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Tytuł:
Design, Synthesis, Computational and Biological Evaluation of Novel Structure Fragments Based on Lithocholic Acid (LCA).
Autorzy:
Peng J; Department of Translational Research and Cellular Therapeutics, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA.
Fan M; Department of Diabetes Complications & Metabolism, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA.
Huang KX; Department of Translational Research and Cellular Therapeutics, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA.
Huang LA; Department of Translational Research and Cellular Therapeutics, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA.
Wang Y; Department of Diabetes Complications & Metabolism, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA.
Yin R; Department of Translational Research and Cellular Therapeutics, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA.
Zhao H; Department of Translational Research and Cellular Therapeutics, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA.
Xu S; Department of Diabetes Complications & Metabolism, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA.
Li H; Department of Molecular Medicine, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA.
Agua A; Department of Diabetes Complications & Metabolism, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA.
Xie J; Department of Molecular Medicine, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA.
Horne DA; Department of Molecular Medicine, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA.
Kandeel F; Department of Translational Research and Cellular Therapeutics, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA.
Huang W; Department of Diabetes Complications & Metabolism, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA.
Li J; Department of Translational Research and Cellular Therapeutics, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Jul 11; Vol. 28 (14). Date of Electronic Publication: 2023 Jul 11.
Typ publikacji:
Journal Article
MeSH Terms:
Lithocholic Acid*/pharmacology
Bile Acids and Salts*/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Vitamin D Receptor Mediates Attenuating Effect of Lithocholic Acid on Dextran Sulfate Sodium Induced Colitis in Mice.
Autorzy:
Kubota H; Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine, 30-1 Oyaguchi-kamicho, Itabashi-ku, Tokyo 173-8610, Japan.; Department of Surgery, The Nippon Dental University School of Life Dentistry, 2-3-16 Fujimi, Chiyoda-ku, Tokyo 102-8158, Japan.
Ishizawa M; Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine, 30-1 Oyaguchi-kamicho, Itabashi-ku, Tokyo 173-8610, Japan.
Kodama M; Department of Pathology, Tokyo Yamate Medical Center, 3-22-1 Hyakunin-cho, Shinjuku-ku, Tokyo 169-0073, Japan.
Nagase Y; Department of Pathology, Tokyo Yamate Medical Center, 3-22-1 Hyakunin-cho, Shinjuku-ku, Tokyo 169-0073, Japan.
Kato S; Graduate School of Science and Technology, Iryo Sosei University, 5-5-1 Iino, Chuodai, Iwaki, Fukushima 970-8044, Japan.; Research Institute of Innovative Medicine, Tokiwa Foundation, Kaminodai-57 Jobankamiyunagayamachi, Iwaki, Fukushima 972-8322, Japan.
Makishima M; Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine, 30-1 Oyaguchi-kamicho, Itabashi-ku, Tokyo 173-8610, Japan.
Sakurai K; Department of Surgery, The Nippon Dental University School of Life Dentistry, 2-3-16 Fujimi, Chiyoda-ku, Tokyo 102-8158, Japan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Feb 09; Vol. 24 (4). Date of Electronic Publication: 2023 Feb 09.
Typ publikacji:
Journal Article
MeSH Terms:
Colitis*/chemically induced
Lithocholic Acid*/metabolism
Receptors, Calcitriol*/metabolism
Animals ; Mice ; Bile Acids and Salts/metabolism ; Dextran Sulfate ; Mice, Inbred C57BL
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Gut microbiota-bile acid-vitamin D axis plays an important role in determining oocyte quality and embryonic development.
Autorzy:
Li A; Fertility Preservation Lab, Guangdong-Hong Kong Metabolism and Reproduction Joint Laboratory, Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, China.; State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot, China.
Li F; Fertility Preservation Lab, Guangdong-Hong Kong Metabolism and Reproduction Joint Laboratory, Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, China.
Song W; Fertility Preservation Lab, Guangdong-Hong Kong Metabolism and Reproduction Joint Laboratory, Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, China.
Lei ZL; Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China, Institute of Chinese Medicine, Guangdong Traditional Chinese Medicine (TCM) Key Laboratory for Metabolic Diseases, Guangdong Pharmaceutical University, Guangzhou, China.
Sha QQ; Fertility Preservation Lab, Guangdong-Hong Kong Metabolism and Reproduction Joint Laboratory, Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, China.
Liu SY; Fertility Preservation Lab, Guangdong-Hong Kong Metabolism and Reproduction Joint Laboratory, Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, China.
Zhou CY; Fertility Preservation Lab, Guangdong-Hong Kong Metabolism and Reproduction Joint Laboratory, Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, China.
Zhang X; Fertility Preservation Lab, Guangdong-Hong Kong Metabolism and Reproduction Joint Laboratory, Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, China.
Li XZ; Fertility Preservation Lab, Guangdong-Hong Kong Metabolism and Reproduction Joint Laboratory, Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, China.
Schatten H; Department of Veterinary Pathobiology, University of Missouri-Columbia, Columbia, Missouri, USA.
Zhang T; State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot, China.
Sun QY; Fertility Preservation Lab, Guangdong-Hong Kong Metabolism and Reproduction Joint Laboratory, Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, China.
Ou XH; Fertility Preservation Lab, Guangdong-Hong Kong Metabolism and Reproduction Joint Laboratory, Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, China.
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Źródło:
Clinical and translational medicine [Clin Transl Med] 2023 Oct; Vol. 13 (10), pp. e1236.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gastrointestinal Microbiome*
Melatonin*/metabolism
Pregnancy ; Female ; Mice ; Animals ; Vitamin D ; Bile Acids and Salts ; Oocytes/metabolism ; Embryonic Development ; Lithocholic Acid/pharmacology ; Lithocholic Acid/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Lithocholic Acid Amides as Potent Vitamin D Receptor Agonists.
Autorzy:
Yoshihara A; Department of Chemistry, Faculty of Science, Ochanomizu University, 2-1-1 Otsuka, Bunkyo-ku, Tokyo 112-8610, Japan.
Kawasaki H; Department of Chemistry, Faculty of Science, Ochanomizu University, 2-1-1 Otsuka, Bunkyo-ku, Tokyo 112-8610, Japan.
Masuno H; Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU), 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan.
Takada K; Medical Research Institute, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
Numoto N; Medical Research Institute, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
Ito N; Medical Research Institute, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
Hirata N; National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki 210-9501, Japan.
Kanda Y; National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki 210-9501, Japan.
Ishizawa M; Department of Biomedical Sciences, Nihon University School of Medicine, 30-1 Ohyaguchikamimachi, Itabashi-ku, Tokyo 173-8610, Japan.
Makishima M; Department of Biomedical Sciences, Nihon University School of Medicine, 30-1 Ohyaguchikamimachi, Itabashi-ku, Tokyo 173-8610, Japan.
Kagechika H; Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU), 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan.
Tanatani A; Department of Chemistry, Faculty of Science, Ochanomizu University, 2-1-1 Otsuka, Bunkyo-ku, Tokyo 112-8610, Japan.
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Źródło:
Biomolecules [Biomolecules] 2022 Jan 14; Vol. 12 (1). Date of Electronic Publication: 2022 Jan 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Lithocholic Acid*/metabolism
Lithocholic Acid*/pharmacology
Receptors, Calcitriol*/metabolism
Amides/pharmacology ; Cholecalciferol ; Humans ; Protein Binding
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
An N-Cyanoamide Derivative of Lithocholic Acid Co-Operates with Lysophosphatidic Acid to Promote Human Osteoblast (MG63) Differentiation.
Autorzy:
Mansell JP; School of Applied Sciences, University of the West of England, Coldharbour Lane, Bristol BS16 1QY, UK.
Tanatani A; Department of Chemistry, Faculty of Science, Ochanomizu University, Bunkyo-ku, Tokyo 112-8610, Japan.
Kagechika H; Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU), Chiyoda-ku, Tokyo 101-0062, Japan.
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Źródło:
Biomolecules [Biomolecules] 2023 Jul 13; Vol. 13 (7). Date of Electronic Publication: 2023 Jul 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Calcitriol*/pharmacology
Osteoblasts*/metabolism
Humans ; Cell Differentiation ; Lithocholic Acid/pharmacology ; Lithocholic Acid/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Micro-Nano formulation of bile-gut delivery: rheological, stability and cell survival, basal and maximum respiration studies.
Autorzy:
Wagle SR; Biotechnology and Drug Development Research Laboratory, School of Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia, Australia.
Walker D; Biotechnology and Drug Development Research Laboratory, School of Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia, Australia.
Kovacevic B; Biotechnology and Drug Development Research Laboratory, School of Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia, Australia.
Gedawy A; Biotechnology and Drug Development Research Laboratory, School of Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia, Australia.
Mikov M; Department of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
Golocorbin-Kon S; Department of Pharmacy, University of Novi Sad, Novi Sad, Serbia.
Mooranian A; Biotechnology and Drug Development Research Laboratory, School of Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia, Australia.
Al-Salami H; Biotechnology and Drug Development Research Laboratory, School of Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia, Australia. .
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Źródło:
Scientific reports [Sci Rep] 2020 May 07; Vol. 10 (1), pp. 7715. Date of Electronic Publication: 2020 May 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Drug Delivery Systems*
Alginates/*chemistry
Lithocholic Acid/*chemistry
Probucol/*chemistry
Alginates/pharmacology ; Animals ; Biological Availability ; Cell Line ; Drug Compounding/methods ; Drug Stability ; Gastrointestinal Microbiome/drug effects ; Humans ; Hydrophobic and Hydrophilic Interactions/drug effects ; Insulin-Secreting Cells/drug effects ; Lithocholic Acid/pharmacology ; Mice ; Probucol/pharmacology ; Rheology ; Water/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Bile acid distributions, sex-specificity, and prognosis in colorectal cancer.
Autorzy:
Cai Y; Department of Environmental Health Sciences, Yale School of Public Health, Yale University, New Haven, CT, 06510, USA.; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, China.
Shen X; Department of Environmental Health Sciences, Yale School of Public Health, Yale University, New Haven, CT, 06510, USA.
Lu L; Department of Chronic Disease Epidemiology, Yale School of Public Health, Yale University, New Haven, CT, 06510, USA.
Yan H; Department of Environmental Health Sciences, Yale School of Public Health, Yale University, New Haven, CT, 06510, USA.
Huang H; Department of Environmental Health Sciences, Yale School of Public Health, Yale University, New Haven, CT, 06510, USA.; National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Gaule P; Department of Pathology, Yale University School of Medicine, New Haven, CT, 06510, USA.
Muca E; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Theriot CM; North Caroline State University, Raleigh, NC, USA.
Rattray Z; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, G4 0RE, UK.
Rattray NJW; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, G4 0RE, UK.
Lu J; Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT, 06520, USA.; Department of Genetics, Yale University School of Medicine, New Haven, CT, 06520, USA.
Ahuja N; Department of Pathology, Yale University School of Medicine, New Haven, CT, 06510, USA.; Department of Surgery, Division of Surgical Oncology, Yale University School of Medicine, New Haven, CT, 06510, USA.
Zhang Y; Department of Environmental Health Sciences, Yale School of Public Health, Yale University, New Haven, CT, 06510, USA.; National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Paty PB; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Khan SA; Department of Surgery, Division of Surgical Oncology, Yale University School of Medicine, New Haven, CT, 06510, USA. .
Johnson CH; Department of Environmental Health Sciences, Yale School of Public Health, Yale University, New Haven, CT, 06510, USA. .
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Źródło:
Biology of sex differences [Biol Sex Differ] 2022 Oct 23; Vol. 13 (1), pp. 61. Date of Electronic Publication: 2022 Oct 23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Colorectal Neoplasms*/metabolism
Colorectal Neoplasms*/pathology
Colonic Neoplasms*
Female ; Humans ; Male ; Bile Acids and Salts ; Ursodeoxycholic Acid/therapeutic use ; Ursodeoxycholic Acid/metabolism ; Glycochenodeoxycholic Acid ; Lithocholic Acid/metabolism ; Chenodeoxycholic Acid/metabolism ; Sex Distribution ; Forkhead Transcription Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Suppression of Hepatic PPARα in Primary Biliary Cholangitis Is Modulated by miR-155.
Autorzy:
Adamowicz M; Department of Medical Biology, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland.
Kempinska-Podhorodecka A; Department of Medical Biology, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland.
Abramczyk J; Department of Medical Biology, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland.
Banales JM; Department of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, University of the Basque Country (UPV/EHU), CIBERehd, Ikerbasque, 20014 San Sebastian, Spain.; Department of Biochemistry and Genetics, School of Sciences, University of Navarra, 31009 Pamplona, Spain.
Milkiewicz P; Liver and Internal Medicine Unit, Medical University of Warsaw, 02-097 Warsaw, Poland.; Translational Medicine Group, Pomeranian Medical University, 70-111 Szczecin, Poland.
Milkiewicz M; Department of Medical Biology, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland.
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Źródło:
Cells [Cells] 2022 Sep 15; Vol. 11 (18). Date of Electronic Publication: 2022 Sep 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Liver Cirrhosis, Biliary*/metabolism
MicroRNAs*/genetics
MicroRNAs*/metabolism
PPAR alpha*/genetics
Bile Acids and Salts ; Glycodeoxycholic Acid ; Humans ; Ligands ; Lipopolysaccharides/pharmacology ; Lithocholic Acid ; Transcription Factors ; Ursodeoxycholic Acid/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Bile Acid-Drug Interaction via Organic Anion-Transporting Polypeptide 4C1 Is a Potential Mechanism of Altered Pharmacokinetics of Renally Excreted Drugs.
Autorzy:
Yamauchi M; Faculty of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Sato T; Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai 980-8574, Japan.
Otake A; Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai 980-8574, Japan.
Kumondai M; Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai 980-8574, Japan.
Sato Y; Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai 980-8574, Japan.
Kikuchi M; Faculty of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.; Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai 980-8574, Japan.
Maekawa M; Faculty of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.; Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai 980-8574, Japan.
Yamaguchi H; Department of Pharmacy, Yamagata University Hospital, Yamagata 990-9585, Japan.; Graduate School of Medical Science, Yamagata University, Yamagata 990-9585, Japan.
Abe T; Division of Nephrology, Endocrinology, and Vascular Medicine, Graduate School of Medicine, Tohoku University, Sendai 980-8574, Japan.; Division of Medical Science, Graduate School of Biomedical Engineering, Tohoku University, Sendai 980-8579, Japan.; Department of Clinical Biology and Hormonal Regulation, Graduate School of Medicine, Tohoku University, Sendai 980-8575, Japan.
Mano N; Faculty of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.; Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai 980-8574, Japan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Jul 31; Vol. 23 (15). Date of Electronic Publication: 2022 Jul 31.
Typ publikacji:
Journal Article
MeSH Terms:
Bile Acids and Salts*/metabolism
Organic Anion Transporters*/metabolism
Anions/metabolism ; Drug Interactions ; Humans ; Lithocholic Acid/metabolism ; Liver/metabolism ; Membrane Transport Proteins/metabolism ; Peptides/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Establishment of In Vitro and In Vivo Anticolorectal Cancer Efficacy of Lithocholic Acid-Based Imidazolium Salts.
Autorzy:
Sawicka D; Department of Experimental Pharmacology, Medical University of Bialystok, Szpitalna Street 37, 15-295 Bialystok, Poland.
Hryniewicka A; Department of Organic Chemistry, Medical University of Bialystok, Mickiewicza Street 2A, 15-222 Bialystok, Poland.
Gohal S; Department of Experimental Pharmacology, Medical University of Bialystok, Szpitalna Street 37, 15-295 Bialystok, Poland.
Sadowska A; Department of Experimental Pharmacology, Medical University of Bialystok, Szpitalna Street 37, 15-295 Bialystok, Poland.
Pryczynicz A; Department of General Pathomorphology, Medical University of Bialystok, Waszyngtona Street 13, 15-269 Bialystok, Poland.
Guzińska-Ustymowicz K; Department of General Pathomorphology, Medical University of Bialystok, Waszyngtona Street 13, 15-269 Bialystok, Poland.
Sokołowska E; Department of Experimental Pharmacology, Medical University of Bialystok, Szpitalna Street 37, 15-295 Bialystok, Poland.
Morzycki JW; Department of Natural Product Chemistry, University of Bialystok, Ciołkowskiego Street 1K, 15-245 Bialystok, Poland.
Car H; Department of Experimental Pharmacology, Medical University of Bialystok, Szpitalna Street 37, 15-295 Bialystok, Poland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Jun 24; Vol. 23 (13). Date of Electronic Publication: 2022 Jun 24.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Colorectal Neoplasms*/drug therapy
Animals ; Apoptosis ; Cell Line, Tumor ; Fluorouracil/pharmacology ; Fluorouracil/therapeutic use ; Humans ; Lithocholic Acid/pharmacology ; Mice ; Salts/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The inhibition of enterocyte proliferation by lithocholic acid exacerbates necrotizing enterocolitis through downregulating the Wnt/β-catenin signalling pathway.
Autorzy:
Feng Z; Department of Pediatrics, Sun Yat-sen University Sixth Affiliated Hospital, Guangzhou, China.; Department of Pediatrics, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Jia C; Department of Pediatrics, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.; Key Laboratory for Major Obstetric Diseases of Guangdong Province, Guangzhou, China.
Lin X; Department of Pediatrics, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Hao H; Department of Pediatrics, Sun Yat-sen University Sixth Affiliated Hospital, Guangzhou, China.
Li S; Department of Pediatrics, Sun Yat-sen University Sixth Affiliated Hospital, Guangzhou, China.
Li F; Department of Pediatrics, Sun Yat-sen University Sixth Affiliated Hospital, Guangzhou, China.
Cui Q; Department of Pediatrics, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Chen Y; Department of Pediatrics, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Wu F; Department of Pediatrics, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.; Key Laboratory for Major Obstetric Diseases of Guangdong Province, Guangzhou, China.
Xiao X; Department of Pediatrics, Sun Yat-sen University Sixth Affiliated Hospital, Guangzhou, China.
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Źródło:
Cell proliferation [Cell Prolif] 2022 May; Vol. 55 (5), pp. e13228. Date of Electronic Publication: 2022 Apr 20.
Typ publikacji:
Journal Article
MeSH Terms:
Enterocolitis, Necrotizing*/drug therapy
Enterocolitis, Necrotizing*/metabolism
Animals ; Cell Proliferation ; Chromatography, Liquid ; Disease Models, Animal ; Enterocytes/metabolism ; Humans ; Infant, Newborn ; Infant, Premature ; Intestinal Mucosa/metabolism ; Lithocholic Acid/metabolism ; Lithocholic Acid/pharmacology ; Rats ; Tandem Mass Spectrometry ; beta Catenin/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Lithocholic Acid Is a Vitamin D Receptor Ligand That Acts Preferentially in the Ileum.
Autorzy:
Ishizawa M; Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine, 30-1 Oyaguchi-kamicho, Itabashi-ku, Tokyo 173-8610, Japan. .
Akagi D; Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine, 30-1 Oyaguchi-kamicho, Itabashi-ku, Tokyo 173-8610, Japan. .
Makishima M; Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine, 30-1 Oyaguchi-kamicho, Itabashi-ku, Tokyo 173-8610, Japan. .
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2018 Jul 06; Vol. 19 (7). Date of Electronic Publication: 2018 Jul 06.
Typ publikacji:
Journal Article
MeSH Terms:
24,25-Dihydroxyvitamin D 3/*metabolism
Ileum/*metabolism
Lithocholic Acid/*metabolism
Receptors, Calcitriol/*metabolism
24,25-Dihydroxyvitamin D 3/administration & dosage ; Administration, Oral ; Animals ; Bone and Bones/metabolism ; Calcium/blood ; Calcium/metabolism ; Calcium Channels/genetics ; Calcium Channels/metabolism ; Corn Oil/administration & dosage ; Humans ; Ligands ; Lithocholic Acid/administration & dosage ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Receptors, Calcitriol/drug effects ; TRPV Cation Channels/genetics ; TRPV Cation Channels/metabolism ; Vitamin D3 24-Hydroxylase/genetics ; Vitamin D3 24-Hydroxylase/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Synergistic Effect of Lithocholic Acid with Gentamicin against Gram-Positive Bacteria but Not against Gram-Negative Bacteria.
Autorzy:
Lv H; Department of Respiratory Medicine, The First Hospital of Jilin University, Changchun 130021, China.
Wang L; Jilin Ginseng Academy, Chang Chun University of Chinese Medicine, Changchun 130117, China.
Liu S; Jilin Jinziyuan Biotech Inc, Changchun 136400, China.
Hu W; Department of Respiratory Medicine, The First Hospital of Jilin University, Changchun 130021, China.
Wang J; Department of Respiratory Medicine, The First Hospital of Jilin University, Changchun 130021, China.
Deng X; Department of Respiratory Medicine, The First Hospital of Jilin University, Changchun 130021, China.
Gao J; Department of Respiratory Medicine, The First Hospital of Jilin University, Changchun 130021, China.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Apr 03; Vol. 27 (7). Date of Electronic Publication: 2022 Apr 03.
Typ publikacji:
Journal Article
MeSH Terms:
Gentamicins*/pharmacology
Listeria monocytogenes*
Anti-Bacterial Agents/pharmacology ; Biofilms ; Escherichia coli ; Gram-Negative Bacteria ; Gram-Positive Bacteria ; Lithocholic Acid/pharmacology ; Microbial Sensitivity Tests ; Staphylococcus aureus
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Enhanced activity and substrate tolerance of 7α-hydroxysteroid dehydrogenase by directed evolution for 7-ketolithocholic acid production.
Autorzy:
Huang B; Hunan Flag Bio-tech Co., Ltd., Changsha, 410100, China. .
Zhao Q; Hunan Flag Bio-tech Co., Ltd., Changsha, 410100, China.
Zhou JH; Hunan Flag Bio-tech Co., Ltd., Changsha, 410100, China.
Xu G; Hunan Flag Bio-tech Co., Ltd., Changsha, 410100, China.; College of Life Science and Technology, Central South University of Forestry and Technology, Changsha, 410004, China.
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Źródło:
Applied microbiology and biotechnology [Appl Microbiol Biotechnol] 2019 Mar; Vol. 103 (6), pp. 2665-2674. Date of Electronic Publication: 2019 Feb 07.
Typ publikacji:
Journal Article
MeSH Terms:
Directed Molecular Evolution*
Clostridium/*enzymology
Hydroxysteroid Dehydrogenases/*metabolism
Lithocholic Acid/*analogs & derivatives
Clostridium/genetics ; Escherichia coli/genetics ; High-Throughput Screening Assays ; Hydroxysteroid Dehydrogenases/genetics ; Kinetics ; Lithocholic Acid/biosynthesis ; Molecular Dynamics Simulation ; Mutagenesis, Site-Directed ; Ursodeoxycholic Acid/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
An Engineered Lithocholate-Based Facial Amphiphile Stabilizes Membrane Proteins: Assessing the Impact of Detergent Customizability on Protein Stability.
Autorzy:
Das M; Department of Bionanotechnology, Hanyang University, Ansan, 155-88, Korea.
Du Y; Molecular and Cellular Physiology, Stanford, CA, 94305, USA.
Mortensen JS; Department of Neuroscience, University of Copenhagen, Copenhagen N, DK-2200, Denmark.
Bae HE; Department of Bionanotechnology, Hanyang University, Ansan, 155-88, Korea.
Byrne B; Department of Life Sciences, Imperial College London, London, SW7 2AZ, UK.
Loland CJ; Department of Neuroscience, University of Copenhagen, Copenhagen N, DK-2200, Denmark.
Kobilka BK; Molecular and Cellular Physiology, Stanford, CA, 94305, USA.
Chae PS; Department of Bionanotechnology, Hanyang University, Ansan, 155-88, Korea.
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Źródło:
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2018 Jul 11; Vol. 24 (39), pp. 9860-9868. Date of Electronic Publication: 2018 Jun 13.
Typ publikacji:
Journal Article
MeSH Terms:
Lithocholic Acid*
Detergents/*chemistry
Membrane Proteins/*chemistry
Hydrophobic and Hydrophilic Interactions ; Micelles ; Protein Stability
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Screening and identification of differential metabolites in serum and urine of bamaxiang pigs bitten by trimeresurus stejnegeri based on UPLC-Q-TOF/MS metabolomics technology.
Autorzy:
Guan Z; Institute of Life Sciences of Guangxi Medical University, China.
Li Y; Institute of Life Sciences of Guangxi Medical University, China.
Hu S; Institute of Life Sciences of Guangxi Medical University, China.
Mo C; Institute of Life Sciences of Guangxi Medical University, China.
He D; Institute of Life Sciences of Guangxi Medical University, China.
Huang Z; Institute of Life Sciences of Guangxi Medical University, China.
Liao M; Institute of Life Sciences of Guangxi Medical University, China.
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Źródło:
The Journal of toxicological sciences [J Toxicol Sci] 2022; Vol. 47 (10), pp. 389-407.
Typ publikacji:
Journal Article
MeSH Terms:
Trimeresurus*
Snake Bites*/veterinary
Animals ; Arginine ; Chromatography, High Pressure Liquid/methods ; Dopamine ; Hypoxanthines ; Lithocholic Acid ; Swine ; Technology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Lithocholic Acid Induces miR21, Promoting PTEN Inhibition via STAT3 and ERK-1/2 Signaling in Colorectal Cancer Cells.
Autorzy:
Nguyen TT; Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju 501-190, Korea.; Nanogen Pharmaceutical Biotechnology Joint Stock Company, Ho Chi Minh City 71207, Vietnam.
Ung TT; Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju 501-190, Korea.; Nanogen Pharmaceutical Biotechnology Joint Stock Company, Ho Chi Minh City 71207, Vietnam.
Li S; Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju 501-190, Korea.
Sah DK; Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju 501-190, Korea.
Park SY; Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju 501-190, Korea.
Lian S; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.
Jung YD; Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju 501-190, Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Sep 22; Vol. 22 (19). Date of Electronic Publication: 2021 Sep 22.
Typ publikacji:
Journal Article
MeSH Terms:
Colorectal Neoplasms/*pathology
Detergents/*pharmacology
Lithocholic Acid/*pharmacology
MicroRNAs/*genetics
PTEN Phosphohydrolase/*antagonists & inhibitors
Cell Line, Tumor ; Chenodeoxycholic Acid/pharmacology ; Cholic Acid/pharmacology ; Deoxycholic Acid/pharmacology ; HCT116 Cells ; HT29 Cells ; Humans ; MAP Kinase Signaling System/physiology ; Mitogen-Activated Protein Kinase 3/metabolism ; STAT3 Transcription Factor/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Effect of the Side Chain on Gelation Properties of Bile Acid Alkyl Amides.
Autorzy:
Kuosmanen RT; Department of Chemistry, University of Jyvaskyla, P.O. Box 35, 40014, Jyväskylä, Finland.
Truong KN; Department of Chemistry, University of Jyvaskyla, P.O. Box 35, 40014, Jyväskylä, Finland.
Rissanen KT; Department of Chemistry, University of Jyvaskyla, P.O. Box 35, 40014, Jyväskylä, Finland.
Sievänen EI; Department of Chemistry, University of Jyvaskyla, P.O. Box 35, 40014, Jyväskylä, Finland.
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Źródło:
ChemistryOpen [ChemistryOpen] 2021 Nov; Vol. 10 (11), pp. 1150-1157.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Amides*
Bile Acids and Salts*
Cholic Acid ; Gels ; Lithocholic Acid
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 988

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