Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.
Autorzy:
Feitosa MF; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America. Kraja AT; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America. Chasman DI; Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.; Harvard Medical School, Boston, Massachusetts, United States of America. Sung YJ; Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America. Winkler TW; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany. Ntalla I; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom. Guo X; Genomic Outcomes, Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, United States of America. Franceschini N; Epidemiology, University of North Carolina Gilling School of Global Public Health, Chapel Hill, North Carolina, United States of America. Cheng CY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. Sim X; Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore. Vojinovic D; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands. Marten J; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom. Musani SK; Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America. Li C; Epidemiology and Biostatistics, University of Georgia at Athens College of Public Health, Athens, Georgia, United States of America. Bentley AR; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America. Brown MR; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America. Schwander K; Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America. Richard MA; Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America. Noordam R; Internal Medicine, Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands. Aschard H; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America.; Centre de Bioinformatique, Biostatistique et Biologie Intégrative (C3BI), Institut Pasteur, Paris, France. Bartz TM; Cardiovascular Health Research Unit, Biostatistics and Medicine, University of Washington, Seattle, Washington, United States of America. Bielak LF; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America. Dorajoo R; Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore. Fisher V; Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America. Hartwig FP; Postgraduate Programme in Epidemiology, Federal University of Pelotas, Pelotas, RS, Brazil.; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom. Horimoto ARVR; Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, SP, Brazil. LohmanKK; Biostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America. Manning AK; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America. Rankinen T; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America. Smith AV; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland. Tajuddin SM; Health Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America. Wojczynski MK; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America. Alver M; Estonian Genome Center, University of Tartu, Tartu, Estonia. Boissel M; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France. Cai Q; Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America. Campbell A; Centre for Genomic & Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom. Chai JF; Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore. Chen X; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Stockholm, Sweden. Divers J; Biostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America. Gao C; Molecular Genetics and Genomics Program, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America. Goel A; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, Oxfordshire, United Kingdom.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, Oxfordshire, United Kingdom. Hagemeijer Y; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Harris SE; Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom.; Medical Genetics Section, Centre for Genomic and Experimental Medicine and MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh, Edinburgh, United Kingdom. He M; Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Hsu FC; Biostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America. Jackson AU; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America. Kähönen M; Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland.; University of Tampere, Tampere, Finland. Kasturiratne A; Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka. Komulainen P; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland. Kühnel B; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. Laguzzi F; Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Luan J; MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom. Matoba N; Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan. Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Padmanabhan S; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom. Riaz M; Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, United Kingdom. Rueedi R; Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.; Swiss Instititute of Bioinformatics, Lausanne, Switzerland. Robino A; Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', Trieste, Italy. Said MA; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Scott RA; MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom. Sofer T; Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America.; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, United States of America. Stančáková A; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland. Takeuchi F; Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan. Tayo BO; Department of Public Health Sciences, Loyola University Chicago, Maywood, Illinois, United States of America. van der Most PJ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Varga TV; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden. Vitart V; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom. Wang Y; Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America. Ware EB; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, United States of America. Warren HR; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.; NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, London, United Kingdom. Weiss S; Interfaculty Institute for Genetics and Functional genomics, University Medicine Ernst Moritz Arndt University Greifsald, Greifswald, Germany.; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany. Wen W; Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America. Yanek LR; Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America. Zhang W; Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom.; Department of Cardiology, Ealing Hospital, Middlesex, United Kingdom. Zhao JH; MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom. Afaq S; Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom. Amin N; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands. Amini M; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Arking DE; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America. Aung T; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. Boerwinkle E; Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas School of Public Health, Houston, Texas, United States of America.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America. Borecki I; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America. Broeckel U; Section of Genomic Pediatrics, Department of Pediatrics, Medicine and Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America. Brown M; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.; NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, London, United Kingdom. Brumat M; Department of Medical Sciences, University of Trieste, Trieste, Italy. Burke GL; Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America. Canouil M; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France. Chakravarti A; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America. Charumathi S; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore. Ida Chen YD; Genomic Outcomes, Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, United States of America. Connell JM; Ninewells Hospital & Medical School, University of Dundee, Dundee, Scotland, United Kingdom. Correa A; Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America. de Las Fuentes L; Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America.; Cardiovascular Division, Department of Medicine, Washington University, St. Louis, Missouri, United States of America. de Mutsert R; Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands. de Silva HJ; Department of Medicine, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka. Deng X; Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America. Ding J; Center on Diabetes, Obesity, and Metabolism, Gerontology and Geriatric Medicine, Wake Forest University Health Sciences, Winston-Salem, North Carolina, United States of America. Duan Q; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America. Eaton CB; Department of Family Medicine and Epidemiology, Alpert Medical School of Brown University, Providence, Rhode Island, United States of America. Ehret G; Cardiology, Geneva University Hospital, Geneva, Switzerland. Eppinga RN; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Evangelou E; Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom.; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece. Faul JD; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, United States of America. Felix SB; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany. Forouhi NG; MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom. Forrester T; The Caribbean Institute for Health Research (CAIHR), University of the West Indies, Mona, Jamaica. Franco OH; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands. Friedlander Y; Braun School of Public Health, Hebrew University-Hadassah Medical Center, Jerusalem, Israel. Gandin I; Department of Medical Sciences, University of Trieste, Trieste, Italy. Gao H; Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom. Ghanbari M; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Gigante B; Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Gu CC; Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America. Gu D; Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Hagenaars SP; Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom.; Psychology, The University of Edinburgh, Edinburgh, United Kingdom. Hallmans G; Department of Public Health and Clinical Medicine, Nutritional Research, Umeå University, Umeå, Västerbotten, Sweden. Harris TB; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America. He J; Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, United States of America.; Medicine, Tulane University School of Medicine, New Orleans, Louisiana, United States of America. Heikkinen S; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.; Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Finland. Heng CK; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore. Hirata M; Laboratory of Genome Technology, Human Genome Center, Institute of Medical Science, The University of Tokyo, Minato-ku, Japan. Howard BV; MedStar Health Research Institute, Hyattsville, Maryland, United States of America.; Center for Clinical and Translational Sciences and Department of Medicine, Georgetown-Howard Universities, Washington, DC, United States of America. Ikram MA; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands. John U; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Institute of Social Medicine and Prevention, University Medicine Greifswald, Greifswald, Germany. Katsuya T; Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Japan.; Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Japan. Khor CC; Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore.; Department of Biochemistry, National University of Singapore, Singapore, Singapore. Kilpeläinen TO; Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Environmental Medicine and Public Health, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America. Koh WP; Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore. Krieger JE; Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, SP, Brazil. Kritchevsky SB; Sticht Center for Healthy Aging and Alzheimer's Prevention, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America. Kubo M; Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan. Kuusisto J; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland. Lakka TA; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.; Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland. Langefeld CD; Biostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America. Langenberg C; MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom. Launer LJ; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America. Lehne B; Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom. Lewis CE; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States of America. Li Y; Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America. Lin S; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America. Liu J; Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore.; Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore. Liu J; WHI CCC, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America. Loh M; Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom.; Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research, Singapore. Louie T; Department of Biostatistics, University of Washington, Seattle, Washington, United States of America. Mägi R; Estonian Genome Center, University of Tartu, Tartu, Estonia. McKenzie CA; The Caribbean Institute for Health Research (CAIHR), University of the West Indies, Mona, Jamaica. Meitinger T; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Human Genetics, Technische Universität München, Munich, Germany. Metspalu A; Estonian Genome Center, University of Tartu, Tartu, Estonia. Milaneschi Y; Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, The Netherlands. Milani L; Estonian Genome Center, University of Tartu, Tartu, Estonia. Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America. Momozawa Y; Laboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan. Nalls MA; Data Tecnica International, Glen Echo, Maryland, United States of America.; Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, United States of America. Nelson CP; Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, United Kingdom. Sotoodehnia N; Cardiovascular Health Research Unit, Division of Cardiology, University of Washington, Seattle, Washington, United States of America. Norris JM; Department of Epidemiology, Colorado School of Public Health, Aurora, Colorado, United States of America. O'Connell JR; Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America. Palmer ND; Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America. Perls T; Geriatrics Section, Boston University Medical Center, Boston, Massachusetts, United States of America. Pedersen NL; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Stockholm, Sweden. Peters A; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Neuherberg, Germany. Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America. Poulter N; School of Public Health, Imperial College London, London, London, United Kingdom. Raffel LJ; Division of Genetic and Genomic Medicine, Department of Pediatrics, University of California, Irvine, California, United States of America. Raitakari OT; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland. Roll K; Genomic Outcomes, Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, United States of America. Rose LM; Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America. Rosendaal FR; Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands. Rotter JI; Genomic Outcomes, Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, United States of America. Schmidt CO; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. Schreiner PJ; Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, United States of America. Schupf N; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, New York, United States of America. Scott WR; Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom.; National Heart and Lung Institute, Imperial College London, London, United Kingdom. Sever PS; National Heart and Lung Institute, Imperial College London, London, United Kingdom. Shi Y; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore. Sidney S; Division of Research, Kaiser Permanente of Northern California, Oakland, California, United States of America. Sims M; Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America. Sitlani CM; Cardiovascular Health Research Unit, Medicine, University of Washington, Seattle, Washington, United States of America. Smith JA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, United States of America. Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Starr JM; Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom.; Alzheimer Scotland Dementia Research Centre, The University of Edinburgh, Edinburgh, United Kingdom. Strauch K; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU, Munich, Germany. Stringham HM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America. Tan NYQ; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore. Tang H; Department of Genetics, Stanford University, Stanford, California, United States of America. Taylor KD; Genomic Outcomes, Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, United States of America. Teo YY; Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore.; Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore.; Life Sciences Institute, National University of Singapore, Singapore, Singapore.; NUS Graduate School for Integrative Science and Engineering, National University of Singapore, Singapore, Singapore.; Department of Statistics and Applied Probability, National University of Singapore, Singapore, Singapore. Tham YC; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore. Turner ST; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, United States of America. Uitterlinden AG; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands. Vollenweider P; Service of Internal Medicine, Department of Internal Medicine, University Hospital, Lausanne, Switzerland. Waldenberger M; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. Wang L; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America. Wang YX; Beijing Institute of Ophthalmology, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Capital Medical University, Beijing, China.; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China. Wei WB; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China. Williams C; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America. Yao J; Genomic Outcomes, Pediatrics, Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California, United States of America. Yu C; Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Yuan JM; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.; Division of Cancer Control and Population Sciences, UPMC Hillman Cancer, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America. Zhao W; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America. Zonderman AB; Behavioral Epidemiology Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America. Becker DM; Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America. Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America. Bowden DW; Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America. Chambers JC; Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom.; Department of Cardiology, Ealing Hospital, Middlesex, United Kingdom.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; Imperial College Healthcare NHS Trust, London, United Kingdom.; MRC-PHE Centre for Environment and Health, Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London, United Kingdom. Deary IJ; Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom.; Psychology, The University of Edinburgh, Edinburgh, United Kingdom. Esko T; Estonian Genome Center, University of Tartu, Tartu, Estonia.; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Boston, Massachusetts, United States of America. Farrall M; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, Oxfordshire, United Kingdom.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, Oxfordshire, United Kingdom. Franks PW; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden.; Harvard T. H. Chan School of Public Health, Department of Nutrition, Harvard University, Boston, Massachusetts, United States of America. Freedman BI; Nephrology, Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America. Froguel P; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France.; Department of Genomics of Common Disease, Imperial College London, London, United Kingdom. Gasparini P; Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', Trieste, Italy.; Department of Medical Sciences, University of Trieste, Trieste, Italy. Gieger C; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany. Jonas JB; Beijing Institute of Ophthalmology, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Capital Medical University, Beijing, China.; Department of Ophthalmology, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany, Germany. Kamatani Y; Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan. Kato N; Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan. Kooner JS; Department of Cardiology, Ealing Hospital, Middlesex, United Kingdom.; National Heart and Lung Institute, Imperial College London, London, United Kingdom.; Imperial College Healthcare NHS Trust, London, United Kingdom.; MRC-PHE Centre for Environment and Health, Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London, United Kingdom. Kutalik Z; Swiss Instititute of Bioinformatics, Lausanne, Switzerland.; Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland. Laakso M; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland. Laurie CC; Department of Biostatistics, University of Washington, Seattle, Washington, United States of America. Leander K; Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland. Study LC; Lifelines Cohort, Groningen, The Netherlands. Magnusson PKE; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Stockholm, Sweden. Oldehinkel AJ; Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Penninx BWJH; Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, The Netherlands. Polasek O; Department of Public Health, Department of Medicine, University of Split, Split, Croatia.; Psychiatric Hospital 'Sveti Ivan', Zagreb, Croatia.; Gen-info Ltd, Zagreb, Croatia. Porteous DJ; Centre for Genomic & Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom. Rauramaa R; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland. Samani NJ; Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, United Kingdom. Scott J; National Heart and Lung Institute, Imperial College London, London, United Kingdom. Shu XO; Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America. van der Harst P; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Wagenknecht LE; Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America. Wareham NJ; MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom. Watkins H; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, Oxfordshire, United Kingdom.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, Oxfordshire, United Kingdom. Weir DR; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, United States of America. Wickremasinghe AR; Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka. Wu T; Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Zheng W; Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America. Bouchard C; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America. Christensen K; The Danish Aging Research Center, Institute of Public Health, University of Southern Denmark, Odense, Denmark. Evans MK; Health Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America. 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Caulfield MJ; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.; NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, London, United Kingdom. Munroe PB; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.; NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, London, United Kingdom. Rao DC; Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America. Province MA; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America. 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Nature [Nature] 2011 Sep 11; Vol. 478 (7367), pp. 103-9. Date of Electronic Publication: 2011 Sep 11.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
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