- Tytuł:
- AMPK Activation Prevents and Reverses Drug-Induced Mitochondrial and Hepatocyte Injury by Promoting Mitochondrial Fusion and Function.
- Autorzy:
- Źródło:
- PloS one [PLoS One] 2016 Oct 28; Vol. 11 (10), pp. e0165638. Date of Electronic Publication: 2016 Oct 28 (Print Publication: 2016).
- Typ publikacji:
- Journal Article
- MeSH Terms:
-
AMP-Activated Protein Kinases/*metabolism
Aminoimidazole Carboxamide/*analogs & derivatives
Chemical and Drug Induced Liver Injury/*pathology
Chemical and Drug Induced Liver Injury/*prevention & control
Hepatocytes/*drug effectsMitochondria /*drug effects
Mitochondrial Dynamics/*drug effects
Ribonucleotides/*pharmacology
Acetaminophen/pharmacology ; Aminoimidazole Carboxamide/pharmacology ; Animals ; Autophagy/drug effects ; Chemical and Drug Induced Liver Injury/drug therapy ; Chemical and Drug Induced Liver Injury/enzymology ; Diclofenac/pharmacology ; Enzyme Activation/drug effects ; Hepatocytes/metabolism ; Hepatocytes/pathology ; Male ;Mitochondria /metabolism ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe