo J; Department of Biomedicine and Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.; Department of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Lee SY; Department of Biomedicine and Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.; Cancer Evolution Research Center, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Kim HS; Department of Biomedicine and Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.; Department of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.; Cancer Evolution Research Center, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2022 Jun 13; Vol. 27 (12). Date of Electronic Publication: 2022 Jun 13.
Typ publikacji :
Journal Article
MeSH Terms :
Prostaglandins A*
Receptors, TNF-Related Apoptosis-Inducing Ligand*/genetics
Receptors, TNF-Related Apoptosis-Inducing Ligand*/metabolism
Activating Transcription Factor 4/genetics ; Activating Transcription Factor 4/metabolism ; Apoptosis ; Cell Line, Tumor ; Humans ; RNA, Messenger ; TNF-Related Apoptosis-Inducing Ligand/metabolism ; Transcription Factor CHOP/genetics ; Transcription Factor CHOP/metabolism ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism
Czasopismo naukowe
Tytuł :
Targeting the apoptosis pathway to treat tumours of the paediatric nervous system.
Autorzy :
Fitzgerald MC; Department of Physiology & Medical Physics, Royal College of Surgeons in Ireland, 31A York Street, Dublin, D02 YN77, Ireland.; National Children's Research Centre at Children's Health Ireland at Crumlin, Dublin, D12 N512, Ireland.
O'Halloran PJ; National Children's Research Centre at Children's Health Ireland at Crumlin, Dublin, D12 N512, Ireland.; Department of Neurosurgery, Queen Elizabeth Hospital, Birmingham, UK.
Connolly NMC; Department of Physiology & Medical Physics, Royal College of Surgeons in Ireland, 31A York Street, Dublin, D02 YN77, Ireland.; Centre for Systems Medicine, Royal College of Surgeons in Ireland, 31A York Street, Dublin, D02 YN77, Ireland.
Murphy BM; Department of Physiology & Medical Physics, Royal College of Surgeons in Ireland, 31A York Street, Dublin, D02 YN77, Ireland. .; National Children's Research Centre at Children's Health Ireland at Crumlin, Dublin, D12 N512, Ireland. .; Centre for Systems Medicine, Royal College of Surgeons in Ireland, 31A York Street, Dublin, D02 YN77, Ireland. .
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Źródło :
Cell death & disease [Cell Death Dis] 2022 May 14; Vol. 13 (5), pp. 460. Date of Electronic Publication: 2022 May 14.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Neoplasms*/drug therapy
Neoplasms*/genetics
Neoplasms*/pathology
TNF-Related Apoptosis-Inducing Ligand*/pharmacology
Apoptosis ; Child ; Humans ; Nervous System/metabolism ; Receptors, TNF-Related Apoptosis-Inducing Ligand/metabolism
Czasopismo naukowe
Tytuł :
Understanding of cell death induced by the constituents of Taxus yunnanensis wood.
Autorzy :
Akao Y; United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu, Japan. .
Terazawa R; United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu, Japan.
Sugito N; United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu, Japan.
Heishima K; United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu, Japan.
Morikawa K; United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu, Japan.
Ito Y; Department of General and Gastroenterological Surgery, Osaka Medical and Pharmaceutical University, Takatsuki, Japan.
Narui R; Karasuma Wada Clinic, Nakagyo-ku, Kyoto, 604-0845, Japan.
Hamaguchi R; Karasuma Wada Clinic, Nakagyo-ku, Kyoto, 604-0845, Japan.
Nobukawa T; Kotosugi Co., Ltd, Sagamihara, Japan.
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Źródło :
Scientific reports [Sci Rep] 2022 Apr 15; Vol. 12 (1), pp. 6282. Date of Electronic Publication: 2022 Apr 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Receptors, TNF-Related Apoptosis-Inducing Ligand*/metabolism
Taxus*/metabolism
Animals ; Apoptosis ; Cell Death ; Cell Line, Tumor ; Membrane Glycoproteins/metabolism ; Mice ; Plant Extracts/pharmacology ; TNF-Related Apoptosis-Inducing Ligand/pharmacology ; Wood/metabolism
Czasopismo naukowe
Tytuł :
Proteasome inhibition triggers the formation of TRAIL receptor 2 platforms for caspase-8 activation that accumulate in the cytosol.
Autorzy :
Hellwig CT; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland.; Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin 2, Ireland.; Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany.; Stuttgart Research Center Systems Biology, University of Stuttgart, Stuttgart, Germany.
Delgado ME; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland.; Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin 2, Ireland.; Biochemical Pharmacology, Department of Biology, University of Konstanz, Konstanz, Germany.
Skoko J; Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany.
Dyck L; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland.
Hanna C; Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany.
Wentges A; Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany.
Langlais C; MRC Toxicology Unit, Cambridge, UK.
Hagenlocher C; Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany.
Mack A; Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany.
Dinsdale D; MRC Toxicology Unit, Cambridge, UK.
Cain K; MRC Toxicology Unit, Cambridge, UK.
MacFarlane M; MRC Toxicology Unit, Cambridge, UK.
Rehm M; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland. .; Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin 2, Ireland. .; Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany. .; Stuttgart Research Center Systems Biology, University of Stuttgart, Stuttgart, Germany. .; Stuttgart Center for Simulation Science (SC SimTech), University of Stuttgart, Stuttgart, Germany. .
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Źródło :
Cell death and differentiation [Cell Death Differ] 2022 Jan; Vol. 29 (1), pp. 147-155. Date of Electronic Publication: 2021 Aug 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Proteasome Endopeptidase Complex*/metabolism
Receptors, TNF-Related Apoptosis-Inducing Ligand*/genetics
Receptors, TNF-Related Apoptosis-Inducing Ligand*/metabolism
Apoptosis ; Caspase 8/metabolism ; Cytosol/metabolism ; TNF-Related Apoptosis-Inducing Ligand/metabolism ; TNF-Related Apoptosis-Inducing Ligand/pharmacology
Czasopismo naukowe
Tytuł :
CSC-3436 sensitizes triple negative breast cancer cells to TRAIL-induced apoptosis through ROS-mediated p38/CHOP/death receptor 5 signaling pathways.
Autorzy :
Huang CC; Department of Biological Science and Technology, College of Life Sciences, China Medical University, Taichung, Taiwan.
Cheng YC; Department of Biological Science and Technology, College of Life Sciences, China Medical University, Taichung, Taiwan.
Lin YC; Division of Neurosurgery, Buddhist Tzu Chi General Hospital, Taichung Branch, Taichung, Taiwan.; School of Medicine, Tzu Chi University, Hualien, Taiwan.; Department of Medical Imaging and Radiological Science, Central Taiwan University of Science and Technology, Taichung, Taiwan.
Chou CH; Ph.D. Program for Biotechnology Industry, College of Life Sciences, China Medical University, Taichung, Taiwan.
Ho CT; Department of Food Science, Rutgers University, New Brunswick, New Jersey, USA.
Wang HK; Department of Neurosurgery, E-Da Hospital/I-Shou University, Kaohsiung, Taiwan.; School of Medicine, I-Shou University, Kaohsiung, Taiwan.
Way TD; Department of Biological Science and Technology, College of Life Sciences, China Medical University, Taichung, Taiwan.; Ph.D. Program for Biotechnology Industry, College of Life Sciences, China Medical University, Taichung, Taiwan.; Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan.
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Źródło :
Environmental toxicology [Environ Toxicol] 2021 Dec; Vol. 36 (12), pp. 2578-2588. Date of Electronic Publication: 2021 Oct 02.
Typ publikacji :
Journal Article
MeSH Terms :
Receptors, TNF-Related Apoptosis-Inducing Ligand*/genetics
Triple Negative Breast Neoplasms*
Apoptosis ; Cell Line, Tumor ; Humans ; Ligands ; Naphthyridines ; Reactive Oxygen Species ; TNF-Related Apoptosis-Inducing Ligand ; Transcription Factor CHOP/genetics
Czasopismo naukowe
Tytuł :
Modulating Oncolytic Adenovirus Immunotherapy by Driving Two Axes of the Immune System by Expressing 4-1BBL and CD40L.
Autorzy :
Lu SC; Virology and Gene Therapy Graduate Program, Mayo Clinic, Rochester, Minnesota, USA.
Hansen MJ; Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA.; Department of Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, USA.
Hemsath JR; Department of Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, USA.
Parrett BJ; Virology and Gene Therapy Graduate Program, Mayo Clinic, Rochester, Minnesota, USA.
Zell BN; Virology and Gene Therapy Graduate Program, Mayo Clinic, Rochester, Minnesota, USA.
Barry MA; Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
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Źródło :
Human gene therapy [Hum Gene Ther] 2022 Mar; Vol. 33 (5-6), pp. 250-261. Date of Electronic Publication: 2022 Jan 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Melanoma, Experimental*/genetics
Melanoma, Experimental*/therapy
Oncolytic Viruses*/genetics
4-1BB Ligand/*metabolism
Adenoviridae/metabolism ; Animals ; CD40 Ligand/genetics ; CD40 Ligand/metabolism ; CD8-Positive T-Lymphocytes/metabolism ; Cell Line, Tumor ; Immunotherapy ; Mice
Czasopismo naukowe
Tytuł :
Generation of TRAIL-resistant cell line models reveals distinct adaptive mechanisms for acquired resistance and re-sensitization.
Autorzy :
Cingöz A; Brain Cancer Research and Therapy Laboratory, Koç University Research Center for Translational Medicine, Istanbul, 34450, Turkey.; Koç University School of Medicine, Istanbul, 34450, Turkey.
Ozyerli-Goknar E; Brain Cancer Research and Therapy Laboratory, Koç University Research Center for Translational Medicine, Istanbul, 34450, Turkey.; Koç University School of Medicine, Istanbul, 34450, Turkey.
Morova T; Koç University School of Medicine, Istanbul, 34450, Turkey.
Seker-Polat F; Brain Cancer Research and Therapy Laboratory, Koç University Research Center for Translational Medicine, Istanbul, 34450, Turkey.; Koç University School of Medicine, Istanbul, 34450, Turkey.
Esai Selvan M; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Gümüş ZH; Koç University School of Medicine, Istanbul, 34450, Turkey.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Bhere D; Center for Stem Cell Therapeutics and Imaging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Shah K; Center for Stem Cell Therapeutics and Imaging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Solaroglu I; Koç University School of Medicine, Istanbul, 34450, Turkey.; Department of Neurosurgery, Koç University School of Medicine, Istanbul, 34010, Turkey.
Bagci-Onder T; Brain Cancer Research and Therapy Laboratory, Koç University Research Center for Translational Medicine, Istanbul, 34450, Turkey. .; Koç University School of Medicine, Istanbul, 34450, Turkey. .
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Źródło :
Oncogene [Oncogene] 2021 May; Vol. 40 (18), pp. 3201-3216. Date of Electronic Publication: 2021 Mar 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
TNF-Related Apoptosis-Inducing Ligand*
Apoptosis ; Apoptosis Regulatory Proteins ; Humans ; Proto-Oncogene Proteins c-bcl-2 ; Receptors, TNF-Related Apoptosis-Inducing Ligand
Czasopismo naukowe
Tytuł :
Recent Insight into Lipid Binding and Lipid Modulation of Pentameric Ligand-Gated Ion Channels.
Autorzy :
Ananchenko A; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, 451 Smyth Road, Ottawa, ON K1H 8M5, Canada.
Hussein TOK; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, 451 Smyth Road, Ottawa, ON K1H 8M5, Canada.
Mody D; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, 451 Smyth Road, Ottawa, ON K1H 8M5, Canada.
Thompson MJ; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, 451 Smyth Road, Ottawa, ON K1H 8M5, Canada.
Baenziger JE; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, 451 Smyth Road, Ottawa, ON K1H 8M5, Canada.
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Źródło :
Biomolecules [Biomolecules] 2022 Jun 10; Vol. 12 (6). Date of Electronic Publication: 2022 Jun 10.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Ligand-Gated Ion Channels*/chemistry
Ligand-Gated Ion Channels*/metabolism
Binding Sites ; Lipids
Czasopismo naukowe
Tytuł :
Optimized Heterologous Expression and Efficient Purification of a New TRAIL-Based Antitumor Fusion Protein SRH-DR5-B with Dual VEGFR2 and DR5 Receptor Specificity.
Autorzy :
Yagolovich AV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 117997 Moscow, Russia.; Faculty of Biology, Lomonosov Moscow State University, 119234 Moscow, Russia.
Artykov AA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 117997 Moscow, Russia.
Isakova AA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 117997 Moscow, Russia.
Vorontsova YV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 117997 Moscow, Russia.
Dolgikh DA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 117997 Moscow, Russia.; Faculty of Biology, Lomonosov Moscow State University, 119234 Moscow, Russia.
Kirpichnikov MP; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 117997 Moscow, Russia.; Faculty of Biology, Lomonosov Moscow State University, 119234 Moscow, Russia.
Gasparian ME; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 117997 Moscow, Russia.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2022 May 24; Vol. 23 (11). Date of Electronic Publication: 2022 May 24.
Typ publikacji :
Journal Article
MeSH Terms :
Receptors, TNF-Related Apoptosis-Inducing Ligand*/metabolism
TNF-Related Apoptosis-Inducing Ligand*/chemistry
TNF-Related Apoptosis-Inducing Ligand*/genetics
TNF-Related Apoptosis-Inducing Ligand*/pharmacology
Apoptosis ; Cell Line, Tumor ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Humans ; Recombinant Proteins/metabolism
Czasopismo naukowe
Tytuł :
TRAIL Triggers CRAC-Dependent Calcium Influx and Apoptosis through the Recruitment of Autophagy Proteins to Death-Inducing Signaling Complex.
Autorzy :
Airiau K; Institut Bergonié, INSERM U1218, University of Bordeaux, 33000 Bordeaux, France.
Vacher P; Institut Bergonié, INSERM U1218, University of Bordeaux, 33000 Bordeaux, France.
Micheau O; Lipides, Nutrition Cancer, INSERM, UMR1231, 21079 Dijon, France.; UFR Science de Santé, Université de Bourgogne, Franche-Comté, 21079 Dijon, France.
Prouzet-Mauleon V; Institut Bergonié, INSERM U1218, University of Bordeaux, 33000 Bordeaux, France.
Kroemer G; Centre de Recherche des Cordeliers, INSERM UMRS 1138, Sorbonne Université, Université de Paris, Equipe 11 Labellisée par la Ligue Contre le Cancer, 75006 Paris, France.; Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, 94805 Villejuif, France.; Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, 75015 Paris, France.
Moosavi MA; Department of Molecular Medicine, National Institute of Genetic Engineering and Biotechnology, Tehran P.O. Box 14965/161, Iran.
Djavaheri-Mergny M; Centre de Recherche des Cordeliers, INSERM UMRS 1138, Sorbonne Université, Université de Paris, Equipe 11 Labellisée par la Ligue Contre le Cancer, 75006 Paris, France.; Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, 94805 Villejuif, France.
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Źródło :
Cells [Cells] 2021 Dec 25; Vol. 11 (1). Date of Electronic Publication: 2021 Dec 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*/drug effects
Autophagy-Related Proteins/*metabolism
Calcium/*metabolism
Calcium Channels/*metabolism
Death Domain Receptor Signaling Adaptor Proteins/*metabolism
TNF-Related Apoptosis-Inducing Ligand/*pharmacology
Cytoprotection/drug effects ; Drug Resistance, Neoplasm/drug effects ; Endoplasmic Reticulum/drug effects ; Endoplasmic Reticulum/metabolism ; Homeostasis/drug effects ; Humans ; Jurkat Cells ; Receptors, TNF-Related Apoptosis-Inducing Ligand/metabolism ; Sequence Analysis, RNA ; Tretinoin/pharmacology
Czasopismo naukowe
Tytuł :
The Novel, Orally Bioavailable CDK9 Inhibitor Atuveciclib Sensitises Pancreatic Cancer Cells to TRAIL-induced Cell Death.
Autorzy :
Ruff JP; Department of General and Visceral Surgery, University of Ulm, Ulm, Germany.
Kretz AL; Department of General and Visceral Surgery, University of Ulm, Ulm, Germany.
Kornmann M; Department of General and Visceral Surgery, University of Ulm, Ulm, Germany.
Henne-Bruns D; Department of General and Visceral Surgery, University of Ulm, Ulm, Germany.
Lemke J; Department of General and Visceral Surgery, University of Ulm, Ulm, Germany .
Traub B; Department of General and Visceral Surgery, University of Ulm, Ulm, Germany.
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Źródło :
Anticancer research [Anticancer Res] 2021 Dec; Vol. 41 (12), pp. 5973-5985.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Cyclin-Dependent Kinase 9/*antagonists & inhibitors
Protein Kinase Inhibitors/*pharmacology
Sulfonamides/*pharmacology
TNF-Related Apoptosis-Inducing Ligand/*pharmacology
Triazines/*pharmacology
Cell Cycle/drug effects ; Cell Line, Tumor ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Drug Synergism ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/pathology ; Receptors, TNF-Related Apoptosis-Inducing Ligand/metabolism
Czasopismo naukowe
Tytuł :
TRAIL signaling promotes entosis in colorectal cancer.
Autorzy :
Bozkurt E; Department of Physiology and Medical Physics, Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.; Department of Genetics and Bioengineering, Faculty of Engineering, Izmir University of Economics, Balcova, Izmir, Turkey.
Düssmann H; Department of Physiology and Medical Physics, Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.
Salvucci M; Department of Physiology and Medical Physics, Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.
Cavanagh BL; Cellular and Molecular Imaging Core, Royal College of Surgeons in Ireland, Dublin, Ireland.
Van Schaeybroeck S; Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK.
Longley DB; Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK.
Martin SJ; Molecular Cell Biology Laboratory, Department of Genetics, The Smurfit Institute, Trinity College, Dublin, Ireland.
Prehn JHM; Department of Physiology and Medical Physics, Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.
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Źródło :
The Journal of cell biology [J Cell Biol] 2021 Nov 01; Vol. 220 (11). Date of Electronic Publication: 2021 Sep 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Colonic Neoplasms/*metabolism
Entosis/*physiology
Signal Transduction/*physiology
TNF-Related Apoptosis-Inducing Ligand/*metabolism
Apoptosis/physiology ; Apoptosis Regulatory Proteins/metabolism ; Caspase 8/metabolism ; Caspases/metabolism ; Cell Death/physiology ; Cell Line, Tumor ; HCT116 Cells ; Humans ; Membrane Glycoproteins/metabolism ; Receptors, TNF-Related Apoptosis-Inducing Ligand/metabolism ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Tytuł :
Overcoming therapeutic efficiency limitations against TRAIL-resistant tumors using re-sensitizing agent-loaded trimeric TRAIL-presenting nanocages.
Autorzy :
Je H; Department of Chemical Engineering, School of Applied Chemical Engineering, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu 41566, Republic of Korea.
Nam GH; Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, 5 Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea.
Kim GB; Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, 5 Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea; KU-KIST Graduate School of Converging Science and Technology, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.
Kim W; Department of Chemical Engineering, School of Applied Chemical Engineering, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu 41566, Republic of Korea.
Kim SR; School of Food Science and Biotechnology, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu 41566, Republic of Korea.
Kim IS; Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, 5 Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea; KU-KIST Graduate School of Converging Science and Technology, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea. Electronic address: .
Lee EJ; Department of Chemical Engineering, School of Applied Chemical Engineering, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu 41566, Republic of Korea. Electronic address: .
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Źródło :
Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2021 Mar 10; Vol. 331, pp. 7-18. Date of Electronic Publication: 2021 Jan 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Neoplasms*/drug therapy
TNF-Related Apoptosis-Inducing Ligand*
Apoptosis ; Cell Line, Tumor ; Doxorubicin ; Humans ; Receptors, TNF-Related Apoptosis-Inducing Ligand
Czasopismo naukowe
Tytuł :
Identification of Novel Genes for Cell Fusion during Osteoclast Formation.
Autorzy :
Cho E; Department of Oral Biochemistry, Dental Science Research Institute, School of Dentistry, Chonnam National University, Gwangju 61186, Korea.
Cheon S; School of Biological Sciences and Technology, Chonnam National University, Gwangju 61186, Korea.; Proteomics Core Facility, Biomedical Research Institute, Seoul National University Hospital, Seoul 03080, Korea.
Ding M; Biomedical Sciences Graduate Program, School of Medical, Chonnam National University, Gwangju 61186, Korea.
Lim K; Center for Genome Engineering, Institute for Basic Science, Daejeon 34126, Korea.
Park SW; Department of Oral Biochemistry, Dental Science Research Institute, School of Dentistry, Chonnam National University, Gwangju 61186, Korea.
Park C; School of Biological Sciences and Technology, Chonnam National University, Gwangju 61186, Korea.
Lee TH; Department of Oral Biochemistry, Dental Science Research Institute, School of Dentistry, Chonnam National University, Gwangju 61186, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2022 Jun 08; Vol. 23 (12). Date of Electronic Publication: 2022 Jun 08.
Typ publikacji :
Journal Article
MeSH Terms :
Osteoclasts*/metabolism
RANK Ligand*/genetics
RANK Ligand*/metabolism
Cell Differentiation/genetics ; Cell Fusion ; Giant Cells/metabolism ; Hematopoietic Stem Cells/metabolism ; Macrophages/metabolism
Czasopismo naukowe
Tytuł :
MicroRNA-148a Inhibits Hepatocellular Carcinoma Cell Growth via Epithelial-to-Mesenchymal Transition and PI3K/AKT Signaling Pathways by Targeting Death Receptor-5.
Autorzy :
Zhang N; Department of General Surgery, Hongqi Hospital affiliated to Mudanjiang Medical University, No.5, Tongxiang Road, Aimin District, Heilongjiang Province, 157000, Mudanjiang City, China.
Zhou J; Department of General Surgery, Hongqi Hospital affiliated to Mudanjiang Medical University, No.5, Tongxiang Road, Aimin District, Heilongjiang Province, 157000, Mudanjiang City, China.
Zhou Y; Department of Stomatology, Hongqi Hospital affiliated to Mudanjiang Medical University, 157000, Mudanjiang City, China.
Guan F; Department of General Surgery, Hongqi Hospital affiliated to Mudanjiang Medical University, No.5, Tongxiang Road, Aimin District, Heilongjiang Province, 157000, Mudanjiang City, China. .
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Źródło :
Applied biochemistry and biotechnology [Appl Biochem Biotechnol] 2022 Jun; Vol. 194 (6), pp. 2731-2746. Date of Electronic Publication: 2022 Mar 10.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Hepatocellular*/pathology
Epithelial-Mesenchymal Transition*/genetics
Liver Neoplasms*/pathology
MicroRNAs*/genetics
MicroRNAs*/metabolism
Receptors, TNF-Related Apoptosis-Inducing Ligand*/genetics
Receptors, TNF-Related Apoptosis-Inducing Ligand*/metabolism
Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
Oncolytic adenovirus-mediated intratumoral expression of TRAIL and CD40L enhances immunotherapy by modulating the tumor microenvironment in immunocompetent mouse models.
Autorzy :
Liu W; National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, 130012, China.
Wang X; National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, 130012, China.
Feng X; National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, 130012, China.
Yu J; National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, 130012, China.
Liu X; National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, 130012, China.
Jia X; National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, 130012, China.
Zhang H; National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, 130012, China.
Wu H; National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, 130012, China.
Wang C; National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, 130012, China.
Wu J; National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, 130012, China.
Yu B; National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, 130012, China. Electronic address: .
Yu X; National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, 130012, China; Key Laboratory for Molecular Enzymology and Engineering, The Ministry of Education, School of Life Sciences, Jilin University, Changchun, 130012, China. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2022 Jun 01; Vol. 535, pp. 215661. Date of Electronic Publication: 2022 Mar 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenoviridae*/genetics
Adenoviridae*/metabolism
CD40 Ligand*/genetics
CD40 Ligand*/metabolism
Animals ; Humans ; Immunotherapy ; Mice ; Mice, Nude ; Tumor Microenvironment ; Virus Replication
Czasopismo naukowe
Tytuł :
Novel Functions of Integrins as Receptors of CD154: Their Role in Inflammation and Apoptosis.
Autorzy :
Hassan GS; Laboratoire d'Immunologie Cellulaire et Moléculaire, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CR-CHUM), 900 rue Saint-Denis, Tour Viger, Montréal, QC H2X 0A9, Canada.
Salti S; Laboratoire d'Immunologie Cellulaire et Moléculaire, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CR-CHUM), 900 rue Saint-Denis, Tour Viger, Montréal, QC H2X 0A9, Canada.
Mourad W; Laboratoire d'Immunologie Cellulaire et Moléculaire, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CR-CHUM), 900 rue Saint-Denis, Tour Viger, Montréal, QC H2X 0A9, Canada.
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Źródło :
Cells [Cells] 2022 May 25; Vol. 11 (11). Date of Electronic Publication: 2022 May 25.
Typ publikacji :
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
CD40 Antigens*/metabolism
CD40 Ligand*/metabolism
Inflammation*/metabolism
Humans ; Platelet Glycoprotein GPIIb-IIIa Complex/metabolism
Czasopismo naukowe
Tytuł :
CD40L-expressing CD4 T cells prime adipose-derived stromal cells to produce inflammatory chemokines.
Autorzy :
Dulong J; UMR 1236, Univ Rennes, INSERM, Etablissement Français du Sang Bretagne, Rennes, France; SITI Laboratory, Etablissement Français du Sang Bretagne, CHU Rennes, Rennes, France.
Loisel S; UMR 1236, Univ Rennes, INSERM, Etablissement Français du Sang Bretagne, Rennes, France; SITI Laboratory, Etablissement Français du Sang Bretagne, CHU Rennes, Rennes, France.
Rossille D; UMR 1236, Univ Rennes, INSERM, Etablissement Français du Sang Bretagne, Rennes, France; SITI Laboratory, Etablissement Français du Sang Bretagne, CHU Rennes, Rennes, France.
Léonard S; UMR 1236, Univ Rennes, INSERM, Etablissement Français du Sang Bretagne, Rennes, France.
Bescher N; UMR 1236, Univ Rennes, INSERM, Etablissement Français du Sang Bretagne, Rennes, France; SITI Laboratory, Etablissement Français du Sang Bretagne, CHU Rennes, Rennes, France.
Bezier I; UMR 1236, Univ Rennes, INSERM, Etablissement Français du Sang Bretagne, Rennes, France; SITI Laboratory, Etablissement Français du Sang Bretagne, CHU Rennes, Rennes, France.
Latour M; UMR 1236, Univ Rennes, INSERM, Etablissement Français du Sang Bretagne, Rennes, France; SITI Laboratory, Etablissement Français du Sang Bretagne, CHU Rennes, Rennes, France.
Monvoisin C; UMR 1236, Univ Rennes, INSERM, Etablissement Français du Sang Bretagne, Rennes, France.
Monnier D; Pôle Biologie, CHU Rennes, Rennes, France.
Bertheuil N; UMR 1236, Univ Rennes, INSERM, Etablissement Français du Sang Bretagne, Rennes, France; SITI Laboratory, Etablissement Français du Sang Bretagne, CHU Rennes, Rennes, France; Department of Plastic Surgery, CHU Rennes, Rennes, France.
Roulois D; UMR 1236, Univ Rennes, INSERM, Etablissement Français du Sang Bretagne, Rennes, France.
Tarte K; UMR 1236, Univ Rennes, INSERM, Etablissement Français du Sang Bretagne, Rennes, France; SITI Laboratory, Etablissement Français du Sang Bretagne, CHU Rennes, Rennes, France; Pôle Biologie, CHU Rennes, Rennes, France. Electronic address: .
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Źródło :
Cytotherapy [Cytotherapy] 2022 May; Vol. 24 (5), pp. 500-507. Date of Electronic Publication: 2022 Feb 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CD40 Ligand*/genetics
CD40 Ligand*/metabolism
NF-kappa B*/metabolism
Adipose Tissue ; CD4-Positive T-Lymphocytes/metabolism ; Cells, Cultured ; Chemokines/metabolism ; Humans ; Interleukin-8/metabolism ; Obesity ; Stromal Cells/pathology ; T-Lymphocytes ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Tytuł :
OX40L Inhibition Suppresses KLH-driven Immune Responses in Healthy Volunteers: A Randomized Controlled Trial Demonstrating Proof-of-Pharmacology for KY1005.
Autorzy :
Saghari M; Centre for Human Drug Research, Leiden, The Netherlands.; Leiden University Medical Centre, Leiden, The Netherlands.
Gal P; Centre for Human Drug Research, Leiden, The Netherlands.; Leiden University Medical Centre, Leiden, The Netherlands.
Gilbert S; Kymab Ltd., Cambridge, UK.
Yateman M; Kymab Ltd., Cambridge, UK.
Porter-Brown B; Kymab Ltd., Cambridge, UK.
Brennan N; Kymab Ltd., Cambridge, UK.
Quaratino S; Kymab Ltd., Cambridge, UK.
Wilson R; Kymab Ltd., Cambridge, UK.
Grievink HW; Centre for Human Drug Research, Leiden, The Netherlands.; Leiden Academic Centre for Drug Research, Leiden, The Netherlands.
Klaassen ES; Centre for Human Drug Research, Leiden, The Netherlands.
Bergmann KR; Centre for Human Drug Research, Leiden, The Netherlands.
Burggraaf J; Centre for Human Drug Research, Leiden, The Netherlands.; Leiden University Medical Centre, Leiden, The Netherlands.; Leiden Academic Centre for Drug Research, Leiden, The Netherlands.
van Doorn MBA; Centre for Human Drug Research, Leiden, The Netherlands.; Department of Dermatology, Erasmus Medical Centre, Rotterdam, The Netherlands.
Powell J; Kymab Ltd., Cambridge, UK.
Moerland M; Centre for Human Drug Research, Leiden, The Netherlands.; Leiden University Medical Centre, Leiden, The Netherlands.
Rissmann R; Centre for Human Drug Research, Leiden, The Netherlands.; Leiden University Medical Centre, Leiden, The Netherlands.; Leiden Academic Centre for Drug Research, Leiden, The Netherlands.
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Źródło :
Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2022 May; Vol. 111 (5), pp. 1121-1132. Date of Electronic Publication: 2022 Mar 01.
Typ publikacji :
Journal Article; Randomized Controlled Trial
MeSH Terms :
Antibodies, Monoclonal*/immunology
Antibodies, Monoclonal*/pharmacology
Antibody Formation*
Hemocyanins*/pharmacology
OX40 Ligand*/antagonists & inhibitors
OX40 Ligand*/immunology
Healthy Volunteers ; Humans ; Male
Czasopismo naukowe
Tytuł :
PD-L1 and PD-L2 expression in pancreatic ductal adenocarcinoma and their correlation with immune infiltrates and DNA damage response molecules.
Autorzy :
Zhang Y; Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China.
Chen X; Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China.
Mo S; Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China.
Ma H; Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China.
Lu Z; Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China.
Yu S; Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China.
Chen J; Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China.
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Źródło :
The journal of pathology. Clinical research [J Pathol Clin Res] 2022 May; Vol. 8 (3), pp. 257-267. Date of Electronic Publication: 2022 Jan 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
B7-H1 Antigen*/biosynthesis
B7-H1 Antigen*/blood
B7-H1 Antigen*/genetics
B7-H1 Antigen*/immunology
Carcinoma, Pancreatic Ductal*/genetics
Carcinoma, Pancreatic Ductal*/immunology
Carcinoma, Pancreatic Ductal*/pathology
DNA Damage*
Lymphocytes, Tumor-Infiltrating*/immunology
Pancreatic Neoplasms*/genetics
Pancreatic Neoplasms*/immunology
Pancreatic Neoplasms*/pathology
Programmed Cell Death 1 Ligand 2 Protein*/biosynthesis
Programmed Cell Death 1 Ligand 2 Protein*/genetics
Programmed Cell Death 1 Ligand 2 Protein*/immunology
Humans
Czasopismo naukowe

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