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Wyszukujesz frazę ""Liu, Yunpeng"" wg kryterium: Autor


Tytuł :
Formation of the IGF1R/CAV1/SRC tri-complex antagonizes TRAIL-induced apoptosis in gastric cancer cells.
Autorzy :
Guo T; Department of Medical Oncology, the First Hospital of China Medical University, Shenyang, 110001, China.; Key Laboratory of Anticancer Drugs and Biotherapy of Liaoning Province, the First Hospital of China Medical University, Shenyang, 110001, China.
Xu L; Department of Medical Oncology, the First Hospital of China Medical University, Shenyang, 110001, China.; Key Laboratory of Anticancer Drugs and Biotherapy of Liaoning Province, the First Hospital of China Medical University, Shenyang, 110001, China.
Che X; Department of Medical Oncology, the First Hospital of China Medical University, Shenyang, 110001, China.; Key Laboratory of Anticancer Drugs and Biotherapy of Liaoning Province, the First Hospital of China Medical University, Shenyang, 110001, China.
Zhang S; Department of Medical Oncology, the First Hospital of China Medical University, Shenyang, 110001, China.; Key Laboratory of Anticancer Drugs and Biotherapy of Liaoning Province, the First Hospital of China Medical University, Shenyang, 110001, China.
Li C; Department of Medical Oncology, the First Hospital of China Medical University, Shenyang, 110001, China.; Key Laboratory of Anticancer Drugs and Biotherapy of Liaoning Province, the First Hospital of China Medical University, Shenyang, 110001, China.
Wang J; Department of Medical Oncology, the First Hospital of China Medical University, Shenyang, 110001, China.; Key Laboratory of Anticancer Drugs and Biotherapy of Liaoning Province, the First Hospital of China Medical University, Shenyang, 110001, China.
Gong J; Department of Medical Oncology, the First Hospital of China Medical University, Shenyang, 110001, China.; Key Laboratory of Anticancer Drugs and Biotherapy of Liaoning Province, the First Hospital of China Medical University, Shenyang, 110001, China.
Ma R; Department of Medical Oncology, the First Hospital of China Medical University, Shenyang, 110001, China.; Key Laboratory of Anticancer Drugs and Biotherapy of Liaoning Province, the First Hospital of China Medical University, Shenyang, 110001, China.
Fan Y; Department of Medical Oncology, the First Hospital of China Medical University, Shenyang, 110001, China.; Key Laboratory of Anticancer Drugs and Biotherapy of Liaoning Province, the First Hospital of China Medical University, Shenyang, 110001, China.
Hou K; Department of Medical Oncology, the First Hospital of China Medical University, Shenyang, 110001, China.; Key Laboratory of Anticancer Drugs and Biotherapy of Liaoning Province, the First Hospital of China Medical University, Shenyang, 110001, China.
Zhou H; Department of Medical Oncology, the First Hospital of China Medical University, Shenyang, 110001, China.; Key Laboratory of Anticancer Drugs and Biotherapy of Liaoning Province, the First Hospital of China Medical University, Shenyang, 110001, China.
Hu X; Department of Respiratory Medicine, the First Hospital of China Medical University, Shenyang, 110001, China.
Liu Y; Department of Medical Oncology, the First Hospital of China Medical University, Shenyang, 110001, China.; Key Laboratory of Anticancer Drugs and Biotherapy of Liaoning Province, the First Hospital of China Medical University, Shenyang, 110001, China.
Qu X; Department of Medical Oncology, the First Hospital of China Medical University, Shenyang, 110001, China.; Key Laboratory of Anticancer Drugs and Biotherapy of Liaoning Province, the First Hospital of China Medical University, Shenyang, 110001, China.
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Źródło :
Cell biology international [Cell Biol Int] 2017 Jul; Vol. 41 (7), pp. 749-760. Date of Electronic Publication: 2017 May 05.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Caveolin 1/*metabolism
Receptors, Somatomedin/*metabolism
Stomach Neoplasms/*drug therapy
TNF-Related Apoptosis-Inducing Ligand/*pharmacology
src-Family Kinases/*metabolism
Cell Line, Tumor ; Humans ; Membrane Microdomains/metabolism ; MicroRNAs/metabolism ; Mitogen-Activated Protein Kinase 3/metabolism ; Phosphatidylinositol 3-Kinase/metabolism ; Receptor, IGF Type 1/metabolism ; Signal Transduction/drug effects ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/pathology ; TNF-Related Apoptosis-Inducing Ligand/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
miR-155-5p antagonizes the apoptotic effect of bufalin in triple-negative breast cancer cells.
Autorzy :
Wang Q; aDepartment of Medical Oncology, The First Hospital of China Medical University bDepartment of Urology, The Liaoning Provincial Tumor Hospital, Shenyang cDepartment of Medical Oncology dCancer Research Center, The First Affiliated Hospital of Liaoning Medical University, Jinzhou, Liaoning, People's Republic of China.
Li C
Zhu Z
Teng Y
Che X
Wang Y
Ma Y
Wang Y
Zheng H
Liu Y
Qu X
Pokaż więcej
Źródło :
Anti-cancer drugs [Anticancer Drugs] 2016 Jan; Vol. 27 (1), pp. 9-16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Bufanolides/*pharmacology
MicroRNAs/*metabolism
Triple Negative Breast Neoplasms/*pathology
Cell Line, Tumor ; Cell Proliferation/drug effects ; DNA (Cytosine-5-)-Methyltransferase 1 ; DNA (Cytosine-5-)-Methyltransferases/metabolism ; Female ; Forkhead Box Protein O3 ; Forkhead Transcription Factors/metabolism ; Gene Expression Regulation ; Humans
Czasopismo naukowe
Tytuł :
Secreted protein acidic and rich in cysteine antagonizes bufalin-induced apoptosis in gastric cancer cells.
Autorzy :
Li A; Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.
Qu X; Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.
Li Z; Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.
Qu J; Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.
Song N; Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.
Ma Y; Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.
Liu Y; Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.
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Źródło :
Molecular medicine reports [Mol Med Rep] 2015 Aug; Vol. 12 (2), pp. 2926-32. Date of Electronic Publication: 2015 Apr 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*drug effects
Bufanolides/*toxicity
Osteonectin/*metabolism
Bufanolides/chemistry ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cyclin A/metabolism ; Cyclin B1/metabolism ; Cytochromes c/metabolism ; G2 Phase Cell Cycle Checkpoints/drug effects ; Humans ; M Phase Cell Cycle Checkpoints/drug effects ; Medicine, Chinese Traditional ; Membrane Potential, Mitochondrial/drug effects ; Mitochondria/metabolism ; Osteonectin/antagonists & inhibitors ; Osteonectin/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Proto-Oncogene Proteins c-bcl-2/metabolism ; RNA Interference ; RNA, Small Interfering/metabolism ; Signal Transduction/drug effects ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/pathology ; bcl-2-Associated X Protein/metabolism ; src-Family Kinases/metabolism
Czasopismo naukowe
Tytuł :
Cetuximab-induced insulin-like growth factor receptor I activation mediates cetuximab resistance in gastric cancer cells.
Autorzy :
Li X; Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.
Xu L; Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.
Li H; Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.
Zhao L; Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.
Luo Y; Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.
Zhu Z; Department of Medical Oncology, The First Affiliated Hospital of Liaoning Medical University, Jinzhou, Liaoning 121001, P.R. China.
Liu Y; Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.
Qu X; Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.
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Źródło :
Molecular medicine reports [Mol Med Rep] 2015 Jun; Vol. 11 (6), pp. 4547-54. Date of Electronic Publication: 2015 Jan 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Cetuximab/*pharmacology
Receptor, IGF Type 1/*metabolism
Antineoplastic Agents/therapeutic use ; Cell Line, Tumor ; Cetuximab/therapeutic use ; Drug Resistance, Neoplasm ; Humans ; Imidazoles/pharmacology ; Phosphorylation/drug effects ; Proto-Oncogene Proteins B-raf/genetics ; Proto-Oncogene Proteins B-raf/metabolism ; Pyrazines/pharmacology ; RNA Interference ; RNA, Small Interfering/metabolism ; Receptor, IGF Type 1/antagonists & inhibitors ; Receptor, IGF Type 1/genetics ; Stomach Neoplasms/drug therapy ; ras Proteins/genetics ; ras Proteins/metabolism ; src-Family Kinases/antagonists & inhibitors ; src-Family Kinases/metabolism
Czasopismo naukowe
Tytuł :
Bufalin enhances TRAIL-induced apoptosis by redistributing death receptors in lipid rafts in breast cancer cells.
Autorzy :
Yan S; aDepartment of Medical Oncology, The First Hospital of China Medical University bDepartment of Oncology, Shengjing Hospital of China Medical University, Shenyang, China.
Qu X
Xu L
Che X
Ma Y
Zhang L
Teng Y
Zou H
Liu Y
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Źródło :
Anti-cancer drugs [Anticancer Drugs] 2014 Jul; Vol. 25 (6), pp. 683-9.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Breast Neoplasms/*metabolism
Bufanolides/*pharmacology
Membrane Microdomains/*metabolism
Receptors, TNF-Related Apoptosis-Inducing Ligand/*metabolism
TNF-Related Apoptosis-Inducing Ligand/*metabolism
Breast Neoplasms/pathology ; Cell Line, Tumor ; Cholesterol/metabolism ; Female ; Humans ; beta-Cyclodextrins/pharmacology
Czasopismo naukowe
Tytuł :
Cbl-b enhances sensitivity to 5-fluorouracil via EGFR- and mitochondria-mediated pathways in gastric cancer cells.
Autorzy :
Feng D
Ma Y
Liu J
Xu L
Zhang Y
Qu J
Liu Y; Department of Medical Oncology, the First Hospital of China Medical University, Shenyang 110001, China. .
Qu X; Department of Medical Oncology, the First Hospital of China Medical University, Shenyang 110001, China. .
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2013 Dec 16; Vol. 14 (12), pp. 24399-411. Date of Electronic Publication: 2013 Dec 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptor Proteins, Signal Transducing/*metabolism
Apoptosis/*drug effects
ErbB Receptors/*metabolism
Fluorouracil/*toxicity
Mitochondria/*metabolism
Proto-Oncogene Proteins c-cbl/*metabolism
Adaptor Proteins, Signal Transducing/antagonists & inhibitors ; Adaptor Proteins, Signal Transducing/genetics ; Cell Line, Tumor ; Cell Proliferation/drug effects ; ErbB Receptors/antagonists & inhibitors ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Humans ; Phosphorylation/drug effects ; Proto-Oncogene Proteins c-akt/metabolism ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Proto-Oncogene Proteins c-cbl/antagonists & inhibitors ; Proto-Oncogene Proteins c-cbl/genetics ; RNA Interference ; RNA, Small Interfering/metabolism ; Signal Transduction/drug effects ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/pathology ; bcl-2-Associated X Protein/metabolism
Czasopismo naukowe
Tytuł :
Lipid raft-regulated IGF-1R activation antagonizes TRAIL-induced apoptosis in gastric cancer cells.
Autorzy :
Xu L; Department of Medical Oncology, The First Hospital of China Medical University, Shenyang 110001, China.
Qu X
Hu X
Zhu Z
Li C
Li E
Ma Y
Song N
Liu Y
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Źródło :
FEBS letters [FEBS Lett] 2013 Nov 29; Vol. 587 (23), pp. 3815-23. Date of Electronic Publication: 2013 Oct 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Membrane Microdomains/*metabolism
Receptor, IGF Type 1/*metabolism
Stomach Neoplasms/*metabolism
TNF-Related Apoptosis-Inducing Ligand/*pharmacology
Adaptor Proteins, Signal Transducing/metabolism ; Cell Line, Tumor ; Humans ; Imidazoles/pharmacology ; Protein Transport ; Proto-Oncogene Proteins c-cbl/metabolism ; Pyrazines/pharmacology ; RNA, Small Interfering ; Receptor, IGF Type 1/antagonists & inhibitors ; Signal Transduction/drug effects ; TNF-Related Apoptosis-Inducing Ligand/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
TRAIL-activated EGFR by Cbl-b-regulated EGFR redistribution in lipid rafts antagonises TRAIL-induced apoptosis in gastric cancer cells.
Autorzy :
Xu L; Department of Medical Oncology, The First Hospital of China Medical University, Shenyang 110001, China.
Zhang Y
Liu J
Qu J
Hu X
Zhang F
Zheng H
Qu X
Liu Y
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Źródło :
European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2012 Nov; Vol. 48 (17), pp. 3288-99. Date of Electronic Publication: 2012 Mar 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptor Proteins, Signal Transducing/*physiology
Apoptosis/*drug effects
ErbB Receptors/*metabolism
Membrane Microdomains/*metabolism
Proto-Oncogene Proteins c-cbl/*physiology
Stomach Neoplasms/*drug therapy
TNF-Related Apoptosis-Inducing Ligand/*pharmacology
Cell Line, Tumor ; Death Domain Receptor Signaling Adaptor Proteins/physiology ; Drug Resistance, Neoplasm ; ErbB Receptors/antagonists & inhibitors ; Humans ; Protein Transport/drug effects ; Stomach Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Inhibition of Jak-STAT3 pathway enhances bufalin-induced apoptosis in colon cancer SW620 cells.
Autorzy :
Zhu Z; Department of Oncology, The First Affiliated Hospital of Liaoning Medical University, Jinzhou, Liaoning, 121001, China. />Li E
Liu Y
Gao Y
Sun H
Ma G
Wang Z
Liu X
Wang Q
Qu X
Liu Y
Yu Y
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Źródło :
World journal of surgical oncology [World J Surg Oncol] 2012 Oct 30; Vol. 10, pp. 228. Date of Electronic Publication: 2012 Oct 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Bufanolides/*pharmacology
Colonic Neoplasms/*pathology
Janus Kinase 1/*antagonists & inhibitors
STAT3 Transcription Factor/*antagonists & inhibitors
Antineoplastic Combined Chemotherapy Protocols ; Blotting, Western ; Cell Cycle/drug effects ; Cell Proliferation/drug effects ; Colonic Neoplasms/drug therapy ; Colonic Neoplasms/metabolism ; Enzyme Inhibitors/pharmacology ; Humans ; Janus Kinase 1/metabolism ; Mitotic Index ; STAT3 Transcription Factor/metabolism ; Tumor Cells, Cultured ; Tyrphostins/pharmacology
Czasopismo naukowe
Tytuł :
Down-regulation of Cbl-b by bufalin results in up-regulation of DR4/DR5 and sensitization of TRAIL-induced apoptosis in breast cancer cells.
Autorzy :
Yan S; Department of Medical Oncology, The First Hospital of China Medical University, No. 155, North Nanjing Street, Heping District, Shenyang 110001, China.
Qu X
Xu C
Zhu Z
Zhang L
Xu L
Song N
Teng Y
Liu Y
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Źródło :
Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2012 Aug; Vol. 138 (8), pp. 1279-89. Date of Electronic Publication: 2012 Mar 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptor Proteins, Signal Transducing/*metabolism
Apoptosis/*drug effects
Bufanolides/*pharmacology
Proto-Oncogene Proteins c-cbl/*metabolism
Receptors, TNF-Related Apoptosis-Inducing Ligand/*metabolism
TNF-Related Apoptosis-Inducing Ligand/*pharmacology
Adaptor Proteins, Signal Transducing/genetics ; Animals ; Blotting, Western ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Down-Regulation/drug effects ; Drug Synergism ; Enzyme Inhibitors/pharmacology ; Female ; Humans ; Mammary Neoplasms, Experimental/drug therapy ; Mammary Neoplasms, Experimental/genetics ; Mammary Neoplasms, Experimental/metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Mitogen-Activated Protein Kinases/antagonists & inhibitors ; Mitogen-Activated Protein Kinases/metabolism ; Proto-Oncogene Proteins c-cbl/genetics ; RNA Interference ; Receptors, TNF-Related Apoptosis-Inducing Ligand/genetics ; Up-Regulation/drug effects ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Bufalin induces lung cancer cell apoptosis via the inhibition of PI3K/Akt pathway.
Autorzy :
Zhu Z; Department of Oncology, the First Affiliated Hospital of Liaoning Medical University, Jinzhou, Liaoning 121001, China; E-Mails: (H.S.); (G.M.); (Z.W.); (E.L.); (Y.L.).
Sun H
Ma G
Wang Z
Li E
Liu Y
Liu Y
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2012; Vol. 13 (2), pp. 2025-35. Date of Electronic Publication: 2012 Feb 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenocarcinoma/*pathology
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Bufanolides/*pharmacology
Lung Neoplasms/*pathology
Oncogene Protein v-akt/*metabolism
Phosphatidylinositol 3-Kinases/*metabolism
Adenocarcinoma/metabolism ; Adenocarcinoma of Lung ; Cell Proliferation/drug effects ; Down-Regulation/drug effects ; Humans ; Lung Neoplasms/metabolism ; Signal Transduction/drug effects ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Synergistic antitumor effect of β-elemene and etoposide is mediated via induction of cell apoptosis and cell cycle arrest in non-small cell lung carcinoma cells.
Autorzy :
Zhang F; Department of Respiratory Medicine, The First Hospital of China Medical University, Shenyang 110001, PR China.
Xu L
Qu X
Zhao M
Jin B
Kang J
Liu Y
Hu X
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Źródło :
Molecular medicine reports [Mol Med Rep] 2011 Nov-Dec; Vol. 4 (6), pp. 1189-93. Date of Electronic Publication: 2011 Jul 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*toxicity
Apoptosis/*drug effects
Carcinoma, Non-Small-Cell Lung/*drug therapy
Cell Cycle Checkpoints/*drug effects
Etoposide/*analogs & derivatives
Lung Neoplasms/*drug therapy
Organophosphorus Compounds/*toxicity
Sesquiterpenes/*toxicity
Antineoplastic Agents/therapeutic use ; Carcinoma, Non-Small-Cell Lung/metabolism ; Cell Line, Tumor ; Curcuma/chemistry ; Cyclin D1/metabolism ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Etoposide/therapeutic use ; Etoposide/toxicity ; Humans ; Lung Neoplasms/metabolism ; Organophosphorus Compounds/therapeutic use ; Poly(ADP-ribose) Polymerases/metabolism ; Sesquiterpenes/therapeutic use ; Tumor Suppressor Protein p53/metabolism ; bcl-2-Associated X Protein/metabolism
Czasopismo naukowe
Tytuł :
Interferon-α sensitizes human gastric cancer cells to TRAIL-induced apoptosis via activation of the c-CBL-dependent MAPK/ERK pathway.
Autorzy :
Qu J; China Medical University, Heping District, Shenyang City. />Zhao M
Teng Y
Zhang Y
Hou K
Jiang Y
Yang X
Shang H
Qu X
Liu Y
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Źródło :
Cancer biology & therapy [Cancer Biol Ther] 2011 Sep 15; Vol. 12 (6), pp. 494-502. Date of Electronic Publication: 2011 Sep 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
MAP Kinase Signaling System*
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Interferon-alpha/*pharmacology
Proto-Oncogene Proteins c-cbl/*metabolism
TNF-Related Apoptosis-Inducing Ligand/*pharmacology
Apoptosis Regulatory Proteins/metabolism ; Caspases/metabolism ; Cell Line, Tumor ; Drug Synergism ; Enzyme Activation ; Gene Expression ; Humans ; Mitogen-Activated Protein Kinases/antagonists & inhibitors ; Mitogen-Activated Protein Kinases/metabolism ; Protein Kinase Inhibitors/pharmacology ; Proto-Oncogene Proteins c-cbl/genetics ; Stomach Neoplasms
Czasopismo naukowe
Tytuł :
β-Elemene-induced autophagy protects human gastric cancer cells from undergoing apoptosis.
Autorzy :
Liu J; Department of Medical Oncology, the First Hospital of China Medical University, Shenyang, PR China.
Zhang Y
Qu J
Xu L
Hou K
Zhang J
Qu X
Liu Y
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Źródło :
BMC cancer [BMC Cancer] 2011 May 20; Vol. 11, pp. 183. Date of Electronic Publication: 2011 May 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Autophagy/*drug effects
Plant Extracts/*pharmacology
Sesquiterpenes/*pharmacology
Stomach Neoplasms/*physiopathology
Cell Line, Tumor ; Cell Survival/drug effects ; Humans ; Phosphoinositide-3 Kinase Inhibitors ; Proto-Oncogene Proteins c-akt/antagonists & inhibitors ; Signal Transduction/drug effects ; TOR Serine-Threonine Kinases/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
Epirubicin enhances TRAIL-induced apoptosis in gastric cancer cells by promoting death receptor clustering in lipid rafts.
Autorzy :
Xu L; Department of Medical Oncology, the First Hospital of China Medical University, Shenyang 110001, P.R. China.
Qu X
Luo Y
Zhang Y
Liu J
Qu J
Zhang L
Liu Y
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Źródło :
Molecular medicine reports [Mol Med Rep] 2011 May-Jun; Vol. 4 (3), pp. 407-11. Date of Electronic Publication: 2011 Feb 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*drug effects
Epirubicin/*pharmacology
Membrane Microdomains/*drug effects
Membrane Microdomains/*metabolism
Receptors, Death Domain/*metabolism
Stomach Neoplasms/*pathology
TNF-Related Apoptosis-Inducing Ligand/*pharmacology
Cell Line, Tumor ; Cell Survival/drug effects ; Cluster Analysis ; Humans ; Nystatin/pharmacology
Czasopismo naukowe
Tytuł :
[Effect of Bufalin on proliferation and apoptosis of human non-small cell lung cancer A549 cell].
Autorzy :
Zhu Z; Department of Oncology, the First Affiliated Hospital of Liaoning Medical University, Jinzhou 121001, China.
Yu Y
Wang K
Li E
Liu Y
Liu Y
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Źródło :
Zhongguo fei ai za zhi = Chinese journal of lung cancer [Zhongguo Fei Ai Za Zhi] 2010 Sep; Vol. 13 (9), pp. 841-5.
Typ publikacji :
English Abstract; Journal Article; Research Support, Non-U.S. Gov't; Retracted Publication
MeSH Terms :
Apoptosis/*drug effects
Bufanolides/*pharmacology
Carcinoma, Non-Small-Cell Lung/*drug therapy
Carcinoma, Non-Small-Cell Lung/*physiopathology
Cell Proliferation/*drug effects
Animals ; Bufonidae ; Carcinoma, Non-Small-Cell Lung/enzymology ; Caspase 3/genetics ; Caspase 3/metabolism ; Cell Cycle/drug effects ; Cell Line, Tumor ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/enzymology ; Lung Neoplasms/physiopathology
Czasopismo naukowe
Tytuł :
Cbl-b promotes chemotherapy-induced apoptosis in rat basophilic leukemia cells by suppressing PI3K/Akt activation and enhancing MEK/ERK activation.
Autorzy :
Qu X; Department of Medical Oncology, The First Hospital of China Medical University, No. 155, North Nanjing Street, Heping District, 110001 Shenyang, China.
Li Y
Liu J
Xu L
Zhang Y
Hu X
Hou K
Liu Y
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Źródło :
Molecular and cellular biochemistry [Mol Cell Biochem] 2010 Jul; Vol. 340 (1-2), pp. 107-14. Date of Electronic Publication: 2010 Feb 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptor Proteins, Signal Transducing/*metabolism
Antimetabolites, Antineoplastic/*pharmacology
Antineoplastic Agents, Phytogenic/*pharmacology
Apoptosis/*drug effects
Extracellular Signal-Regulated MAP Kinases/*metabolism
Leukemia, Basophilic, Acute/*enzymology
Mitogen-Activated Protein Kinase Kinases/*metabolism
Phosphatidylinositol 3-Kinases/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
Proto-Oncogene Proteins c-cbl/*metabolism
Adaptor Proteins, Signal Transducing/genetics ; Animals ; Cell Line, Tumor ; Cell Survival ; Cytarabine/pharmacology ; Dose-Response Relationship, Drug ; Enzyme Activation ; Enzyme Inhibitors/pharmacology ; Etoposide/pharmacology ; Extracellular Signal-Regulated MAP Kinases/antagonists & inhibitors ; Inhibitory Concentration 50 ; Leukemia, Basophilic, Acute/genetics ; Leukemia, Basophilic, Acute/pathology ; Mutation ; Phosphoinositide-3 Kinase Inhibitors ; Proto-Oncogene Proteins c-cbl/genetics ; Rats ; Time Factors ; Transfection
Czasopismo naukowe
Tytuł :
Arsenic trioxide induces apoptosis and G2/M phase arrest by inducing Cbl to inhibit PI3K/Akt signaling and thereby regulate p53 activation.
Autorzy :
Li Y; Department of Medical Oncology, The First Hospital, China Medical University, Heping District, Shenyang City 110001, China.
Qu X
Qu J
Zhang Y
Liu J
Teng Y
Hu X
Hou K
Liu Y
Pokaż więcej
Źródło :
Cancer letters [Cancer Lett] 2009 Nov 01; Vol. 284 (2), pp. 208-15. Date of Electronic Publication: 2009 May 19.
Typ publikacji :
Journal Article
MeSH Terms :
Phosphoinositide-3 Kinase Inhibitors*
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Arsenicals/*pharmacology
G2 Phase/*drug effects
Metaphase/*drug effects
Neoplasm Proteins/*drug effects
Oxides/*pharmacology
Proto-Oncogene Proteins c-akt/*antagonists & inhibitors
Proto-Oncogene Proteins c-cbl/*drug effects
Tumor Suppressor Protein p53/*physiology
Adenocarcinoma/metabolism ; Adenocarcinoma/pathology ; Apoptosis/physiology ; Arsenic Trioxide ; Cell Line, Tumor/drug effects ; Cell Line, Tumor/metabolism ; G2 Phase/physiology ; Gene Expression Regulation, Leukemic/drug effects ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Leukemia, Promyelocytic, Acute/metabolism ; Leukemia, Promyelocytic, Acute/pathology ; Metaphase/physiology ; Neoplasm Proteins/physiology ; Phosphatidylinositol 3-Kinases/physiology ; Protein Processing, Post-Translational/drug effects ; Proto-Oncogene Proteins c-akt/physiology ; Proto-Oncogene Proteins c-cbl/physiology ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/pathology ; Ubiquitination/drug effects ; Up-Regulation/drug effects
Czasopismo naukowe
Tytuł :
Oxaliplatin enhances TRAIL-induced apoptosis in gastric cancer cells by CBL-regulated death receptor redistribution in lipid rafts.
Autorzy :
Xu L; Department of Medical Oncology, The First Hospital of China Medical University, Shenyang 110001, China.
Qu X
Zhang Y
Hu X
Yang X
Hou K
Teng Y
Zhang J
Sada K
Liu Y
Pokaż więcej
Źródło :
FEBS letters [FEBS Lett] 2009 Mar 04; Vol. 583 (5), pp. 943-8. Date of Electronic Publication: 2009 Feb 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*drug effects
Membrane Microdomains/*metabolism
Organoplatinum Compounds/*pharmacology
Proto-Oncogene Proteins c-cbl/*metabolism
Receptors, Death Domain/*metabolism
Stomach Neoplasms/*metabolism
TNF-Related Apoptosis-Inducing Ligand/*pharmacology
Cell Line ; Down-Regulation/drug effects ; Gene Expression Regulation, Neoplastic/drug effects ; Membrane Microdomains/drug effects ; Nystatin/pharmacology ; Oxaliplatin ; Proto-Oncogene Proteins c-cbl/genetics ; Stomach Neoplasms/pathology
Czasopismo naukowe

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