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Wyszukujesz frazę ""Liu, David"" wg kryterium: Autor


Tytuł:
DNA capture by a CRISPR-Cas9-guided adenine base editor.
Autorzy:
Lapinaite A; Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
Knott GJ; Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.; Monash Biomedicine Discovery Institute, Department of Biochemistry & Molecular Biology, Monash University, Victoria 3800, Australia.
Palumbo CM; Department of Chemistry, University of California, Davis, CA 95616, USA.
Lin-Shiao E; Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
Richter MF; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA 02141, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA.
Zhao KT; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA 02141, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA.
Beal PA; Department of Chemistry, University of California, Davis, CA 95616, USA.
Liu DR; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA 02141, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA.
Doudna JA; Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA. .; Innovative Genomics Institute, University of California, Berkeley, CA 94720, USA.; MBIB Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.; Department of Chemistry, University of California, Berkeley, CA 94720, USA.; Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA.; Gladstone Institute of Data Science and Biotechnology, Gladstone Institutes, San Francisco, CA 94158, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2020 Jul 31; Vol. 369 (6503), pp. 566-571.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
CRISPR-Cas Systems*
Gene Editing*
Adenine/*chemistry
Adenosine Deaminase/*chemistry
CRISPR-Associated Protein 9/*chemistry
DNA/*chemistry
Escherichia coli Proteins/*chemistry
Adenosine Deaminase/genetics ; CRISPR-Associated Protein 9/genetics ; Cryoelectron Microscopy ; Deamination ; Escherichia coli Proteins/genetics
Czasopismo naukowe
Tytuł:
Broad specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage specificity.
Autorzy:
Guilinger JP; 1] Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, USA. [2] Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts, USA.
Pattanayak V; 1] Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, USA. [2] Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts, USA.
Reyon D; 1] Molecular Pathology Unit, Center for Cancer Research, and Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, Massachusetts, USA. [2] Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA.
Tsai SQ; 1] Molecular Pathology Unit, Center for Cancer Research, and Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, Massachusetts, USA. [2] Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA.
Sander JD; 1] Molecular Pathology Unit, Center for Cancer Research, and Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, Massachusetts, USA. [2] Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA.
Joung JK; 1] Molecular Pathology Unit, Center for Cancer Research, and Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, Massachusetts, USA. [2] Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA.
Liu DR; 1] Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, USA. [2] Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts, USA.
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Źródło:
Nature methods [Nat Methods] 2014 Apr; Vol. 11 (4), pp. 429-35. Date of Electronic Publication: 2014 Feb 16.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA/*metabolism
Deoxyribonucleases/*metabolism
Protein Engineering/*methods
Substrate Specificity/*physiology
Base Sequence ; Binding Sites ; Cell Line ; Deoxyribonucleases/genetics ; Gene Targeting ; Humans ; Protein Binding
Czasopismo naukowe
Tytuł:
Enzyme-free translation of DNA into sequence-defined synthetic polymers structurally unrelated to nucleic acids.
Autorzy:
Niu J; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
Hili R
Liu DR
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Źródło:
Nature chemistry [Nat Chem] 2013 Apr; Vol. 5 (4), pp. 282-92. Date of Electronic Publication: 2013 Mar 03.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA/*chemistry
Peptide Nucleic Acids/*chemistry
Polymers/*chemical synthesis
Codon ; DNA/genetics ; Electrophoresis, Polyacrylamide Gel ; Polymers/chemistry ; Protein Biosynthesis ; Substrate Specificity ; Templates, Genetic
Czasopismo naukowe
Tytuł:
Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection.
Autorzy:
Pattanayak V; Department of Chemistry and Chemical Biology, and Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts, USA.
Ramirez CL
Joung JK
Liu DR
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Źródło:
Nature methods [Nat Methods] 2011 Aug 07; Vol. 8 (9), pp. 765-70. Date of Electronic Publication: 2011 Aug 07.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Substrate Specificity*
Zinc Fingers*/genetics
DNA/*metabolism
Endodeoxyribonucleases/*metabolism
Base Sequence ; Binding Sites ; Cells, Cultured ; DNA-Binding Proteins/metabolism ; Humans ; K562 Cells
Czasopismo naukowe
Tytuł:
A biomolecule-compatible visible-light-induced azide reduction from a DNA-encoded reaction-discovery system.
Autorzy:
Chen Y; Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA.
Kamlet AS
Steinman JB
Liu DR
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Źródło:
Nature chemistry [Nat Chem] 2011 Feb; Vol. 3 (2), pp. 146-53. Date of Electronic Publication: 2011 Jan 09.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Light*
Azides/*chemistry
DNA/*chemistry
Ruthenium/*chemistry
Carboxylic Acids/chemistry ; Molecular Structure ; Oligonucleotide Array Sequence Analysis ; Oxidation-Reduction
Czasopismo naukowe
Tytuł:
Autonomous multistep organic synthesis in a single isothermal solution mediated by a DNA walker.
Autorzy:
He Y; Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.
Liu DR
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Źródło:
Nature nanotechnology [Nat Nanotechnol] 2010 Nov; Vol. 5 (11), pp. 778-82. Date of Electronic Publication: 2010 Oct 10.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Chemistry, Organic/*methods
DNA/*chemistry
Nanotechnology/*methods
Base Sequence ; DNA/chemical synthesis ; Hybridization, Genetic ; Mass Spectrometry ; Solutions ; Templates, Genetic
Czasopismo naukowe
Tytuł:
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1.
Autorzy:
Tahiliani M; Department of Pathology, Harvard Medical School and Immune Disease Institute, 200 Longwood Avenue, Boston, MA 02115, USA.
Koh KP
Shen Y
Pastor WA
Bandukwala H
Brudno Y
Agarwal S
Iyer LM
Liu DR
Aravind L
Rao A
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Źródło:
Science (New York, N.Y.) [Science] 2009 May 15; Vol. 324 (5929), pp. 930-5. Date of Electronic Publication: 2009 Apr 16.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
5-Methylcytosine/*metabolism
Cytosine/*analogs & derivatives
DNA/*metabolism
DNA-Binding Proteins/*metabolism
Proto-Oncogene Proteins/*metabolism
Amino Acid Sequence ; Animals ; Cell Line ; Cytosine/analysis ; Cytosine/metabolism ; DNA/chemistry ; DNA Methylation ; DNA-Binding Proteins/chemistry ; DNA-Binding Proteins/genetics ; Dinucleoside Phosphates/metabolism ; Embryonic Stem Cells/chemistry ; Embryonic Stem Cells/metabolism ; Humans ; Hydroxylation ; Mass Spectrometry ; Mice ; Mixed Function Oxygenases ; Molecular Sequence Data ; Proto-Oncogene Proteins/chemistry ; Proto-Oncogene Proteins/genetics ; RNA Interference ; Sequence Alignment ; Transfection
Czasopismo naukowe
Tytuł:
Reaction discovery enabled by DNA-templated synthesis and in vitro selection.
Autorzy:
Kanan MW; Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.
Rozenman MM
Sakurai K
Snyder TM
Liu DR
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Źródło:
Nature [Nature] 2004 Sep 30; Vol. 431 (7008), pp. 545-9.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
MeSH Terms:
DNA/*chemical synthesis
DNA/*chemistry
Alkenes/chemistry ; Alkynes/chemistry ; Base Pairing ; Carbon/chemistry ; Catalysis ; Cyclization ; DNA Replication ; Molecular Structure ; Oligonucleotide Array Sequence Analysis ; Palladium/chemistry ; Polymerase Chain Reaction ; Substrate Specificity ; Templates, Genetic
Czasopismo naukowe
Tytuł:
DNA-templated organic synthesis and selection of a library of macrocycles.
Autorzy:
Gartner ZJ; Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA.
Tse BN
Grubina R
Doyon JB
Snyder TM
Liu DR
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Źródło:
Science (New York, N.Y.) [Science] 2004 Sep 10; Vol. 305 (5690), pp. 1601-5. Date of Electronic Publication: 2004 Aug 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
MeSH Terms:
DNA/*chemical synthesis
DNA/*chemistry
Heterocyclic Compounds, 1-Ring/*chemical synthesis
Oligodeoxyribonucleotides/*chemistry
Amides ; Biotinylation ; Codon ; Cyclization ; DNA/isolation & purification ; Electrophoresis, Polyacrylamide Gel ; Gene Library ; Heterocyclic Compounds, 1-Ring/isolation & purification ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Czasopismo naukowe
Tytuł:
Translating DNA into synthetic molecules.
Autorzy:
Liu DR; Department of Chemistry and Chemical Biology at Harvard University, Cambridge, Massachusetts, USA. liu@chemistry.harvard.edu
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Źródło:
PLoS biology [PLoS Biol] 2004 Jul; Vol. 2 (7), pp. E223. Date of Electronic Publication: 2004 Jul 13.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Genetic Engineering*
DNA/*chemistry
Evolution, Molecular ; Gene Library ; Genetic Techniques ; Nucleic Acid Hybridization ; Nucleic Acids/chemistry ; Oligonucleotides/chemistry ; Peptide Library ; Peptides/chemistry
Czasopismo naukowe
Tytuł:
Nucleic acid evolution and minimization by nonhomologous random recombination.
Autorzy:
Bittker JA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
Le BV
Liu DR
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Źródło:
Nature biotechnology [Nat Biotechnol] 2002 Oct; Vol. 20 (10), pp. 1024-9. Date of Electronic Publication: 2002 Sep 09.
Typ publikacji:
Comparative Study; Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Evolution, Molecular*
Recombination, Genetic*
Sequence Homology, Nucleic Acid*
DNA/*genetics
Nucleic Acid Amplification Techniques/*methods
Sequence Analysis, DNA/*methods
Base Sequence ; Cloning, Molecular ; DNA Primers ; Directed Molecular Evolution/methods ; Molecular Sequence Data ; Polymerase Chain Reaction ; Random Amplified Polymorphic DNA Technique/methods ; Reproducibility of Results ; Sensitivity and Specificity ; Streptavidin/genetics
Czasopismo naukowe
Tytuł:
P07 Optimizing DNA specificity and applicability of base and prime editors on COL7A1 variants causing recessive dystrophic epidermolysis bullosa.
Autorzy:
Brooks, Imogen
Rudnytska, Maria
Gebrezgabher, Ruta
Laczmanski, Lukasz
Newby, Gregory
Liu, David
McGrath, John
Jackow, Joanna
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Temat:
EPIDERMOLYSIS bullosa
GENOME editing
DNA
BASAL lamina
RNA editing
Źródło:
British Journal of Dermatology; Jul2023, Vol. 189 Issue 1, pe16-e17, 2p
Czasopismo naukowe

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