Temat: "Long terminal repeat" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Bioinformatics Insights on Viral Gene Expression Transactivation: From HIV-1 to SARS-CoV-2.
Autorzy:: Patarca R; ACCESS Health International, 384 West Lane, Ridgefield, CT 06877, USA.; Feinstein Institutes for Medical Research, 350 Community Dr, Manhasset, NY 11030, USA.
Haseltine WA; ACCESS Health International, 384 West Lane, Ridgefield, CT 06877, USA.; Feinstein Institutes for Medical Research, 350 Community Dr, Manhasset, NY 11030, USA.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2024 Mar 16; Vol. 25 (6). Date of Electronic Publication: 2024 Mar 16.
Typ publikacji:: Journal Article
MeSH Terms:: HIV-1*/physiology
COVID-19*/genetics
Humans ; SARS-CoV-2/genetics ; SARS-CoV-2/metabolism ; Transcriptional Activation ; HIV Long Terminal Repeat ; Gene Products, tat/genetics ; Lentivirus/genetics ; Gene Expression ; tat Gene Products, Human Immunodeficiency Virus/genetics ; tat Gene Products, Human Immunodeficiency Virus/metabolism ; RNA, Viral/metabolism

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Skocz do pozycji: 2.

Tytuł:: Preclinical toxicity analyses of lentiviral vectors expressing the HIV-1 LTR-specific designer-recombinase Brec1.
Autorzy:: Beschorner N; Leibniz-Institute of Virology (LIV), Hamburg, Germany.; German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Germany.; PROVIREX Genome Editing Therapies GmbH, Hamburg, Germany.
Künzle P; Leibniz-Institute of Virology (LIV), Hamburg, Germany.; German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Germany.
Voges M; Leibniz-Institute of Virology (LIV), Hamburg, Germany.; PROVIREX Genome Editing Therapies GmbH, Hamburg, Germany.
Hauber I; Leibniz-Institute of Virology (LIV), Hamburg, Germany.; PROVIREX Genome Editing Therapies GmbH, Hamburg, Germany.
Indenbirken D; Leibniz-Institute of Virology (LIV), Hamburg, Germany.; German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Germany.
Nakel J; Leibniz-Institute of Virology (LIV), Hamburg, Germany.; German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Germany.
Virdi S; Leibniz-Institute of Virology (LIV), Hamburg, Germany.; German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Germany.
Bradtke P; Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Lory NC; Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Rothe M; Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany.
Paszkowski-Rogacz M; Medical Systems Biology, UCC, Medical Faculty Carl Gustav Carus, TU Dresden, Dresden, Germany.
Buchholz F; PROVIREX Genome Editing Therapies GmbH, Hamburg, Germany.; Medical Systems Biology, UCC, Medical Faculty Carl Gustav Carus, TU Dresden, Dresden, Germany.
Grundhoff A; Leibniz-Institute of Virology (LIV), Hamburg, Germany.; German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Germany.
Schambach A; Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany.
Thirion C; SIRION Biotech GmbH, Gräfelfing, Germany.
Mittrücker HW; Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Schulze Zur Wiesch J; German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Germany.; Infectious Diseases Unit, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Hauber J; Leibniz-Institute of Virology (LIV), Hamburg, Germany.; German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Germany.; PROVIREX Genome Editing Therapies GmbH, Hamburg, Germany.
Chemnitz J; Leibniz-Institute of Virology (LIV), Hamburg, Germany.; German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Germany.; PROVIREX Genome Editing Therapies GmbH, Hamburg, Germany.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2024 Mar 08; Vol. 19 (3), pp. e0298542. Date of Electronic Publication: 2024 Mar 08 (Print Publication: 2024).
Typ publikacji:: Journal Article
MeSH Terms:: HIV-1*/physiology
HIV Infections*/therapy
Humans ; Lentivirus/genetics ; Lentivirus/metabolism ; Recombinases/metabolism ; Proviruses/genetics ; HIV Long Terminal Repeat/genetics ; Genetic Vectors/genetics

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Skocz do pozycji: 3.

Tytuł:: Design, Synthesis, and Evaluation of Neomycin-Imidazole Conjugates for RNA Cleavage.
Autorzy:: Martin C; Université Côte d'Azur, CNRS, Institute of Chemistry of Nice (ICN), 06108, Nice Cedex 2, France.
Bonnet M; Université Côte d'Azur, CNRS, Institute of Chemistry of Nice (ICN), 06108, Nice Cedex 2, France.
Patino N; Université Côte d'Azur, CNRS, Institute of Chemistry of Nice (ICN), 06108, Nice Cedex 2, France.
Azoulay S; Université Côte d'Azur, CNRS, Institute of Chemistry of Nice (ICN), 06108, Nice Cedex 2, France.
Di Giorgio A; Université Côte d'Azur, CNRS, Institute of Chemistry of Nice (ICN), 06108, Nice Cedex 2, France.
Duca M; Université Côte d'Azur, CNRS, Institute of Chemistry of Nice (ICN), 06108, Nice Cedex 2, France.; Pokaż więcej
Źródło:: ChemPlusChem [Chempluschem] 2022 Nov; Vol. 87 (11), pp. e202200250. Date of Electronic Publication: 2022 Sep 23.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Neomycin*/pharmacology
Neomycin*/chemistry
Neomycin*/metabolism
HIV Long Terminal Repeat*
RNA Cleavage ; Molecular Docking Simulation ; RNA, Viral/chemistry ; RNA, Viral/metabolism ; Imidazoles

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Skocz do pozycji: 4.

Tytuł:: Targeting Tat-TAR RNA Interaction for HIV-1 Inhibition.
Autorzy:: Alanazi A; Department of Microbiology, College of Medicine, Howard University, Washington, DC 20059, USA.
Ivanov A; Center for Sickle Cell Disease, College of Medicine, Howard University, Washington, DC 20059, USA.
Kumari N; Department of Microbiology, College of Medicine, Howard University, Washington, DC 20059, USA.
Lin X; Center for Sickle Cell Disease, College of Medicine, Howard University, Washington, DC 20059, USA.; Department of Oral and Maxillofacial Pathology, College of Dentistry, Howard University, Washington, DC 20059, USA.
Wang S; Department of Microbiology, College of Medicine, Howard University, Washington, DC 20059, USA.
Kovalskyy D; Department of Biochemistry, University of Texas Health Science Center, San Antonio, TX 78229, USA.
Nekhai S; Department of Microbiology, College of Medicine, Howard University, Washington, DC 20059, USA.; Center for Sickle Cell Disease, College of Medicine, Howard University, Washington, DC 20059, USA.; Department of Medicine, College of Medicine, Howard University, Washington, DC 20059, USA.; Pokaż więcej
Źródło:: Viruses [Viruses] 2021 Oct 06; Vol. 13 (10). Date of Electronic Publication: 2021 Oct 06.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: HIV Infections/*prevention & control
HIV Long Terminal Repeat/*genetics
tat Gene Products, Human Immunodeficiency Virus/*genetics
Cyclin T/metabolism ; Cyclin-Dependent Kinase 9/metabolism ; Gene Expression/genetics ; Gene Expression Regulation, Viral/genetics ; HEK293 Cells ; HIV Infections/genetics ; HIV Long Terminal Repeat/drug effects ; HIV Long Terminal Repeat/physiology ; HIV-1/genetics ; HIV-1/metabolism ; HIV-1/pathogenicity ; Humans ; Leukocytes, Mononuclear/metabolism ; Molecular Docking Simulation ; Phosphorylation ; Protein Binding/drug effects ; RNA, Viral/genetics ; Small Molecule Libraries/pharmacology ; Virus Replication/drug effects ; tat Gene Products, Human Immunodeficiency Virus/drug effects ; tat Gene Products, Human Immunodeficiency Virus/metabolism

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Skocz do pozycji: 5.

Tytuł:: An emerging and variant viral promoter of HIV-1 subtype C exhibits low-level gene expression noise.
Autorzy:: Ali H; Molecular Biology and Genetics Unit, HIV AIDS Laboratory, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore, 560064, India.
Bhange D; Molecular Biology and Genetics Unit, HIV AIDS Laboratory, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore, 560064, India.
Mehta K; Molecular Biology and Genetics Unit, HIV AIDS Laboratory, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore, 560064, India.
Gohil Y; Molecular Biology and Genetics Unit, HIV AIDS Laboratory, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore, 560064, India.
Prajapati HK; Molecular Biology and Genetics Unit, HIV AIDS Laboratory, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore, 560064, India.
Byrareddy SN; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA.
Buch S; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA.
Ranga U; Molecular Biology and Genetics Unit, HIV AIDS Laboratory, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore, 560064, India. .; Pokaż więcej
Źródło:: Retrovirology [Retrovirology] 2021 Sep 19; Vol. 18 (1), pp. 27. Date of Electronic Publication: 2021 Sep 19.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: HIV Long Terminal Repeat*
Promoter Regions, Genetic*
HIV-1/*genetics
Binding Sites ; Gene Expression Regulation, Viral ; Genes, Reporter ; Genetic Variation ; HIV Infections/virology ; HIV-1/classification ; HIV-1/isolation & purification ; HIV-1/physiology ; Humans ; NF-kappa B ; Transcription, Genetic ; Virus Replication ; rev Gene Products, Human Immunodeficiency Virus/genetics ; rev Gene Products, Human Immunodeficiency Virus/metabolism ; tat Gene Products, Human Immunodeficiency Virus/genetics ; tat Gene Products, Human Immunodeficiency Virus/metabolism

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Skocz do pozycji: 6.

Tytuł:: Genetic variation of the HIV-1 subtype C transmitted/founder viruses long terminal repeat elements and the impact on transcription activation potential and clinical disease outcomes.
Autorzy:: Madlala P; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.
Mkhize Z; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
Naicker S; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
Khathi SP; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
Maikoo S; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
Gopee K; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
Dong KL; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, Massachusetts, United States of America.; Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America.; Harvard Medical School, Boston, Massachusetts, United States of America.
Ndung'u T; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, Massachusetts, United States of America.; Africa Health Research Institute (AHRI), Durban, South Africa.; Division of Infection and Immunity, University College London, London, United Kingdom.; Pokaż więcej
Źródło:: PLoS pathogens [PLoS Pathog] 2023 Jun 12; Vol. 19 (6), pp. e1011194. Date of Electronic Publication: 2023 Jun 12 (Print Publication: 2023).
Typ publikacji:: Journal Article
MeSH Terms:: HIV-1*/physiology
HIV Infections*/genetics
Humans ; Transcriptional Activation ; Transcription, Genetic ; tat Gene Products, Human Immunodeficiency Virus/genetics ; Tumor Necrosis Factor-alpha/metabolism ; HIV Long Terminal Repeat/genetics ; Genetic Variation ; Gene Expression Regulation, Viral

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Skocz do pozycji: 7.

Tytuł:: DNA topoisomerase 1 represses HIV-1 promoter activity through its interaction with a guanine quadruplex present in the LTR sequence.
Autorzy:: Lista MJ; Université Paris Cité, Institut Cochin, INSERM, CNRS, F-75014, Paris, France.; Department of Infectious Diseases, School of Immunology and Microbial Sciences, King's College London, London, UK.
Jousset AC; Université Paris Cité, Institut Cochin, INSERM, CNRS, F-75014, Paris, France.; Université de Strasbourg, CNRS UPR 9002, Architecture et réactivité de l'ARN, 67000, Strasbourg, France.
Cheng M; CNRS UMR 5320, INSERM U1212, ARNA, Univ. Bordeaux, IECB, 33000, Bordeaux, France.; School of Engineering, China Pharmaceutical University, Nanjing, 211198, China.
Saint-André V; Institut Pasteur, Bioinformatics and Biostatistics Hub, Université Paris Cité, 75015, Paris, France.
Perrot E; Institut Pasteur, Departement of Virology, Université Paris Cité, 75015, Paris, France.
Rodrigues M; Institut Pasteur, Departement of Virology, Université Paris Cité, 75015, Paris, France.
Di Primo C; CNRS UMR 5320, INSERM U1212, ARNA, Univ. Bordeaux, IECB, 33000, Bordeaux, France.
Gadelle D; Institut de Biologie Integrative de la Cellule, CNRS, Université Paris-Saclay, 91198, Gif Sur Yvette, Cedex, France.
Toccafondi E; Université Paris Cité, Institut Cochin, INSERM, CNRS, F-75014, Paris, France.; Université de Strasbourg, CNRS UPR 9002, Architecture et réactivité de l'ARN, 67000, Strasbourg, France.
Segeral E; Université Paris Cité, Institut Cochin, INSERM, CNRS, F-75014, Paris, France.
Berlioz-Torrent C; Université Paris Cité, Institut Cochin, INSERM, CNRS, F-75014, Paris, France.
Emiliani S; Université Paris Cité, Institut Cochin, INSERM, CNRS, F-75014, Paris, France.
Mergny JL; CNRS UMR 5320, INSERM U1212, ARNA, Univ. Bordeaux, IECB, 33000, Bordeaux, France.; Laboratoire d'Optique et Biosciences, Ecole Polytechnique, CNRS, INSERM, Institut Polytechnique de Paris, 91120, Palaiseau, France.
Lavigne M; Université Paris Cité, Institut Cochin, INSERM, CNRS, F-75014, Paris, France. .; Institut Pasteur, Departement of Virology, Université Paris Cité, 75015, Paris, France. .; Pokaż więcej
Źródło:: Retrovirology [Retrovirology] 2023 May 30; Vol. 20 (1), pp. 10. Date of Electronic Publication: 2023 May 30.
Typ publikacji:: Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:: HIV-1*/genetics
Humans ; Guanine ; Transcription Factors/genetics ; Chromatin ; HIV Long Terminal Repeat/genetics ; Transcription, Genetic

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Skocz do pozycji: 8.

Tytuł:: Bis-3-Chloropiperidines Targeting TAR RNA as A Novel Strategy to Impair the HIV-1 Nucleocapsid Protein.
Autorzy:: Sosic A; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Francesco Marzolo 5, 35131 Padova, Italy.
Olivato G; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Francesco Marzolo 5, 35131 Padova, Italy.
Carraro C; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Francesco Marzolo 5, 35131 Padova, Italy.
Göttlich R; Institute of Organic Chemistry, Justus Liebig University Giessen, Heinrich-Buff-Ring 17, 35392 Giessen, Germany.
Fabris D; Departments of Chemistry and Biological Sciences, University at Albany-SUNY, 1400 Washington Avenue, Albany, NY 12222, USA.
Gatto B; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Francesco Marzolo 5, 35131 Padova, Italy.; Pokaż więcej
Źródło:: Molecules (Basel, Switzerland) [Molecules] 2021 Mar 26; Vol. 26 (7). Date of Electronic Publication: 2021 Mar 26.
Typ publikacji:: Journal Article
MeSH Terms:: HIV Long Terminal Repeat*
Gene Expression/*drug effects
HIV-1/*genetics
Nucleocapsid Proteins/*metabolism
Piperidines/*pharmacology
RNA, Viral/*metabolism
Binding Sites ; Nucleic Acid Conformation

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Skocz do pozycji: 9.

Tytuł:: Loss of In Vivo Replication Fitness of HIV-1 Variants Resistant to the Tat Inhibitor, dCA.
Autorzy:: Ling L; International Center for the Advancement of Translational Science, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Leda AR; Department of Immunology and Microbiology, University of Florida Scripps Biomedical Research, Jupiter, FL 33458, USA.
Begum N; International Center for the Advancement of Translational Science, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Spagnuolo RA; International Center for the Advancement of Translational Science, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Wahl A; International Center for the Advancement of Translational Science, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Garcia JV; International Center for the Advancement of Translational Science, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Valente ST; Department of Immunology and Microbiology, University of Florida Scripps Biomedical Research, Jupiter, FL 33458, USA.; Pokaż więcej
Źródło:: Viruses [Viruses] 2023 Apr 12; Vol. 15 (4). Date of Electronic Publication: 2023 Apr 12.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: HIV Infections*/drug therapy
HIV-1*/physiology
HIV Seropositivity*
Mice ; Animals ; tat Gene Products, Human Immunodeficiency Virus/genetics ; tat Gene Products, Human Immunodeficiency Virus/metabolism ; Virus Replication ; HIV Long Terminal Repeat

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Skocz do pozycji: 10.

Tytuł:: HIV-1 Tat amino acid residues that influence Tat-TAR binding affinity: a scoping review.
Autorzy:: Gotora PT; Human Metabolomics, North-West University, Potchefstroom, South Africa.
van der Sluis R; Human Metabolomics, North-West University, Potchefstroom, South Africa.
Williams ME; Human Metabolomics, North-West University, Potchefstroom, South Africa. .; Pokaż więcej
Źródło:: BMC infectious diseases [BMC Infect Dis] 2023 Mar 17; Vol. 23 (1), pp. 164. Date of Electronic Publication: 2023 Mar 17.
Typ publikacji:: Review; Journal Article
MeSH Terms:: HIV-1*/genetics
Humans ; tat Gene Products, Human Immunodeficiency Virus/genetics ; tat Gene Products, Human Immunodeficiency Virus/metabolism ; HIV Long Terminal Repeat ; Amino Acids/genetics ; Amino Acids/metabolism ; RNA, Viral/metabolism

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Skocz do pozycji: 11.

Tytuł:: Analysis and Molecular Determinants of HIV RNase H Cleavage Specificity at the PPT/U3 Junction.
Autorzy:: Álvarez M; Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas & Universidad Autónoma de Madrid), Campus de Cantoblanco-UAM, 28049 Madrid, Spain.
Sapena-Ventura E; Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas & Universidad Autónoma de Madrid), Campus de Cantoblanco-UAM, 28049 Madrid, Spain.
Luczkowiak J; Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas & Universidad Autónoma de Madrid), Campus de Cantoblanco-UAM, 28049 Madrid, Spain.
Martín-Alonso S; Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas & Universidad Autónoma de Madrid), Campus de Cantoblanco-UAM, 28049 Madrid, Spain.
Menéndez-Arias L; Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas & Universidad Autónoma de Madrid), Campus de Cantoblanco-UAM, 28049 Madrid, Spain.; Pokaż więcej
Źródło:: Viruses [Viruses] 2021 Jan 18; Vol. 13 (1). Date of Electronic Publication: 2021 Jan 18.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Genome, Viral*
HIV Long Terminal Repeat*
RNA, Viral*/chemistry
HIV Infections/*virology
HIV-1/*physiology
Ribonuclease H, Human Immunodeficiency Virus/*metabolism
Base Sequence ; HIV Infections/drug therapy ; HIV-1/drug effects ; Humans ; Models, Molecular ; Molecular Conformation ; Mutagenesis ; Protein Binding ; Proteolysis ; Reverse Transcriptase Inhibitors/pharmacology ; Reverse Transcriptase Inhibitors/therapeutic use ; Ribonuclease H, Human Immunodeficiency Virus/chemistry

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Skocz do pozycji: 12.

Tytuł:: Y44A Mutation in the Acidic Domain of HIV-2 Tat Impairs Viral Reverse Transcription and LTR-Transactivation.
Autorzy:: Szojka Z; Laboratory of Retroviral Biochemistry, Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.; Doctoral School of Molecular Cell and Immune Biology, University of Debrecen, 4032 Debrecen, Hungary.
Mótyán JA; Laboratory of Retroviral Biochemistry, Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Miczi M; Laboratory of Retroviral Biochemistry, Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.; Doctoral School of Molecular Cell and Immune Biology, University of Debrecen, 4032 Debrecen, Hungary.
Mahdi M; Laboratory of Retroviral Biochemistry, Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Tőzsér J; Laboratory of Retroviral Biochemistry, Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2020 Aug 17; Vol. 21 (16). Date of Electronic Publication: 2020 Aug 17.
Typ publikacji:: Journal Article
MeSH Terms:: HIV Long Terminal Repeat*
Mutation, Missense*
Reverse Transcription*
HIV-2/*genetics
tat Gene Products, Human Immunodeficiency Virus/*metabolism
HIV-2/physiology ; Protein Domains ; Virus Replication ; tat Gene Products, Human Immunodeficiency Virus/chemistry ; tat Gene Products, Human Immunodeficiency Virus/genetics

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Skocz do pozycji: 13.

Tytuł:: Inhibition of the TRIM24 bromodomain reactivates latent HIV-1.
Autorzy:: Horvath RM; Department of Biochemistry and Molecular Biology, Molecular Epigenetics Group, LSI, University of British Columbia, UBC, 2350 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada.
Brumme ZL; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada.; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada.
Sadowski I; Department of Biochemistry and Molecular Biology, Molecular Epigenetics Group, LSI, University of British Columbia, UBC, 2350 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2023 Jan 11; Vol. 13 (1), pp. 556. Date of Electronic Publication: 2023 Jan 11.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: HIV Infections*/metabolism
HIV-1*/pathogenicity
Tripartite Motif Proteins*/antagonists & inhibitors
Tripartite Motif Proteins*/metabolism
Virus Latency*/genetics
Humans ; CD4-Positive T-Lymphocytes ; HIV Long Terminal Repeat ; HIV Seropositivity ; Proviruses/genetics ; Virus Activation

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Skocz do pozycji: 14.

Tytuł:: Nucleolar protein NOP2/NSUN1 suppresses HIV-1 transcription and promotes viral latency by competing with Tat for TAR binding and methylation.
Autorzy:: Kong W; Department of Pathology, Ohio State University College of Medicine, Columbus, Ohio, United States of America.; Gladstone Institute of Virology and Immunology, University of California, San Francisco, California, United States of America.
Biswas A; Department of Pathology, Ohio State University College of Medicine, Columbus, Ohio, United States of America.
Zhou D; Department of Pathology, Ohio State University College of Medicine, Columbus, Ohio, United States of America.
Fiches G; Department of Pathology, Ohio State University College of Medicine, Columbus, Ohio, United States of America.
Fujinaga K; Department of Medicine, University of California San Francisco, San Francisco, California, United States of America.
Santoso N; Department of Pathology, Ohio State University College of Medicine, Columbus, Ohio, United States of America.
Zhu J; Department of Pathology, Ohio State University College of Medicine, Columbus, Ohio, United States of America.; Pokaż więcej
Źródło:: PLoS pathogens [PLoS Pathog] 2020 Mar 16; Vol. 16 (3), pp. e1008430. Date of Electronic Publication: 2020 Mar 16 (Print Publication: 2020).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: DNA Methylation*
HIV Long Terminal Repeat*
Transcription, Genetic*
DNA, Viral/*metabolism
HIV-1/*physiology
Nuclear Proteins/*metabolism
RNA, Viral/*metabolism
Virus Latency/*physiology
tRNA Methyltransferases/*metabolism
tat Gene Products, Human Immunodeficiency Virus/*metabolism
Humans ; Jurkat Cells

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Skocz do pozycji: 15.

Tytuł:: Nuclear Transit and HIV LTR Binding of NF-κB Subunits Held by IκB Proteins: Implications for HIV-1 Activation.
Autorzy:: Khan SZ; Department of Pediatrics, Child Health Research Center, and the Pendleton Pediatric Infectious Disease Laboratory, University of Virginia, Charlottesville, VA 22908, USA.
Gasperino S; Department of Pediatrics, Child Health Research Center, and the Pendleton Pediatric Infectious Disease Laboratory, University of Virginia, Charlottesville, VA 22908, USA.
Zeichner SL; Department of Pediatrics, Child Health Research Center, and the Pendleton Pediatric Infectious Disease Laboratory, University of Virginia, Charlottesville, VA 22908, USA.; Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA 22908, USA.; Pokaż więcej
Źródło:: Viruses [Viruses] 2019 Dec 16; Vol. 11 (12). Date of Electronic Publication: 2019 Dec 16.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: HIV Long Terminal Repeat*
Host-Pathogen Interactions*
HIV Infections/*metabolism
HIV Infections/*virology
HIV-1/*physiology
NF-kappa B/*metabolism
Protein Subunits/*metabolism
Cell Nucleus/metabolism ; Gene Expression Regulation, Viral ; Humans ; NF-kappa B/chemistry ; Protein Binding ; Protein Transport ; RNA, Small Interfering/genetics ; Transcription, Genetic ; Virus Activation

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Skocz do pozycji: 16.

Tytuł:: Longitudinal variation in human immunodeficiency virus long terminal repeat methylation in individuals on suppressive antiretroviral therapy.
Autorzy:: Cortés-Rubio CN; Centre for Research in Infectious Diseases, National Institute of Respiratory Diseases, Tlalpan 4502, 14080, Mexico City, Mexico.
Salgado-Montes de Oca G; Centre for Research in Infectious Diseases, National Institute of Respiratory Diseases, Tlalpan 4502, 14080, Mexico City, Mexico.
Prado-Galbarro FJ; National Institute of Public Health, Mexico City, Mexico.
Matías-Florentino M; Centre for Research in Infectious Diseases, National Institute of Respiratory Diseases, Tlalpan 4502, 14080, Mexico City, Mexico.
Murakami-Ogasawara A; Centre for Research in Infectious Diseases, National Institute of Respiratory Diseases, Tlalpan 4502, 14080, Mexico City, Mexico.
Kuri-Cervantes L; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Carranco-Arenas AP; Centre for Research in Infectious Diseases, National Institute of Respiratory Diseases, Tlalpan 4502, 14080, Mexico City, Mexico.
Ormsby CE; Centre for Research in Infectious Diseases, National Institute of Respiratory Diseases, Tlalpan 4502, 14080, Mexico City, Mexico.
Cortés-Rubio IK; Adolfo López Mateos Hospital, ISSSTE, Mexico City, Mexico.
Reyes-Terán G; Centre for Research in Infectious Diseases, National Institute of Respiratory Diseases, Tlalpan 4502, 14080, Mexico City, Mexico.
Ávila-Ríos S; Centre for Research in Infectious Diseases, National Institute of Respiratory Diseases, Tlalpan 4502, 14080, Mexico City, Mexico. .; Pokaż więcej
Źródło:: Clinical epigenetics [Clin Epigenetics] 2019 Sep 13; Vol. 11 (1), pp. 134. Date of Electronic Publication: 2019 Sep 13.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: DNA Methylation*
HIV Long Terminal Repeat*
HIV Infections/*drug therapy
HIV-1/*physiology
Adult ; Age Factors ; Antiretroviral Therapy, Highly Active ; CD4-Positive T-Lymphocytes/virology ; Cross-Sectional Studies ; Female ; HIV Infections/virology ; HIV-1/genetics ; High-Throughput Nucleotide Sequencing ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Principal Component Analysis ; Proviruses/genetics ; Proviruses/physiology ; Sequence Analysis, RNA ; Virus Latency

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Skocz do pozycji: 17.

Tytuł:: Multifaceted Aspects of HIV-1 Nucleocapsid Inhibition by TAR-Targeting Peptidyl-Anthraquinones Bearing Terminal Aromatic Moieties.
Autorzy:: Sosic A; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Francesco Marzolo 5, 35131 Padova, Italy.
Frecentese F; Dipartimento di Farmacia, Università di Napoli 'Federico II', Via D. Montesano 49, 80131 Napoli, Italy.
Olivato G; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Francesco Marzolo 5, 35131 Padova, Italy.
Rollo D; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Francesco Marzolo 5, 35131 Padova, Italy.
Carraro C; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Francesco Marzolo 5, 35131 Padova, Italy.
Gamba E; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Francesco Marzolo 5, 35131 Padova, Italy.
Santagada V; Dipartimento di Farmacia, Università di Napoli 'Federico II', Via D. Montesano 49, 80131 Napoli, Italy.
Gatto B; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Francesco Marzolo 5, 35131 Padova, Italy.; Pokaż więcej
Źródło:: Viruses [Viruses] 2022 Sep 27; Vol. 14 (10). Date of Electronic Publication: 2022 Sep 27.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: HIV-1*/genetics
Nucleic Acids*/metabolism
Anthraquinones/chemistry ; Anthraquinones/metabolism ; Anthraquinones/pharmacology ; Nucleocapsid/metabolism ; Nucleocapsid Proteins/genetics ; RNA/metabolism ; Amino Acids/genetics ; Tyrosine/metabolism ; HIV Long Terminal Repeat ; Nucleic Acid Conformation ; RNA, Viral/genetics

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Skocz do pozycji: 18.

Tytuł:: HIV 2-LTR experiment design optimization.
Autorzy:: Cannon L; Department of Biomedical Engineering, University of Delaware, Newark, DE, United States of America.; Department of Pathology & Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.
Vargas-Garcia CA; Department of Electrical and Computer Engineering, University of Delaware, Newark, DE, United States of America.; Fundación Universitaria Konrad Lorenz, Bogota, Colombia.
Jagarapu A; Department of Biomedical Engineering, University of Delaware, Newark, DE, United States of America.
Piovoso MJ; Department of Electrical and Computer Engineering, University of Delaware, Newark, DE, United States of America.
Zurakowski R; Department of Biomedical Engineering, University of Delaware, Newark, DE, United States of America.; Department of Electrical and Computer Engineering, University of Delaware, Newark, DE, United States of America.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2018 Nov 08; Vol. 13 (11), pp. e0206700. Date of Electronic Publication: 2018 Nov 08 (Print Publication: 2018).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: HIV/*drug effects
HIV/*genetics
HIV Long Terminal Repeat/*drug effects
HIV Long Terminal Repeat/*genetics
Algorithms ; Bayes Theorem ; Clinical Trials as Topic/methods ; Clinical Trials as Topic/statistics & numerical data ; Computer Simulation ; HIV/physiology ; HIV Infections/therapy ; HIV Infections/virology ; HIV Long Terminal Repeat/physiology ; Humans ; Immunotherapy, Adoptive ; Markov Chains ; Models, Biological ; Models, Statistical ; Monte Carlo Method ; RNA, Viral/biosynthesis ; RNA, Viral/genetics ; Research Design ; Virus Replication/drug effects ; Virus Replication/genetics

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Skocz do pozycji: 19.

Tytuł:: HIV UTR, LTR, and Epigenetic Immunity.
Autorzy:: Zhang J; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Crumpacker C; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.; Pokaż więcej
Źródło:: Viruses [Viruses] 2022 May 18; Vol. 14 (5). Date of Electronic Publication: 2022 May 18.
Typ publikacji:: Journal Article; Review
MeSH Terms:: HIV Infections*
HIV-1*/genetics
Chromatin ; Epigenesis, Genetic ; HIV Long Terminal Repeat/genetics ; Humans

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Skocz do pozycji: 20.

Tytuł:: Tat inhibition by didehydro-Cortistatin A promotes heterochromatin formation at the HIV-1 long terminal repeat.
Autorzy:: Li C; Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL, USA.
Mousseau G; Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL, USA.
Valente ST; Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL, USA. .; Pokaż więcej
Źródło:: Epigenetics & chromatin [Epigenetics Chromatin] 2019 Apr 16; Vol. 12 (1), pp. 23. Date of Electronic Publication: 2019 Apr 16.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: HIV Long Terminal Repeat*
Heterochromatin/*metabolism
tat Gene Products, Human Immunodeficiency Virus/*antagonists & inhibitors
HeLa Cells ; Heterocyclic Compounds, 4 or More Rings/pharmacology ; Humans ; Isoquinolines/pharmacology ; Transcriptional Activation ; tat Gene Products, Human Immunodeficiency Virus/metabolism

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