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    Wyświetlanie 1-20 z 20
    Tytuł:
    An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis.
    Autorzy:
    Zhao P; Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA. .
    Sun X; Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
    Chaggan C; Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
    Liao Z; Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
    In Wong K; Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
    He F; Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
    Singh S; NAFLD Research Center, Division of Gastroenterology, Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
    Loomba R; NAFLD Research Center, Division of Gastroenterology, Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
    Karin M; Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
    Witztum JL; Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
    Saltiel AR; Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA. .; Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
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    Źródło:
    Science (New York, N.Y.) [Science] 2020 Feb 07; Vol. 367 (6478), pp. 652-660.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    AMP-Activated Protein Kinases/*metabolism
    Caspase 6/*metabolism
    Liver/*enzymology
    Liver/*pathology
    Non-alcoholic Fatty Liver Disease/*enzymology
    Non-alcoholic Fatty Liver Disease/*pathology
    AMP-Activated Protein Kinases/genetics ; Animals ; Apoptosis/genetics ; Caspase 3/metabolism ; Caspase 7/metabolism ; Caspase Inhibitors/pharmacology ; Caspase Inhibitors/therapeutic use ; Enzyme Activation ; Hepatocytes/enzymology ; Hepatocytes/pathology ; Humans ; Mice ; Mice, Knockout ; Non-alcoholic Fatty Liver Disease/drug therapy ; Phosphorylation
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Standardising the interpretation of liver biopsies in non-alcoholic fatty liver disease clinical trials.
    Autorzy:
    Pai RK; Scottsdale, AZ, USA.
    Kleiner DE; Bethesda, MD, USA.
    Hart J; Chicago, IL, USA.
    Adeyi OA; Toronto, ON, Canada.
    Clouston AD; Brisbane, Qld, Australia.
    Behling CA; San Diego, CA, USA.
    Jain D; New Haven, CT, USA.
    Kakar S; San Francisco, CA, USA.
    Brahmania M; London, ON, Canada.
    Burgart L; Minneapolis, MN, USA.
    Batts KP; Minneapolis, MN, USA.
    Valasek MA; La Jolla, CA, USA.
    Torbenson MS; Rochester, MN, USA.
    Guindi M; Los Angeles, CA, USA.
    Wang HL; Los Angeles, CA, USA.
    Ajmera V; La Jolla, CA, USA.
    Adams LA; Perth, WA, Australia.
    Parker CE; London, ON, Canada.
    Feagan BG; London, ON, Canada.
    Loomba R; La Jolla, CA, USA.
    Jairath V; London, ON, Canada.
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    Źródło:
    Alimentary pharmacology & therapeutics [Aliment Pharmacol Ther] 2019 Nov; Vol. 50 (10), pp. 1100-1111. Date of Electronic Publication: 2019 Oct 03.
    Typ publikacji:
    Evaluation Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Liver/*pathology
    Non-alcoholic Fatty Liver Disease/*pathology
    Practice Patterns, Physicians'/*standards
    Randomized Controlled Trials as Topic/*standards
    Research Design/*standards
    Biopsy/methods ; Biopsy/standards ; Humans ; Image Interpretation, Computer-Assisted/methods ; Image Interpretation, Computer-Assisted/standards ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/pathology ; Randomized Controlled Trials as Topic/methods ; Reference Standards ; Reproducibility of Results ; Retrospective Studies ; Surveys and Questionnaires
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Relationship between three commonly used non-invasive fibrosis biomarkers and improvement in fibrosis stage in patients with non-alcoholic steatohepatitis.
    Autorzy:
    Chalasani N; Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
    Abdelmalek MF; Department of Medicine, Duke University, Durham, North Carolina.
    Loomba R; Department of Medicine, University of California, San Diego, La Jolla, California.
    Kowdley KV; Organ Transplant Center, Swedish Medical Center, Seattle, Washington.
    McCullough AJ; Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, Ohio.
    Dasarathy S; Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, Ohio.
    Neuschwander-Tetri BA; Department of Internal Medicine, Saint Louis University, Saint Louis, Missouri.
    Terrault N; Departments of Medicine and Surgery, University of California, San Francisco, San Francisco, California.
    Ferguson B; Intercept Pharmaceuticals, Inc, San Diego, California.
    Shringarpure R; Intercept Pharmaceuticals, Inc, San Diego, California.
    Shapiro D; Intercept Pharmaceuticals, Inc, San Diego, California.
    Sanyal AJ; Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia.
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    Źródło:
    Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2019 May; Vol. 39 (5), pp. 924-932. Date of Electronic Publication: 2019 Feb 21.
    Typ publikacji:
    Clinical Trial, Phase II; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Biomarkers/*blood
    Chenodeoxycholic Acid/*analogs & derivatives
    Liver/*pathology
    Liver Cirrhosis/*diagnosis
    Non-alcoholic Fatty Liver Disease/*drug therapy
    Adult ; Biopsy ; Chenodeoxycholic Acid/administration & dosage ; Female ; Humans ; Liver Cirrhosis/blood ; Liver Cirrhosis/etiology ; Logistic Models ; Male ; Middle Aged ; Non-alcoholic Fatty Liver Disease/blood ; Non-alcoholic Fatty Liver Disease/complications ; United States
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    A simple clinical model predicts incident hepatic steatosis in a community-based cohort: The Framingham Heart Study.
    Autorzy:
    Long MT; Section of Gastroenterology, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.; Framingham Heart Study, Framingham, MA, USA.
    Pedley A; Framingham Heart Study, Framingham, MA, USA.; Merck Research Labs, Kenilworth, NJ, USA.
    Massaro JM; Framingham Heart Study, Framingham, MA, USA.; Department of Mathematics and Statistics, Boston University, Boston, MA, USA.
    Hoffmann U; Radiology Department, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
    Ma J; Framingham Heart Study, Framingham, MA, USA.; Population Sciences Branch, National Heart, Lung, and Blood Institute, Framingham, MA, USA.
    Loomba R; NAFLD Research Center, Department of Medicine, University of California at San Diego, La Jolla, CA, USA.; Division of Epidemiology, Department of Family and Preventive Medicine, University of California at San Diego, La Jolla, CA, USA.; Division of Gastroenterology, Department of Medicine, University of California at San Diego, La Jolla, CA, USA.
    Chung RT; Liver Center, Gastrointestinal Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
    Benjamin EJ; Framingham Heart Study, Framingham, MA, USA.; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.; Cardiology and Preventive Medicine Sections, Evans Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
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    Źródło:
    Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2018 Aug; Vol. 38 (8), pp. 1495-1503. Date of Electronic Publication: 2018 Mar 12.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Fatty Liver/*diagnostic imaging
    Fatty Liver/*epidemiology
    Intra-Abdominal Fat/*diagnostic imaging
    Liver/*diagnostic imaging
    Adult ; Body Mass Index ; Boston/epidemiology ; Female ; Humans ; Incidence ; Liver/pathology ; Logistic Models ; Longitudinal Studies ; Male ; Middle Aged ; Multidetector Computed Tomography ; Multivariate Analysis ; Predictive Value of Tests ; ROC Curve ; Risk Factors ; Triglycerides/blood
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Correlation between liver histology and novel magnetic resonance imaging in adult patients with non-alcoholic fatty liver disease - MRI accurately quantifies hepatic steatosis in NAFLD.
    Autorzy:
    Permutt Z; Division of Internal Medicine, Department of Medicine, University of California, San Diego, USA.
    Le TA
    Peterson MR
    Seki E
    Brenner DA
    Sirlin C
    Loomba R
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    Źródło:
    Alimentary pharmacology & therapeutics [Aliment Pharmacol Ther] 2012 Jul; Vol. 36 (1), pp. 22-9. Date of Electronic Publication: 2012 May 03.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Magnetic Resonance Imaging*
    Fatty Liver/*diagnosis
    Liver/*pathology
    Liver Cirrhosis/*pathology
    Adult ; Biopsy ; Cohort Studies ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Non-alcoholic Fatty Liver Disease ; Predictive Value of Tests ; Prospective Studies ; Severity of Illness Index
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Meta-analysis: pioglitazone improves liver histology and fibrosis in patients with non-alcoholic steatohepatitis.
    Autorzy:
    Boettcher E; Division of Gastroenterology, Department of Medicine, University of California at San Diego, La Jolla, CA 92093, USA.
    Csako G
    Pucino F
    Wesley R
    Loomba R
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    Źródło:
    Alimentary pharmacology & therapeutics [Aliment Pharmacol Ther] 2012 Jan; Vol. 35 (1), pp. 66-75. Date of Electronic Publication: 2011 Nov 04.
    Typ publikacji:
    Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Fatty Liver/*drug therapy
    Hypoglycemic Agents/*therapeutic use
    Liver/*drug effects
    Liver Cirrhosis/*drug therapy
    Thiazolidinediones/*therapeutic use
    Fatty Liver/complications ; Humans ; Non-alcoholic Fatty Liver Disease ; Pioglitazone ; Randomized Controlled Trials as Topic
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Clinical trial: pilot study of metformin for the treatment of non-alcoholic steatohepatitis.
    Autorzy:
    Loomba R; Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.
    Lutchman G
    Kleiner DE
    Ricks M
    Feld JJ
    Borg BB
    Modi A
    Nagabhyru P
    Sumner AE
    Liang TJ
    Hoofnagle JH
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    Źródło:
    Alimentary pharmacology & therapeutics [Aliment Pharmacol Ther] 2009 Jan; Vol. 29 (2), pp. 172-82. Date of Electronic Publication: 2008 Oct 09.
    Typ publikacji:
    Clinical Trial; Journal Article; Research Support, N.I.H., Intramural
    MeSH Terms:
    Fatty Liver/*drug therapy
    Hypoglycemic Agents/*therapeutic use
    Liver/*drug effects
    Metformin/*therapeutic use
    Adult ; Biopsy ; Female ; Humans ; Male ; Middle Aged ; Pilot Projects ; Statistics as Topic ; Treatment Outcome
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Assessment of treatment response in non-alcoholic steatohepatitis using advanced magnetic resonance imaging.
    Autorzy:
    Lin, S. C.
    Heba, E.
    Bettencourt, R.
    Lin, G. Y.
    Valasek, M. A.
    Lunde, O.
    Hamilton, G.
    Sirlin, C. B.
    Loomba, R.
    Pokaż więcej
    Temat:
    FATTY liver
    THERAPEUTICS
    LIVER
    BIOMARKERS
    HISTOLOGY
    DIAGNOSIS
    MAGNETIC resonance imaging
    Źródło:
    Alimentary Pharmacology & Therapeutics; 3/15/2017, Vol. 45 Issue 6, p844-854, 11p
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
      Wyświetlanie 1-20 z 20

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