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Tytuł:
Inhibition of UTX/KDM6A improves recovery of spinal cord injury by attenuating BSCB permeability and macrophage infiltration through the MLCK/p-MLC pathway.
Autorzy:
Xie Y; Department of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.; Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, China.; Hunan Engineering Research Center of Sports and Health, Changsha, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Luo Z; Department of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.; Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, China.; Hunan Engineering Research Center of Sports and Health, Changsha, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Peng W; Department of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.; Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, China.; Hunan Engineering Research Center of Sports and Health, Changsha, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Liu Y; Department of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.; Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, China.; Hunan Engineering Research Center of Sports and Health, Changsha, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Yuan F; Department of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.; Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, China.; Hunan Engineering Research Center of Sports and Health, Changsha, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Xu J; Department of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.; Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, China.; Hunan Engineering Research Center of Sports and Health, Changsha, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Sun Y; Department of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.; Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, China.; Hunan Engineering Research Center of Sports and Health, Changsha, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Lu H; Department of Sports Medicine, Xiangya Hospital, Central South University, Changsha, China.; Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, China.; Hunan Engineering Research Center of Sports and Health, Changsha, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Wu T; Department of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University, Changsha, China. .; Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, China. .; Hunan Engineering Research Center of Sports and Health, Changsha, China. .; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China. .
Jiang L; Department of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University, Changsha, China. .; Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, China. .; Hunan Engineering Research Center of Sports and Health, Changsha, China. .; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China. .
Hu J; Department of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University, Changsha, China. .; Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, China. .; Hunan Engineering Research Center of Sports and Health, Changsha, China. .; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China. .
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Źródło:
Journal of neuroinflammation [J Neuroinflammation] 2023 Nov 11; Vol. 20 (1), pp. 259. Date of Electronic Publication: 2023 Nov 11.
Typ publikacji:
Journal Article
MeSH Terms:
Myosin Light Chains*/metabolism
Spinal Cord Injuries*/metabolism
Animals ; Mice ; Rats ; Blood-Brain Barrier/metabolism ; Endothelial Cells/metabolism ; Histone Demethylases/genetics ; Myosin-Light-Chain Kinase/metabolism ; Permeability ; Phosphorylation ; Rats, Sprague-Dawley ; Spinal Cord/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
MYL9 expressed in cancer-associated fibroblasts regulate the immune microenvironment of colorectal cancer and promotes tumor progression in an autocrine manner.
Autorzy:
Deng S; Center for Liver Transplantation, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.; Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Cheng D; Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Wang J; Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Gu J; Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Xue Y; Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Jiang Z; Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Qin L; Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Mao F; Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Cao Y; Department of Digestive Surgical Oncology, Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. .
Cai K; Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. .
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Źródło:
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2023 Nov 06; Vol. 42 (1), pp. 294. Date of Electronic Publication: 2023 Nov 06.
Typ publikacji:
Journal Article
MeSH Terms:
Cancer-Associated Fibroblasts*/metabolism
Colorectal Neoplasms*/pathology
Myosin Light Chains*/genetics
Animals ; Cell Line, Tumor ; Cell Proliferation ; Fibroblasts/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Transcription Factors/metabolism ; Transforming Growth Factor beta1/metabolism ; Tumor Microenvironment ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Clinicopathological characteristics and prognosis in patients with monoclonal gammopathy and renal damage in central China: a multicenter retrospective cohort study.
Autorzy:
He, Huimin (AUTHOR)
Wang, Zheng (AUTHOR)
Xu, Jiayun (AUTHOR)
Liu, Yun (AUTHOR)
Shao, Yeqing (AUTHOR)
Hou, Yulong (AUTHOR)
Gu, Jinping (AUTHOR)
Hu, Ruimin (AUTHOR)
Xing, Guolan (AUTHOR)
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Źródło:
Scientific Reports. 4/1/2024, Vol. 14 Issue 1, p1-10. 10p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Germline-encoded amino acid-binding motifs drive immunodominant public antibody responses.
Autorzy:
Shrock EL; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA.; Program in Biological and Biomedical Sciences, Harvard University, Boston, MA 02115, USA.
Timms RT; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK.
Kula T; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA.; Program in Biological and Biomedical Sciences, Harvard University, Boston, MA 02115, USA.
Mena EL; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA.
West AP Jr; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Guo R; Division of Infectious Disease, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA.
Lee IH; Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Cohen AA; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
McKay LGA; National Emerging Infectious Diseases Laboratories, Boston University School of Medicine, Boston University, Boston, MA 02118, USA.
Bi C; Division of Allergy and Immunology, Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Massachusetts Consortium on Pathogen Readiness, Boston, MA 02115, USA.
Leng Y; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA.
Fujimura E; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA.
Horns F; Department of Bioengineering, Department of Applied Physics, Chan Zuckerberg Biohub and Stanford University, Stanford, CA 94305, USA.
Li M; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA.
Wesemann DR; Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA.; Division of Allergy and Immunology, Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Massachusetts Consortium on Pathogen Readiness, Boston, MA 02115, USA.; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, 02139 USA.
Griffiths A; National Emerging Infectious Diseases Laboratories, Boston University School of Medicine, Boston University, Boston, MA 02118, USA.
Gewurz BE; Division of Infectious Disease, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA.; Graduate Program in Virology, Division of Medical Sciences, Harvard Medical School, Boston, MA 02115, USA.
Bjorkman PJ; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Elledge SJ; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2023 Apr 07; Vol. 380 (6640), pp. eadc9498. Date of Electronic Publication: 2023 Apr 07.
Typ publikacji:
Journal Article
MeSH Terms:
Antibody Formation*
Immunodominant Epitopes*/chemistry
Immunodominant Epitopes*/genetics
Immunoglobulin Heavy Chains*/genetics
Immunoglobulin Heavy Chains*/immunology
Amino Acid Motifs*
Immunoglobulin Light Chains*/genetics
Immunoglobulin Light Chains*/immunology
Host-Pathogen Interactions*/genetics
Host-Pathogen Interactions*/immunology
Animals ; Humans ; Mice ; Germ Cells ; Epitope Mapping
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Widespread amyloidogenicity potential of multiple myeloma patient-derived immunoglobulin light chains.
Autorzy:
Sternke-Hoffmann R; Institut für Physikalische Biologie, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany.; Department of Biology and Chemistry, Paul Scherrer Institute, Villigen, Switzerland.
Pauly T; Institut für Physikalische Biologie, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany.; Forschungszentrum Jülich GmbH, IBI-7, Jülich, Germany.
Norrild RK; Department of Biotechnology and Biomedicine, Technical University of Denmark, Lyngby, Denmark.
Hansen J; Condensed Matter Physics Laboratory, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany.
Tucholski F; Institut für Physikalische Biologie, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany.
Høie MH; Department of Health Technology, Technical University of Denmark, Lyngby, Denmark.
Marcatili P; Department of Health Technology, Technical University of Denmark, Lyngby, Denmark.
Dupré M; Mass Spectrometry for Biology Unit, CNRS USR2000, Institut Pasteur, 75015, Paris, France.
Duchateau M; Mass Spectrometry for Biology Unit, CNRS USR2000, Institut Pasteur, 75015, Paris, France.
Rey M; Mass Spectrometry for Biology Unit, CNRS USR2000, Institut Pasteur, 75015, Paris, France.
Malosse C; Mass Spectrometry for Biology Unit, CNRS USR2000, Institut Pasteur, 75015, Paris, France.
Metzger S; Cologne Biocenter, Cluster of Excellence on Plant Sciences, Mass Spectrometry Platform, University of Cologne, Cologne, Germany.
Boquoi A; Department of Hematology, Oncology and Clinical Oncology, Heinrich-Heine Universität Düsseldorf, Düsseldorf, Germany.
Platten F; Condensed Matter Physics Laboratory, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany.; Forschungszentrum Jülich GmbH, IBI-4, Jülich, Germany.
Egelhaaf SU; Condensed Matter Physics Laboratory, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany.
Chamot-Rooke J; Mass Spectrometry for Biology Unit, CNRS USR2000, Institut Pasteur, 75015, Paris, France.
Fenk R; Department of Hematology, Oncology and Clinical Oncology, Heinrich-Heine Universität Düsseldorf, Düsseldorf, Germany.
Nagel-Steger L; Institut für Physikalische Biologie, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany.; Forschungszentrum Jülich GmbH, IBI-7, Jülich, Germany.
Haas R; Department of Hematology, Oncology and Clinical Oncology, Heinrich-Heine Universität Düsseldorf, Düsseldorf, Germany. .
Buell AK; Institut für Physikalische Biologie, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany. .; Department of Biotechnology and Biomedicine, Technical University of Denmark, Lyngby, Denmark. .
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Źródło:
BMC biology [BMC Biol] 2023 Feb 03; Vol. 21 (1), pp. 21. Date of Electronic Publication: 2023 Feb 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Immunoglobulin Light Chains*/chemistry
Immunoglobulin Light Chains*/metabolism
Multiple Myeloma*
Humans ; Amyloid/metabolism ; Amino Acid Sequence ; Proteolysis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Phenotypes and outcome of diffuse pulmonary non-amyloid light chain deposition disease.
Autorzy:
Lestelle F; Hospices Civils de Lyon, Centre de Référence Coordinateur Des Maladies Pulmonaires Rares (OrphaLung), Hôpital Louis Pradel, Service de Pneumologie, 69677, Lyon, France.
Beigelman C; Service de Radiologie Et de Radiologie Interventionnelle, Hôpital Universitaire de Lausanne, Université de Lausanne, Lausanne, Suisse.
Rotzinger D; Service de Radiologie Et de Radiologie Interventionnelle, Hôpital Universitaire de Lausanne, Université de Lausanne, Lausanne, Suisse.
Si-Mohamed S; Hospices Civils de Lyon, Hôpital Louis Pradel, Service de Radiologie, Lyon 69677U1206, Université de Lyon, INSA-Lyon, Université Claude Bernard Lyon 1, UJM-Saint Etienne, CNRS, Inserm, CREATIS, UMR 5220, F-69621, 7 Avenue Jean Capelle O, 69100, Villeurbanne, France.
Nasser M; Hospices Civils de Lyon, Centre de Référence Coordinateur Des Maladies Pulmonaires Rares (OrphaLung), Hôpital Louis Pradel, Service de Pneumologie, 69677, Lyon, France.
Wemeau L; Centre de Référence Constitutif Des Maladies Pulmonaires Rares (OrphaLung), CHU Lille, Service de Pneumologie, Lille, France.
Hirschi S; Centre de Compétence Des Maladies Pulmonaires Rares (OrphaLung), CHU Strasbourg, Service de Pneumologie, Strasbourg, France.
Prevot G; Centre de Compétence Des Maladies Pulmonaires Rares (OrphaLung), CHU Toulouse, Hôpital LarreyUniversité Paul Sabatier, Toulouse, France.
Roux A; Service de Pneumologie Et de Transplantation Pulmonaire, Hopital Foch, Suresnes, France.
Bunel V; Service de Pneumologie B Et de Transplantation Pulmonaire, AP-HP, Hôpital Bichat Claude-Bernard, Inserm U1152, Paris, France.
Gomez E; Centre de Compétence Des Maladies Pulmonaires Rares (OrphaLung), CHU Nancy, Service de Pneumologie, Nancy, France.
Sohier L; Centre Hospitalier Bretagne Sud, Service de Pneumologie, Lorient, France.
Pradier HM; Centre de Compétence Des Maladies Pulmonaires Rares (OrphaLung), CHU Rouen, Service de Pneumologie, Rouen, France.
Gaubert MR; Service de Pneumologie Et Transplantation Pulmonaire, CHU Marseille Nord, Aix-Marseille Université Marseille, Assistance Publique-Hôpitaux de Marseille, Marseille, France.
Gondouin A; Centre de Compétence Des Maladies Pulmonaires Rares (OrphaLung), CHU Besançon, Service de Pneumologie, Besançon, France.
Lazor R; Service de Pneumologie, Centre Hospitalier Universitaire Vaudois, Lausanne, CH, Suisse.
Glerant JC; Hospices Civils de Lyon, Hôpital Louis Pradel, Service d'explorations Fonctionnelles Respiratoires, 69677, Lyon, France.
Bejui FT; Hospices Civils de Lyon, Hôpital Louis Pradel, Service d'Anatomopathologie, 69677, Lyon, France.
Colombat M; CHU Toulouse, Institut Universitaire du Cancer de Toulouse, Service d'anatomie Et Cytologie Pathologiques, Toulouse, France.
Cottin V; Hospices Civils de Lyon, Centre de Référence Coordinateur Des Maladies Pulmonaires Rares (OrphaLung), Hôpital Louis Pradel, Service de Pneumologie, 69677, Lyon, France. .; UMR754, INRAE; Member of RespiFil and ERN-LUNG, Université, Claude Bernard Lyon 1, Lyon, France. .
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Corporate Authors:
OrphaLung network
Źródło:
Respiratory research [Respir Res] 2024 Apr 10; Vol. 25 (1), pp. 159. Date of Electronic Publication: 2024 Apr 10.
Typ publikacji:
Multicenter Study; Journal Article
MeSH Terms:
Bronchiectasis*
Cysts*/pathology
Humans ; Female ; Young Adult ; Adult ; Male ; Immunoglobulin Light Chains ; Retrospective Studies ; Lung/diagnostic imaging ; Lung/pathology ; Phenotype
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Myosin light chain of shark fast skeletal muscle exhibits intrinsic urea-resistibility.
Autorzy:
Kanoh S; Graduate School of Bioresources, Mie University, Tsu, Mie, 514-8507, Japan.
Noma T; Graduate School of Bioresources, Mie University, Tsu, Mie, 514-8507, Japan.; Kogakkan High School, Ise, Mie, 516-8577, Japan.
Ito H; Graduate School of Bioresources, Mie University, Tsu, Mie, 514-8507, Japan.; ASGEN Pharmaceutical Co., Ltd., Mizunami, Gifu, 509-6104, Japan.
Tsureyama M; Graduate School of Bioresources, Mie University, Tsu, Mie, 514-8507, Japan.; Kracie Foods, Ltd., Minato, Tokyo, 108-8080, Japan.
Funabara D; Graduate School of Bioresources, Mie University, Tsu, Mie, 514-8507, Japan. .
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Źródło:
Scientific reports [Sci Rep] 2023 Mar 25; Vol. 13 (1), pp. 4909. Date of Electronic Publication: 2023 Mar 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Myosin Light Chains*
Sharks*
Animals ; Urea/chemistry ; Muscle, Skeletal
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Chromosomal analysis of clonally related B-cell lymphomas with discordant immunoglobulin light-chain restrictions at different anatomical sites.
Autorzy:
Nonaka K; Division of Aging and Carcinogenesis, Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo, Japan.
Kurata M; Department of Comprehensive Pathology, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan.
Tachibana M; Department of Chemotherapy, Tokyo Metropolitan Geriatric Hospital, Itabashi-ku, Tokyo, Japan.
Komatsu A; Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Itabashi-ku, Tokyo, Japan.
Shichi Y; Division of Aging and Carcinogenesis, Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo, Japan.
Gomi F; Division of Aging and Carcinogenesis, Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo, Japan.
Ishiwata T; Division of Aging and Carcinogenesis, Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo, Japan.
Miyamoto K; Department of Chemotherapy, Tokyo Metropolitan Geriatric Hospital, Itabashi-ku, Tokyo, Japan.
Arai T; Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Itabashi-ku, Tokyo, Japan.
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Źródło:
Pathology international [Pathol Int] 2023 Feb; Vol. 73 (2), pp. 100-102. Date of Electronic Publication: 2022 Dec 12.
Typ publikacji:
Letter
MeSH Terms:
Immunoglobulin Light Chains*
Lymphoma, B-Cell*/pathology
Humans ; Immunoglobulin kappa-Chains ; Immunoglobulin lambda-Chains/analysis
Opinia redakcyjna
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Vaccination induces HIV broadly neutralizing antibody precursors in humans.
Autorzy:
Leggat DJ; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Cohen KW; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Willis JR; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Fulp WJ; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
deCamp AC; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Kalyuzhniy O; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Cottrell CA; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Menis S; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Finak G; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Ballweber-Fleming L; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Srikanth A; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Plyler JR; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Schiffner T; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Liguori A; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Rahaman F; IAVI, New York, NY 10004, USA.
Lombardo A; IAVI, New York, NY 10004, USA.
Philiponis V; IAVI, New York, NY 10004, USA.
Whaley RE; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Seese A; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Brand J; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Ruppel AM; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Hoyland W; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Yates NL; Center for Human Systems Immunology, Departments of Surgery, Immunology, Molecular Genetics and Microbiology, Duke University, Durham, NC 27701, USA.
Williams LD; Center for Human Systems Immunology, Departments of Surgery, Immunology, Molecular Genetics and Microbiology, Duke University, Durham, NC 27701, USA.
Greene K; Duke University Medical Center, Durham, NC 27701, USA.
Gao H; Duke University Medical Center, Durham, NC 27701, USA.
Mahoney CR; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Corcoran MM; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Cagigi A; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Taylor A; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Brown DM; The Foundation for the National Institutes of Health, North Bethesda, MD 20852, USA.
Ambrozak DR; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Sincomb T; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Hu X; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Tingle R; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Georgeson E; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Eskandarzadeh S; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Alavi N; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Lu D; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Mullen TM; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Kubitz M; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Groschel B; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Maenza J; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.; Department of Medicine, University of Washington, Seattle, WA 98195, USA.
Kolokythas O; Department of Radiology, University of Washington, Seattle, WA 98195, USA.
Khati N; Department of Radiology, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20037, USA.
Bethony J; Department of Microbiology, Immunology and Tropical Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20037, USA.
Crotty S; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego, La Jolla, CA 92037, USA.
Roederer M; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Karlsson Hedestam GB; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.; Department of Medicine, University of Washington, Seattle, WA 98195, USA.
Tomaras GD; Center for Human Systems Immunology, Departments of Surgery, Immunology, Molecular Genetics and Microbiology, Duke University, Durham, NC 27701, USA.
Montefiori D; Duke University Medical Center, Durham, NC 27701, USA.
Diemert D; Department of Microbiology, Immunology and Tropical Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20037, USA.; Department of Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20052, USA.
Koup RA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Laufer DS; IAVI, New York, NY 10004, USA.
McElrath MJ; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.; Department of Medicine, University of Washington, Seattle, WA 98195, USA.
McDermott AB; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Schief WR; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.; The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2022 Dec 02; Vol. 378 (6623), pp. eadd6502. Date of Electronic Publication: 2022 Dec 02.
Typ publikacji:
Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
AIDS Vaccines*/immunology
Broadly Neutralizing Antibodies*/genetics
Broadly Neutralizing Antibodies*/immunology
HIV Infections*/prevention & control
HIV Antibodies*/genetics
HIV Antibodies*/immunology
Germ Cells*/immunology
Immunoglobulin Light Chains*/genetics
Immunoglobulin Light Chains*/immunology
Immunoglobulin Heavy Chains*/genetics
Immunoglobulin Heavy Chains*/immunology
Humans ; Adjuvants, Immunologic ; Vaccination ; B-Lymphocytes/immunology ; Mutation ; Male ; Female ; Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Serum Neurofilament and Free Light Chain Levels in Patients Undergoing Treatment for Chronic Inflammatory Demyelinating Polyneuropathy.
Autorzy:
Luigetti M; Dipartimento di Neuroscienze, Organi di Senso e Torace, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy.; Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Primiano G; Dipartimento di Neuroscienze, Organi di Senso e Torace, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy.; Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.; Fondazione UILDM Lazio Onlus, 00167 Rome, Italy.
Basile V; Clinical Pathology Unit and Cancer Biobank, Department of Research and Advanced Technologies, I.R.C.C.S. Regina Elena National Cancer Institute, 00144 Rome, Italy.
Vitali F; Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Pignalosa S; Dipartimento di Patologia Clinica, Ospedale Santa Maria Goretti, A.U.S.L. Latina, 04100 Latina, Italy.
Romano A; Dipartimento di Neuroscienze, Organi di Senso e Torace, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy.
Sabino A; Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Marino M; Sezione di Patologia Generale, Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.; Fondazione Policlinico Universitario 'A. Gemelli' I.R.C.C.S., 00168 Rome, Italy.
Di Santo R; Fondazione Policlinico Universitario 'A. Gemelli' I.R.C.C.S., 00168 Rome, Italy.; Sezione di Fisica, Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Ciasca G; Fondazione Policlinico Universitario 'A. Gemelli' I.R.C.C.S., 00168 Rome, Italy.; Sezione di Fisica, Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Basile U; Dipartimento di Patologia Clinica, Ospedale Santa Maria Goretti, A.U.S.L. Latina, 04100 Latina, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 19; Vol. 25 (2). Date of Electronic Publication: 2024 Jan 19.
Typ publikacji:
Journal Article
MeSH Terms:
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating*/diagnosis
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating*/drug therapy
Humans ; Intermediate Filaments ; Immunoglobulin Light Chains ; Biomarkers
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Comparison of Rheological Properties of Healthy versus Dupuytren Fibroblasts When Treated with a Cell Contraction Inhibitor by Atomic Force Microscope.
Autorzy:
Pérez-Domínguez S; Institute of Biophysics, University of Bremen, 28359 Bremen, Germany.
López-Alonso J; University of Lille, CNRS, INSERM, CHU Lille, Institute Pasteur Lille, U1019-UMR 9017-CIIL-Center for Infection and Immunity of Lille, 59021 Lille, France.
Lafont F; University of Lille, CNRS, INSERM, CHU Lille, Institute Pasteur Lille, U1019-UMR 9017-CIIL-Center for Infection and Immunity of Lille, 59021 Lille, France.
Radmacher M; Institute of Biophysics, University of Bremen, 28359 Bremen, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jan 20; Vol. 24 (3). Date of Electronic Publication: 2023 Jan 20.
Typ publikacji:
Journal Article
MeSH Terms:
Cytoskeleton*/drug effects
Cytoskeleton*/metabolism
Cytoskeleton*/physiology
Cytoskeleton*/ultrastructure
Dupuytren Contracture*/drug therapy
Dupuytren Contracture*/metabolism
Dupuytren Contracture*/pathology
Fibroblasts*/drug effects
Fibroblasts*/metabolism
Microscopy, Atomic Force*
Myosin Light Chains*/metabolism
Muscle Contraction*/drug effects
Muscle Contraction*/physiology
Humans ; Mechanical Phenomena ; Myosin-Light-Chain Kinase/pharmacology ; Myosin-Light-Chain Kinase/therapeutic use
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Myosin light chain phosphorylation exhibits a gradient across the wall of cerebellar arteries under sustained ex vivo vascular tone.
Autorzy:
Sun Z; Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO, 65211, USA. .; Department of Medical Pharmacology and Physiology, School of Medicine, University of Missouri, Columbia, MO, USA. .
Li Z; Department of Radiology, School of Medicine, University of Missouri, Columbia, MO, USA.
Rodgers M; Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO, 65211, USA.
Zhang L; Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO, 65211, USA.
Hill MA; Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO, 65211, USA. .; Department of Medical Pharmacology and Physiology, School of Medicine, University of Missouri, Columbia, MO, USA. .
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Źródło:
Scientific reports [Sci Rep] 2023 Jan 17; Vol. 13 (1), pp. 909. Date of Electronic Publication: 2023 Jan 17.
Typ publikacji:
Journal Article
MeSH Terms:
Myosin Light Chains*/metabolism
Actins*/metabolism
Rats ; Animals ; Muscle, Smooth, Vascular/metabolism ; Phosphorylation ; Cerebral Arteries/metabolism ; Vasoconstriction/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Development and characterization of NILK-2301, a novel CEACAM5xCD3 κλ bispecific antibody for immunotherapy of CEACAM5-expressing cancers.
Autorzy:
Seckinger, Anja (AUTHOR)
Majocchi, Sara (AUTHOR)
Moine, Valéry (AUTHOR)
Nouveau, Lise (AUTHOR)
Ngoc, Hoang (AUTHOR)
Daubeuf, Bruno (AUTHOR)
Ravn, Ulla (AUTHOR)
Pleche, Nicolas (AUTHOR)
Calloud, Sebastien (AUTHOR)
Broyer, Lucile (AUTHOR)
Cons, Laura (AUTHOR)
Lesnier, Adeline (AUTHOR)
Chatel, Laurence (AUTHOR)
Papaioannou, Anne (AUTHOR)
Salgado-Pires, Susana (AUTHOR)
Krämer, Sebastian (AUTHOR)
Gockel, Ines (AUTHOR)
Lordick, Florian (AUTHOR)
Masternak, Krzysztof (AUTHOR)
Poitevin, Yves (AUTHOR)
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Źródło:
Journal of Hematology & Oncology. 12/12/2023, Vol. 16 Issue 1, p1-23. 23p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 4998

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