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Tytuł:
CFTR Rescue by Lumacaftor (VX-809) Induces an Extensive Reorganization of Mitochondria in the Cystic Fibrosis Bronchial Epithelium.
Autorzy:
Braccia C; D3 PharmaChemistry, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy.
Christopher JA; Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.
Crook OM; Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.; Department of Statistics, University of Oxford, 29 St Giles', Oxford OX1 3LB, UK.
Breckels LM; Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.
Queiroz RML; Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.
Liessi N; Analytical Chemistry Facility, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy.
Tomati V; UOC Genetica Medica, IRCCS Istituto Giannina Gaslini, Via Gerolamo Gaslini 5, 16147 Genova, Italy.
Capurro V; UOC Genetica Medica, IRCCS Istituto Giannina Gaslini, Via Gerolamo Gaslini 5, 16147 Genova, Italy.
Bandiera T; D3 PharmaChemistry, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy.
Baldassari S; UOC Genetica Medica, IRCCS Istituto Giannina Gaslini, Via Gerolamo Gaslini 5, 16147 Genova, Italy.
Pedemonte N; UOC Genetica Medica, IRCCS Istituto Giannina Gaslini, Via Gerolamo Gaslini 5, 16147 Genova, Italy.
Lilley KS; Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.
Armirotti A; Analytical Chemistry Facility, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy.
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Źródło:
Cells [Cells] 2022 Jun 16; Vol. 11 (12). Date of Electronic Publication: 2022 Jun 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cystic Fibrosis*/metabolism
Aminopyridines ; Benzodioxoles ; Cystic Fibrosis Transmembrane Conductance Regulator/metabolism ; Epithelium/metabolism ; Humans ; Infant, Newborn ; Mitochondria/metabolism ; Proteome/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A Bayesian semi-parametric model for thermal proteome profiling.
Autorzy:
Fang S; Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Cambridge, UK.; Milner Therapeutics Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.
Kirk PDW; MRC Biostatistics Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK.; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK.
Bantscheff M; Cellzome GmbH, GlaxoSmithKline, Heidelberg, Germany.
Lilley KS; Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Cambridge, UK. .; Milner Therapeutics Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK. .
Crook OM; Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Cambridge, UK. .; MRC Biostatistics Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK. .; Milner Therapeutics Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK. .
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Źródło:
Communications biology [Commun Biol] 2021 Jun 29; Vol. 4 (1), pp. 810. Date of Electronic Publication: 2021 Jun 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Bayes Theorem*
Protein Stability*
Proteome*
Solubility ; Temperature ; Thermodynamics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A semi-supervised Bayesian approach for simultaneous protein sub-cellular localisation assignment and novelty detection.
Autorzy:
Crook OM; Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Cambridge, UK.; MRC Biostatistics Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK.; Milner Therapeutics Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Puddicombe Way, Cambridge CB2 0AW, Cambridge, UK.
Geladaki A; Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Cambridge, UK.; Department of Genetics, Universtiy of Cambridge, Cambridge, UK.
Nightingale DJH; Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Cambridge, UK.
Vennard OL; Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Cambridge, UK.; Milner Therapeutics Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Puddicombe Way, Cambridge CB2 0AW, Cambridge, UK.
Lilley KS; Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Cambridge, UK.; Milner Therapeutics Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Puddicombe Way, Cambridge CB2 0AW, Cambridge, UK.
Gatto L; de Duve Institute, UCLouvain, Avenue Hippocrate 75, 1200 Brussels, Belgium.
Kirk PDW; MRC Biostatistics Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK.; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, UK.
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Źródło:
PLoS computational biology [PLoS Comput Biol] 2020 Nov 09; Vol. 16 (11), pp. e1008288. Date of Electronic Publication: 2020 Nov 09 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Bayes Theorem*
Saccharomyces cerevisiae Proteins/*metabolism
Subcellular Fractions/*metabolism
Algorithms ; Animals ; Datasets as Topic ; Humans ; Machine Learning ; Mass Spectrometry ; Mice ; Proteomics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Proteomics of intracellular freezing survival.
Autorzy:
Thorne MAS; British Antarctic Survey, Cambridge, United Kingdom.
Britovšek NK; Cambridge Centre for Proteomics, University of Cambridge, Cambridge, United Kingdom.
Hawkins L; Biochemistry Department, Carleton University, Ottawa, Canada.
Lilley KS; Cambridge Centre for Proteomics, University of Cambridge, Cambridge, United Kingdom.
Storey KB; Biochemistry Department, Carleton University, Ottawa, Canada.
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Źródło:
PloS one [PLoS One] 2020 May 26; Vol. 15 (5), pp. e0233048. Date of Electronic Publication: 2020 May 26 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Regulatory Networks*
Acclimatization/*physiology
Proteomics/*methods
Rhabditida/*physiology
Animals ; Antioxidants/metabolism ; Cold Temperature ; Gene Expression Regulation ; Helminth Proteins/metabolism ; Peptide Hydrolases/metabolism ; Protein Interaction Maps
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Biotin proximity tagging favours unfolded proteins and enables the study of intrinsically disordered regions.
Autorzy:
Minde DP; Department of Biochemistry, Cambridge Centre for Proteomics, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QR, UK. .
Ramakrishna M; Medical Research Council Toxicology Unit, University of Cambridge, Lancaster Road, Leicester, LE1 9HN, UK.
Lilley KS; Department of Biochemistry, Cambridge Centre for Proteomics, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QR, UK. k.s.lilley@bioc.cam.ac.uk.
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Źródło:
Communications biology [Commun Biol] 2020 Jan 22; Vol. 3 (1), pp. 38. Date of Electronic Publication: 2020 Jan 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Protein Interaction Domains and Motifs*
Protein Unfolding*
Biotin/*metabolism
Intrinsically Disordered Proteins/*chemistry
Intrinsically Disordered Proteins/*metabolism
Amino Acid Sequence ; Biotin/chemistry ; Biotinylation ; Humans ; Lysine/metabolism ; Models, Molecular ; Protein Binding ; Protein Conformation ; Protein Processing, Post-Translational ; Protein Transport ; Proteomics/methods ; Ribosomes/metabolism ; Structure-Activity Relationship ; Tyrosine/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Changes in the Arabidopsis RNA-binding proteome reveal novel stress response mechanisms.
Autorzy:
Marondedze C; Cambridge Centre for Proteomics, Cambridge Systems Biology Centre, and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1GA, UK. .; Division of Biological and Environmental Sciences and Engineering, King Abdullah University of Science and Technology, 23955-6900, Thuwal, Kingdom of Saudi Arabia. .; Present Address: Laboratoire de Physiologie Cellulaire et Végétale, Université Grenoble Alpes, CEA/DRF/BIG, INRA UMR1417, CNRS UMR5168, 38054, Grenoble Cedex 9, France. .
Thomas L; Division of Biological and Environmental Sciences and Engineering, King Abdullah University of Science and Technology, 23955-6900, Thuwal, Kingdom of Saudi Arabia.; Present Address: HM.Clause, rue Louis Saillant, 26802, Portes-lès-Valence, France.
Gehring C; Division of Biological and Environmental Sciences and Engineering, King Abdullah University of Science and Technology, 23955-6900, Thuwal, Kingdom of Saudi Arabia.; Department of Chemistry, Biology and Biotechnology, University of Perugia, 74 Borgo XX Giugno, 06121, Perugia, Italy.
Lilley KS; Cambridge Centre for Proteomics, Cambridge Systems Biology Centre, and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1GA, UK.
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Źródło:
BMC plant biology [BMC Plant Biol] 2019 Apr 11; Vol. 19 (1), pp. 139. Date of Electronic Publication: 2019 Apr 11.
Typ publikacji:
Journal Article
MeSH Terms:
Proteome*
Stress, Physiological*
Arabidopsis/*physiology
Arabidopsis Proteins/*metabolism
Abscisic Acid/metabolism ; Adaptation, Physiological ; Arabidopsis/genetics ; Arabidopsis Proteins/genetics ; Plant Growth Regulators/metabolism ; RNA, Messenger/genetics ; RNA, Plant/genetics ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A proteomic time course through the differentiation of human induced pluripotent stem cells into hepatocyte-like cells.
Autorzy:
Hurrell T; Department of Pharmacology, Faculty of Health Sciences, School of Medicine, University of Pretoria, Private Bag X323, Arcadia, 0007, South Africa. .; Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QR, United Kingdom. .
Segeritz CP; Wellcome-MRC Cambridge Stem Cell Institute, Anne McLaren Laboratory, University of Cambridge, Cambridge, CB2 0SZ, UK.; University of Cambridge, Robinson Way, Cambridge, CB2 0SZ, United Kingdom.
Vallier L; Wellcome-MRC Cambridge Stem Cell Institute, Anne McLaren Laboratory, University of Cambridge, Cambridge, CB2 0SZ, UK.; University of Cambridge, Robinson Way, Cambridge, CB2 0SZ, United Kingdom.; Wellcome Trust Sanger Institute, Hinxton, United Kingdom.
Lilley KS; Wellcome Trust Sanger Institute, Hinxton, United Kingdom.; Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QR, United Kingdom.
Cromarty AD; Department of Pharmacology, Faculty of Health Sciences, School of Medicine, University of Pretoria, Private Bag X323, Arcadia, 0007, South Africa.
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Źródło:
Scientific reports [Sci Rep] 2019 Mar 01; Vol. 9 (1), pp. 3270. Date of Electronic Publication: 2019 Mar 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell Differentiation*
Antigens, Differentiation/*metabolism
Hepatocytes/*metabolism
Induced Pluripotent Stem Cells/*metabolism
Antigens, Differentiation/genetics ; Hepatocytes/cytology ; Humans ; Induced Pluripotent Stem Cells/cytology ; Proteomics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A Bayesian mixture modelling approach for spatial proteomics.
Autorzy:
Crook OM; Computational Proteomics Unit, Department of Biochemistry, University of Cambridge, Cambridge, UK.; Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Cambridge, UK.; MRC Biostatistics Unit, Cambridge Institute for Public Health, Cambridge, UK.
Mulvey CM; Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Cambridge, UK.
Kirk PDW; MRC Biostatistics Unit, Cambridge Institute for Public Health, Cambridge, UK.
Lilley KS; Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Cambridge, UK.
Gatto L; Computational Proteomics Unit, Department of Biochemistry, University of Cambridge, Cambridge, UK.; Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Cambridge, UK.
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Źródło:
PLoS computational biology [PLoS Comput Biol] 2018 Nov 27; Vol. 14 (11), pp. e1006516. Date of Electronic Publication: 2018 Nov 27 (Print Publication: 2018).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Bayes Theorem*
Models, Theoretical*
Proteomics*
Algorithms ; Animals ; Embryonic Stem Cells/metabolism ; Machine Learning ; Mice ; Reproducibility of Results ; Subcellular Fractions/metabolism ; Uncertainty
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Early Responses to Severe Drought Stress in the Arabidopsis thaliana Cell Suspension Culture Proteome.
Autorzy:
Alqurashi M; Department of Biochemistry, Cambridge Centre for Proteomics, Cambridge System Biology Centre, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK. .; Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia. .
Chiapello M; Department of Biochemistry, Cambridge Centre for Proteomics, Cambridge System Biology Centre, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK. .
Bianchet C; Department of Chemistry, Biology & Biotechnology, Borgo XX giugno 74, 06121 Perugia, Italy. .
Paolocci F; CNR, Institute of Biosciences and Bioresources, Perugia Division, Via Madonna Alta, 130 06128 Perugia, Italy. .
Lilley KS; Department of Biochemistry, Cambridge Centre for Proteomics, Cambridge System Biology Centre, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK. .
Gehring C; Biological and Environmental Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia. .; Department of Chemistry, Biology & Biotechnology, Borgo XX giugno 74, 06121 Perugia, Italy. .
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Źródło:
Proteomes [Proteomes] 2018 Oct 02; Vol. 6 (4). Date of Electronic Publication: 2018 Oct 02.
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A subcellular map of the human proteome.
Autorzy:
Thul PJ; Science for Life Laboratory, School of Biotechnology, KTH Royal Institute of Technology, SE-171 21 Stockholm, Sweden.
Åkesson L; Science for Life Laboratory, School of Biotechnology, KTH Royal Institute of Technology, SE-171 21 Stockholm, Sweden.
Wiking M; Science for Life Laboratory, School of Biotechnology, KTH Royal Institute of Technology, SE-171 21 Stockholm, Sweden.
Mahdessian D; Science for Life Laboratory, School of Biotechnology, KTH Royal Institute of Technology, SE-171 21 Stockholm, Sweden.
Geladaki A; Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.; Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK.
Ait Blal H; Science for Life Laboratory, School of Biotechnology, KTH Royal Institute of Technology, SE-171 21 Stockholm, Sweden.
Alm T; Science for Life Laboratory, School of Biotechnology, KTH Royal Institute of Technology, SE-171 21 Stockholm, Sweden.
Asplund A; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, SE-751 85 Uppsala, Sweden.
Björk L; Science for Life Laboratory, School of Biotechnology, KTH Royal Institute of Technology, SE-171 21 Stockholm, Sweden.
Breckels LM; Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.; Computational Proteomics Unit, Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.
Bäckström A; Science for Life Laboratory, School of Biotechnology, KTH Royal Institute of Technology, SE-171 21 Stockholm, Sweden.
Danielsson F; Science for Life Laboratory, School of Biotechnology, KTH Royal Institute of Technology, SE-171 21 Stockholm, Sweden.
Fagerberg L; Science for Life Laboratory, School of Biotechnology, KTH Royal Institute of Technology, SE-171 21 Stockholm, Sweden.
Fall J; Science for Life Laboratory, School of Biotechnology, KTH Royal Institute of Technology, SE-171 21 Stockholm, Sweden.
Gatto L; Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.; Computational Proteomics Unit, Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.
Gnann C; Science for Life Laboratory, School of Biotechnology, KTH Royal Institute of Technology, SE-171 21 Stockholm, Sweden.
Hober S; Department of Proteomics, School of Biotechnology, KTH Royal Institute of Technology, SE-106 91 Stockholm, Sweden.
Hjelmare M; Science for Life Laboratory, School of Biotechnology, KTH Royal Institute of Technology, SE-171 21 Stockholm, Sweden.
Johansson F; Science for Life Laboratory, School of Biotechnology, KTH Royal Institute of Technology, SE-171 21 Stockholm, Sweden.
Lee S; Science for Life Laboratory, School of Biotechnology, KTH Royal Institute of Technology, SE-171 21 Stockholm, Sweden.
Lindskog C; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, SE-751 85 Uppsala, Sweden.
Mulder J; Science for Life Laboratory, Department of Neuroscience, Karolinska Institute, SE-171 77 Stockholm, Sweden.
Mulvey CM; Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.
Nilsson P; Science for Life Laboratory, School of Biotechnology, KTH Royal Institute of Technology, SE-171 21 Stockholm, Sweden.
Oksvold P; Science for Life Laboratory, School of Biotechnology, KTH Royal Institute of Technology, SE-171 21 Stockholm, Sweden.
Rockberg J; Department of Proteomics, School of Biotechnology, KTH Royal Institute of Technology, SE-106 91 Stockholm, Sweden.
Schutten R; Science for Life Laboratory, School of Biotechnology, KTH Royal Institute of Technology, SE-171 21 Stockholm, Sweden.
Schwenk JM; Science for Life Laboratory, School of Biotechnology, KTH Royal Institute of Technology, SE-171 21 Stockholm, Sweden.
Sivertsson Å; Science for Life Laboratory, School of Biotechnology, KTH Royal Institute of Technology, SE-171 21 Stockholm, Sweden.
Sjöstedt E; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, SE-751 85 Uppsala, Sweden.
Skogs M; Science for Life Laboratory, School of Biotechnology, KTH Royal Institute of Technology, SE-171 21 Stockholm, Sweden.
Stadler C; Science for Life Laboratory, School of Biotechnology, KTH Royal Institute of Technology, SE-171 21 Stockholm, Sweden.
Sullivan DP; Science for Life Laboratory, School of Biotechnology, KTH Royal Institute of Technology, SE-171 21 Stockholm, Sweden.
Tegel H; Department of Proteomics, School of Biotechnology, KTH Royal Institute of Technology, SE-106 91 Stockholm, Sweden.
Winsnes C; Science for Life Laboratory, School of Biotechnology, KTH Royal Institute of Technology, SE-171 21 Stockholm, Sweden.
Zhang C; Science for Life Laboratory, School of Biotechnology, KTH Royal Institute of Technology, SE-171 21 Stockholm, Sweden.
Zwahlen M; Science for Life Laboratory, School of Biotechnology, KTH Royal Institute of Technology, SE-171 21 Stockholm, Sweden.
Mardinoglu A; Science for Life Laboratory, School of Biotechnology, KTH Royal Institute of Technology, SE-171 21 Stockholm, Sweden.
Pontén F; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, SE-751 85 Uppsala, Sweden.
von Feilitzen K; Science for Life Laboratory, School of Biotechnology, KTH Royal Institute of Technology, SE-171 21 Stockholm, Sweden.
Lilley KS; Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.
Uhlén M; Science for Life Laboratory, School of Biotechnology, KTH Royal Institute of Technology, SE-171 21 Stockholm, Sweden. .
Lundberg E; Science for Life Laboratory, School of Biotechnology, KTH Royal Institute of Technology, SE-171 21 Stockholm, Sweden. .
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Źródło:
Science (New York, N.Y.) [Science] 2017 May 26; Vol. 356 (6340). Date of Electronic Publication: 2017 May 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Molecular Imaging*
Protein Interaction Maps*
Single-Cell Analysis*
Organelles/*chemistry
Organelles/*metabolism
Proteome/*analysis
Proteome/*metabolism
Cell Line ; Datasets as Topic ; Female ; Humans ; Male ; Mass Spectrometry ; Microscopy, Fluorescence ; Protein Interaction Mapping ; Proteome/genetics ; Reproducibility of Results ; Subcellular Fractions ; Transcriptome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The RNA-binding protein repertoire of Arabidopsis thaliana.
Autorzy:
Marondedze C; Cambridge Centre for Proteomics, Cambridge Systems Biology Centre, and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK.
Thomas L; Bioscience Core Laboratory, 4700 King Abdullah University of Science and Technology, 23955-6900 Thuwal, Kingdom of Saudi Arabia.
Serrano NL; Division of Biological and Environmental Sciences and Engineering, 4700 King Abdullah University of Science and Technology, 23955-6900 Thuwal, Kingdom of Saudi Arabia.
Lilley KS; Cambridge Centre for Proteomics, Cambridge Systems Biology Centre, and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK.
Gehring C; Division of Biological and Environmental Sciences and Engineering, 4700 King Abdullah University of Science and Technology, 23955-6900 Thuwal, Kingdom of Saudi Arabia.
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Źródło:
Scientific reports [Sci Rep] 2016 Jul 11; Vol. 6, pp. 29766. Date of Electronic Publication: 2016 Jul 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Arabidopsis*/genetics
Arabidopsis*/metabolism
Arabidopsis Proteins*/genetics
Arabidopsis Proteins*/metabolism
RNA-Binding Proteins*/genetics
RNA-Binding Proteins*/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Learning from Heterogeneous Data Sources: An Application in Spatial Proteomics.
Autorzy:
Breckels LM; Computational Proteomics Unit, Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom.; Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom.
Holden SB; Computer Laboratory, University of Cambridge, Cambridge, United Kingdom.
Wojnar D; Quantitative Biology Center, Universität Tübingen, Tübingen, Germany.
Mulvey CM; Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom.
Christoforou A; Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom.
Groen A; Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom.
Trotter MW; Celgene Institute for Translational Research Europe (CITRE), Sevilla, Spain.
Kohlbacher O; Quantitative Biology Center, Universität Tübingen, Tübingen, Germany.; Center for Bioinformatics, Universität Tübingen, Tübingen, Germany.; Biomolecular Interactions, Max Planck Institute for Developmental Biology, Tübingen, Germany.
Lilley KS; Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom.
Gatto L; Computational Proteomics Unit, Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom.; Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom.
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Źródło:
PLoS computational biology [PLoS Comput Biol] 2016 May 13; Vol. 12 (5), pp. e1004920. Date of Electronic Publication: 2016 May 13 (Print Publication: 2016).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Proteome/*metabolism
Proteomics/*statistics & numerical data
Algorithms ; Animals ; Arabidopsis ; Computational Biology ; Data Interpretation, Statistical ; Drosophila ; Embryonic Stem Cells/metabolism ; Humans ; Information Storage and Retrieval ; Mass Spectrometry ; Mice ; Proteome/classification ; Software ; Subcellular Fractions/metabolism ; Support Vector Machine
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Drosophila Ionotropic Receptor 25a mediates circadian clock resetting by temperature.
Autorzy:
Chen C; Department of Cell and Developmental Biology, University College London, 21 University Street, London WC1E 6DE, UK.
Buhl E; School of Physiology and Pharmacology, University of Bristol, University Walk, Bristol BS8 1TD, UK.
Xu M; Department of Cell and Developmental Biology, University College London, 21 University Street, London WC1E 6DE, UK.
Croset V; Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, CH-1015 Lausanne, Switzerland.
Rees JS; Cambridge Centre for Proteomics, Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK.
Lilley KS; Cambridge Centre for Proteomics, Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK.
Benton R; Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, CH-1015 Lausanne, Switzerland.
Hodge JJ; School of Physiology and Pharmacology, University of Bristol, University Walk, Bristol BS8 1TD, UK.
Stanewsky R; Department of Cell and Developmental Biology, University College London, 21 University Street, London WC1E 6DE, UK.
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Źródło:
Nature [Nature] 2015 Nov 26; Vol. 527 (7579), pp. 516-20. Date of Electronic Publication: 2015 Nov 18.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Temperature*
Circadian Clocks/*physiology
Circadian Rhythm/*physiology
Drosophila Proteins/*metabolism
Drosophila melanogaster/*physiology
Receptors, Ionotropic Glutamate/*metabolism
Animals ; CLOCK Proteins/metabolism ; Drosophila Proteins/genetics ; Drosophila melanogaster/cytology ; Extremities/innervation ; Female ; Male ; Mechanoreceptors/cytology ; Mechanoreceptors/metabolism ; Receptors, Ionotropic Glutamate/genetics ; Sensory Receptor Cells/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Proteome labeling and protein identification in specific tissues and at specific developmental stages in an animal.
Autorzy:
Elliott TS; 1] Medical Research Council Laboratory of Molecular Biology, Cambridge, England, UK. [2].
Townsley FM; 1] Medical Research Council Laboratory of Molecular Biology, Cambridge, England, UK. [2].
Bianco A; 1] Medical Research Council Laboratory of Molecular Biology, Cambridge, England, UK. [2].
Ernst RJ; Medical Research Council Laboratory of Molecular Biology, Cambridge, England, UK.
Sachdeva A; Medical Research Council Laboratory of Molecular Biology, Cambridge, England, UK.
Elsässer SJ; Medical Research Council Laboratory of Molecular Biology, Cambridge, England, UK.
Davis L; Medical Research Council Laboratory of Molecular Biology, Cambridge, England, UK.
Lang K; Medical Research Council Laboratory of Molecular Biology, Cambridge, England, UK.
Pisa R; 1] Medical Research Council Laboratory of Molecular Biology, Cambridge, England, UK. [2] Department of Chemistry, University of Cambridge, Cambridge, England, UK.
Greiss S; Medical Research Council Laboratory of Molecular Biology, Cambridge, England, UK.
Lilley KS; Department of Biochemistry, University of Cambridge, Cambridge, England, UK.
Chin JW; 1] Medical Research Council Laboratory of Molecular Biology, Cambridge, England, UK. [2] Department of Chemistry, University of Cambridge, Cambridge, England, UK.
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Źródło:
Nature biotechnology [Nat Biotechnol] 2014 May; Vol. 32 (5), pp. 465-72. Date of Electronic Publication: 2014 Apr 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Proteins/*analysis
Proteome/*analysis
Proteomics/*methods
Amino Acids/chemistry ; Amino Acids/metabolism ; Animals ; Biotechnology ; Computational Biology ; Drosophila melanogaster ; Electrophoresis, Gel, Two-Dimensional ; Escherichia coli ; Female ; HEK293 Cells ; Humans ; Image Processing, Computer-Assisted ; Molecular Probes ; Organ Specificity ; Ovary/chemistry ; Ovary/growth & development ; Proteins/chemistry ; Proteins/metabolism ; Proteins/physiology ; Proteome/chemistry ; Proteome/metabolism ; Proteome/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
RNA-seq reveals the RNA binding proteins, Hfq and RsmA, play various roles in virulence, antibiotic production and genomic flux in Serratia sp. ATCC 39006.
Autorzy:
Wilf NM
Reid AJ
Ramsay JP
Williamson NR
Croucher NJ
Gatto L
Hester SS
Goulding D
Barquist L
Lilley KS
Kingsley RA
Dougan G
Salmond GP; Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QW, UK. .
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Źródło:
BMC genomics [BMC Genomics] 2013 Nov 22; Vol. 14, pp. 822. Date of Electronic Publication: 2013 Nov 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Anti-Bacterial Agents/*biosynthesis
Bacterial Proteins/*genetics
Bacterial Proteins/*metabolism
Host Factor 1 Protein/*genetics
Host Factor 1 Protein/*metabolism
Serratia/*genetics
Serratia/*metabolism
Bacteriophages/genetics ; Bacteriophages/metabolism ; Cluster Analysis ; Electron Transport/genetics ; Flagella/genetics ; Flagella/metabolism ; Gene Expression Regulation, Bacterial ; Genome, Bacterial ; Mutation ; Operon ; Prodigiosin/metabolism ; Proteome ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Regulatory Sequences, Nucleic Acid ; Sequence Analysis, RNA ; Serratia/pathogenicity ; Serratia/virology ; Transcriptome ; Virulence/genetics ; Virulence Factors/genetics ; Virulence Factors/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I.
Autorzy:
Chouchani ET; Medical Research Council Mitochondrial Biology Unit, Cambridge, UK.
Methner C
Nadtochiy SM
Logan A
Pell VR
Ding S
James AM
Cochemé HM
Reinhold J
Lilley KS
Partridge L
Fearnley IM
Robinson AJ
Hartley RC
Smith RA
Krieg T
Brookes PS
Murphy MP
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Źródło:
Nature medicine [Nat Med] 2013 Jun; Vol. 19 (6), pp. 753-9. Date of Electronic Publication: 2013 May 26.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Cysteine/*metabolism
Electron Transport Complex I/*metabolism
Mitochondria, Heart/*metabolism
Mitochondrial Proteins/*metabolism
Myocardial Reperfusion Injury/*prevention & control
Animals ; Male ; Mice ; Mice, Inbred C57BL ; Nitrosation ; Protein Subunits ; Rats ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Structural and functional characteristics of cGMP-dependent methionine oxidation in Arabidopsis thaliana proteins.
Autorzy:
Marondedze C; Division of Chemical and Life Sciences and Engineering, King Abdullah University of Science and Technology, Thuwal, 23955-6900, Saudi Arabia. .
Turek I
Parrott B
Thomas L
Jankovic B
Lilley KS
Gehring C
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Źródło:
Cell communication and signaling : CCS [Cell Commun Signal] 2013 Jan 05; Vol. 11 (1), pp. 1. Date of Electronic Publication: 2013 Jan 05.
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Isobaric tagging approaches in quantitative proteomics: the ups and downs.
Autorzy:
Christoforou AL; Cambridge Centre for Proteomics, Cambridge Systems Biology Centre, Department of Biochemistry, University of Cambridge, Cambridge, UK. />Lilley KS
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Źródło:
Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2012 Sep; Vol. 404 (4), pp. 1029-37. Date of Electronic Publication: 2012 May 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Proteins/*chemistry
Proteomics/*methods
Animals ; Humans ; Isotope Labeling/instrumentation ; Isotope Labeling/methods ; Mass Spectrometry/instrumentation ; Mass Spectrometry/methods ; Proteins/metabolism ; Proteomics/instrumentation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 30

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