- Tytuł:
- Metabolism and excretion of ( S )-6-(3-cyclopentyl-2-(4-trifluoromethyl)-1 H -imidazol-1-yl)propanamido)nicotinic acid (PF-04991532), a hepatoselective glucokinase activator, in humans: confirmation of the MIST potential noted in first-in-Human metabolite scouting studies.
- Autorzy:
- Źródło:
- Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2019 Dec; Vol. 49 (12), pp. 1447-1457. Date of Electronic Publication: 2019 Mar 07.
- Typ publikacji:
- Clinical Trial; Journal Article; Video-Audio Media
- MeSH Terms:
-
Imidazoles /*pharmacokinetics
Nicotinic Acids/*pharmacokinetics
Adolescent ; Adult ; Animals ; Carbon Radioisotopes/administration & dosage ; Carbon Radioisotopes/pharmacokinetics ; Cytochrome P-450 Enzyme System/genetics ; Cytochrome P-450 Enzyme System/metabolism ; Feces/chemistry ; Humans ;Imidazoles /metabolism ; Inactivation, Metabolic ; Macaca fascicularis ; Male ; Middle Aged ; Nicotinic Acids/metabolism ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Young Adult
Czasopismo naukowe