Temat: "Lim Kinases" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: LIM Kinases: From Molecular to Pathological Features.
Autorzy:: Bénédetti H; Centre de Biophysique Moléculaire, UPR4301, CNRS, University of Orleans and INSERM, CEDEX 2, 45071 Orleans, France.
Vallée B; Centre de Biophysique Moléculaire, UPR4301, CNRS, University of Orleans and INSERM, CEDEX 2, 45071 Orleans, France.; Pokaż więcej
Źródło:: Cells [Cells] 2023 Jun 16; Vol. 12 (12). Date of Electronic Publication: 2023 Jun 16.
Typ publikacji:: Editorial; Research Support, Non-U.S. Gov't
MeSH Terms:: Lim Kinases*/genetics

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Skocz do pozycji: 2.

Tytuł:: LIM Kinases, LIMK1 and LIMK2, Are Crucial Node Actors of the Cell Fate: Molecular to Pathological Features.
Autorzy:: Villalonga E; Centre de Biophysique Moléculaire; UPR4301, CNRS, University of Orleans and INSERM, CEDEX 2, 45071 Orleans, France.
Mosrin C; Centre de Biophysique Moléculaire; UPR4301, CNRS, University of Orleans and INSERM, CEDEX 2, 45071 Orleans, France.
Normand T; Centre de Biophysique Moléculaire; UPR4301, CNRS, University of Orleans and INSERM, CEDEX 2, 45071 Orleans, France.
Girardin C; Centre de Biophysique Moléculaire; UPR4301, CNRS, University of Orleans and INSERM, CEDEX 2, 45071 Orleans, France.
Serrano A; Centre de Biophysique Moléculaire; UPR4301, CNRS, University of Orleans and INSERM, CEDEX 2, 45071 Orleans, France.
Žunar B; Laboratory for Biochemistry, Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, 10000 Zagreb, Croatia.
Doudeau M; Centre de Biophysique Moléculaire; UPR4301, CNRS, University of Orleans and INSERM, CEDEX 2, 45071 Orleans, France.
Godin F; Centre de Biophysique Moléculaire; UPR4301, CNRS, University of Orleans and INSERM, CEDEX 2, 45071 Orleans, France.
Bénédetti H; Centre de Biophysique Moléculaire; UPR4301, CNRS, University of Orleans and INSERM, CEDEX 2, 45071 Orleans, France.
Vallée B; Centre de Biophysique Moléculaire; UPR4301, CNRS, University of Orleans and INSERM, CEDEX 2, 45071 Orleans, France.; Pokaż więcej
Źródło:: Cells [Cells] 2023 Mar 04; Vol. 12 (5). Date of Electronic Publication: 2023 Mar 04.
Typ publikacji:: Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:: Lim Kinases*/metabolism
Cytoskeleton*/metabolism
Phosphorylation ; Actin Cytoskeleton/metabolism ; Cell Differentiation

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Skocz do pozycji: 3.

Tytuł:: Developing a prognosis and chemotherapy evaluating model for colon adenocarcinoma based on mitotic catastrophe-related genes.
Autorzy:: Liu Y; Nantong Tumor Hospital and Affiliated Tumor Hospital of Nantong University, Nantong, China.; Affiliated Hospital 2 of Nantong University, Nantong First People's Hospital, Nantong, China.
Zhao Y; Nantong Tumor Hospital and Affiliated Tumor Hospital of Nantong University, Nantong, China.; The Second People's Hospital of Nantong, Nantong, China.
Zhang S; Nantong Tumor Hospital and Affiliated Tumor Hospital of Nantong University, Nantong, China.
Rong S; Nantong Tumor Hospital and Affiliated Tumor Hospital of Nantong University, Nantong, China.
He S; Affiliated Hospital 2 of Nantong University, Nantong First People's Hospital, Nantong, China.
Hua L; Affiliated Hospital 2 of Nantong University, Nantong First People's Hospital, Nantong, China.
Wang X; Nantong Tumor Hospital and Affiliated Tumor Hospital of Nantong University, Nantong, China. .
Chen H; Nantong Tumor Hospital and Affiliated Tumor Hospital of Nantong University, Nantong, China. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2024 Jan 18; Vol. 14 (1), pp. 1655. Date of Electronic Publication: 2024 Jan 18.
Typ publikacji:: Journal Article
MeSH Terms:: Colonic Neoplasms*/drug therapy
Colonic Neoplasms*/genetics
Adenocarcinoma*/drug therapy
Adenocarcinoma*/genetics
Humans ; DNA Copy Number Variations/genetics ; Prognosis ; Cell Death ; Tumor Microenvironment ; Lim Kinases ; Transcription Factors ; Adaptor Proteins, Signal Transducing ; LIM Domain Proteins

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Skocz do pozycji: 4.

Tytuł:: LIM Kinases, Promising but Reluctant Therapeutic Targets: Chemistry and Preclinical Validation In Vivo.
Autorzy:: Berabez R; Institut de Chimie Organique et Analytique, University of Orléans, CNRS UMR 7311, CEDEX 2, 45067 Orléans, France.
Routier S; Institut de Chimie Organique et Analytique, University of Orléans, CNRS UMR 7311, CEDEX 2, 45067 Orléans, France.
Bénédetti H; Centre de Biophysique Moléculaire, UPR 4301, CNRS, University of Orléans and INSERM, CEDEX 2, 45071 Orléans, France.
Plé K; Institut de Chimie Organique et Analytique, University of Orléans, CNRS UMR 7311, CEDEX 2, 45067 Orléans, France.
Vallée B; Centre de Biophysique Moléculaire, UPR 4301, CNRS, University of Orléans and INSERM, CEDEX 2, 45071 Orléans, France.; Pokaż więcej
Źródło:: Cells [Cells] 2022 Jun 30; Vol. 11 (13). Date of Electronic Publication: 2022 Jun 30.
Typ publikacji:: Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:: Actins*/metabolism
Lim Kinases*/metabolism
Actin Cytoskeleton/metabolism ; Actin Depolymerizing Factors/metabolism ; Cytoskeleton/metabolism ; Humans

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Skocz do pozycji: 5.

Tytuł:: Protein domain-based prediction of drug/compound-target interactions and experimental validation on LIM kinases.
Autorzy:: Doğan T; Department of Computer Engineering, Hacettepe University, Ankara, Turkey.; Institute of Informatics, Hacettepe University, Ankara, Turkey.; CanSyL, Graduate School of Informatics, Middle East Technical University, Ankara, Turkey.
Akhan Güzelcan E; CanSyL, Graduate School of Informatics, Middle East Technical University, Ankara, Turkey.; Center for Genomics and Rare Diseases & Biobank for Rare Diseases, Hacettepe University, Ankara, Turkey.
Baumann M; School of Chemistry, University College Dublin, Dublin, Ireland.
Koyas A; CanSyL, Graduate School of Informatics, Middle East Technical University, Ankara, Turkey.
Atas H; CanSyL, Graduate School of Informatics, Middle East Technical University, Ankara, Turkey.
Baxendale IR; Department of Chemistry, University of Durham, Durham, United Kingdom.
Martin M; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom.
Cetin-Atalay R; CanSyL, Graduate School of Informatics, Middle East Technical University, Ankara, Turkey.; Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, Illinois, United States of America.; Pokaż więcej
Źródło:: PLoS computational biology [PLoS Comput Biol] 2021 Nov 29; Vol. 17 (11), pp. e1009171. Date of Electronic Publication: 2021 Nov 29 (Print Publication: 2021).
Typ publikacji:: Journal Article; Validation Study
MeSH Terms:: Lim Kinases/*antagonists & inhibitors
Lim Kinases/*chemistry
Actin Depolymerizing Factors/chemistry ; Actin Depolymerizing Factors/metabolism ; Cell Line, Tumor ; Cell Movement/drug effects ; Computational Biology ; Computer Simulation ; Drug Development ; Drug Discovery ; Drug Evaluation, Preclinical ; Drug Interactions ; Humans ; In Vitro Techniques ; Ligands ; Lim Kinases/metabolism ; Machine Learning ; Molecular Docking Simulation ; Neoplasm Invasiveness/prevention & control ; Neoplasms/drug therapy ; Neoplasms/enzymology ; Network Pharmacology/statistics & numerical data ; Phosphorylation/drug effects ; Protein Domains ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/pharmacology ; User-Computer Interface

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Skocz do pozycji: 6.

Tytuł:: The Role of LIM Kinases during Development: A Lens to Get a Glimpse of Their Implication in Pathologies.
Autorzy:: Ribba AS; Institute for Advanced Biosciences, Team Cytoskeletal Dynamics and Nuclear Functions, INSERM U1209, CNRS UMR5309, Université Grenoble Alpes, 38000 Grenoble, France.
Fraboulet S; Institute for Advanced Biosciences, Team Cytoskeletal Dynamics and Nuclear Functions, INSERM U1209, CNRS UMR5309, Université Grenoble Alpes, 38000 Grenoble, France.
Sadoul K; Institute for Advanced Biosciences, Team Cytoskeletal Dynamics and Nuclear Functions, INSERM U1209, CNRS UMR5309, Université Grenoble Alpes, 38000 Grenoble, France.
Lafanechère L; Institute for Advanced Biosciences, Team Cytoskeletal Dynamics and Nuclear Functions, INSERM U1209, CNRS UMR5309, Université Grenoble Alpes, 38000 Grenoble, France.; Pokaż więcej
Źródło:: Cells [Cells] 2022 Jan 25; Vol. 11 (3). Date of Electronic Publication: 2022 Jan 25.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:: Lim Kinases*/metabolism
Protein Kinases*/metabolism
Actin Depolymerizing Factors/metabolism ; Animals ; Phosphorylation ; Phylogeny

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Skocz do pozycji: 7.

Tytuł:: The Role of LIM Kinase in the Male Urogenital System.
Autorzy:: Park J; Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
Kim SW; Department of Urology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul 03080, Korea.
Cho MC; Department of Urology, SMG-SNU Boramae Medical Center, Seoul National University College of Medicine, Seoul 07061, Korea.; Pokaż więcej
Źródło:: Cells [Cells] 2021 Dec 28; Vol. 11 (1). Date of Electronic Publication: 2021 Dec 28.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:: Genitalia, Male/*enzymology
Lim Kinases/*metabolism
Animals ; Fibrosis ; Gametogenesis ; Genital Diseases, Male/enzymology ; Genital Diseases, Male/pathology ; Humans ; Lim Kinases/chemistry ; Male ; Models, Biological

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Skocz do pozycji: 8.

Tytuł:: LIM-Kinases in Synaptic Plasticity, Memory, and Brain Diseases.
Autorzy:: Ben Zablah Y; Program in Neurosciences and Mental Health, The Hospital for Sick Children, Peter Gilgan Centre for Research and Learning, Toronto, ON M5G 0A4, Canada.; Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.
Zhang H; Program in Neurosciences and Mental Health, The Hospital for Sick Children, Peter Gilgan Centre for Research and Learning, Toronto, ON M5G 0A4, Canada.; Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.
Gugustea R; Program in Neurosciences and Mental Health, The Hospital for Sick Children, Peter Gilgan Centre for Research and Learning, Toronto, ON M5G 0A4, Canada.; Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.
Jia Z; Program in Neurosciences and Mental Health, The Hospital for Sick Children, Peter Gilgan Centre for Research and Learning, Toronto, ON M5G 0A4, Canada.; Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.; Pokaż więcej
Źródło:: Cells [Cells] 2021 Aug 13; Vol. 10 (8). Date of Electronic Publication: 2021 Aug 13.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:: Brain Diseases/*pathology
Lim Kinases/*metabolism
Neuronal Plasticity/*physiology
Animals ; Brain Diseases/metabolism ; Humans ; Lim Kinases/deficiency ; Lim Kinases/genetics ; Memory/physiology ; Signal Transduction ; Synapses/metabolism

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Skocz do pozycji: 9.

Tytuł:: Endoglin Is an Endothelial Housekeeper against Inflammation: Insight in ECFC-Related Permeability through LIMK/Cofilin Pathway.
Autorzy:: Rossi E; Faculty of Pharmacy, University of Paris, F-75006 Paris, France.; IThEM, Inserm UMR-S 1140, F-75006 Paris, France.
Kauskot A; HITh, UMR-S 1176, INSERM-Faculty of Medicine, University Paris-Saclay, F-94270 Le Kremlin-Bicêtre, France.
Saller F; HITh, UMR-S 1176, INSERM-Faculty of Medicine, University Paris-Saclay, F-94270 Le Kremlin-Bicêtre, France.
Frezza E; Faculty of Pharmacy, University of Paris, F-75006 Paris, France.; CiTCoM, CNRS, Université de Paris, F-75006 Paris, France.
Poirault-Chassac S; Faculty of Pharmacy, University of Paris, F-75006 Paris, France.; IThEM, Inserm UMR-S 1140, F-75006 Paris, France.
Lokajczyk A; Faculty of Pharmacy, University of Paris, F-75006 Paris, France.; IThEM, Inserm UMR-S 1140, F-75006 Paris, France.
Bourdoncle P; Plate-Forme IMAG'IC Institut Cochin Inserm U1016-CNRS UMR8104, Université Paris Descartes, F-75006 Paris, France.
Saubaméa B; Faculty of Pharmacy, University of Paris, F-75006 Paris, France.; UMR-S 1144, F-75006 Paris, France.
Gaussem P; Faculty of Pharmacy, University of Paris, F-75006 Paris, France.; IThEM, Inserm UMR-S 1140, F-75006 Paris, France.; AP-HP, Hematology Department, Hôpital Européen Georges Pompidou, F-75015 Paris, France.
Pericacho M; Department of Physiology and Pharmacology, Universidad de Salamanca, 37008 Salamanca, Spain.
Bobe R; HITh, UMR-S 1176, INSERM-Faculty of Medicine, University Paris-Saclay, F-94270 Le Kremlin-Bicêtre, France.
Bachelot-Loza C; Faculty of Pharmacy, University of Paris, F-75006 Paris, France.; IThEM, Inserm UMR-S 1140, F-75006 Paris, France.
Pasquali S; Faculty of Pharmacy, University of Paris, F-75006 Paris, France.; CiTCoM, CNRS, Université de Paris, F-75006 Paris, France.
Bernabeu C; Centro de Investigaciones Biológicas Margarita Salas, 28040 Madrid, Spain.; Consejo Superior de Investigaciones Científicas (CSIC) and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), 28040 Madrid, Spain.
Smadja DM; Faculty of Pharmacy, University of Paris, F-75006 Paris, France.; IThEM, Inserm UMR-S 1140, F-75006 Paris, France.; AP-HP, Hematology Department, Hôpital Européen Georges Pompidou, F-75015 Paris, France.; Biosurgical Research Lab (Carpentier Foundation), F-75000 Paris, France.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Aug 17; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 17.
Typ publikacji:: Journal Article
MeSH Terms:: Cell Membrane Permeability*
Actin Depolymerizing Factors/*metabolism
Endoglin/*metabolism
Endothelial Cells/*pathology
Inflammation/*pathology
Lim Kinases/*metabolism
Neovascularization, Pathologic/*pathology
Actin Depolymerizing Factors/genetics ; Animals ; Endoglin/genetics ; Endothelial Cells/metabolism ; Inflammation/genetics ; Inflammation/metabolism ; Lim Kinases/genetics ; Mice ; Neovascularization, Pathologic/genetics ; Neovascularization, Pathologic/metabolism

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Skocz do pozycji: 10.

Tytuł:: Exosomal lncRNA H19 promotes the progression of hepatocellular carcinoma treated with Propofol via miR-520a-3p/LIMK1 axis.
Autorzy:: Wang D; Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Xing N; Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yang T; Department of Anesthesiology, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Liu J; Department of Radiotherapy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Zhao H; Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
He J; Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Ai Y; Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yang J; Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.; Pokaż więcej
Źródło:: Cancer medicine [Cancer Med] 2020 Oct; Vol. 9 (19), pp. 7218-7230. Date of Electronic Publication: 2020 Aug 07.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Agents/*pharmacology
Exosomes/*metabolism
Lim Kinases/*metabolism
Liver Neoplasms/*drug therapy
MicroRNAs/*metabolism
Propofol/*pharmacology
RNA, Long Noncoding/*metabolism
Animals ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Coculture Techniques ; Disease Progression ; Exosomes/genetics ; Exosomes/pathology ; Gene Expression Regulation, Neoplastic ; Humans ; Lim Kinases/genetics ; Liver Neoplasms/enzymology ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; Mice, Inbred BALB C ; Mice, Nude ; MicroRNAs/genetics ; Neoplasm Metastasis ; RNA, Long Noncoding/genetics ; Signal Transduction ; Tumor Burden/drug effects ; Xenograft Model Antitumor Assays

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Skocz do pozycji: 11.

Tytuł:: Effects of miR-373 Inhibition on Glioblastoma Growth by Reducing Limk1 In Vitro .
Autorzy:: Peng T; Department of Neurosurgery, The First Hospital of Jilin University, Xinmin Street 1#, Changchun 130021, China.
Wang T; Division of Orthopaedic Traumatology, The First Hospital of Jilin University, Xinmin Street 1#, Changchun 130021, China.
Liu G; Emergency Surgery, The First Hospital of Jilin University, Xinmin Street 1#, Changchun 130021, China.
Zhou L; Department of Neurosurgery, The First Hospital of Jilin University, Xinmin Street 1#, Changchun 130021, China.; Pokaż więcej
Źródło:: Journal of immunology research [J Immunol Res] 2020 Sep 28; Vol. 2020, pp. 7671502. Date of Electronic Publication: 2020 Sep 28 (Print Publication: 2020).
Typ publikacji:: Journal Article
MeSH Terms:: Brain Neoplasms/*genetics
Glioblastoma/*genetics
Growth Inhibitors/*genetics
Lim Kinases/*metabolism
MicroRNAs/*genetics
Apoptosis ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Humans ; Lim Kinases/genetics ; Proliferating Cell Nuclear Antigen/metabolism ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Radiation-Sensitizing Agents ; bcl-2-Associated X Protein/metabolism

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Skocz do pozycji: 12.

Tytuł:: RHOA inhibits chondrogenic differentiation of mesenchymal stem cells in adolescent idiopathic scoliosis.
Autorzy:: Yang M; Department of Orthopedics, Changhai Hospital, Navy Medical University, Shanghai, People's Republic of China.
Chen K; Department of Orthopedics, Changhai Hospital, Navy Medical University, Shanghai, People's Republic of China.
Hou C; Department of Orthopedics, Changhai Hospital, Navy Medical University, Shanghai, People's Republic of China.
Yang Y; Department of Orthopedics, Changhai Hospital, Navy Medical University, Shanghai, People's Republic of China.
Zhai X; Department of Orthopedics, Changhai Hospital, Navy Medical University, Shanghai, People's Republic of China.
Chen K; Department of Orthopedics, Changhai Hospital, Navy Medical University, Shanghai, People's Republic of China.
Wei X; Department of Orthopedics, Changhai Hospital, Navy Medical University, Shanghai, People's Republic of China.
Bai Y; Department of Orthopedics, Changhai Hospital, Navy Medical University, Shanghai, People's Republic of China.
Li M; Department of Orthopedics, Changhai Hospital, Navy Medical University, Shanghai, People's Republic of China.; Pokaż więcej
Źródło:: Connective tissue research [Connect Tissue Res] 2022 Sep; Vol. 63 (5), pp. 475-484. Date of Electronic Publication: 2022 Jan 12.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Mesenchymal Stem Cells*
Scoliosis*/metabolism
rhoA GTP-Binding Protein*/metabolism
Actin Depolymerizing Factors/metabolism ; Actin Depolymerizing Factors/pharmacology ; Actins/metabolism ; Actins/pharmacology ; Adolescent ; Aggrecans/metabolism ; Aggrecans/pharmacology ; Cell Differentiation ; Cells, Cultured ; Chondrogenesis ; Collagen/metabolism ; Glycosaminoglycans/metabolism ; Humans ; Lim Kinases/metabolism ; RNA, Messenger/metabolism ; SOX9 Transcription Factor/metabolism

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Skocz do pozycji: 13.

Tytuł:: Chronic administration of LIMK2 inhibitors alleviates cavernosal veno-occlusive dysfunction through suppression of cavernosal fibrosis in a rat model of erectile dysfunction after cavernosal nerve injury.
Autorzy:: Park J; Department of Urology, Seoul National University College of Medicine, Boramae Medical Center, Seoul, Korea.
Son H; Department of Urology, Seoul National University College of Medicine, Boramae Medical Center, Seoul, Korea.
Chai JS; Department of Urology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea.
Kim SW; Department of Urology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea.
Paick JS; Department of Urology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea.
Cho MC; Department of Urology, Seoul National University College of Medicine, Boramae Medical Center, Seoul, Korea.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2019 Mar 14; Vol. 14 (3), pp. e0213586. Date of Electronic Publication: 2019 Mar 14 (Print Publication: 2019).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Erectile Dysfunction*/drug therapy
Erectile Dysfunction*/enzymology
Erectile Dysfunction*/pathology
Lim Kinases*/antagonists & inhibitors
Lim Kinases*/metabolism
Penis*/enzymology
Penis*/pathology
Peripheral Nerve Injuries*/drug therapy
Peripheral Nerve Injuries*/enzymology
Peripheral Nerve Injuries*/pathology
Protein Kinase Inhibitors/*pharmacology
Signal Transduction/*drug effects
Actin Depolymerizing Factors/metabolism ; Actins/metabolism ; Animals ; Disease Models, Animal ; Fibrosis ; Male ; Rats

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Skocz do pozycji: 14.

Tytuł:: Deletion of Limk1 and Limk2 in mice does not alter cochlear development or auditory function.
Autorzy:: Fang Q; Department of Biomedical Engineering, Southern University of Science and Technology, 518000, Shenzhen, China.; Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, 210096, Nanjing, China.; Department of Pathology and Laboratory Medicine, Medical University of South Carolina, 29425, Charleston, South Carolina, USA.
Zhang Y; Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, 210096, Nanjing, China.
Da P; Department of Otolaryngology-Head and Neck Surgery, Affiliated Hospital of Nantong University, 226001, Nantong, China.
Shao B; Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, 210096, Nanjing, China.
Pan H; Department of Otolaryngology, Affiliated Sixth People's Hospital, Shanghai Jiao Tong University, 600 Yishan Road, 200233, Shanghai, China.; The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, 112008, Wenzhou, China.
He Z; Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, 210096, Nanjing, China.; Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022, Wuhan, China.
Cheng C; Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, 210096, Nanjing, China.
Li D; Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, 210096, Nanjing, China.
Guo J; Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, 210096, Nanjing, China.
Wu X; Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, 210096, Nanjing, China.
Guan M; Department of Otolaryngology, Hangzhou First People's Hospital, 310006, Hangzhou, Zhejiang, China.
Liao M; Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, 210096, Nanjing, China.
Zhang Y; Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, 210096, Nanjing, China.
Sha S; Department of Pathology and Laboratory Medicine, Medical University of South Carolina, 29425, Charleston, South Carolina, USA.
Zhou Z; Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, 210096, Nanjing, China.
Wang J; Department of Otolaryngology, Affiliated Sixth People's Hospital, Shanghai Jiao Tong University, 600 Yishan Road, 200233, Shanghai, China.; School of Human Communication Disorders, Dalhousie University, B3J1Y6, Halifax, NS, Canada.
Wang T; Department of Otolaryngology-Head and Neck Surgery, The second Xiangya Hospital, Central South University, 410011, Changsha, Hunan Province, China.
Su K; Department of Otolaryngology, Affiliated Sixth People's Hospital, Shanghai Jiao Tong University, 600 Yishan Road, 200233, Shanghai, China. .
Chai R; Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, 210096, Nanjing, China. .; Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, 211189, Nanjing, China. .; Co-innovation Center of Neuroregeneration, Nantong University, 226001, Nantong, China. .; Institute for Stem Cell and Regeneration, Chinese Academy of Science, Beijing, China. .
Chen F; Department of Biomedical Engineering, Southern University of Science and Technology, 518000, Shenzhen, China. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2019 Mar 04; Vol. 9 (1), pp. 3357. Date of Electronic Publication: 2019 Mar 04.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Cochlea/*growth & development
Hearing/*physiology
Lim Kinases/*genetics
Actin Depolymerizing Factors/metabolism ; Actins/metabolism ; Animals ; Hair Cells, Auditory ; Lim Kinases/deficiency ; Lim Kinases/physiology ; Mice ; Mice, Knockout ; Synapses

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Skocz do pozycji: 15.

Tytuł:: Inhibition of human prostate smooth muscle contraction by the LIM kinase inhibitors, SR7826 and LIMKi3.
Autorzy:: Yu Q; Department of Urology, Ludwig Maximilian University of Munich, Munich, Germany.
Gratzke C; Department of Urology, Ludwig Maximilian University of Munich, Munich, Germany.
Wang Y; Department of Urology, Ludwig Maximilian University of Munich, Munich, Germany.
Herlemann A; Department of Urology, Ludwig Maximilian University of Munich, Munich, Germany.
Sterr CM; Department of Urology, Ludwig Maximilian University of Munich, Munich, Germany.
Rutz B; Department of Urology, Ludwig Maximilian University of Munich, Munich, Germany.
Ciotkowska A; Department of Urology, Ludwig Maximilian University of Munich, Munich, Germany.
Wang X; Department of Urology, Ludwig Maximilian University of Munich, Munich, Germany.
Strittmatter F; Department of Urology, Ludwig Maximilian University of Munich, Munich, Germany.
Stief CG; Department of Urology, Ludwig Maximilian University of Munich, Munich, Germany.
Hennenberg M; Department of Urology, Ludwig Maximilian University of Munich, Munich, Germany.; Pokaż więcej
Źródło:: British journal of pharmacology [Br J Pharmacol] 2018 Jun; Vol. 175 (11), pp. 2077-2096. Date of Electronic Publication: 2018 Apr 29.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Lim Kinases/*antagonists & inhibitors
Muscle Contraction/*drug effects
Muscle, Smooth/*drug effects
Prostatic Neoplasms/*drug therapy
Protein Kinase Inhibitors/*pharmacology
Pyrazoles/*pharmacology
Thiazoles/*pharmacology
Actin Depolymerizing Factors/analysis ; Actin Depolymerizing Factors/metabolism ; Cell Survival/drug effects ; Cells, Cultured ; Electric Stimulation ; Humans ; Lim Kinases/analysis ; Lim Kinases/metabolism ; Male ; Muscle, Smooth/pathology ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/pathology ; Protein Kinase Inhibitors/chemistry ; Pyrazoles/chemistry ; Thiazoles/chemistry

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Skocz do pozycji: 16.

Tytuł:: Structural Aspects of LIMK Regulation and Pharmacology.
Autorzy:: Chatterjee D; Structural Genomics Consortium, Buchmann Institute for Molecular Life Sciences, Max-von-Laue-Str 15, 60438 Frankfurt am Main, Germany.; Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe-University, Max-von-Laue-Str 9, 60438 Frankfurt am Main, Germany.
Preuss F; Structural Genomics Consortium, Buchmann Institute for Molecular Life Sciences, Max-von-Laue-Str 15, 60438 Frankfurt am Main, Germany.; Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe-University, Max-von-Laue-Str 9, 60438 Frankfurt am Main, Germany.
Dederer V; Structural Genomics Consortium, Buchmann Institute for Molecular Life Sciences, Max-von-Laue-Str 15, 60438 Frankfurt am Main, Germany.; Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe-University, Max-von-Laue-Str 9, 60438 Frankfurt am Main, Germany.
Knapp S; Structural Genomics Consortium, Buchmann Institute for Molecular Life Sciences, Max-von-Laue-Str 15, 60438 Frankfurt am Main, Germany.; Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe-University, Max-von-Laue-Str 9, 60438 Frankfurt am Main, Germany.
Mathea S; Structural Genomics Consortium, Buchmann Institute for Molecular Life Sciences, Max-von-Laue-Str 15, 60438 Frankfurt am Main, Germany.; Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe-University, Max-von-Laue-Str 9, 60438 Frankfurt am Main, Germany.; Pokaż więcej
Źródło:: Cells [Cells] 2022 Jan 02; Vol. 11 (1). Date of Electronic Publication: 2022 Jan 02.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:: Actin Depolymerizing Factors/*metabolism
Actins/*metabolism
Lim Kinases/*metabolism
Lim Kinases/*pharmacology
Phosphorylation/*physiology
Humans ; Models, Molecular

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Skocz do pozycji: 17.

Tytuł:: LIM Kinases in Osteosarcoma Development.
Autorzy:: Brion R; INSERM UMR1238, PHY-OS, Bone Sarcomas and Remodeling of Calcified Tissues, Nantes University, 44000 Nantes, France.; Centre Hospitalier Universitaire, Université de Nantes, 44000 Nantes, France.
Regnier L; INSERM UMR1238, PHY-OS, Bone Sarcomas and Remodeling of Calcified Tissues, Nantes University, 44000 Nantes, France.
Mullard M; INSERM UMR1238, PHY-OS, Bone Sarcomas and Remodeling of Calcified Tissues, Nantes University, 44000 Nantes, France.
Amiaud J; INSERM UMR1238, PHY-OS, Bone Sarcomas and Remodeling of Calcified Tissues, Nantes University, 44000 Nantes, France.
Rédini F; INSERM UMR1238, PHY-OS, Bone Sarcomas and Remodeling of Calcified Tissues, Nantes University, 44000 Nantes, France.
Verrecchia F; INSERM UMR1238, PHY-OS, Bone Sarcomas and Remodeling of Calcified Tissues, Nantes University, 44000 Nantes, France.; Pokaż więcej
Źródło:: Cells [Cells] 2021 Dec 15; Vol. 10 (12). Date of Electronic Publication: 2021 Dec 15.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Lim Kinases/*metabolism
Osteosarcoma/*enzymology
Osteosarcoma/*pathology
Animals ; Bone Neoplasms/enzymology ; Bone Remodeling ; Humans ; Models, Biological ; Osteogenesis

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Skocz do pozycji: 18.

Tytuł:: A mutation in Nischarin causes otitis media via LIMK1 and NF-κB pathways.
Autorzy:: Crompton M; Mammalian Genetics Unit, MRC Harwell Institute, Harwell, Oxfordshire, United Kingdom.; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, Oxfordshire, United Kingdom.
Purnell T; Mammalian Genetics Unit, MRC Harwell Institute, Harwell, Oxfordshire, United Kingdom.
Tyrer HE; Mammalian Genetics Unit, MRC Harwell Institute, Harwell, Oxfordshire, United Kingdom.
Parker A; Mammalian Genetics Unit, MRC Harwell Institute, Harwell, Oxfordshire, United Kingdom.
Ball G; Mammalian Genetics Unit, MRC Harwell Institute, Harwell, Oxfordshire, United Kingdom.
Hardisty-Hughes RE; Mammalian Genetics Unit, MRC Harwell Institute, Harwell, Oxfordshire, United Kingdom.
Gale R; Mammalian Genetics Unit, MRC Harwell Institute, Harwell, Oxfordshire, United Kingdom.
Williams D; Mammalian Genetics Unit, MRC Harwell Institute, Harwell, Oxfordshire, United Kingdom.
Dean CH; Mammalian Genetics Unit, MRC Harwell Institute, Harwell, Oxfordshire, United Kingdom.; Inflammation, Repair and Development Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Simon MM; Mammalian Genetics Unit, MRC Harwell Institute, Harwell, Oxfordshire, United Kingdom.
Mallon AM; Mammalian Genetics Unit, MRC Harwell Institute, Harwell, Oxfordshire, United Kingdom.
Wells S; Mary Lyon Centre, MRC Harwell Institute, Harwell, Oxfordshire, United Kingdom.
Bhutta MF; Mammalian Genetics Unit, MRC Harwell Institute, Harwell, Oxfordshire, United Kingdom.; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, Oxfordshire, United Kingdom.; School of Paediatrics, University of Western Australia, Subiaco, Australia.
Burton MJ; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, Oxfordshire, United Kingdom.
Tateossian H; Mammalian Genetics Unit, MRC Harwell Institute, Harwell, Oxfordshire, United Kingdom.
Brown SDM; Mammalian Genetics Unit, MRC Harwell Institute, Harwell, Oxfordshire, United Kingdom.; Pokaż więcej
Źródło:: PLoS genetics [PLoS Genet] 2017 Aug 14; Vol. 13 (8), pp. e1006969. Date of Electronic Publication: 2017 Aug 14 (Print Publication: 2017).
Typ publikacji:: Journal Article
MeSH Terms:: Mutation, Missense*
Intracellular Signaling Peptides and Proteins/*genetics
Lim Kinases/*metabolism
NF-kappa B/*metabolism
Otitis Media/*genetics
Alleles ; Animals ; Chromosome Mapping ; Chronic Disease ; Disease Models, Animal ; Ear, Middle/metabolism ; Ethylnitrosourea/toxicity ; Female ; Genotyping Techniques ; Heterozygote ; Homozygote ; Humans ; Imidazoline Receptors ; Inflammation/genetics ; Integrin alpha6/genetics ; Integrin alpha6/metabolism ; Intracellular Signaling Peptides and Proteins/metabolism ; Lim Kinases/genetics ; Male ; Mice ; Mice, Knockout ; NF-kappa B/genetics ; Neuropeptides/genetics ; Neuropeptides/metabolism ; Otitis Media/metabolism ; Penetrance ; Sequence Analysis, DNA ; Up-Regulation ; Vascular Endothelial Growth Factor A/genetics ; Vascular Endothelial Growth Factor A/metabolism ; p21-Activated Kinases/genetics ; p21-Activated Kinases/metabolism ; rac1 GTP-Binding Protein/genetics ; rac1 GTP-Binding Protein/metabolism

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Skocz do pozycji: 19.

Tytuł:: Cleavage and activation of LIM kinase 1 as a novel mechanism for calpain 2-mediated regulation of nuclear dynamics.
Autorzy:: Rodríguez-Fernández L; Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad de Valencia, Avda. Blasco Ibañez, 15, 46010, Valencia, Spain.
Company S; Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad de Valencia, Avda. Blasco Ibañez, 15, 46010, Valencia, Spain.
Zaragozá R; Fundación Investigación Hospital Clínico-INCLIVA, Valencia, Spain.; Departamento de Anatomía y Embriología Humana, Facultad de Medicina, Universidad de Valencia, Valencia, Spain.
Viña JR; Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad de Valencia, Avda. Blasco Ibañez, 15, 46010, Valencia, Spain.; Fundación Investigación Hospital Clínico-INCLIVA, Valencia, Spain.
García-Trevijano ER; Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad de Valencia, Avda. Blasco Ibañez, 15, 46010, Valencia, Spain. .; Fundación Investigación Hospital Clínico-INCLIVA, Valencia, Spain. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2021 Aug 11; Vol. 11 (1), pp. 16339. Date of Electronic Publication: 2021 Aug 11.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Calpain/*metabolism
Cell Nucleus/*metabolism
Lim Kinases/*metabolism
Actins/metabolism ; Cell Line, Tumor ; Chromosomes/metabolism ; Cofilin 1/metabolism ; Cytoskeleton/metabolism ; Humans ; MCF-7 Cells ; Mitosis/physiology ; Phosphorylation/physiology ; Protein Binding/physiology ; Proteome/metabolism ; Proteomics/methods ; Transcription, Genetic/physiology

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Skocz do pozycji: 20.

Tytuł:: Aberrant expression of LIMK1 impairs neuronal migration during neocortex development.
Autorzy:: Xie J; College of Veterinary Medicine, Northwest A&F University, No.22 Xinong Road, Yangling, 712100, Shaanxi, People's Republic of China.
Li X; College of Veterinary Medicine, Northwest A&F University, No.22 Xinong Road, Yangling, 712100, Shaanxi, People's Republic of China.
Zhang W; College of Veterinary Medicine, Northwest A&F University, No.22 Xinong Road, Yangling, 712100, Shaanxi, People's Republic of China.
Chai X; College of Veterinary Medicine, Northwest A&F University, No.22 Xinong Road, Yangling, 712100, Shaanxi, People's Republic of China.
Huang Y; College of Veterinary Medicine, Northwest A&F University, No.22 Xinong Road, Yangling, 712100, Shaanxi, People's Republic of China.
Li K; College of Veterinary Medicine, Northwest A&F University, No.22 Xinong Road, Yangling, 712100, Shaanxi, People's Republic of China.
Cheng X; College of Veterinary Medicine, Northwest A&F University, No.22 Xinong Road, Yangling, 712100, Shaanxi, People's Republic of China.
Zhao S; College of Veterinary Medicine, Northwest A&F University, No.22 Xinong Road, Yangling, 712100, Shaanxi, People's Republic of China. .; Pokaż więcej
Źródło:: Histochemistry and cell biology [Histochem Cell Biol] 2017 Apr; Vol. 147 (4), pp. 471-479. Date of Electronic Publication: 2016 Nov 14.
Typ publikacji:: Journal Article
MeSH Terms:: Cell Movement*
Lim Kinases/*metabolism
Neocortex/*embryology
Neocortex/*pathology
Neurons/*metabolism
Neurons/*pathology
Animals ; Gene Expression Profiling ; Lim Kinases/genetics ; Mice ; Mice, Inbred C57BL

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