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    Wyświetlanie 1-16 z 16
    Tytuł:
    Regulatory guidelines do not accurately predict tolvaptan and metabolite interactions at BCRP, OATP1B1, and OAT3 transporters.
    Autorzy:
    Shoaf SE; Quantitative Pharmacology, Otsuka Pharmaceutical Development & Commercialization, Inc., Rockville, Maryland, USA.
    Bricmont P; Global Clinical Management, Otsuka Pharmaceutical Development & Commercialization, Inc, Rockville, Maryland, USA.
    Repella Gordon J; Global Clinical Management, Otsuka Pharmaceutical Development & Commercialization, Inc, Rockville, Maryland, USA.
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    Źródło:
    Clinical and translational science [Clin Transl Sci] 2021 Jul; Vol. 14 (4), pp. 1535-1542. Date of Electronic Publication: 2021 Apr 09.
    Typ publikacji:
    Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    ATP Binding Cassette Transporter, Subfamily G, Member 2/*antagonists & inhibitors
    Drug Approval/*statistics & numerical data
    Liver-Specific Organic Anion Transporter 1/*antagonists & inhibitors
    Neoplasm Proteins/*antagonists & inhibitors
    Organic Anion Transporters, Sodium-Independent/*antagonists & inhibitors
    Tolvaptan/*pharmacology
    ATP Binding Cassette Transporter, Subfamily G, Member 2/metabolism ; Adult ; Clinical Trials as Topic/standards ; Cross-Over Studies ; Drug Interactions ; Female ; Furosemide/pharmacology ; Furosemide/therapeutic use ; Guidelines as Topic ; HEK293 Cells ; Half-Life ; Humans ; Liver-Specific Organic Anion Transporter 1/metabolism ; Male ; Neoplasm Proteins/metabolism ; Organic Anion Transporters, Sodium-Independent/metabolism ; Rosuvastatin Calcium/pharmacology ; Rosuvastatin Calcium/therapeutic use ; Tolvaptan/metabolism ; Tolvaptan/therapeutic use ; United States ; United States Food and Drug Administration/standards ; Young Adult
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Organic anion transporting polypeptide 1B3 can form homo- and hetero-oligomers.
    Autorzy:
    Zhang Y; Department of Pharmacology, Toxicology and Therapeutics, the University of Kansas Medical Center, Kansas City, Kansas, United States of America.
    Boxberger KH; Department of Pharmacology, Toxicology and Therapeutics, the University of Kansas Medical Center, Kansas City, Kansas, United States of America.
    Hagenbuch B; Department of Pharmacology, Toxicology and Therapeutics, the University of Kansas Medical Center, Kansas City, Kansas, United States of America.
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    Źródło:
    PloS one [PLoS One] 2017 Jun 23; Vol. 12 (6), pp. e0180257. Date of Electronic Publication: 2017 Jun 23 (Print Publication: 2017).
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Organic Anion Transporters, Sodium-Independent/*metabolism
    Blotting, Western ; Cytoplasm/metabolism ; Extracellular Space/metabolism ; Fluorescent Antibody Technique ; HEK293 Cells ; Humans ; Immunoprecipitation ; Liver-Specific Organic Anion Transporter 1/metabolism ; Mutation ; Organic Anion Transporters, Sodium-Dependent/metabolism ; Organic Anion Transporters, Sodium-Independent/chemistry ; Organic Anion Transporters, Sodium-Independent/genetics ; Protein Domains ; Protein Multimerization ; Solute Carrier Organic Anion Transporter Family Member 1B3 ; Symporters/metabolism ; Transfection
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Preference of Conjugated Bile Acids over Unconjugated Bile Acids as Substrates for OATP1B1 and OATP1B3.
    Autorzy:
    Suga T; Graduate School of Pharmaceutical Sciences, Tohoku University, 1-1 Seiryo-machi, Aoba-ku, Sendai, Japan.
    Yamaguchi H; Graduate School of Pharmaceutical Sciences, Tohoku University, 1-1 Seiryo-machi, Aoba-ku, Sendai, Japan.; Department of Pharmaceutical Sciences, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai, Japan.
    Sato T; Department of Pharmaceutical Sciences, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai, Japan.
    Maekawa M; Department of Pharmaceutical Sciences, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai, Japan.
    Goto J; Department of Pharmaceutical Sciences, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai, Japan.
    Mano N; Graduate School of Pharmaceutical Sciences, Tohoku University, 1-1 Seiryo-machi, Aoba-ku, Sendai, Japan.; Department of Pharmaceutical Sciences, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai, Japan.
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    Źródło:
    PloS one [PLoS One] 2017 Jan 06; Vol. 12 (1), pp. e0169719. Date of Electronic Publication: 2017 Jan 06 (Print Publication: 2017).
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Bile Acids and Salts/*metabolism
    Liver-Specific Organic Anion Transporter 1/*metabolism
    Organic Anion Transporters, Sodium-Independent/*metabolism
    Bile Acids and Salts/chemistry ; Biological Transport ; Glycine/metabolism ; HEK293 Cells ; Humans ; Kinetics ; Liver/metabolism ; Molecular Structure ; Solute Carrier Organic Anion Transporter Family Member 1B3 ; Substrate Specificity ; Time Factors
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    In vitro and clinical evaluation of OATP-mediated drug interaction potential of sacubitril/valsartan (LCZ696).
    Autorzy:
    Ayalasomayajula S; Translational Medicine, Drug Metabolism and Pharmacokintinetics, NIBR, East Hanover, NJ, USA.
    Han Y; Translational Medicine, Drug Metabolism and Pharmacokinetics, NIBR, Shanghai, China.
    Langenickel T; Translational Medicine, Clinical Pharmacology and Profiling, NIBR, Basel, Switzerland.
    Malcolm K; CS&I, Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
    Zhou W; Translational Medicine, Drug Metabolism and Pharmacokintinetics, NIBR, East Hanover, NJ, USA.
    Hanna I; Translational Medicine, Drug Metabolism and Pharmacokintinetics, NIBR, East Hanover, NJ, USA.
    Alexander N; Translational Medicine, Drug Metabolism and Pharmacokintinetics, NIBR, East Hanover, NJ, USA.
    Natrillo A; Translational Medicine, Drug Metabolism and Pharmacokintinetics, NIBR, East Hanover, NJ, USA.
    Goswami B; Biostatistical Sciences, Novartis Healthcare Private Limited, Hyderabad, India.
    Hinder M; Translational Medicine, Clinical Pharmacology and Profiling, NIBR, Basel, Switzerland.
    Sunkara G; Translational Medicine, Drug Metabolism and Pharmacokintinetics, NIBR, East Hanover, NJ, USA.
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    Źródło:
    Journal of clinical pharmacy and therapeutics [J Clin Pharm Ther] 2016 Aug; Vol. 41 (4), pp. 424-31. Date of Electronic Publication: 2016 Jun 19.
    Typ publikacji:
    Controlled Clinical Trial; Journal Article
    MeSH Terms:
    Aminobutyrates/*pharmacology
    Angiotensin Receptor Antagonists/*pharmacology
    Liver-Specific Organic Anion Transporter 1/*antagonists & inhibitors
    Organic Anion Transporters, Sodium-Independent/*antagonists & inhibitors
    Tetrazoles/*pharmacology
    Adult ; Aminobutyrates/administration & dosage ; Angiotensin Receptor Antagonists/administration & dosage ; Area Under Curve ; Biphenyl Compounds/pharmacology ; Drug Combinations ; Drug Interactions ; Female ; HEK293 Cells ; Humans ; Inhibitory Concentration 50 ; Male ; Middle Aged ; Simvastatin/analogs & derivatives ; Simvastatin/pharmacokinetics ; Solute Carrier Organic Anion Transporter Family Member 1B3 ; Tetrazoles/administration & dosage ; Time Factors ; Valsartan ; Young Adult
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    OATP1B1 and tumour OATP1B3 modulate exposure, toxicity, and survival after irinotecan-based chemotherapy.
    Autorzy:
    Teft WA; Department of Medicine, Division of Clinical Pharmacology, London Health Sciences Centre-University Hospital, Western University, Room B9-132, 339 Windermere Road, London, Ontario, Canada N6A 5A5.
    Welch S; Department of Oncology, London Health Sciences Centre-Victoria Hospital, Western University, 800 Commissioners Road East, PO Box 5010, London, Ontario, Canada N6A 5W9.
    Lenehan J; Department of Oncology, London Health Sciences Centre-Victoria Hospital, Western University, 800 Commissioners Road East, PO Box 5010, London, Ontario, Canada N6A 5W9.
    Parfitt J; Department of Pathology, London Health Sciences Centre - University Hospital, Western University, 339 Windermere Road, London, Ontario, Canada N6A 5A5.
    Choi YH; Department of Epidemiology and Biostatistics, Kresge Building, Western University, London Ontario, Canada N6A 5C1.
    Winquist E; Department of Oncology, London Health Sciences Centre-Victoria Hospital, Western University, 800 Commissioners Road East, PO Box 5010, London, Ontario, Canada N6A 5W9.
    Kim RB; 1] Department of Medicine, Division of Clinical Pharmacology, London Health Sciences Centre-University Hospital, Western University, Room B9-132, 339 Windermere Road, London, Ontario, Canada N6A 5A5 [2] Department of Oncology, London Health Sciences Centre-Victoria Hospital, Western University, 800 Commissioners Road East, PO Box 5010, London, Ontario, Canada N6A 5W9 [3] Department of Physiology and Pharmacology, Medical Sciences Building, Western University, London, Ontario, Canada N6A 5C1.
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    Źródło:
    British journal of cancer [Br J Cancer] 2015 Mar 03; Vol. 112 (5), pp. 857-65. Date of Electronic Publication: 2015 Jan 22.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Antineoplastic Agents, Phytogenic/*pharmacokinetics
    Camptothecin/*analogs & derivatives
    Colorectal Neoplasms/*drug therapy
    Multidrug Resistance-Associated Proteins/*genetics
    Organic Anion Transporters/*genetics
    Organic Anion Transporters, Sodium-Independent/*genetics
    Adult ; Aged ; Aged, 80 and over ; Antineoplastic Agents, Phytogenic/adverse effects ; Antineoplastic Agents, Phytogenic/therapeutic use ; Camptothecin/adverse effects ; Camptothecin/pharmacokinetics ; Camptothecin/therapeutic use ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Disease-Free Survival ; Female ; Humans ; Irinotecan ; Liver-Specific Organic Anion Transporter 1 ; Male ; Middle Aged ; Multidrug Resistance-Associated Protein 2 ; Polymorphism, Single Nucleotide ; Solute Carrier Organic Anion Transporter Family Member 1B3
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Association of neonatal hyperbilirubinemia in breast-fed infants with UGT1A1 or SLCOs polymorphisms.
    Autorzy:
    Sato H; Department of Pediatrics, Yamagata University School of Medicine, Yamagata, Japan.
    Uchida T; Department of Pediatrics, Yamagata Prefectural Central Hospital, Yamagata, Japan.
    Toyota K; Department of Pediatrics, Yamagata University School of Medicine, Yamagata, Japan.
    Nakamura T; Statistical genetics and genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
    Tamiya G; Statistical genetics and genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
    Kanno M; Department of Pediatrics, Yamagata University School of Medicine, Yamagata, Japan.
    Hashimoto T; Department of Pediatrics, Yamagata University School of Medicine, Yamagata, Japan.
    Watanabe M; Department of Pediatrics, Yamagata Prefectural Central Hospital, Yamagata, Japan.
    Aoki K; Department of Pediatrics, Yamagata University School of Medicine, Yamagata, Japan.
    Hayasaka K; Department of Pediatrics, Yamagata University School of Medicine, Yamagata, Japan.
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    Źródło:
    Journal of human genetics [J Hum Genet] 2015 Jan; Vol. 60 (1), pp. 35-40. Date of Electronic Publication: 2014 Nov 13.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Polymorphism, Genetic*
    Breast Feeding/*adverse effects
    Glucuronosyltransferase/*genetics
    Hyperbilirubinemia, Neonatal/*genetics
    Organic Anion Transporters/*genetics
    Organic Anion Transporters, Sodium-Independent/*genetics
    Bilirubin/genetics ; Bilirubin/metabolism ; Epigenesis, Genetic ; Female ; Genetic Association Studies ; Humans ; Hyperbilirubinemia, Neonatal/etiology ; Infant, Newborn ; Japan ; Liver-Specific Organic Anion Transporter 1 ; Male ; Risk Factors ; Solute Carrier Organic Anion Transporter Family Member 1B3 ; Weight Loss/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    SLCO1B1, SLCO2B1, and SLCO1B3 polymorphisms and susceptibility to bladder cancer risk.
    Autorzy:
    Bui HT; Departments of Urology ,1.
    Fujimoto N
    Kubo T
    Inatomi H
    Matsumoto T
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    Źródło:
    Cancer investigation [Cancer Invest] 2014 Jul; Vol. 32 (6), pp. 256-61. Date of Electronic Publication: 2014 Apr 24.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Organic Anion Transporters/*genetics
    Organic Anion Transporters, Sodium-Independent/*genetics
    Urinary Bladder Neoplasms/*genetics
    Aged ; Aged, 80 and over ; Female ; Genetic Association Studies ; Genetic Predisposition to Disease ; Humans ; Liver-Specific Organic Anion Transporter 1 ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Risk Factors ; Solute Carrier Organic Anion Transporter Family Member 1B3 ; Urinary Bladder Neoplasms/pathology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Introduction of aromatic ring-containing substituents in cyclic nucleotides is associated with inhibition of toxin uptake by the hepatocyte transporters OATP 1B1 and 1B3.
    Autorzy:
    Herfindal L; Department of Biomedicine, University of Bergen, Bergen, Norway; Translational Signaling Group, Haukeland University Hospital, Bergen, Norway.
    Krakstad C; Department of Biomedicine, University of Bergen, Bergen, Norway.
    Myhren L; Department of Biomedicine, University of Bergen, Bergen, Norway.
    Hagland H; Department of Biomedicine, University of Bergen, Bergen, Norway.
    Kopperud R; Department of Biomedicine, University of Bergen, Bergen, Norway.
    Teigen K; Department of Biomedicine, University of Bergen, Bergen, Norway.
    Schwede F; BIOLOG Life Science Institute, Bremen, Germany.
    Kleppe R; Department of Biomedicine, University of Bergen, Bergen, Norway.
    Døskeland SO; Department of Biomedicine, University of Bergen, Bergen, Norway.
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    Źródło:
    PloS one [PLoS One] 2014 Apr 16; Vol. 9 (4), pp. e94926. Date of Electronic Publication: 2014 Apr 16 (Print Publication: 2014).
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Bacterial Toxins/*metabolism
    Hepatocytes/*drug effects
    Nucleotides, Cyclic/*pharmacology
    Organic Anion Transporters/*metabolism
    Organic Anion Transporters, Sodium-Independent/*metabolism
    Animals ; Apoptosis/drug effects ; Bacterial Toxins/pharmacokinetics ; Bacterial Toxins/pharmacology ; Biological Transport/drug effects ; Cells, Cultured ; Cyclic AMP/analogs & derivatives ; Cyclic AMP/metabolism ; Cyclic AMP/pharmacology ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Cyclic GMP/analogs & derivatives ; Cyclic GMP/metabolism ; Cyclic GMP/pharmacology ; Cyclic GMP-Dependent Protein Kinases/metabolism ; Dose-Response Relationship, Drug ; Glycocholic Acid/metabolism ; Glycocholic Acid/pharmacokinetics ; Glycocholic Acid/pharmacology ; Guanine Nucleotide Exchange Factors/metabolism ; HEK293 Cells ; Hepatocytes/cytology ; Hepatocytes/metabolism ; Humans ; Liver-Specific Organic Anion Transporter 1 ; Male ; Microscopy, Confocal ; Models, Molecular ; Nucleotides, Cyclic/chemistry ; Organic Anion Transporters/chemistry ; Organic Anion Transporters/genetics ; Organic Anion Transporters, Sodium-Independent/chemistry ; Organic Anion Transporters, Sodium-Independent/genetics ; Peptides, Cyclic/metabolism ; Peptides, Cyclic/pharmacokinetics ; Peptides, Cyclic/pharmacology ; Protein Structure, Tertiary ; Rats, Wistar ; Solute Carrier Organic Anion Transporter Family Member 1B3
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Selectivity and potency of microcystin congeners against OATP1B1 and OATP1B3 expressing cancer cells.
    Autorzy:
    Niedermeyer TH; Cyano Biotech GmbH, Berlin, Germany; Interfaculty Institute for Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany.
    Daily A; Department of Pediatrics, University of Kentucky, Lexington, Kentucky, United States of America.
    Swiatecka-Hagenbruch M; Cyano Biotech GmbH, Berlin, Germany.
    Moscow JA; Department of Pediatrics, University of Kentucky, Lexington, Kentucky, United States of America.
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    Źródło:
    PloS one [PLoS One] 2014 Mar 10; Vol. 9 (3), pp. e91476. Date of Electronic Publication: 2014 Mar 10 (Print Publication: 2014).
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Microcystins/*pharmacology
    Neoplasms/*metabolism
    Organic Anion Transporters/*antagonists & inhibitors
    Organic Anion Transporters, Sodium-Independent/*antagonists & inhibitors
    Cell Line, Tumor ; Humans ; Inhibitory Concentration 50 ; Liver-Specific Organic Anion Transporter 1 ; Microcystins/chemistry ; Organic Anion Transporters/metabolism ; Organic Anion Transporters, Sodium-Independent/metabolism ; Peptides, Cyclic/chemistry ; Solute Carrier Organic Anion Transporter Family Member 1B3
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    In vitro OATP1B1 and OATP1B3 inhibition is associated with observations of benign clinical unconjugated hyperbilirubinemia.
    Autorzy:
    Chiou WJ; Department of Drug Metabolism and Pharmacokinetics, Division of Development Sciences, Global Pharmaceutical Research and Development, AbbVie, Inc. , North Chicago, IL 60064 , USA.
    de Morais SM
    Kikuchi R
    Voorman RL
    Li X
    Bow DA
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    Źródło:
    Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2014 Mar; Vol. 44 (3), pp. 276-82. Date of Electronic Publication: 2013 Jul 25.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Antirheumatic Agents/*pharmacology
    HIV Protease Inhibitors/*pharmacology
    Hyperbilirubinemia/*metabolism
    Organic Anion Transporters/*antagonists & inhibitors
    Organic Anion Transporters, Sodium-Independent/*antagonists & inhibitors
    Atazanavir Sulfate ; Bilirubin/metabolism ; Carbamates ; Cyclosporine ; Furans ; Glucuronosyltransferase/antagonists & inhibitors ; In Vitro Techniques ; Indinavir ; Liver-Specific Organic Anion Transporter 1 ; Oligopeptides ; Organic Anion Transporters/metabolism ; Organic Anion Transporters, Sodium-Independent/metabolism ; Pyridines ; Rifampin ; Rifamycins ; Saquinavir ; Solute Carrier Organic Anion Transporter Family Member 1B3 ; Sulfonamides
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Characterization of ursodeoxycholic and norursodeoxycholic acid as substrates of the hepatic uptake transporters OATP1B1, OATP1B3, OATP2B1 and NTCP.
    Autorzy:
    König J; Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany.
    Klatt S
    Dilger K
    Fromm MF
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    Źródło:
    Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2012 Aug; Vol. 111 (2), pp. 81-6. Date of Electronic Publication: 2012 Mar 09.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Organic Anion Transporters/*metabolism
    Organic Anion Transporters, Sodium-Dependent/*metabolism
    Organic Anion Transporters, Sodium-Independent/*metabolism
    Symporters/*metabolism
    Ursodeoxycholic Acid/*analogs & derivatives
    Ursodeoxycholic Acid/*pharmacokinetics
    Cloning, Molecular ; HEK293 Cells ; Hepatocytes/drug effects ; Hepatocytes/metabolism ; Humans ; Liver/drug effects ; Liver/metabolism ; Liver-Specific Organic Anion Transporter 1 ; Solute Carrier Organic Anion Transporter Family Member 1B3
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Association study of genetic polymorphisms of drug transporters, SLCO1B1, SLCO1B3 and ABCC2, in African-Americans, Hispanics and Caucasians and olmesartan exposure.
    Autorzy:
    Endo S; Translational Medicine and Clinical Pharmacology Department, Daiichi Sankyo, Tokyo, Japan.
    Fukahori A
    Tokuhiro S
    Shinagawa A
    Walker J
    Yoshihara K
    Ishizuka H
    Ieiri I
    Sugiyama Y
    Pokaż więcej
    Źródło:
    Journal of human genetics [J Hum Genet] 2012 Aug; Vol. 57 (8), pp. 531-44. Date of Electronic Publication: 2012 Jun 14.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Imidazoles*/pharmacokinetics
    Imidazoles*/therapeutic use
    Tetrazoles*/pharmacokinetics
    Tetrazoles*/therapeutic use
    Multidrug Resistance-Associated Proteins/*genetics
    Organic Anion Transporters/*genetics
    Organic Anion Transporters, Sodium-Independent/*genetics
    Adult ; Black or African American/genetics ; Female ; Gene Frequency ; Genetic Association Studies ; Haplotypes ; Humans ; Linkage Disequilibrium ; Liver-Specific Organic Anion Transporter 1 ; Male ; Middle Aged ; Multidrug Resistance-Associated Protein 2 ; Polymorphism, Single Nucleotide ; Solute Carrier Organic Anion Transporter Family Member 1B3 ; White People/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Influence of genomic ancestry on the distribution of SLCO1B1, SLCO1B3 and ABCB1 gene polymorphisms among Brazilians.
    Autorzy:
    Sortica Vde A; Genetics Department, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
    Ojopi EB
    Genro JP
    Callegari-Jacques S
    Ribeiro-Dos-Santos A
    de Moraes MO
    Romano-Silva MA
    Pena SD
    Suarez-Kurtz G
    Hutz MH
    Pokaż więcej
    Źródło:
    Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2012 May; Vol. 110 (5), pp. 460-8. Date of Electronic Publication: 2011 Dec 29.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Genetics, Population*
    Polymorphism, Single Nucleotide*
    ATP Binding Cassette Transporter, Subfamily B, Member 1/*genetics
    Organic Anion Transporters/*genetics
    Organic Anion Transporters, Sodium-Independent/*genetics
    Racial Groups/*genetics
    ATP Binding Cassette Transporter, Subfamily B ; Brazil ; Cohort Studies ; Gene Frequency ; Haplotypes ; Humans ; Liver-Specific Organic Anion Transporter 1 ; Molecular Targeted Therapy ; Pharmacogenetics ; Solute Carrier Organic Anion Transporter Family Member 1B3
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Organic anion transporting polypeptides OATP1B1 and OATP1B3 and their genetic variants influence the pharmacokinetics and pharmacodynamics of raloxifene.
    Autorzy:
    Trdan Lušin T; Department of Clinical Biochemistry, University of Ljubljana, Ljubljana, Slovenia. />Stieger B
    Marc J
    Mrhar A
    Trontelj J
    Zavratnik A
    Ostanek B
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    Źródło:
    Journal of translational medicine [J Transl Med] 2012 Apr 25; Vol. 10, pp. 76. Date of Electronic Publication: 2012 Apr 25.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Genetic Variation*
    Organic Anion Transporters/*physiology
    Organic Anion Transporters, Sodium-Independent/*physiology
    Raloxifene Hydrochloride/*pharmacology
    Selective Estrogen Receptor Modulators/*pharmacokinetics
    Absorptiometry, Photon ; Aged ; Animals ; Bone Density ; CHO Cells ; Cricetinae ; Cricetulus ; Female ; Genotype ; Haplotypes ; Humans ; Liver-Specific Organic Anion Transporter 1 ; Middle Aged ; Organic Anion Transporters/genetics ; Organic Anion Transporters, Sodium-Independent/genetics ; Raloxifene Hydrochloride/pharmacokinetics ; Selective Estrogen Receptor Modulators/pharmacology ; Solute Carrier Organic Anion Transporter Family Member 1B3
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Catalog of 258 single-nucleotide polymorphisms (SNPs) in genes encoding three organic anion transporters, three organic anion-transporting polypeptides, and three NADH:ubiquinone oxidoreductase flavoproteins.
    Autorzy:
    Iida A; Laboratory for Genotyping. RIKEN SNP Research Center, Tokyo, Japan.
    Saito S
    Sekine A
    Mishima C
    Kondo K
    Kitamura Y
    Harigae S
    Osawa S
    Nakamura Y
    Pokaż więcej
    Źródło:
    Journal of human genetics [J Hum Genet] 2001; Vol. 46 (11), pp. 668-83.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Organic Anion Transporters, Sodium-Independent*
    Liver-Specific Organic Anion Transporter 1/*genetics
    NADH, NADPH Oxidoreductases/*genetics
    Organic Anion Transporters/*genetics
    Polymorphism, Single Nucleotide/*genetics
    Chromosome Mapping ; DNA/blood ; DNA/isolation & purification ; Electron Transport Complex I ; Exons ; Flavoproteins/genetics ; Humans ; Japan ; Multigene Family ; White People/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-16 z 16

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