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Wyszukujesz frazę ""Lithospermum"" wg kryterium: Temat


Tytuł :
Alcohol Dehydrogenase Activity Converts 3″-Hydroxy-geranylhydroquinone to an Aldehyde Intermediate for Shikonin and Benzoquinone Derivatives in Lithospermum erythrorhizon.
Autorzy :
Yamamoto H; Department of Applied Biosciences, Faculty of Life Sciences, Toyo University, Izumino 1-1-1, Itakura-machi, Ora-gun, Gunma, 374-0193 Japan.; Graduate School of Life Sciences, Toyo University, Izumino 1-1-1, Itakura-machi, Ora-gun, Gunma, 374-0193 Japan.
Tsukahara M; Graduate School of Life Sciences, Toyo University, Izumino 1-1-1, Itakura-machi, Ora-gun, Gunma, 374-0193 Japan.
Yamano Y; Laboratory of Organic Chemistry for Life Science, Kobe Pharmaceutical University, 4-19-1 Motoyamakita-machi, Higashinada-ku, Kobe, Hyogo, 658-8558 Japan.
Wada A; Laboratory of Organic Chemistry for Life Science, Kobe Pharmaceutical University, 4-19-1 Motoyamakita-machi, Higashinada-ku, Kobe, Hyogo, 658-8558 Japan.
Yazaki K; Research Institute for Sustainable Humanosphere, Kyoto University, Gokasho, Uji, Kyoto, 611-0011 Japan.
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Źródło :
Plant & cell physiology [Plant Cell Physiol] 2020 Oct 01; Vol. 61 (10), pp. 1798-1806.
Typ publikacji :
Journal Article
MeSH Terms :
Alcohol Dehydrogenase/*metabolism
Aldehydes/*metabolism
Benzoquinones/*metabolism
Lithospermum/*enzymology
Naphthoquinones/*metabolism
Terpenes/*metabolism
Lithospermum/metabolism ; Metabolic Networks and Pathways
Czasopismo naukowe
Tytuł :
Effectiveness of gromwell (Lithospermum erythrorhizon) oil in the treatment of toxic epidermal necrolysis in a patient with dermatomyositis.
Autorzy :
Liang H; Department of Nursing, The First People's Hospital of Yunnan Province, Kunming, Yunnan, China.; The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China.; Department of Rheumatology and Immunology, The First People's Hospital of Yunnan Province, Kunming, Yunnan, China.
Wang S; The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China.; Department of Rheumatology and Immunology, The First People's Hospital of Yunnan Province, Kunming, Yunnan, China.
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Źródło :
Dermatologic therapy [Dermatol Ther] 2020 Nov; Vol. 33 (6), pp. e14067. Date of Electronic Publication: 2020 Aug 13.
Typ publikacji :
Letter; Research Support, Non-U.S. Gov't
MeSH Terms :
Dermatomyositis*/diagnosis
Dermatomyositis*/drug therapy
Lithospermum*
Stevens-Johnson Syndrome*/diagnosis
Stevens-Johnson Syndrome*/drug therapy
Stevens-Johnson Syndrome*/etiology
Humans ; Plant Extracts
Raport
Tytuł :
Two BAHD Acyltransferases Catalyze the Last Step in the Shikonin/Alkannin Biosynthetic Pathway.
Autorzy :
Oshikiri H; Department of Biology, Faculty of Science, Shinshu University, Nagano 390-8621, Japan.
Watanabe B; Institute for Chemical Research, Kyoto University, Kyoto 611-0011, Japan.
Yamamoto H; Department of Applied Biology, Faculty of Life Sciences, Toyo University, Gunma 374-0193, Japan.
Yazaki K; Research Institute for Sustainable Humanosphere, Kyoto University, Kyoto 611-0011, Japan.
Takanashi K; Department of Biology, Faculty of Science, Shinshu University, Nagano 390-8621, Japan .
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Źródło :
Plant physiology [Plant Physiol] 2020 Oct; Vol. 184 (2), pp. 753-761. Date of Electronic Publication: 2020 Jul 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acyltransferases/*metabolism
Lithospermum/*enzymology
Naphthoquinones/*metabolism
Acyltransferases/genetics ; Escherichia coli ; Lithospermum/genetics ; Substrate Specificity
Czasopismo naukowe
Tytuł :
Potential role of two cytochrome P450s obtained from Lithospermum erythrorhizon in catalyzing the oxidation of geranylhydroquinone during Shikonin biosynthesis.
Autorzy :
Song W; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China; Key Laboratory of Systems Microbial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China; University of Chinese Academy of Sciences, Beijing, China.
Zhuang Y; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China; Key Laboratory of Systems Microbial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.
Liu T; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China; Key Laboratory of Systems Microbial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China. Electronic address: .
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Źródło :
Phytochemistry [Phytochemistry] 2020 Jul; Vol. 175, pp. 112375. Date of Electronic Publication: 2020 Apr 16.
Typ publikacji :
Journal Article
MeSH Terms :
Lithospermum*
Naphthoquinones*
Cytochrome P-450 Enzyme System ; Terpenes
Czasopismo naukowe
Tytuł :
Apple latent spherical virus (ALSV)-induced gene silencing in a medicinal plant, Lithospermum erythrorhizon.
Autorzy :
Izuishi Y; Laboratory of Plant Gene Expression, Research Institute for Sustainable Humanosphere, Kyoto University, Gokasho, Uji, 611-0011, Japan.
Isaka N; Laboratory of Plant Gene Expression, Research Institute for Sustainable Humanosphere, Kyoto University, Gokasho, Uji, 611-0011, Japan.
Li H; Laboratory of Plant Gene Expression, Research Institute for Sustainable Humanosphere, Kyoto University, Gokasho, Uji, 611-0011, Japan.
Nakanishi K; Laboratory of Plant Gene Expression, Research Institute for Sustainable Humanosphere, Kyoto University, Gokasho, Uji, 611-0011, Japan.
Kageyama J; Laboratory of Plant Gene Expression, Research Institute for Sustainable Humanosphere, Kyoto University, Gokasho, Uji, 611-0011, Japan.
Ishikawa K; Graduate School of Science, Kyoto University, Sakyo-ku, Kyoto, 606-8502, Japan.
Shimada T; Graduate School of Science, Kyoto University, Sakyo-ku, Kyoto, 606-8502, Japan.
Masuta C; Research Faculty of Agriculture, Hokkaido University, Kita 9 Nishi 9, Kita-ku, Sapporo, 060-8589, Japan.
Yoshikawa N; Agri-Innovation Center, Iwate University, Morioka 3-18-8, Iwate, 020-8550, Japan.
Kusano H; Laboratory of Plant Gene Expression, Research Institute for Sustainable Humanosphere, Kyoto University, Gokasho, Uji, 611-0011, Japan.
Yazaki K; Laboratory of Plant Gene Expression, Research Institute for Sustainable Humanosphere, Kyoto University, Gokasho, Uji, 611-0011, Japan. .
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Źródło :
Scientific reports [Sci Rep] 2020 Aug 11; Vol. 10 (1), pp. 13555. Date of Electronic Publication: 2020 Aug 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Plant*
Gene Silencing*
Lithospermum/*genetics
Plant Diseases/*genetics
Plant Leaves/*genetics
Plant Proteins/*antagonists & inhibitors
Plants, Medicinal/*genetics
Secoviridae/*genetics
Lithospermum/virology ; Plant Diseases/virology ; Plant Leaves/virology ; Plant Proteins/genetics ; Plants, Medicinal/virology ; Secoviridae/pathogenicity
SCR Organism :
Apple latent spherical virus
Czasopismo naukowe
Tytuł :
Roots of Lithospermum erythrorhizon promotes retinal cell survival in optic nerve crush-induced retinal degeneration.
Autorzy :
Kang TK; Natural Product Research Center, Korea Institute of Science & Technology, Gangneung, 25451, Republic of Korea.
Le TT; Natural Product Research Center, Korea Institute of Science & Technology, Gangneung, 25451, Republic of Korea; Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Gangneung, 25451, Republic of Korea.
Kim KA; Division of Medical Oncology, Yonsei Cancer Center, Department of Internal Medicine, Yonsei University, Republic of Korea.
Kim YJ; Natural Product Research Center, Korea Institute of Science & Technology, Gangneung, 25451, Republic of Korea.
Lee WB; Natural Product Research Center, Korea Institute of Science & Technology, Gangneung, 25451, Republic of Korea. Electronic address: .
Jung SH; Natural Product Research Center, Korea Institute of Science & Technology, Gangneung, 25451, Republic of Korea; Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Gangneung, 25451, Republic of Korea. Electronic address: .
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Źródło :
Experimental eye research [Exp Eye Res] 2021 Feb; Vol. 203, pp. 108419. Date of Electronic Publication: 2020 Dec 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Lithospermum/*chemistry
Optic Nerve Injuries/*drug therapy
Phytotherapy/*methods
Plant Extracts/*therapeutic use
Plant Roots/*chemistry
Retinal Degeneration/*drug therapy
Retinal Ganglion Cells/*drug effects
Animals ; Apoptosis Regulatory Proteins/metabolism ; Benzofurans/pharmacology ; Cell Culture Techniques ; Cell Survival/drug effects ; Chromatography, High Pressure Liquid ; Depsides/pharmacology ; Electrophoresis, Polyacrylamide Gel ; Male ; Mice ; Mice, Inbred C57BL ; Nerve Crush ; Optic Nerve Injuries/metabolism ; Oxidative Stress/drug effects ; Reactive Oxygen Species/metabolism ; Retinal Degeneration/metabolism ; Retinal Ganglion Cells/metabolism ; Tomography, Optical Coherence
Czasopismo naukowe
Tytuł :
Uncovering the antitumor effects and mechanisms of Shikonin against colon cancer on comprehensive analysis.
Autorzy :
Chen Y; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Si L; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Zhang J; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Yu H; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Liu X; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Chen Y; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Wu Y; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address: .
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Źródło :
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2021 Feb; Vol. 82, pp. 153460. Date of Electronic Publication: 2021 Jan 08.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*therapeutic use
Colonic Neoplasms/*drug therapy
Naphthoquinones/*therapeutic use
Animals ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Survival/drug effects ; Humans ; Lithospermum/chemistry ; Metabolomics ; Mice ; Naphthoquinones/pharmacology ; Plant Roots/chemistry ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Shikonin is a novel and selective IMPDH2 inhibitor that target triple-negative breast cancer.
Autorzy :
Wang W; State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, China.
Wu Y; State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, China.
Chen S; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.
Liu X; State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, China.
He J; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.
Wang S; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.
Lu W; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.
Tang Y; Department of Urology, Wuming Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Huang J; State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, China.
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Źródło :
Phytotherapy research : PTR [Phytother Res] 2021 Jan; Vol. 35 (1), pp. 463-476. Date of Electronic Publication: 2020 Aug 10.
Typ publikacji :
Journal Article
MeSH Terms :
Enzyme Inhibitors/*pharmacology
IMP Dehydrogenase/*antagonists & inhibitors
Naphthoquinones/*pharmacology
Triple Negative Breast Neoplasms/*pathology
Animals ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Female ; Gene Knockdown Techniques ; Humans ; Lithospermum/chemistry ; Mice ; Molecular Docking Simulation ; Triple Negative Breast Neoplasms/drug therapy
Czasopismo naukowe
Tytuł :
A Trp-574-Leu mutation in the acetolactate synthase (ALS) gene of Lithospermum arvense L. confers broad-spectrum resistance to ALS inhibitors.
Autorzy :
Wang Q; College of Plant Protection, Shandong Agricultural University, Tai'an 271018, Shandong, China; Key Laboratory of Pesticide Toxicology and Application Technology, Shandong Agricultural University, Tai'an 271018, Shandong, China.
Ge L; College of Plant Protection, Shandong Agricultural University, Tai'an 271018, Shandong, China; Key Laboratory of Pesticide Toxicology and Application Technology, Shandong Agricultural University, Tai'an 271018, Shandong, China.
Zhao N; College of Plant Protection, Shandong Agricultural University, Tai'an 271018, Shandong, China; Key Laboratory of Pesticide Toxicology and Application Technology, Shandong Agricultural University, Tai'an 271018, Shandong, China.
Zhang L; Administration Bureau of the Yellow River Delta National Nature Reserve, Dongying 257091, Shandong, China.
You L; College of Plant Protection, Shandong Agricultural University, Tai'an 271018, Shandong, China; Key Laboratory of Pesticide Toxicology and Application Technology, Shandong Agricultural University, Tai'an 271018, Shandong, China.
Wang D; College of Plant Protection, Shandong Agricultural University, Tai'an 271018, Shandong, China; Key Laboratory of Pesticide Toxicology and Application Technology, Shandong Agricultural University, Tai'an 271018, Shandong, China.
Liu W; College of Plant Protection, Shandong Agricultural University, Tai'an 271018, Shandong, China; Key Laboratory of Pesticide Toxicology and Application Technology, Shandong Agricultural University, Tai'an 271018, Shandong, China. Electronic address: .
Wang J; College of Plant Protection, Shandong Agricultural University, Tai'an 271018, Shandong, China; Key Laboratory of Pesticide Toxicology and Application Technology, Shandong Agricultural University, Tai'an 271018, Shandong, China. Electronic address: .
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Źródło :
Pesticide biochemistry and physiology [Pestic Biochem Physiol] 2019 Jul; Vol. 158, pp. 12-17. Date of Electronic Publication: 2019 Apr 01.
Typ publikacji :
Journal Article
MeSH Terms :
Acetolactate Synthase/*genetics
Lithospermum/*drug effects
Lithospermum/*enzymology
Mutation/*genetics
Arylsulfonates/toxicity ; Benzoates/toxicity ; Herbicide Resistance/genetics ; Herbicides/toxicity ; Lithospermum/genetics ; Nicotinic Acids/toxicity ; Plant Proteins/genetics ; Pyrimidines/toxicity ; Sulfonamides/toxicity
Czasopismo naukowe
Tytuł :
Comparative Proteomic Analysis of Lithospermum erythrorhizon Reveals Regulation of a Variety of Metabolic Enzymes Leading to Comprehensive Understanding of the Shikonin Biosynthetic Pathway.
Autorzy :
Takanashi K; Research Institute for Sustainable Humanosphere, Kyoto University, Uji, Japan.; Institute of Mountain Science, Shinshu University, Matsumoto, Japan.
Nakagawa Y; Research Institute for Sustainable Humanosphere, Kyoto University, Uji, Japan.
Aburaya S; Graduate School of Agriculture, Kyoto University, Kyoto, Japan.
Kaminade K; Research Institute for Sustainable Humanosphere, Kyoto University, Uji, Japan.
Aoki W; Graduate School of Agriculture, Kyoto University, Kyoto, Japan.
Saida-Munakata Y; Research Institute for Sustainable Humanosphere, Kyoto University, Uji, Japan.
Sugiyama A; Research Institute for Sustainable Humanosphere, Kyoto University, Uji, Japan.
Ueda M; Graduate School of Agriculture, Kyoto University, Kyoto, Japan.
Yazaki K; Research Institute for Sustainable Humanosphere, Kyoto University, Uji, Japan.
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Źródło :
Plant & cell physiology [Plant Cell Physiol] 2019 Jan 01; Vol. 60 (1), pp. 19-28.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Biosynthetic Pathways*
Proteomics*
Lithospermum/*enzymology
Lithospermum/*metabolism
Naphthoquinones/*metabolism
Cluster Analysis ; Gene Expression Regulation, Plant ; Lithospermum/genetics ; Naphthoquinones/chemistry ; Plant Proteins/metabolism ; Proteome/metabolism ; Reproducibility of Results ; Sequence Analysis, RNA
Czasopismo naukowe
Tytuł :
Harnessing Integrated Omics Approaches for Plant Specialized Metabolism Research: New Insights into Shikonin Biosynthesis.
Autorzy :
Wong DCJ; Ecology and Evolution, Research School of Biology, The Australian National University, Acton, ACT 2601, Australia.
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Źródło :
Plant & cell physiology [Plant Cell Physiol] 2019 Jan 01; Vol. 60 (1), pp. 4-6.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Lithospermum*
Naphthoquinones*
Biosynthetic Pathways ; Proteomics
Czasopismo naukowe
Tytuł :
De Novo Transcriptome Assembly and Characterization of Lithospermum officinale to Discover Putative Genes Involved in Specialized Metabolites Biosynthesis.
Autorzy :
Rai A; Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.
Nakaya T; Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.
Shimizu Y; Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.
Rai M; Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.
Nakamura M; Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.
Suzuki H; Kazusa DNA Research Institute, Chiba, Japan.
Saito K; Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.
Yamazaki M; Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.
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Źródło :
Planta medica [Planta Med] 2018 Aug; Vol. 84 (12-13), pp. 920-934. Date of Electronic Publication: 2018 May 29.
Typ publikacji :
Journal Article
MeSH Terms :
Metabolome*
Transcriptome*
Benzofurans/*metabolism
Chlorogenic Acid/*metabolism
Depsides/*metabolism
Lithospermum/*genetics
Naphthoquinones/*metabolism
Biosynthetic Pathways ; Gene Ontology ; Lithospermum/chemistry ; Lithospermum/metabolism ; Plant Leaves/chemistry ; Plant Leaves/genetics ; Plant Leaves/metabolism ; Plant Roots/chemistry ; Plant Roots/genetics ; Plant Roots/metabolism ; Plant Stems/chemistry ; Plant Stems/genetics ; Plant Stems/metabolism
Czasopismo naukowe
Tytuł :
Gromwell (Lithospermum erythrorhizon) root extract protects against glycation and related inflammatory and oxidative stress while offering UV absorption capability.
Autorzy :
Glynn KM; Research & Development, Amway Corporation, Ada, Michigan.
Anderson P; Research & Development, Amway Corporation, Ada, Michigan.
Fast DJ; Research & Development, Amway Corporation, Ada, Michigan.
Koedam J; Research & Development, Amway Corporation, Ada, Michigan.
Rebhun JF; Research & Development, Amway Corporation, Ada, Michigan.
Velliquette RA; Research & Development, Amway Corporation, Ada, Michigan.
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Źródło :
Experimental dermatology [Exp Dermatol] 2018 Sep; Vol. 27 (9), pp. 1043-1047. Date of Electronic Publication: 2018 Jul 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Lithospermum*
Absorption, Radiation/*drug effects
Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
Glycation End Products, Advanced/*metabolism
Naphthoquinones/*pharmacology
Oxidative Stress/*drug effects
Plant Extracts/*pharmacology
Cosmetics/pharmacology ; Glutathione/biosynthesis ; Hep G2 Cells ; Humans ; Inflammation/prevention & control ; Lactoylglutathione Lyase/genetics ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; NF-kappa B/metabolism ; Plant Roots ; Tumor Necrosis Factor-alpha/metabolism ; Ultraviolet Rays ; Up-Regulation
Czasopismo naukowe
Tytuł :
Involvement of LeMRP, an ATP-binding cassette transporter, in shikonin transport and biosynthesis in Lithospermum erythrorhizon.
Autorzy :
Zhu Y; Institute of Plant Molecular Biology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China.; Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, China.
Chu SJ; Institute of Plant Molecular Biology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China.; Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, China.
Luo YL; Institute of Plant Molecular Biology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China.; Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, China.
Fu JY; Institute of Plant Molecular Biology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China.; Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, China.
Tang CY; Institute of Plant Molecular Biology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China.; Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, China.
Lu GH; Institute of Plant Molecular Biology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China.; Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, China.
Pang YJ; Institute of Plant Molecular Biology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China.; Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, China.
Wang XM; Institute of Plant Molecular Biology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China.; Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, China.
Yang RW; Institute of Plant Molecular Biology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China.; Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, China.
Qi JL; Institute of Plant Molecular Biology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China.; Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, China.
Yang YH; Institute of Plant Molecular Biology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China.; Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, China.
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Źródło :
Plant biology (Stuttgart, Germany) [Plant Biol (Stuttg)] 2018 Mar; Vol. 20 (2), pp. 365-373. Date of Electronic Publication: 2017 Dec 10.
Typ publikacji :
Journal Article
MeSH Terms :
ATP-Binding Cassette Transporters/*metabolism
Lithospermum/*metabolism
Naphthoquinones/*metabolism
Plant Proteins/*metabolism
ATP-Binding Cassette Transporters/genetics ; Cloning, Molecular ; Gene Expression Regulation, Plant ; Lithospermum/genetics ; Membrane Transport Proteins/metabolism ; Phylogeny ; Plant Proteins/genetics ; Plants, Genetically Modified ; Real-Time Polymerase Chain Reaction ; Sequence Analysis, DNA
Czasopismo naukowe
Tytuł :
A Cytosol-Localized Geranyl Diphosphate Synthase from Lithospermum erythrorhizon and Its Molecular Evolution.
Autorzy :
Ueoka H; Research Institute for Sustainable Humanosphere, Kyoto University, Uji 611-0011, Japan.
Sasaki K; Research Institute for Sustainable Humanosphere, Kyoto University, Uji 611-0011, Japan.
Miyawaki T; Research Institute for Sustainable Humanosphere, Kyoto University, Uji 611-0011, Japan.
Ichino T; Research Institute for Sustainable Humanosphere, Kyoto University, Uji 611-0011, Japan.
Tatsumi K; Research Institute for Sustainable Humanosphere, Kyoto University, Uji 611-0011, Japan.
Suzuki S; Research Institute for Sustainable Humanosphere, Kyoto University, Uji 611-0011, Japan.
Yamamoto H; Faculty of Life Sciences, Toyo University, Itakura 374-0193, Japan.
Sakurai N; Kazusa DNA Research Institute, Kisarazu, Chiba 292-0818, Japan.
Suzuki H; Kazusa DNA Research Institute, Kisarazu, Chiba 292-0818, Japan.
Shibata D; Kazusa DNA Research Institute, Kisarazu, Chiba 292-0818, Japan.
Yazaki K; Research Institute for Sustainable Humanosphere, Kyoto University, Uji 611-0011, Japan .
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Źródło :
Plant physiology [Plant Physiol] 2020 Apr; Vol. 182 (4), pp. 1933-1945. Date of Electronic Publication: 2020 Jan 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cytosol/*metabolism
Geranyltranstransferase/*metabolism
Lithospermum/*metabolism
Coumarins/metabolism ; Geranyltranstransferase/genetics ; Monoterpenes/metabolism ; Mutagenesis, Site-Directed ; Naphthoquinones/metabolism ; Plastids/genetics ; Plastids/metabolism
Czasopismo naukowe
Tytuł :
Transcriptome analysis explores genes related to shikonin biosynthesis in Lithospermeae plants and provides insights into Boraginales' evolutionary history.
Autorzy :
Wu FY; State Key Laboratory of Pharmaceutical Biotechnology, NJU-NJFU Joint Institute of Plant Molecular Biology, School of Life Sciences, Nanjing University, Nanjing, 210093, China.
Tang CY; State Key Laboratory of Pharmaceutical Biotechnology, NJU-NJFU Joint Institute of Plant Molecular Biology, School of Life Sciences, Nanjing University, Nanjing, 210093, China. .
Guo YM; State Key Laboratory of Pharmaceutical Biotechnology, NJU-NJFU Joint Institute of Plant Molecular Biology, School of Life Sciences, Nanjing University, Nanjing, 210093, China.
Bian ZW; State Key Laboratory of Pharmaceutical Biotechnology, NJU-NJFU Joint Institute of Plant Molecular Biology, School of Life Sciences, Nanjing University, Nanjing, 210093, China.
Fu JY; State Key Laboratory of Pharmaceutical Biotechnology, NJU-NJFU Joint Institute of Plant Molecular Biology, School of Life Sciences, Nanjing University, Nanjing, 210093, China.
Lu GH; State Key Laboratory of Pharmaceutical Biotechnology, NJU-NJFU Joint Institute of Plant Molecular Biology, School of Life Sciences, Nanjing University, Nanjing, 210093, China.
Qi JL; State Key Laboratory of Pharmaceutical Biotechnology, NJU-NJFU Joint Institute of Plant Molecular Biology, School of Life Sciences, Nanjing University, Nanjing, 210093, China.
Pang YJ; State Key Laboratory of Pharmaceutical Biotechnology, NJU-NJFU Joint Institute of Plant Molecular Biology, School of Life Sciences, Nanjing University, Nanjing, 210093, China. .
Yang YH; State Key Laboratory of Pharmaceutical Biotechnology, NJU-NJFU Joint Institute of Plant Molecular Biology, School of Life Sciences, Nanjing University, Nanjing, 210093, China. .
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Źródło :
Scientific reports [Sci Rep] 2017 Jun 30; Vol. 7 (1), pp. 4477. Date of Electronic Publication: 2017 Jun 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Biological Evolution*
Gene Expression Regulation, Plant*
Transcriptome*
Biosynthetic Pathways/*genetics
Lithospermum/*genetics
Lithospermum/*metabolism
Naphthoquinones/*metabolism
Boraginaceae/genetics ; Boraginaceae/metabolism ; Chromatography, High Pressure Liquid ; Computational Biology/methods ; Gene Expression Profiling ; High-Throughput Nucleotide Sequencing ; Lithospermum/classification ; Molecular Sequence Annotation ; Naphthoquinones/analysis ; Phylogeny ; Selection, Genetic
Czasopismo naukowe
Tytuł :
Lithospermum erythrorhizon extract inhibits Der p2-induced inflammatory response through alleviation of thymic stromal lymphopoietin, nuclear factor Kappa B, and inflammasome expression in human bronchial epithelial cells.
Autorzy :
Yen CY; Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan; Department of Dermatology, Taichung Veterans General Hospital, Taichung 40705, Taiwan. Electronic address: .
Chiang WD; Department of Food Science, Tunghai University, Taichung 40704, Taiwan. Electronic address: .
Liu SY; Department of Food Science, Tunghai University, Taichung 40704, Taiwan. Electronic address: .
Wang KT; Brion Research Institute, New Taipei City 23143, Taiwan. Electronic address: .
Liao EC; Department of Medicine, Mackay Medical College, New Taipei City 25245, Taiwan. Electronic address: .
Hsieh CL; Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan; Department of Chinese Medicine, China Medical University Hospital, Taichung 40447, Taiwan; Graduate Institute of Acupuncture Science, China Medical University, Taichung 40402, Taiwan; Research Center for Chinese Medicine and Acupuncture, China Medical University, Taichung 40402, Taiwan. Electronic address: .
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2017 Apr 06; Vol. 201, pp. 1-8. Date of Electronic Publication: 2017 Feb 28.
Typ publikacji :
Journal Article
MeSH Terms :
Angelica*
Lithospermum*
Anti-Inflammatory Agents/*pharmacology
Epithelial Cells/*drug effects
Plant Extracts/*pharmacology
Allergens ; Antigens, Dermatophagoides ; Arthropod Proteins ; Bronchi/cytology ; CARD Signaling Adaptor Proteins ; Caspase 1/metabolism ; Cell Line ; Cytokines/metabolism ; Cytoskeletal Proteins/metabolism ; Epithelial Cells/metabolism ; Humans ; Inflammasomes/metabolism ; NF-kappa B/metabolism ; STAT3 Transcription Factor/metabolism
Czasopismo naukowe
Tytuł :
Regulations of miR-183-5p and Snail-Mediated Shikonin-Reduced Epithelial-Mesenchymal Transition in Cervical Cancer Cells.
Autorzy :
Tang Q; Laboratory of Tumor Biology, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province 510120, People's Republic of China.
Liu L; Department of Gynecology, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province 510120, People's Republic of China.
Zhang H; Department of Gynecology, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province 510120, People's Republic of China.
Xiao J; Department of Gynecology, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province 510120, People's Republic of China.
Hann SS; Laboratory of Tumor Biology, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province 510120, People's Republic of China.; Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province 510120, People's Republic of China.
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Źródło :
Drug design, development and therapy [Drug Des Devel Ther] 2020 Feb 11; Vol. 14, pp. 577-589. Date of Electronic Publication: 2020 Feb 11 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents, Phytogenic/*pharmacology
MicroRNAs/*genetics
Naphthoquinones/*pharmacology
Uterine Cervical Neoplasms/*drug therapy
Animals ; Antigens, CD/genetics ; Antineoplastic Agents, Phytogenic/administration & dosage ; Cadherins/genetics ; Cell Line, Tumor ; Dose-Response Relationship, Drug ; Epithelial-Mesenchymal Transition/drug effects ; Epithelial-Mesenchymal Transition/genetics ; Female ; Gene Expression Regulation, Neoplastic ; HeLa Cells ; Humans ; Lithospermum/chemistry ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Naphthoquinones/administration & dosage ; Snail Family Transcription Factors/genetics ; Uterine Cervical Neoplasms/genetics ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Molecular identification and phytochemical screening of endophytic fungi isolated from Lithospermum officinale L. roots: A new source of shikonin.
Autorzy :
Mollaei S; Phytochemical Laboratory, Department of Chemistry, Faculty of Sciences, Azarbaijan Shahid Madani University, Tabriz, Iran. Electronic address: .
Khanehbarndaz O; Phytochemical Laboratory, Department of Chemistry, Faculty of Sciences, Azarbaijan Shahid Madani University, Tabriz, Iran.
Gerami-Khashal Z; Department of Biology, Faculty of Sciences, Azarbaijan Shahid Madani University, Tabriz, Iran.
Ebadi M; Department of Biology, Faculty of Sciences, Azarbaijan Shahid Madani University, Tabriz, Iran. Electronic address: .
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Źródło :
Phytochemistry [Phytochemistry] 2019 Dec; Vol. 168, pp. 112116. Date of Electronic Publication: 2019 Sep 09.
Typ publikacji :
Journal Article
MeSH Terms :
Antioxidants/*isolation & purification
Endophytes/*chemistry
Lithospermum/*microbiology
Naphthoquinones/*isolation & purification
Naphthoquinones/*pharmacology
Phytochemicals/*isolation & purification
Antioxidants/chemistry ; Antioxidants/pharmacology ; Biphenyl Compounds/antagonists & inhibitors ; Drug Evaluation, Preclinical ; Naphthoquinones/chemistry ; Phylogeny ; Phytochemicals/chemistry ; Phytochemicals/pharmacology ; Picrates/antagonists & inhibitors ; Plant Roots/microbiology
Czasopismo naukowe
Tytuł :
Cartilage protective and anti-analgesic effects of ALM16 on monosodium iodoacetate induced osteoarthritis in rats.
Autorzy :
Choi DJ; Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA, Eumseong, 27709, Republic of Korea.
Choi SI; Plant Resources Research Institute, Duksung Women's University, Seoul, 01369, Republic of Korea.
Choi BR; Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA, Eumseong, 27709, Republic of Korea.
Lee YS; Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA, Eumseong, 27709, Republic of Korea.
Lee DY; Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA, Eumseong, 27709, Republic of Korea.
Kim GS; Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA, Eumseong, 27709, Republic of Korea. .
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Źródło :
BMC complementary and alternative medicine [BMC Complement Altern Med] 2019 Nov 21; Vol. 19 (1), pp. 325. Date of Electronic Publication: 2019 Nov 21.
Typ publikacji :
Journal Article
MeSH Terms :
Osteoarthritis*/chemically induced
Osteoarthritis*/metabolism
Osteoarthritis*/physiopathology
Analgesics/*pharmacology
Anti-Inflammatory Agents/*pharmacology
Cartilage, Articular/*drug effects
Plant Extracts/*pharmacology
Animals ; Astragalus propinquus/chemistry ; Cartilage, Articular/metabolism ; Cell Line, Tumor ; Disease Models, Animal ; Glycosaminoglycans/analysis ; Humans ; Iodoacetic Acid/adverse effects ; Lithospermum/chemistry ; Male ; Matrix Metalloproteinases/analysis ; Medicine, East Asian Traditional ; Mice, Inbred ICR ; Protective Agents/pharmacology ; Rats
Czasopismo naukowe

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