Autor: "Liu YT" - OpacWWW - Prolib Integro

Skocz do pozycji: 1.

Tytuł:: In silico identification and biological evaluation of a selective MAP4K4 inhibitor against pancreatic cancer.
Autorzy:: Chang CD; Ph.D. Program in Drug Discovery and Development Industry, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.
Chao MW; School of Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung, Taiwan.; Institute of Biopharmaceutical Sciences, College of Medicine, National Sun Yat-sen University, Kaohsiung, Taiwan.
Lee HY; Ph.D. Program in Drug Discovery and Development Industry, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.; School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, Taiwan.
Liu YT; School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.
Tu HJ; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
Lien ST; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
Lin TE; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
Sung TY; Biomedical Translation Research Center, Academia Sinica, Taipei, Taiwan.
Yen SC; Warshel Institute for Computational Biology, The Chinese University of Hong Kong (Shenzhen), Shenzhen, Guangdong, People's Republic of China.
Huang SH; Graphen Inc, New York, NY, USA.
Hsu KC; Ph.D. Program in Drug Discovery and Development Industry, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, Taiwan.; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.; TMU Research Center for Drug Discovery, Taipei Medical University, Taipei, Taiwan.; Cancer Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
Pan SL; Ph.D. Program in Drug Discovery and Development Industry, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, Taiwan.; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.; TMU Research Center for Drug Discovery, Taipei Medical University, Taipei, Taiwan.; Pokaż więcej
Źródło:: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2023 Dec; Vol. 38 (1), pp. 2166039.
Typ publikacji:: Journal Article
MeSH Terms:: Pancreatic Neoplasms*/enzymology
Protein Serine-Threonine Kinases*/antagonists & inhibitors
Protein Kinase Inhibitors*/chemistry
Protein Kinase Inhibitors*/pharmacology
Antineoplastic Agents*/chemistry
Antineoplastic Agents*/pharmacology
Humans ; Cell Line, Tumor ; Gemcitabine/chemistry ; Gemcitabine/pharmacology ; Intracellular Signaling Peptides and Proteins ; Computer Simulation ; Pancreatic Neoplasms

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Skocz do pozycji: 2.

Tytuł:: Platyphyllenone Induces Autophagy and Apoptosis by Modulating the AKT and JNK Mitogen-Activated Protein Kinase Pathways in Oral Cancer Cells.
Autorzy:: Liu YT; Oral Cancer Research Center, Changhua Christian Hospital, Changhua 500, Taiwan.; Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.; Department of Family Medicine, Changhua Christian Hospital, Changhua 500, Taiwan.; Department of Holistic Wellness, Mingdao University, Changhua 52345, Taiwan.; Post Baccalaureate Medicine, National Chung Hsing University, Taichung 402, Taiwan.
Ho HY; Oral Cancer Research Center, Changhua Christian Hospital, Changhua 500, Taiwan.
Lin CC; Oral Cancer Research Center, Changhua Christian Hospital, Changhua 500, Taiwan.
Chuang YC; Oral Cancer Research Center, Changhua Christian Hospital, Changhua 500, Taiwan.
Lo YS; Oral Cancer Research Center, Changhua Christian Hospital, Changhua 500, Taiwan.
Hsieh MJ; Oral Cancer Research Center, Changhua Christian Hospital, Changhua 500, Taiwan.; Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.; Department of Holistic Wellness, Mingdao University, Changhua 52345, Taiwan.; Post Baccalaureate Medicine, National Chung Hsing University, Taichung 402, Taiwan.; Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404, Taiwan.
Chen MK; Department of Otorhinolaryngology, Head and Neck Surgery, Changhua Christian Hospital, Changhua 500, Taiwan.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Apr 19; Vol. 22 (8). Date of Electronic Publication: 2021 Apr 19.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Autophagy/*drug effects
JNK Mitogen-Activated Protein Kinases/*metabolism
Ketones/*pharmacology
Mouth Neoplasms/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
Blotting, Western ; Caspase 3 ; Caspase 8/metabolism ; Cell Cycle Checkpoints/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Humans ; Membrane Potential, Mitochondrial/drug effects ; Signal Transduction/drug effects

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Skocz do pozycji: 3.

Tytuł:: Structure-guided design of anti-cancer ribonucleotide reductase inhibitors.
Autorzy:: Misko TA; a Department of Pharmacology, School of Medicine , Case Western Reserve University , Cleveland , OH , USA.
Liu YT; b School of Pharmacy, College of Pharmacy , Taipei Medical University , Taipei , Taiwan.
Harris ME; c Department of Chemistry , University of Florida , Gainesville , FL , United States.
Oleinick NL; d Department of Radiation Oncology, School of Medicine , Case Western Reserve University , Cleveland , OH , USA.
Pink J; e Case Comprehensive Cancer Center, School of Medicine , Case Western Reserve University , Cleveland , OH , USA.
Lee HY; b School of Pharmacy, College of Pharmacy , Taipei Medical University , Taipei , Taiwan.; f Ph.D Program in Biotechnology Research and Development, College of Pharmacy , Taipei Medical University , Taipei , Taiwan.
Dealwis CG; a Department of Pharmacology, School of Medicine , Case Western Reserve University , Cleveland , OH , USA.; g Department of Chemistry, Center for Proteomics , Case Western Reserve University , Cleveland , OH , USA.; Pokaż więcej
Źródło:: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2019 Dec; Vol. 34 (1), pp. 438-450.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Agents/*pharmacology
Enzyme Inhibitors/*pharmacology
Ribonucleotide Reductases/*antagonists & inhibitors
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Humans ; Models, Molecular ; Molecular Structure ; Ribonucleotide Reductases/metabolism ; Structure-Activity Relationship

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Skocz do pozycji: 4.

Tytuł:: Downregulation of survivin expression and concomitant induction of apoptosis by celecoxib and its non-cyclooxygenase-2-inhibitory analog, dimethyl-celecoxib (DMC), in tumor cells in vitro and in vivo.
Autorzy:: Pyrko P; Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, USA. />Soriano N
Kardosh A
Liu YT
Uddin J
Petasis NA
Hofman FM
Chen CS
Chen TC
Schönthal AH; Pokaż więcej
Źródło:: Molecular cancer [Mol Cancer] 2006 May 18; Vol. 5, pp. 19. Date of Electronic Publication: 2006 May 18.
Typ publikacji:: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Gene Expression Regulation/*drug effects
Microtubule-Associated Proteins/*metabolism
Neoplasm Proteins/*metabolism
Pyrazoles/*pharmacology
Sulfonamides/*pharmacology
Animals ; Antineoplastic Agents/therapeutic use ; Camptothecin/analogs & derivatives ; Camptothecin/pharmacology ; Celecoxib ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Down-Regulation ; HCT116 Cells ; Humans ; Inhibitor of Apoptosis Proteins ; Irinotecan ; Male ; Mice ; Mice, Nude ; Microtubule-Associated Proteins/genetics ; Neoplasm Proteins/genetics ; Neuroblastoma/drug therapy ; Neuroblastoma/pathology ; Promoter Regions, Genetic/genetics ; Pyrazoles/therapeutic use ; Sulfonamides/therapeutic use ; Survivin ; Transcription, Genetic ; Transfection ; Xenograft Model Antitumor Assays

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