DNA methylation of insulin signaling pathways is associated with HOMA2-IR in primary myoblasts from older adults.
Autorzy:
Burton MA; Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, UK. Garratt ES; Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, UK.; NIHR Southampton Biomedical Research Centre, University of Southampton & University Hospital Southampton NHS Foundation Trust, Southampton, UK. Hewitt MO; Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, UK. Sharkh HY; Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, UK.; Biological Sciences, University of Southampton, Southampton, UK. Antoun E; Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, UK. Westbury LD; MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK. Dennison EM; NIHR Southampton Biomedical Research Centre, University of Southampton & University Hospital Southampton NHS Foundation Trust, Southampton, UK.; MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK. Harvey NC; NIHR Southampton Biomedical Research Centre, University of Southampton & University Hospital Southampton NHS Foundation Trust, Southampton, UK.; MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK. Cooper C; NIHR Southampton Biomedical Research Centre, University of Southampton & University Hospital Southampton NHS Foundation Trust, Southampton, UK.; MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK.; NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK. MacIsaac JL; Department of Medical Genetics, Faculty of Medicine, Edwin S.H. Leong Healthy Aging Program, University of British Columbia, Vancouver, Canada. Kobor MS; Department of Medical Genetics, Faculty of Medicine, Edwin S.H. Leong Healthy Aging Program, University of British Columbia, Vancouver, Canada. Patel HP; NIHR Southampton Biomedical Research Centre, University of Southampton & University Hospital Southampton NHS Foundation Trust, Southampton, UK.; MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK.; Faculty of Medicine, Academic Geriatric Medicine, University of Southampton, Southampton, UK. Godfrey KM; Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, UK.; NIHR Southampton Biomedical Research Centre, University of Southampton & University Hospital Southampton NHS Foundation Trust, Southampton, UK.; MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK. LillycropKA; Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, UK. .; NIHR Southampton Biomedical Research Centre, University of Southampton & University Hospital Southampton NHS Foundation Trust, Southampton, UK. .; Biological Sciences, University of Southampton, Southampton, UK. .
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Źródło:
Skeletal muscle [Skelet Muscle] 2023 Oct 28; Vol. 13 (1), pp. 17. Date of Electronic Publication: 2023 Oct 28.
DNA methylation signatures associated with cardiometabolic risk factors in children from India and The Gambia: results from the EMPHASIS study.
Autorzy:
Antoun E; School of Medicine, University of Southampton, Southampton, UK. Issarapu P; Genomic Research On Complex Diseases (GRC Group), CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India. di Gravio C; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK. Shrestha S; Genomic Research On Complex Diseases (GRC Group), CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.; School of Basic and Applied Sciences, Dayananda Sagar University, Bangalore, India. Betts M; MRC Unit The Gambia at the London, School of Hygiene and Tropical Medicine, Fajara, The Gambia. Saffari A; MRC Unit The Gambia at the London, School of Hygiene and Tropical Medicine, London, UK. Sahariah SA; Centre for the Study of Social Change, Mumbai, India. Sankareswaran A; Genomic Research On Complex Diseases (GRC Group), CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India. Arumalla M; Genomic Research On Complex Diseases (GRC Group), CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India. Prentice AM; MRC Unit The Gambia at the London, School of Hygiene and Tropical Medicine, Fajara, The Gambia. Fall CHD; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK. Silver MJ; MRC Unit The Gambia at the London, School of Hygiene and Tropical Medicine, London, UK. Chandak GR; Genomic Research On Complex Diseases (GRC Group), CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India. LillycropKA; School of Medicine, University of Southampton, Southampton, UK. .; Biological Sciences, University of Southampton, Southampton, UK. .
Genetically modified plants are an alternative to oily fish for providing n -3 polyunsaturated fatty acids in the human diet: A summary of the findings of a Biotechnology and Biological Sciences Research Council funded project.
Autorzy:
West AL; Faculty of Medicine School of Human Development and Health University of Southampton Southampton UK. Miles EA; Faculty of Medicine School of Human Development and Health University of Southampton Southampton UK. LillycropKA; Faculty of Natural and Environmental Sciences Centre for Biological Sciences University of Southampton Southampton UK. Napier JA; Department of Plant Sciences Rothamsted Research Harpenden UK. Calder PC; Faculty of Medicine School of Human Development and Health University of Southampton Southampton UK.; NIHR Southampton Biomedical Research Centre University Hospital Southampton NHS Foundation Trust University of Southampton Southampton UK. Burdge GC; Faculty of Medicine School of Human Development and Health University of Southampton Southampton UK.
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Źródło:
Nutrition bulletin [Nutr Bull] 2021 Mar; Vol. 46 (1), pp. 60-68. Date of Electronic Publication: 2020 Dec 23.
Childhood DNA methylation as a marker of early life rapid weight gain and subsequent overweight.
Autorzy:
Robinson N; Population Health Sciences, Newcastle University Medical School, Newcastle University, Newcastle upon Tyne, UK. . Brown H; Population Health Sciences, Newcastle University Medical School, Newcastle University, Newcastle upon Tyne, UK. Antoun E; Institute of Developmental Sciences, Biological Sciences and NIHR Southampton Biomedical Research Centre, University of Southampton, Southampton, UK. Godfrey KM; MRC Lifecourse Epidemiology Unit and NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK. Hanson MA; Institute of Developmental Sciences, Biological Sciences and NIHR Southampton Biomedical Research Centre, University of Southampton, Southampton, UK. LillycropKA; Institute of Developmental Sciences, Biological Sciences and NIHR Southampton Biomedical Research Centre, University of Southampton, Southampton, UK. Crozier SR; MRC Lifecourse Epidemiology Unit and NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK. Murray R; Institute of Developmental Sciences, Biological Sciences and NIHR Southampton Biomedical Research Centre, University of Southampton, Southampton, UK. Pearce MS; Population Health Sciences, Newcastle University Medical School, Newcastle University, Newcastle upon Tyne, UK. Relton CL; MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. Albani V; Population Health Sciences, Newcastle University Medical School, Newcastle University, Newcastle upon Tyne, UK. McKay JA; Department of Applied Sciences, Northumbria University, Newcastle upon Tyne, UK.
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Źródło:
Clinical epigenetics [Clin Epigenetics] 2021 Jan 12; Vol. 13 (1), pp. 8. Date of Electronic Publication: 2021 Jan 12.
Typ publikacji:
Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Maternal dysglycaemia, changes in the infant's epigenome modified with a diet and physical activity intervention in pregnancy: Secondary analysis of a randomised control trial.
Autorzy:
Antoun E; Biological Sciences, Institute of Developmental Sciences, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, United Kingdom. Kitaba NT; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom. Titcombe P; MRC Lifecourse Epidemiology Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom. Dalrymple KV; Department of Women and Children's Health, School of Life Course Sciences, King's College London, London, United Kingdom. Garratt ES; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Trust, Southampton, United Kingdom. Barton SJ; MRC Lifecourse Epidemiology Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom. Murray R; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom. Seed PT; Department of Women and Children's Health, School of Life Course Sciences, King's College London, London, United Kingdom. Holbrook JD; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom. Kobor MS; BC Childrens Hospital Research Institute, Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, Canada. Lin DT; BC Childrens Hospital Research Institute, Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, Canada. MacIsaac JL; BC Childrens Hospital Research Institute, Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, Canada. Burdge GC; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom. White SL; Department of Women and Children's Health, School of Life Course Sciences, King's College London, London, United Kingdom. Poston L; Department of Women and Children's Health, School of Life Course Sciences, King's College London, London, United Kingdom. Godfrey KM; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Trust, Southampton, United Kingdom. LillycropKA; Biological Sciences, Institute of Developmental Sciences, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, United Kingdom.; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Trust, Southampton, United Kingdom.
Maternal Obesity during Pregnancy Alters Daily Activity and Feeding Cycles, and Hypothalamic Clock Gene Expression in Adult Male Mouse Offspring.
Autorzy:
Cleal JK; School of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK. . Bruce KD; School of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK. . Shearer JL; School of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK. . Thomas H; School of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK. . Plume J; Centre for Biological Sciences, Faculty of Natural and Environmental Sciences, University of Southampton, Southampton SO17 1BJ, UK. . Gregory L; Centre for Biological Sciences, Faculty of Natural and Environmental Sciences, University of Southampton, Southampton SO17 1BJ, UK. . Shepard JN; Centre for Biological Sciences, Faculty of Natural and Environmental Sciences, University of Southampton, Southampton SO17 1BJ, UK. . Spiers-Fitzgerald KL; School of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK. . Mani R; School of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK. . Lewis RM; School of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK. . LillycropKA; Centre for Biological Sciences, Faculty of Natural and Environmental Sciences, University of Southampton, Southampton SO17 1BJ, UK. K.A.Lillycrop@soton.ac.uk. Hanson MA; School of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK. . Byrne CD; School of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK. . Cagampang FR; School of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK. .
Correction: Fat and Carbohydrate Intake over Three Generations Modify Growth, Metabolism and Cardiovascular Phenotype in Female Mice in an Age-Related Manner.
DNA methylation of Th2 lineage determination genes at birth is associated with allergic outcomes in childhood.
Autorzy:
Barton SJ; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK. Ngo S; Liggins Institute, University of Auckland, Auckland, New Zealand. Costello P; Human Development and Health Academic Unit, University of Southampton, Southampton, UK. Garratt E; Human Development and Health Academic Unit, University of Southampton, Southampton, UK. El-Heis S; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK. Antoun E; Human Development and Health Academic Unit, University of Southampton, Southampton, UK. Clarke-Harris R; Human Development and Health Academic Unit, University of Southampton, Southampton, UK.; NIHR Southampton Biomedical Research Centre, Southampton General Hospital, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, UK. Murray R; Human Development and Health Academic Unit, University of Southampton, Southampton, UK. Bhatt T; Human Development and Health Academic Unit, University of Southampton, Southampton, UK. Burdge G; Human Development and Health Academic Unit, University of Southampton, Southampton, UK. Cooper C; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.; NIHR Southampton Biomedical Research Centre, Southampton General Hospital, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, UK. Inskip H; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.; NIHR Southampton Biomedical Research Centre, Southampton General Hospital, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, UK. van der Beek EM; Nutricia Research, Danone Nutricia Early Life Nutrition, Utrecht, The Netherlands.; Department of Pediatrics, University medical Centre Groningen, Groningen, The Netherlands. Sheppard A; Liggins Institute, University of Auckland, Auckland, New Zealand. Godfrey KM; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.; Human Development and Health Academic Unit, University of Southampton, Southampton, UK.; NIHR Southampton Biomedical Research Centre, Southampton General Hospital, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, UK. LillycropKA; NIHR Southampton Biomedical Research Centre, Southampton General Hospital, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, UK.; Centre for Biological Sciences, University of Southampton, Southampton, UK.
Fat and carbohydrate intake over three generations modify growth, metabolism and cardiovascular phenotype in female mice in an age-related manner.
Autorzy:
Hoile SP; Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom. Grenfell LR; Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom. Hanson MA; Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom. LillycropKA; Centre for Biological Sciences, Faculty of Environmental and Natural Sciences, University of Southampton, Southampton, United Kingdom. Burdge GC; Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
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Źródło:
PloS one [PLoS One] 2015 Aug 12; Vol. 10 (8), pp. e0134664. Date of Electronic Publication: 2015 Aug 12 (Print Publication: 2015).
Supplementation with N-3 long-chain polyunsaturated fatty acids or olive oil in men and women with renal disease induces differential changes in the DNA methylation of FADS2 and ELOVL5 in peripheral blood mononuclear cells.
Autorzy:
Hoile SP; Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom. Clarke-Harris R; Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom. Huang RC; Telethon Kids Institute, Perth, Australia. Calder PC; Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom; NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, United Kingdom. Mori TA; School of Medicine and Pharmacology, Royal Perth Hospital Unit, University of Western Australia, Perth, Australia. Beilin LJ; School of Medicine and Pharmacology, Royal Perth Hospital Unit, University of Western Australia, Perth, Australia. LillycropKA; Centre for Biological Sciences, Faculty of Natural and Environmental Sciences, University of Southampton, Southampton, United Kingdom. Burdge GC; Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
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Źródło:
PloS one [PLoS One] 2014 Oct 17; Vol. 9 (10), pp. e109896. Date of Electronic Publication: 2014 Oct 17 (Print Publication: 2014).
Typ publikacji:
Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
Differential pathways to adult metabolic dysfunction following poor nutrition at two critical developmental periods in sheep.
Autorzy:
Poore KR; Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom. Hollis LJ; Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom. Murray RJ; Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom. Warlow A; Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom. Brewin A; Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom. Fulford L; Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom. Cleal JK; Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom. LillycropKA; Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom. Burdge GC; Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom. Hanson MA; Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom. Green LR; Academic Unit of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
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Źródło:
PloS one [PLoS One] 2014 Mar 06; Vol. 9 (3), pp. e90994. Date of Electronic Publication: 2014 Mar 06 (Print Publication: 2014).
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