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Tytuł :
Metformin and Berberine suppress glycogenolysis by inhibiting glycogen phosphorylase and stabilizing the molecular structure of glycogen in db/db mice.
Autorzy :
Liu X; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China.
Wang K; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China.
Zhou J; Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.
Sullivan MA; Glycation and Diabetes Group, Mater Research Institute-The University of Queensland, Translational Research Institute, Brisbane, Queensland, 4072, Australia.
Liu Y; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China.
Gilbert RG; Joint International Research Laboratory of Agriculture and Agri-Product Safety, College of Agriculture, Yangzhou University, 225009, Yangzhou, Jiangsu Province, China; Centre for Nutrition and Food Sciences, Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, Brisbane, Queensland, 4072, Australia.
Deng B; Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China. Electronic address: .
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Źródło :
Carbohydrate polymers [Carbohydr Polym] 2020 Sep 01; Vol. 243, pp. 116435. Date of Electronic Publication: 2020 May 24.
Typ publikacji :
Journal Article
MeSH Terms :
Berberine/*therapeutic use
Diabetes Mellitus, Experimental/*drug therapy
Glycogenolysis/*drug effects
Hypoglycemic Agents/*therapeutic use
Liver Glycogen/*metabolism
Metformin/*therapeutic use
Animals ; Drug Therapy, Combination ; Liver/drug effects ; Liver/metabolism ; Liver/pathology ; Liver Glycogen/chemistry ; Male ; Mice ; Mice, Inbred C57BL ; Molecular Structure
Czasopismo naukowe
Tytuł :
Effects of fasting on liver glycogen structure in rats with type 2 diabetes.
Autorzy :
Wang L; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221000, Jiangsu Province, China; Department of Bioinformatics, School of Medical Informatics and Engineering, Xuzhou Medical University, Xuzhou 221000, Jiangsu Province, China.
Liu Q; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221000, Jiangsu Province, China; Department of Pharmaceutical Analysis, School of Pharmacy, Xuzhou Medical University, Xuzhou 221000, Jiangsu Province, China.
Wang M; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221000, Jiangsu Province, China; Department of Pharmaceutical Analysis, School of Pharmacy, Xuzhou Medical University, Xuzhou 221000, Jiangsu Province, China.
Du Y; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221000, Jiangsu Province, China; Department of Pharmaceutical Analysis, School of Pharmacy, Xuzhou Medical University, Xuzhou 221000, Jiangsu Province, China.
Tan X; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia; Centre for Nutrition and Food Sciences, Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, Brisbane, Queensland 4072, Australia.
Xu B; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221000, Jiangsu Province, China; Department of Pharmaceutical Analysis, School of Pharmacy, Xuzhou Medical University, Xuzhou 221000, Jiangsu Province, China.
Cheung U; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia.
Li E; Joint International Research Laboratory of Agriculture and Agri-Product Safety, College of Agriculture, Yangzhou University, Yangzhou 225009, Jiangsu Province, China.
Gilbert RG; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia; Centre for Nutrition and Food Sciences, Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, Brisbane, Queensland 4072, Australia; Joint International Research Laboratory of Agriculture and Agri-Product Safety, College of Agriculture, Yangzhou University, Yangzhou 225009, Jiangsu Province, China. Electronic address: .
Tang D; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221000, Jiangsu Province, China; Department of Pharmaceutical Analysis, School of Pharmacy, Xuzhou Medical University, Xuzhou 221000, Jiangsu Province, China.
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Źródło :
Carbohydrate polymers [Carbohydr Polym] 2020 Jun 01; Vol. 237, pp. 116144. Date of Electronic Publication: 2020 Mar 09.
Typ publikacji :
Journal Article
MeSH Terms :
Fasting*
Diabetes Mellitus, Experimental/*metabolism
Diabetes Mellitus, Type 2/*metabolism
Liver Glycogen/*chemistry
Animals ; Chromatography, Gel ; Liver Glycogen/metabolism ; Male ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Structure-Activity Relationship and Biological Investigation of SR18292 ( 16 ), a Suppressor of Glucagon-Induced Glucose Production.
Autorzy :
Lin H; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, Florida 33458, United States.; Biomedical Research Center of South China, College of Life Sciences, Fujian Normal University, Fuzhou 350117, China.
Sharabi K; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States.; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, United States.
Lin L; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, Florida 33458, United States.
Ruiz C; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, Florida 33458, United States.
Zhu D; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, Florida 33458, United States.
Cameron MD; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, Florida 33458, United States.
Novick SJ; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, Florida 33458, United States.
Griffin PR; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, Florida 33458, United States.
Puigserver P; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States.; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, United States.
Kamenecka TM; Department of Molecular Medicine, The Scripps Research Institute, Jupiter, Florida 33458, United States.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Jan 28; Vol. 64 (2), pp. 980-990. Date of Electronic Publication: 2021 Jan 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Glucagon/*antagonists & inhibitors
Gluconeogenesis/*drug effects
Hypoglycemic Agents/*pharmacology
Indoles/*pharmacology
Propanols/*pharmacology
Adipocytes, Brown/drug effects ; Adipocytes, Brown/metabolism ; Animals ; Diabetes Mellitus, Type 2/drug therapy ; Hepatocytes/drug effects ; Hepatocytes/metabolism ; Hypoglycemic Agents/chemistry ; Indoles/chemistry ; Lipolysis/drug effects ; Liver Glycogen/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; PPAR gamma/drug effects ; Propanols/chemistry ; Receptors, Adrenergic, beta/drug effects ; Signal Transduction/drug effects ; Structure-Activity Relationship ; Sympathetic Nervous System/drug effects
Czasopismo naukowe
Tytuł :
Defective liver glycogen autophagy related to hyperinsulinemia in intrauterine growth-restricted newborn wistar rats.
Autorzy :
de Toro-Martín J; Centre Nutrition, Santé et Société (NUTRISS)-Institut sur la nutrition et les aliments fonctionnels (INAF), Université Laval, Québec City, QC, Canada.
Fernández-Marcelo T; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERdem), ISCIII, 28029, Madrid, Spain.
González-Rodríguez Á; Hospital Universitario Santa Cristina, Instituto de Investigación Sanitaria Princesa, Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), ISCIII, Madrid, Spain.
Escrivá F; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERdem), ISCIII, 28029, Madrid, Spain.; Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia, UCM, Ciudad Universitaria s/n, 28040, Madrid, Spain.
Valverde ÁM; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERdem), ISCIII, 28029, Madrid, Spain.; Instituto de Investigaciones Biomédicas Alberto Sols (IIBm) (CSIC/UAM), C/ Arturo Duperier 4, 28029, Madrid, Spain.
Álvarez C; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERdem), ISCIII, 28029, Madrid, Spain. .; Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia, UCM, Ciudad Universitaria s/n, 28040, Madrid, Spain. .
Fernández-Millán E; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERdem), ISCIII, 28029, Madrid, Spain. .; Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia, UCM, Ciudad Universitaria s/n, 28040, Madrid, Spain. .
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Źródło :
Scientific reports [Sci Rep] 2020 Oct 19; Vol. 10 (1), pp. 17651. Date of Electronic Publication: 2020 Oct 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Autophagy*
Fetal Growth Retardation/*metabolism
Hyperinsulinism/*metabolism
Liver Glycogen/*metabolism
Animals ; Animals, Newborn/metabolism ; Female ; Glucose/metabolism ; Liver/metabolism ; Malnutrition/metabolism ; Pregnancy ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Antisense Inhibition of Glucagon Receptor by IONIS-GCGR Rx Improves Type 2 Diabetes Without Increase in Hepatic Glycogen Content in Patients With Type 2 Diabetes on Stable Metformin Therapy.
Autorzy :
Morgan ES; Ionis Pharmaceuticals, Inc., Carlsbad, CA.
Tai LJ; Ionis Pharmaceuticals, Inc., Carlsbad, CA.
Pham NC; Ionis Pharmaceuticals, Inc., Carlsbad, CA.
Overman JK; Ionis Pharmaceuticals, Inc., Carlsbad, CA.
Watts LM; Ionis Pharmaceuticals, Inc., Carlsbad, CA.
Smith A; Ionis Pharmaceuticals, Inc., Carlsbad, CA.
Jung SW; Ionis Pharmaceuticals, Inc., Carlsbad, CA.
Gajdošík M; Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Austria.; High Field MR Centre, Department of Biomedical Imaging and Image Guided Therapy, Medical University of Vienna, Vienna, Austria.
Krššák M; Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Austria.; High Field MR Centre, Department of Biomedical Imaging and Image Guided Therapy, Medical University of Vienna, Vienna, Austria.
Krebs M; Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Austria.
Geary RS; Ionis Pharmaceuticals, Inc., Carlsbad, CA.
Baker BF; Ionis Pharmaceuticals, Inc., Carlsbad, CA.
Bhanot S; Ionis Pharmaceuticals, Inc., Carlsbad, CA .
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Źródło :
Diabetes care [Diabetes Care] 2019 Apr; Vol. 42 (4), pp. 585-593. Date of Electronic Publication: 2019 Feb 14.
Typ publikacji :
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Diabetes Mellitus, Type 2/*drug therapy
Liver Glycogen/*metabolism
Metformin/*therapeutic use
Adolescent ; Adult ; Aged ; Blood Glucose/metabolism ; Diabetes Mellitus, Type 2/metabolism ; Double-Blind Method ; Humans ; Liver Glycogen/analysis ; Middle Aged ; Receptors, Glucagon/metabolism ; Young Adult
Czasopismo naukowe
Tytuł :
The effect of Psidium guajava aqueous leaf extract on liver glycogen enzymes, hormone sensitive lipase and serum lipid profile in diabetic rats.
Autorzy :
Tella T; Discipline of Biochemistry, School of Life Sciences, University of KwaZulu-Natal (Westville Campus), Private Bag X54001, Durban 4000, South Africa.
Masola B; Discipline of Biochemistry, School of Life Sciences, University of KwaZulu-Natal (Westville Campus), Private Bag X54001, Durban 4000, South Africa.
Mukaratirwa S; Discipline of Biological Sciences, School of Life Sciences, University of KwaZulu-Natal (Westville Campus), Private Bag X54001, Durban 4000, South Africa. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2019 Jan; Vol. 109, pp. 2441-2446. Date of Electronic Publication: 2018 Dec 01.
Typ publikacji :
Journal Article
MeSH Terms :
Psidium*
Diabetes Mellitus, Experimental/*metabolism
Lipids/*blood
Liver Glycogen/*metabolism
Plant Extracts/*therapeutic use
Sterol Esterase/*metabolism
Animals ; Diabetes Mellitus, Experimental/drug therapy ; Lipids/antagonists & inhibitors ; Liver Glycogen/antagonists & inhibitors ; Male ; Plant Extracts/isolation & purification ; Plant Extracts/pharmacology ; Plant Leaves ; Rats ; Rats, Sprague-Dawley ; Sterol Esterase/antagonists & inhibitors ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Determining the contribution of a high-fructose corn syrup formulation to hepatic glycogen synthesis during ad-libitum feeding in mice.
Autorzy :
DiNunzio G; Center for Neurosciences and Cell Biology, University of Coimbra, UC-Biotech, Biocant Park, 3060-197, Cantanhede, Portugal.
Belew GD; Center for Neurosciences and Cell Biology, University of Coimbra, UC-Biotech, Biocant Park, 3060-197, Cantanhede, Portugal.
Torres AN; Center for Neurosciences and Cell Biology, University of Coimbra, UC-Biotech, Biocant Park, 3060-197, Cantanhede, Portugal.
Silva JG; Center for Neurosciences and Cell Biology, University of Coimbra, UC-Biotech, Biocant Park, 3060-197, Cantanhede, Portugal.
Silva LP; Center for Neurosciences and Cell Biology, University of Coimbra, UC-Biotech, Biocant Park, 3060-197, Cantanhede, Portugal.
Barosa C; Center for Neurosciences and Cell Biology, University of Coimbra, UC-Biotech, Biocant Park, 3060-197, Cantanhede, Portugal.
Tavares L; Center for Neurosciences and Cell Biology, University of Coimbra, UC-Biotech, Biocant Park, 3060-197, Cantanhede, Portugal.
Jones JG; Center for Neurosciences and Cell Biology, University of Coimbra, UC-Biotech, Biocant Park, 3060-197, Cantanhede, Portugal. .
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Źródło :
Scientific reports [Sci Rep] 2020 Jul 30; Vol. 10 (1), pp. 12852. Date of Electronic Publication: 2020 Jul 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Animal Nutritional Physiological Phenomena/*physiology
Diet, High-Fat/*adverse effects
Glycogen/*biosynthesis
High Fructose Corn Syrup/*adverse effects
High Fructose Corn Syrup/*metabolism
Liver/*metabolism
Liver Glycogen/*metabolism
Animals ; Citric Acid Cycle/physiology ; High Fructose Corn Syrup/administration & dosage ; Male ; Mice ; Mice, Inbred C57BL
Czasopismo naukowe
Tytuł :
Biocompatible modified water as a non-pharmaceutical approach to prevent metabolic syndrome features in obesogenic diet-fed mice.
Autorzy :
Lambert K; PhyMedExp, Université Montpellier, INSERM, CNRS, France.
Gondeau C; IRMB, Université Montpellier, INSERM, CHU Montpellier, Montpellier, France.
Briolotti P; IRMB, Université Montpellier, INSERM, Montpellier, France.
Scheuermann V; PhyMedExp, Université Montpellier, INSERM, CNRS, France.
Daujat-Chavanieu M; IRMB, Université Montpellier, INSERM, CHU Montpellier, Montpellier, France.
Aimond F; PhyMedExp, Université Montpellier, INSERM, CNRS, France. Electronic address: .
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Źródło :
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2020 Jul; Vol. 141, pp. 111403. Date of Electronic Publication: 2020 May 06.
Typ publikacji :
Journal Article
MeSH Terms :
Biocompatible Materials*
Diet, High-Fat*
Drinking Water*
Metabolic Syndrome/*prevention & control
Obesity/*etiology
Animals ; Basal Metabolism ; Biomarkers/metabolism ; Insulin Resistance ; Lipogenesis ; Liver Glycogen/metabolism ; Male ; Metabolic Syndrome/complications ; Metabolic Syndrome/metabolism ; Mice ; Mice, Inbred C57BL ; Obesity/complications
Czasopismo naukowe
Tytuł :
In vivo studies of glucagon secretion by human islets transplanted in mice.
Autorzy :
Tellez K; Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA, USA.
Hang Y; Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA, USA.; Stanford Diabetes Research Center, Stanford University School of Medicine, Stanford, CA, USA.
Gu X; Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA, USA.
Chang CA; Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA, USA.
Stein RW; Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN, USA.
Kim SK; Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA, USA. .; Stanford Diabetes Research Center, Stanford University School of Medicine, Stanford, CA, USA. .; Department of Medicine (Endocrinology Division), Stanford University School of Medicine, Stanford, CA, USA. .
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Źródło :
Nature metabolism [Nat Metab] 2020 Jun; Vol. 2 (6), pp. 547-557. Date of Electronic Publication: 2020 Jun 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Islets of Langerhans Transplantation*
Glucagon/*metabolism
Islets of Langerhans/*metabolism
Adult ; Animals ; CRISPR-Cas Systems ; Diabetes Mellitus, Type 2/metabolism ; Female ; Glucagon/genetics ; Glucagon-Secreting Cells/metabolism ; Glucose Tolerance Test ; Humans ; Liver/metabolism ; Liver Glycogen/metabolism ; Male ; Mice ; Mice, Knockout ; Middle Aged
Czasopismo naukowe
Tytuł :
Genetic ablation of aldehyde reductase (Akr1a) augments exercise endurance in mice via activation of the PGC-1α-involved pathway.
Autorzy :
Takahashi M; Department of Biochemistry and Molecular Biology, Graduate School of Medical Science, Yamagata University, Yamagata 990-9585, Japan.
Homma T; Department of Biochemistry and Molecular Biology, Graduate School of Medical Science, Yamagata University, Yamagata 990-9585, Japan.
Yamada KI; Physical Chemistry for Life Science Laboratory, Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi Higashi-ku, Fukuoka 812-8582, Japan; AMED-CREST, Japan Agency for Medical Research and Development, Tokyo, Japan.
Miyata S; Miyata Diabetes and Metabolism Clinic, 5-17-21 Fukushima, Osaka, Osaka 553-0003, Japan.
Nakajima O; Research Laboratory for Molecular Genetics, Yamagata University School of Medicine, Yamagata University, 2-2-2 Iidanishi, Yamagata 990-9585, Japan.
Fujii J; Department of Biochemistry and Molecular Biology, Graduate School of Medical Science, Yamagata University, Yamagata 990-9585, Japan. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 May 15; Vol. 249, pp. 117501. Date of Electronic Publication: 2020 Mar 03.
Typ publikacji :
Journal Article
MeSH Terms :
Physical Conditioning, Animal*
Physical Endurance*
Aldehyde Reductase/*genetics
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/*metabolism
Aldehyde Reductase/metabolism ; Animals ; Blood Glucose/metabolism ; Energy Metabolism ; Fatty Acids, Nonesterified/blood ; Lipid Metabolism ; Liver Glycogen/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/genetics
Czasopismo naukowe
Tytuł :
Technical note: Extrapolation of hepatic glycogen concentration of the whole organ by performing a liver biopsy.
Autorzy :
Duplessis M; Agriculture et Agroalimentaire Canada, Centre de recherche et développement de Sherbrooke, Sherbrooke, QC, J1M 0C8, Canada. Electronic address: .
Blais L; Département de microbiologie et d'infectiologie, Université de Sherbrooke, Sherbrooke, QC, J1K 2R1, Canada.
Poisson W; Département des sciences animales, Université Laval, Québec, QC, G1V 0A6, Canada.
Girard CL; Agriculture et Agroalimentaire Canada, Centre de recherche et développement de Sherbrooke, Sherbrooke, QC, J1M 0C8, Canada.
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Źródło :
Journal of dairy science [J Dairy Sci] 2020 May; Vol. 103 (5), pp. 4858-4862. Date of Electronic Publication: 2020 Feb 26.
Typ publikacji :
Journal Article
MeSH Terms :
Cattle/*metabolism
Liver/*metabolism
Liver Glycogen/*metabolism
Animals ; Biopsy/veterinary ; Female ; Glucose/metabolism ; Lactation
Czasopismo naukowe
Tytuł :
Metabolic control analysis of hepatic glycogen synthesis in vivo.
Autorzy :
Nozaki Y; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.; Department of Gastroenterology and Hepatology, National Center for Global Health and Medicine, 1628655 Tokyo, Japan.
Petersen MC; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.; Department of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT 06520.
Zhang D; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.
Vatner DF; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.
Perry RJ; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.; Department of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT 06520.
Abulizi A; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.
Haedersdal S; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.; Center for Clinical Metabolic Research, Gentofte and Herlev Hospital, 2900 Hellerup, Denmark.; Type 2 Biology, Steno Diabetes Center Copenhagen, 2820 Gentofte, Denmark.
Zhang XM; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.
Butrico GM; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.
Samuel VT; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.; Department of Medicine, Veterans Affairs Medical Center, West Haven, CT 06516.
Mason GF; Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT 06520.; Department of Psychiatry, Yale School of Medicine, New Haven, CT 06520.
Cline GW; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.
Petersen KF; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.
Rothman DL; Center for Clinical Metabolic Research, Gentofte and Herlev Hospital, 2900 Hellerup, Denmark.; Department of Biomedical Engineering, Yale School of Medicine, New Haven, CT 06520.
Shulman GI; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520; .; Department of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT 06520.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Apr 07; Vol. 117 (14), pp. 8166-8176. Date of Electronic Publication: 2020 Mar 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Fatty Liver/*pathology
Glucokinase/*metabolism
Glucose/*metabolism
Liver/*metabolism
Liver Glycogen/*biosynthesis
Animals ; Diet, High-Fat/adverse effects ; Disease Models, Animal ; Fatty Liver/etiology ; Gene Knockdown Techniques ; Glucokinase/genetics ; Glucose/administration & dosage ; Glucose-6-Phosphate/analysis ; Glucose-6-Phosphate/metabolism ; Humans ; Hyperglycemia/etiology ; Hyperglycemia/pathology ; Hyperinsulinism/etiology ; Hyperinsulinism/pathology ; Insulin/metabolism ; Insulin Resistance ; Liver/pathology ; Male ; Metabolomics ; Phosphorylation ; Rats
Czasopismo naukowe
Tytuł :
Performance Effects of Carbohydrate Ingestion Between Bouts of Intense Aerobic Interval Exercise.
Autorzy :
McCarthy DG; 1 Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada.
Spriet LL; 1 Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada.
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Źródło :
International journal of sports physiology and performance [Int J Sports Physiol Perform] 2020 Feb 01; Vol. 15 (2), pp. 262-267. Date of Electronic Publication: 2019 Jun 12.
Typ publikacji :
Journal Article; Randomized Controlled Trial
MeSH Terms :
High-Intensity Interval Training*
Dietary Carbohydrates/*administration & dosage
Physical Endurance/*physiology
Blood Glucose/metabolism ; Cross-Over Studies ; Energy Metabolism ; Glycogen/biosynthesis ; Glycogen/metabolism ; Humans ; Liver Glycogen/biosynthesis ; Male ; Muscle Fatigue/physiology ; Muscle, Skeletal/metabolism ; Oxygen Consumption ; Perception/physiology ; Physical Exertion/physiology ; Pulmonary Gas Exchange ; Rest ; Single-Blind Method ; Time Factors ; Young Adult
Czasopismo naukowe
Tytuł :
Some molecular structural features of glycogen in the kidneys of diabetic rats.
Autorzy :
Wang Z; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia; Centre for Nutrition and Food Sciences, Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, Brisbane, Queensland 4072, Australia.
Liu Q; Jiangsu Provincial Key Laboratory of New Drug Research and Clinical Pharmacy, School of Pharmacy, Xuzhou Medical University, Xuzhou 221000, Jiangsu Province, China; Department of Pharmaceutical Analysis, School of Pharmacy, Xuzhou Medical University, Xuzhou 221000, Jiangsu Province, China.
Wang L; Jiangsu Provincial Key Laboratory of New Drug Research and Clinical Pharmacy, School of Pharmacy, Xuzhou Medical University, Xuzhou 221000, Jiangsu Province, China; Department of Bioinformatics, School of Medical Informatics and Engineering, Xuzhou Medical University, Xuzhou 221000, Jiangsu Province, China.
Tan X; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia; Centre for Nutrition and Food Sciences, Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, Brisbane, Queensland 4072, Australia.
Deng B; Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Li E; Joint International Research Laboratory of Agriculture and Agri-Product Safety, College of Agriculture, Yangzhou University, Yangzhou 225009, Jiangsu Province, China.
Gilbert RG; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia; Centre for Nutrition and Food Sciences, Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, Brisbane, Queensland 4072, Australia; Joint International Research Laboratory of Agriculture and Agri-Product Safety, College of Agriculture, Yangzhou University, Yangzhou 225009, Jiangsu Province, China. Electronic address: .
Sullivan MA; Glycation and Diabetes, Mater Research Institute - The University of Queensland, Translational Research Institute, Brisbane, QLD 4102, Australia. Electronic address: .
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Źródło :
Carbohydrate polymers [Carbohydr Polym] 2020 Feb 01; Vol. 229, pp. 115526. Date of Electronic Publication: 2019 Oct 24.
Typ publikacji :
Journal Article
MeSH Terms :
Glycogen/*chemistry
Kidney/*metabolism
Animals ; Blood Glucose/analysis ; Chromatography, Gel ; Diabetes Mellitus, Experimental/chemically induced ; Diabetes Mellitus, Experimental/pathology ; Diet, High-Fat ; Liver Glycogen/chemistry ; Microscopy, Electron, Transmission ; Muscle, Skeletal/metabolism ; Rats
Czasopismo naukowe
Tytuł :
Glycogenic Hepatopathy Causing Elevated Lactic Acid and Liver Enzymes.
Autorzy :
Regan JA; Department of Medicine, Duke University School of Medicine, Durham, NC.
Golubski B; Department of Medicine, Duke University School of Medicine, Durham, NC.
Gilbert EB; Department of Medicine, Duke University School of Medicine, Durham, NC; Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC.
Sullivan B; Division of Gastroenterology, Department of Medicine, Duke University School of Medicine, Durham, NC.
McCall SJ; Department of Pathology, Duke University School of Medicine, Durham, NC; Department of Surgery, Duke University School of Medicine, Durham, NC.
Sata SS; Department of Medicine, Duke University School of Medicine, Durham, NC. Electronic address: .
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Źródło :
The American journal of medicine [Am J Med] 2020 Feb; Vol. 133 (2), pp. 191-194. Date of Electronic Publication: 2019 Jul 29.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Diabetes Mellitus, Type 1/*complications
Lactic Acid/*blood
Liver/*enzymology
Liver Diseases/*etiology
Liver Glycogen/*metabolism
Alanine Transaminase/blood ; Alkaline Phosphatase/blood ; Aspartate Aminotransferases/blood ; Blood Glucose ; Female ; Glycogen Storage Disease/etiology ; Glycogen Storage Disease/pathology ; Humans ; Hyperglycemia ; Liver Diseases/pathology ; Young Adult
Czasopismo naukowe
Tytuł :
Response of Liver Metabolic Pathways to Ketogenic Diet and Exercise Are Not Additive.
Autorzy :
Huang TY; Skeletal Muscle Metabolism Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA.
Goldsmith FR; Skeletal Muscle Metabolism Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA.
Fuller SE
Simon J; Skeletal Muscle Metabolism Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA.
Batdorf HM
Scott MC; Skeletal Muscle Metabolism Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA.
Essajee NM; Skeletal Muscle Metabolism Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA.
Brown JM; Skeletal Muscle Metabolism Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA.
Burk DH; Cell Biology and Bioimaging Core, Pennington Biomedical Research Center, Baton Rouge, LA.
Morrison CD; Laboratory of Neurosignaling, Pennington Biomedical Research Center, Baton Rouge, LA.
Burke SJ; Laboratory of Immunogenetics, Pennington Biomedical Research Center, Baton Rouge, LA.
Collier JJ; Laboratory of Islet Biology and Inflammation, Pennington Biomedical Research Center, Baton Rouge, LA.
Noland RC; Skeletal Muscle Metabolism Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA.
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Źródło :
Medicine and science in sports and exercise [Med Sci Sports Exerc] 2020 Jan; Vol. 52 (1), pp. 37-48.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Diet, Ketogenic*
Liver/*metabolism
Physical Conditioning, Animal/*physiology
3-Hydroxybutyric Acid/blood ; AMP-Activated Protein Kinases/metabolism ; Animals ; Blood Glucose/metabolism ; Energy Metabolism ; Fatty Acids/metabolism ; Ketones/metabolism ; Leucine/metabolism ; Lipid Metabolism ; Liver Glycogen/metabolism ; Male ; Metabolic Networks and Pathways ; Mice, Inbred C57BL ; Mitochondrial Dynamics ; Oxidation-Reduction ; Pancreas/metabolism ; Pancreatic Hormones/metabolism ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/metabolism ; Peroxisomes/metabolism ; Triglycerides/metabolism
Czasopismo naukowe
Tytuł :
Effect of acrylamide on glucose homeostasis in female rats and its mechanisms.
Autorzy :
Yue Z; College of Life Sciences and Agronomy, Zhoukou Normal University, Zhoukou, 466001, China; Institute of Food and Drug Inspection, Zhoukou Normal University, Zhoukou, 466001, China.
Chen Y; School of Mechanical and Electrical Engineering, Zhoukou Normal University, Zhoukou, 466001, China.
Song Y; College of Life Sciences and Agronomy, Zhoukou Normal University, Zhoukou, 466001, China.
Zhang J; College of Life Sciences and Agronomy, Zhoukou Normal University, Zhoukou, 466001, China; Institute of Food and Drug Inspection, Zhoukou Normal University, Zhoukou, 466001, China.
Yang X; College of Life Sciences and Agronomy, Zhoukou Normal University, Zhoukou, 466001, China; Institute of Food and Drug Inspection, Zhoukou Normal University, Zhoukou, 466001, China.
Wang J; Key Laboratory of Plant Genetics and Molecular Breeding, Zhoukou Normal University, Zhoukou, 466001, China.
Li L; College of Life Sciences and Agronomy, Zhoukou Normal University, Zhoukou, 466001, China; Institute of Food and Drug Inspection, Zhoukou Normal University, Zhoukou, 466001, China; Key Laboratory of Plant Genetics and Molecular Breeding, Zhoukou Normal University, Zhoukou, 466001, China.
Sun Z; College of Life Sciences and Agronomy, Zhoukou Normal University, Zhoukou, 466001, China; Institute of Food and Drug Inspection, Zhoukou Normal University, Zhoukou, 466001, China. Electronic address: .
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Źródło :
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2020 Jan; Vol. 135, pp. 110894. Date of Electronic Publication: 2019 Oct 20.
Typ publikacji :
Journal Article
MeSH Terms :
Acrylamide/*adverse effects
Blood Glucose/*metabolism
Homeostasis/*drug effects
Animals ; Female ; Gene Expression/drug effects ; Gluconeogenesis/genetics ; Glucose Intolerance/chemically induced ; Glycogenolysis/genetics ; Glycolysis/genetics ; Insulin/metabolism ; Islets of Langerhans/drug effects ; Islets of Langerhans/pathology ; Liver/drug effects ; Liver Glycogen/metabolism ; Rats, Sprague-Dawley ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
Effect of nano yam polysaccharide on the blood glucose and blood lipid in rats.
Autorzy :
Yu L; School of Pharmaceutical Science, Jiamusi University, Jiamusi, China.
Zhang J; School of Pharmaceutical Science, Jiamusi University, Jiamusi, China.
Jiao J; School of Pharmaceutical Science, Jiamusi University, Jiamusi, China.
Su J; School of Pharmaceutical Science, Jiamusi University, Jiamusi, China.
Sun WT; School of Pharmaceutical Science, Jiamusi University, Jiamusi, China.
Guo Y; School of Pharmaceutical Science, Jiamusi University, Jiamusi, China.
Ma SX; School of Basic Medical Science, Jiamusi University, Jiamusi, China.
Zhang T; School of Basic Medical Science, Jiamusi University, Jiamusi, China.
Meng DX; School of Pharmaceutical Science, Jiamusi University, Jiamusi, China.
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Źródło :
Pakistan journal of pharmaceutical sciences [Pak J Pharm Sci] 2020 Jan; Vol. 33 (1(Special)), pp. 481-487.
Typ publikacji :
Journal Article
MeSH Terms :
Blood Glucose/*analysis
Diabetes Mellitus, Experimental/*drug therapy
Dioscorea/*chemistry
Lipids/*blood
Polysaccharides/*therapeutic use
Alloxan ; Animals ; C-Peptide/blood ; Diabetes Mellitus, Experimental/blood ; Female ; Liver Glycogen/analysis ; Male ; Polysaccharides/pharmacology ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Electronic cigarette exposure reduces exercise performance and changes the biochemical profile of female mice.
Autorzy :
Chen YM; Health Technology College, Jilin Sport University, Changchun, Jilin, China.
Huang CC; Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan, Taiwan.
Sung HC; Department of Anatomy, College of Medicine, Chang Gung University, Taoyuan, Taiwan.; Aesthetic Medical Center, Department of Dermatology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Lee MC; Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan, Taiwan.
Hsiao CY; Aesthetic Medical Center, Department of Dermatology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.; Department of Nutrition and Health Sciences, Chang Gung University of Science and Technology, Taoyuan, Taiwan.; Research Center for Industry of Human Ecology and Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan.
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Źródło :
Bioscience, biotechnology, and biochemistry [Biosci Biotechnol Biochem] 2019 Dec; Vol. 83 (12), pp. 2318-2326. Date of Electronic Publication: 2019 Aug 08.
Typ publikacji :
Journal Article
MeSH Terms :
Electronic Nicotine Delivery Systems*
Physical Conditioning, Animal*
Animals ; Dose-Response Relationship, Drug ; Female ; Glycogen/metabolism ; Liver Glycogen/metabolism ; Mice ; Mice, Inbred ICR ; Models, Animal ; Muscle, Skeletal/metabolism
Czasopismo naukowe
Tytuł :
Fuel Use during Exercise at Altitude in Women with Glucose-Fructose Ingestion.
Autorzy :
O'Hara JP; Research Institute for Sport, Physical Activity and Leisure, Leeds Beckett University, Leeds, UNITED KINGDOM.
Duckworth L; Research Institute for Sport, Physical Activity and Leisure, Leeds Beckett University, Leeds, UNITED KINGDOM.
Black A; Research Institute for Sport, Physical Activity and Leisure, Leeds Beckett University, Leeds, UNITED KINGDOM.
Woods DR; Research Institute for Sport, Physical Activity and Leisure, Leeds Beckett University, Leeds, UNITED KINGDOM.; Royal Centre for Defence Medicine, Birmingham, UNITED KINGDOM.; Northumbria NHS Trust and Newcastle Trust, UNITED KINGDOM.
Mellor A; Research Institute for Sport, Physical Activity and Leisure, Leeds Beckett University, Leeds, UNITED KINGDOM.; Royal Centre for Defence Medicine, Birmingham, UNITED KINGDOM.; James Cook University Hospital, Middlesborough, UNITED KINGDOM.
Boos C; Research Institute for Sport, Physical Activity and Leisure, Leeds Beckett University, Leeds, UNITED KINGDOM.; Department of Cardiology, Poole Hospital, Poole, Dorset, UNITED KINGDOM.
Gallagher L; Research Institute for Sport, Physical Activity and Leisure, Leeds Beckett University, Leeds, UNITED KINGDOM.
Tsakirides C; Research Institute for Sport, Physical Activity and Leisure, Leeds Beckett University, Leeds, UNITED KINGDOM.
Arjomandkhah NC; School of Social and Health Sciences, Leeds Trinity University, Leeds, UNITED KINGDOM.
Morrison DJ; Scottish Universities Environmental Research Centre, University of Glasgow, East Kilbridge, UNITED KINGDOM.
Preston T; Scottish Universities Environmental Research Centre, University of Glasgow, East Kilbridge, UNITED KINGDOM.
King RFGJ; Research Institute for Sport, Physical Activity and Leisure, Leeds Beckett University, Leeds, UNITED KINGDOM.
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Źródło :
Medicine and science in sports and exercise [Med Sci Sports Exerc] 2019 Dec; Vol. 51 (12), pp. 2586-2594.
Typ publikacji :
Journal Article
MeSH Terms :
Altitude*
Energy Drinks*
Energy Metabolism*
Exercise/*physiology
Fructose/*administration & dosage
Glycogen/*administration & dosage
Hypoxia/*physiopathology
Bicycling/physiology ; Blood Glucose/metabolism ; Female ; Fructose/metabolism ; Glycogen/metabolism ; Humans ; Liver Glycogen/metabolism ; Muscle, Skeletal/metabolism ; Oxidation-Reduction
Czasopismo naukowe

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