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    Wyświetlanie 1-18 z 18
    Tytuł:
    Chromosomal phase improves aneuploidy detection in non-invasive prenatal testing at low fetal DNA fractions.
    Autorzy:
    Genovese G; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA. .; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA. .; Department of Genetics, Harvard Medical School, Boston, MA, 02115, USA. .
    Mello CJ; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Department of Genetics, Harvard Medical School, Boston, MA, 02115, USA.
    Loh PR; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
    Handsaker RE; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Department of Genetics, Harvard Medical School, Boston, MA, 02115, USA.
    Kashin S; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Department of Genetics, Harvard Medical School, Boston, MA, 02115, USA.
    Whelan CW; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Department of Genetics, Harvard Medical School, Boston, MA, 02115, USA.
    Bayer-Zwirello LA; Steward St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA, 02135, USA.
    McCarroll SA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Department of Genetics, Harvard Medical School, Boston, MA, 02115, USA.
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    Źródło:
    Scientific reports [Sci Rep] 2022 Jul 14; Vol. 12 (1), pp. 12025. Date of Electronic Publication: 2022 Jul 14.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Cell-Free Nucleic Acids*/genetics
    Prenatal Diagnosis*/methods
    Aneuploidy ; Chromosomes ; DNA/genetics ; Female ; Fetus ; Humans ; Placenta ; Pregnancy ; Trisomy/diagnosis ; Trisomy/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Protein-coding repeat polymorphisms strongly shape diverse human phenotypes.
    Autorzy:
    Mukamel RE; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard University, Boston, MA, USA.
    Handsaker RE; Program in Medical and Population Genetics, Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard University, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard University, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
    Sherman MA; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard University, Boston, MA, USA.; Computer Science and Artificial Intelligence Laboratory, MIT, Boston, MA, USA.
    Barton AR; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard University, Boston, MA, USA.; Bioinformatics and Integrative Genomics Program, Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
    Zheng Y; Program in Medical and Population Genetics, Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard University, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard University, Boston, MA, USA.
    McCarroll SA; Program in Medical and Population Genetics, Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard University, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard University, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
    Loh PR; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard University, Boston, MA, USA.
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    Źródło:
    Science (New York, N.Y.) [Science] 2021 Sep 24; Vol. 373 (6562), pp. 1499-1505. Date of Electronic Publication: 2021 Sep 23.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Genome, Human*
    Phenotype*
    Polymorphism, Genetic*
    Minisatellite Repeats/*genetics
    Aggrecans/genetics ; Antigens/genetics ; Black People ; Body Height/genetics ; Genetic Association Studies ; Hair ; Haplotypes ; Humans ; Intermediate Filament Proteins/genetics ; Kidney/physiology ; Lipoprotein(a)/blood ; Lipoprotein(a)/genetics ; Mucin-1/genetics ; Polymorphism, Single Nucleotide ; Polynucleotide Adenylyltransferase/genetics ; White People/genetics ; Exome Sequencing
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Estimating the effective sample size in association studies of quantitative traits.
    Autorzy:
    Ziyatdinov A; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
    Kim J; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
    Prokopenko D; Genetics and Aging Unit and McCance Center for Brain Health, Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.; Harvard Medical School, Boston, MA 02115, USA.
    Privé F; National Centre for Register-Based Research, Aarhus University, Aarhus 8210, Denmark.
    Laporte F; Department of Computational Biology-USR 3756 CNRS, Institut Pasteur, Paris 75015, France.
    Loh PR; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
    Kraft P; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
    Aschard H; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.; Department of Computational Biology-USR 3756 CNRS, Institut Pasteur, Paris 75015, France.
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    Źródło:
    G3 (Bethesda, Md.) [G3 (Bethesda)] 2021 Jun 17; Vol. 11 (6).
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural
    MeSH Terms:
    Genome-Wide Association Study*/methods
    Multifactorial Inheritance*/genetics
    Humans ; Sample Size ; Phenotype ; Linear Models ; Polymorphism, Single Nucleotide
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Genetically predicted telomere length is associated with clonal somatic copy number alterations in peripheral leukocytes.
    Autorzy:
    Brown DW; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, United States of America.; Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, Rockville, MD, United States of America.
    Lin SH; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, United States of America.
    Loh PR; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States of America.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, United States of America.
    Chanock SJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, United States of America.
    Savage SA; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, United States of America.
    Machiela MJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, United States of America.
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    Źródło:
    PLoS genetics [PLoS Genet] 2020 Oct 22; Vol. 16 (10), pp. e1009078. Date of Electronic Publication: 2020 Oct 22 (Print Publication: 2020).
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Clonal Evolution/*genetics
    Neoplasms/*blood
    Telomere/*genetics
    Telomere Homeostasis/*genetics
    Adult ; Aged ; Cell Division/genetics ; DNA Copy Number Variations/genetics ; Female ; Genetics, Population ; Humans ; Leukocytes/metabolism ; Leukocytes/pathology ; Male ; Middle Aged ; Neoplasms/epidemiology ; Neoplasms/genetics ; United Kingdom/epidemiology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Mental Health and Coping in Parents of Children with Autism Spectrum Disorder (ASD) in Singapore: An Examination of Gender Role in Caring.
    Autorzy:
    Ang KQP; James Cook University, 149 Sims Drive, Singapore, 387380, Singapore. .
    Loh PR; National Institute of Education, Nanyang Technological University, 1 Nanyang Walk, Singapore, 637616, Singapore.
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    Źródło:
    Journal of autism and developmental disorders [J Autism Dev Disord] 2019 May; Vol. 49 (5), pp. 2129-2145.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Adaptation, Psychological*
    Empathy*
    Gender Identity*
    Mental Health*
    Autism Spectrum Disorder/*psychology
    Adult ; Child ; Female ; Humans ; Male ; Middle Aged ; Parents/psychology ; Singapore
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Stepwise Distributed Open Innovation Contests for Software Development: Acceleration of Genome-Wide Association Analysis.
    Autorzy:
    Hill A; Research Business Technology, Pfizer Research, 1 Portland Street, Cambridge, Massachusetts, 02139 USA.
    Loh PR; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts, 02142 USA.
    Bharadwaj RB; Babbage Analytic and Innovation, Boston Massachusetts, USA.; Current affiliation, Nyrasta LLC.
    Pons P; Current affiliation, Criteo Labs, 32 Rue Blanche, 75009, Paris, France.
    Shang J; Current affiliation, Computer Science Department, University of Illinois at Urbana-Champaign 201 N Goodwin Ave, Urbana, Illinois, USA.
    Guinan E; Department of Radiation Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts, 02215, USA.; Harvard Business School, Boston, Massachusetts, 02163 USA.
    Lakhani K; Babbage Analytic and Innovation, Boston Massachusetts, USA.; Harvard Business School, Boston, Massachusetts, 02163 USA.; Harvard-NASA Tournament Lab, Institute for Quantitative Social Science 1737 Cambridge Street, Cambridge Massachusetts, 02138, USA.
    Kilty I; Department of Inflammation and Immunology, Pfizer Research, 1 Portland Street, Cambridge, Massachusetts, 02139, USA.
    Jelinsky SA; Department of Inflammation and Immunology, Pfizer Research, 1 Portland Street, Cambridge, Massachusetts, 02139, USA.
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    Źródło:
    GigaScience [Gigascience] 2017 May 01; Vol. 6 (5), pp. 1-10.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural
    MeSH Terms:
    Crowdsourcing*
    Genome-Wide Association Study*
    Software*
    Genotype ; Humans ; Inventions ; Logistic Models ; Phenotype
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Calibrating the Human Mutation Rate via Ancestral Recombination Density in Diploid Genomes.
    Autorzy:
    Lipson M; Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America.
    Loh PR; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America.; Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America.
    Sankararaman S; Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America.; Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America.
    Patterson N; Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America.
    Berger B; Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America.; Department of Mathematics and Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America.
    Reich D; Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America.; Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America.; Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, United States of America.
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    Źródło:
    PLoS genetics [PLoS Genet] 2015 Nov 12; Vol. 11 (11), pp. e1005550. Date of Electronic Publication: 2015 Nov 12 (Print Publication: 2015).
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Evolution, Molecular*
    Mutation Rate*
    Recombination, Genetic*
    Mutation/*genetics
    Animals ; Diploidy ; Genetics, Population ; Genome, Human ; Hominidae/genetics ; Humans ; Pedigree ; Phylogeny
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Partitioning heritability by functional annotation using genome-wide association summary statistics.
    Autorzy:
    Finucane HK; Department of Mathematics, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
    Bulik-Sullivan B; Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
    Gusev A; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
    Trynka G; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Division of Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Partners Center for Personalized Genetic Medicine, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.
    Reshef Y; Department of Computer Science, Harvard University, Cambridge, Massachusetts, USA.
    Loh PR; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
    Anttila V; Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
    Xu H; Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
    Zang C; Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
    Farh K; Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.; Epigenomics Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
    Ripke S; Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
    Day FR; Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
    Purcell S; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Division of Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA.
    Stahl E; Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA.
    Lindstrom S; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
    Perry JR; Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
    Okada Y; Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
    Raychaudhuri S; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Division of Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Partners Center for Personalized Genetic Medicine, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK.
    Daly MJ; Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
    Patterson N; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
    Neale BM; Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
    Price AL; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
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    Corporate Authors:
    ReproGen Consortium
    Schizophrenia Working Group of the Psychiatric Genomics Consortium
    RACI Consortium
    Źródło:
    Nature genetics [Nat Genet] 2015 Nov; Vol. 47 (11), pp. 1228-35. Date of Electronic Publication: 2015 Sep 28.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Polymorphism, Single Nucleotide*
    Disease/*genetics
    Genetic Predisposition to Disease/*genetics
    Genome-Wide Association Study/*methods
    Algorithms ; Computer Simulation ; Female ; Gene Frequency ; Histones/metabolism ; Humans ; Inheritance Patterns ; Lysine/metabolism ; Male ; Methylation ; Models, Genetic
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    An atlas of genetic correlations across human diseases and traits.
    Autorzy:
    Bulik-Sullivan B; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Stanley Center for Psychiatric Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
    Finucane HK; Department of Mathematics, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
    Anttila V; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Stanley Center for Psychiatric Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
    Gusev A; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
    Day FR; Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
    Loh PR; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
    Duncan L; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Stanley Center for Psychiatric Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
    Perry JR; Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
    Patterson N; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
    Robinson EB; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Stanley Center for Psychiatric Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
    Daly MJ; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Stanley Center for Psychiatric Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
    Price AL; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
    Neale BM; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Stanley Center for Psychiatric Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
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    Corporate Authors:
    ReproGen Consortium
    Psychiatric Genomics Consortium
    Genetic Consortium for Anorexia Nervosa of the Wellcome Trust Case Control Consortium 3
    Źródło:
    Nature genetics [Nat Genet] 2015 Nov; Vol. 47 (11), pp. 1236-41. Date of Electronic Publication: 2015 Sep 28.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Disease/*genetics
    Genetic Association Studies/*methods
    Genome-Wide Association Study/*methods
    Quantitative Trait Loci/*genetics
    Algorithms ; Computer Simulation ; Female ; Genetic Association Studies/statistics & numerical data ; Genetic Predisposition to Disease/genetics ; Genome-Wide Association Study/statistics & numerical data ; Genotype ; Humans ; Linkage Disequilibrium ; Male ; Models, Genetic ; Phenotype ; Polymorphism, Single Nucleotide ; Regression Analysis
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Efficient Bayesian mixed-model analysis increases association power in large cohorts.
    Autorzy:
    Loh PR; 1] Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. [2] Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.
    Tucker G; 1] Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. [2] Department of Mathematics, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. [3] Computer Science and Artificial Intelligence Laboratory, Cambridge, Massachusetts, USA.
    Bulik-Sullivan BK; 1] Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA. [2] Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.
    Vilhjálmsson BJ; 1] Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. [2] Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.
    Finucane HK; Department of Mathematics, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
    Salem RM; 1] Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA. [2] Department of Endocrinology, Children's Hospital Boston, Boston, Massachusetts, USA.
    Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
    Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
    Neale BM; 1] Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA. [2] Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.
    Berger B; 1] Department of Mathematics, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. [2] Computer Science and Artificial Intelligence Laboratory, Cambridge, Massachusetts, USA.
    Patterson N; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.
    Price AL; 1] Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. [2] Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA. [3] Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
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    Źródło:
    Nature genetics [Nat Genet] 2015 Mar; Vol. 47 (3), pp. 284-90. Date of Electronic Publication: 2015 Feb 02.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Bayes Theorem*
    Genome, Human*
    Genetic Association Studies/*methods
    Algorithms ; Female ; Genotyping Techniques ; Humans ; Linear Models ; Polymorphism, Single Nucleotide ; Quantitative Trait Loci
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    LD Score regression distinguishes confounding from polygenicity in genome-wide association studies.
    Autorzy:
    Bulik-Sullivan BK; 1] Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. [2] Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA. [3] Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
    Loh PR; 1] Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. [2] Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
    Finucane HK; 1] Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. [2] Department of Mathematics, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
    Ripke S; 1] Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA. [2] Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
    Yang J; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
    Patterson N; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
    Daly MJ; 1] Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. [2] Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA. [3] Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
    Price AL; 1] Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. [2] Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. [3] Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
    Neale BM; 1] Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. [2] Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA. [3] Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
    Pokaż więcej
    Corporate Authors:
    Schizophrenia Working Group of the Psychiatric Genomics Consortium
    Źródło:
    Nature genetics [Nat Genet] 2015 Mar; Vol. 47 (3), pp. 291-5. Date of Electronic Publication: 2015 Feb 02.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Linkage Disequilibrium*
    Genome-Wide Association Study/*methods
    Computer Simulation ; Genome, Human ; Humans ; Polymorphism, Single Nucleotide ; Regression Analysis ; Sample Size
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Network topology and parameter estimation: from experimental design methods to gene regulatory network kinetics using a community based approach.
    Autorzy:
    Meyer P
    Cokelaer T
    Chandran D
    Kim KH
    Loh PR
    Tucker G
    Lipson M
    Berger B
    Kreutz C
    Raue A
    Steiert B
    Timmer J
    Bilal E
    Sauro HM
    Stolovitzky G
    Saez-Rodriguez J
    Pokaż więcej
    Źródło:
    BMC systems biology [BMC Syst Biol] 2014 Feb 07; Vol. 8, pp. 13. Date of Electronic Publication: 2014 Feb 07.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Gene Regulatory Networks*
    Computational Biology/*methods
    Computer Simulation ; Kinetics ; Models, Genetic ; Time Factors
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    A sampling framework for incorporating quantitative mass spectrometry data in protein interaction analysis.
    Autorzy:
    Tucker G; Mathematics Department and Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. .
    Loh PR
    Berger B
    Pokaż więcej
    Źródło:
    BMC bioinformatics [BMC Bioinformatics] 2013 Oct 04; Vol. 14, pp. 299. Date of Electronic Publication: 2013 Oct 04.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Computational Biology/*methods
    Mass Spectrometry/*methods
    Protein Interaction Mapping/*methods
    Proteins/*chemistry
    Proteins/*metabolism
    Chromatography, Affinity/methods ; Databases, Protein
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Prize-based contests can provide solutions to computational biology problems.
    Autorzy:
    Lakhani KR
    Boudreau KJ
    Loh PR
    Backstrom L
    Baldwin C
    Lonstein E
    Lydon M
    MacCormack A
    Arnaout RA
    Guinan EC
    Pokaż więcej
    Źródło:
    Nature biotechnology [Nat Biotechnol] 2013 Feb; Vol. 31 (2), pp. 108-11.
    Typ publikacji:
    Letter; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Awards and Prizes*
    Computational Biology*/economics
    Computational Biology*/legislation & jurisprudence
    Computational Biology*/methods
    Humans
    Raport
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Reconstructing Roma history from genome-wide data.
    Autorzy:
    Moorjani P; Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America. />Patterson N
    Loh PR
    Lipson M
    Kisfali P
    Melegh BI
    Bonin M
    Kádaši L
    Rieß O
    Berger B
    Reich D
    Melegh B
    Pokaż więcej
    Źródło:
    PloS one [PLoS One] 2013; Vol. 8 (3), pp. e58633. Date of Electronic Publication: 2013 Mar 13.
    Typ publikacji:
    Historical Article; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Genome, Human*
    Ethnicity/*genetics
    Ethnicity/*history
    Asia/ethnology ; Europe/ethnology ; Founder Effect ; Gene Flow/genetics ; History, Medieval ; Humans ; Oligonucleotide Array Sequence Analysis ; Polymorphism, Single Nucleotide/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Compressive genomics.
    Autorzy:
    Loh PR; Department of Mathematics and Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
    Baym M
    Berger B
    Pokaż więcej
    Źródło:
    Nature biotechnology [Nat Biotechnol] 2012 Jul 10; Vol. 30 (7), pp. 627-30. Date of Electronic Publication: 2012 Jul 10.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Algorithms*
    Genome, Human*
    Computational Biology/*methods
    Data Mining ; High-Throughput Nucleotide Sequencing ; Humans ; Yeasts/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Assessing statistical significance in causal graphs.
    Autorzy:
    Chindelevitch L; Computational Sciences Center of Emphasis, Pfizer Worldwide Research & Development, Cambridge, MA, USA.
    Loh PR
    Enayetallah A
    Berger B
    Ziemek D
    Pokaż więcej
    Źródło:
    BMC bioinformatics [BMC Bioinformatics] 2012 Feb 20; Vol. 13, pp. 35. Date of Electronic Publication: 2012 Feb 20.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Algorithms*
    Models, Biological*
    Animals ; Chondrocytes/cytology ; Chondrocytes/metabolism ; Dexamethasone ; Gene Expression Profiling ; Hypoxia/drug therapy ; Hypoxia/genetics ; Hypoxia/metabolism ; Mice ; Oligonucleotide Array Sequence Analysis ; Receptors, Glucocorticoid/metabolism ; Statistical Distributions
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Phenotype prediction using regularized regression on genetic data in the DREAM5 Systems Genetics B Challenge.
    Autorzy:
    Loh PR; Department of Mathematics and Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
    Tucker G
    Berger B
    Pokaż więcej
    Źródło:
    PloS one [PLoS One] 2011; Vol. 6 (12), pp. e29095. Date of Electronic Publication: 2011 Dec 28.
    Typ publikacji:
    Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Phytophthora/*physiology
    Glycine max/*microbiology
    Genotype ; Phenotype ; Glycine max/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-18 z 18

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