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Tytuł :
Omega-3 long-chain polyunsaturated fatty acids promote antibacterial and inflammation-resolving effects in Mycobacterium tuberculosis -infected C3HeB/FeJ mice, dependent on fatty acid status.
Autorzy :
Nienaber A; Centre of Excellence for Nutrition, North-West University, Potchefstroom, North West, South Africa, 2531.
Ozturk M; International Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town-Component, University of Cape Town, Cape Town, Western Cape, South Africa, 7925.; Institute of Infectious Diseases and Molecular Medicine (IDM), Division of Immunology and South African Medical Research Council (SAMRC) Immunology of Infectious Diseases, University of Cape Town, Cape Town, Western Cape, South Africa, 7925.
Dolman RC; Centre of Excellence for Nutrition, North-West University, Potchefstroom, North West, South Africa, 2531.
Blaauw R; Division of Human Nutrition, Stellenbosch University, Tygerberg, Cape Town, Western Cape, South Africa, 7505.
Zandberg L; Centre of Excellence for Nutrition, North-West University, Potchefstroom, North West, South Africa, 2531.
King S; Centre of Excellence for Nutrition, North-West University, Potchefstroom, North West, South Africa, 2531.
Britz M; Centre of Excellence for Nutrition, North-West University, Potchefstroom, North West, South Africa, 2531.
Hayford FEA; Centre of Excellence for Nutrition, North-West University, Potchefstroom, North West, South Africa, 2531.; Department of Nutrition and Dietetics, University of Ghana, Accra, Ghana.
Brombacher F; International Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town-Component, University of Cape Town, Cape Town, Western Cape, South Africa, 7925.; Institute of Infectious Diseases and Molecular Medicine (IDM), Division of Immunology and South African Medical Research Council (SAMRC) Immunology of Infectious Diseases, University of Cape Town, Cape Town, Western Cape, South Africa, 7925.; Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa), Institute of Infectious Diseases and Molecular Medicine (IDM), University of Cape Town, Cape Town, Western Cape, South Africa, 7925.
Loots DT; Human Metabolomics, Faculty of Natural and Agricultural Sciences, North-West University, Potchefstroom, North West, South Africa, 2531.
Smuts CM; Centre of Excellence for Nutrition, North-West University, Potchefstroom, North West, South Africa, 2531.
Parihar SP; International Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town-Component, University of Cape Town, Cape Town, Western Cape, South Africa, 7925.; Institute of Infectious Diseases and Molecular Medicine (IDM), Division of Immunology and South African Medical Research Council (SAMRC) Immunology of Infectious Diseases, University of Cape Town, Cape Town, Western Cape, South Africa, 7925.; Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa), Institute of Infectious Diseases and Molecular Medicine (IDM), University of Cape Town, Cape Town, Western Cape, South Africa, 7925.; Division of Medical Microbiology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, Western Cape, South Africa, 7925.
Malan L; Centre of Excellence for Nutrition, North-West University, Potchefstroom, North West, South Africa, 2531.
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Źródło :
The British journal of nutrition [Br J Nutr] 2021 Apr 05, pp. 1-35. Date of Electronic Publication: 2021 Apr 05.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Genome Sequence Resource of Pseudomonas fulva HARBPS9.1-Candidate Biocontrol Agent.
Autorzy :
Adeniji AA; Human Metabolomics, Faculty of Natural and Agricultural Science, North-West University, Private Bag X6001, Box 269, Potchefstroom, 2531, South Africa.
Ayangbenro AS; Food Security and Safety Niche Area, Faculty of Natural and Agricultural Science, North-West University, Private Bag X2046, Mmabatho 2735, South Africa.
Loots DT; Human Metabolomics, Faculty of Natural and Agricultural Science, North-West University, Private Bag X6001, Box 269, Potchefstroom, 2531, South Africa.
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Źródło :
Phytopathology [Phytopathology] 2021 Mar 22, pp. PHYTO10200478A. Date of Electronic Publication: 2021 Mar 22.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
M. tuberculosis curli pili (MTP) is associated with alterations in carbon, fatty acid and amino acid metabolism in a THP-1 macrophage infection model.
Autorzy :
Ashokcoomar S; Medical Microbiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, 1st Floor Doris Duke Medical Research Institute, Congella, Private Bag 7, Durban, 4013, South Africa. Electronic address: .
Loots DT; Human Metabolomics, North-West University, Potchefstroom, Private Bag X6001, Box 269, 2531, South Africa. Electronic address: Dutoit.Loots@nwu.ac.za.
Beukes D; Human Metabolomics, North-West University, Potchefstroom, Private Bag X6001, Box 269, 2531, South Africa. Electronic address: .
van Reenen M; Human Metabolomics, North-West University, Potchefstroom, Private Bag X6001, Box 269, 2531, South Africa. Electronic address: .
Pillay B; Microbiology, School of Life Sciences, College of Agriculture, Engineering and Science, University of KwaZulu-Natal, Westville Campus, Private Bag X54001, Durban. 4000, South Africa. Electronic address: .
Pillay M; Medical Microbiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, 1st Floor Doris Duke Medical Research Institute, Congella, Private Bag 7, Durban, 4013, South Africa. Electronic address: .
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Źródło :
Microbial pathogenesis [Microb Pathog] 2021 Feb 18; Vol. 154, pp. 104806. Date of Electronic Publication: 2021 Feb 18.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Metabolic characterization of tuberculous meningitis in a South African paediatric population using H NMR metabolomics.
Autorzy :
van Zyl CW; Human Metabolomics, Faculty of Natural and Agricultural Sciences, North-West University, Potchefstroom 2531, South Africa.
Loots DT; Human Metabolomics, Faculty of Natural and Agricultural Sciences, North-West University, Potchefstroom 2531, South Africa.
Solomons R; Department of Pediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.
van Reenen M; Human Metabolomics, Faculty of Natural and Agricultural Sciences, North-West University, Potchefstroom 2531, South Africa.
Mason S; Human Metabolomics, Faculty of Natural and Agricultural Sciences, North-West University, Potchefstroom 2531, South Africa. Electronic address: .
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Źródło :
The Journal of infection [J Infect] 2020 Nov; Vol. 81 (5), pp. 743-752. Date of Electronic Publication: 2020 Jul 24.
Typ publikacji :
Journal Article
MeSH Terms :
Tuberculosis, Meningeal*/diagnosis
Child ; Cohort Studies ; Humans ; Metabolomics ; Proton Magnetic Resonance Spectroscopy
Czasopismo naukowe
Tytuł :
Mycobacterium tuberculosis curli pili (MTP) is associated with significant host metabolic pathways in an A549 epithelial cell infection model and contributes to the pathogenicity of Mycobacterium tuberculosis.
Autorzy :
Reedoy KS; Medical Microbiology School of Laboratory Medicine and Medical Sciences, College of Health Sciences, Doris Duke Medical Research Institute, University of KwaZulu-Natal, 1st Floor, Congella, Private Bag 7, Durban, 4013, South Africa.
Loots DT; Human Metabolomics, Faculty of Natural and Agricultural Sciences, North-West University, Private Bag x6001, Box 269, Potchefstroom, 2531, South Africa.
Beukes D; Human Metabolomics, Faculty of Natural and Agricultural Sciences, North-West University, Private Bag x6001, Box 269, Potchefstroom, 2531, South Africa.
Reenen MV; Human Metabolomics, Faculty of Natural and Agricultural Sciences, North-West University, Private Bag x6001, Box 269, Potchefstroom, 2531, South Africa.
Pillay B; School of Life Sciences, College of Agriculture, Engineering and Science, University of KwaZulu-Natal, Westville Campus, Private Bag X54001, Durban, 4000, South Africa.
Pillay M; Medical Microbiology School of Laboratory Medicine and Medical Sciences, College of Health Sciences, Doris Duke Medical Research Institute, University of KwaZulu-Natal, 1st Floor, Congella, Private Bag 7, Durban, 4013, South Africa. .
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Źródło :
Metabolomics : Official journal of the Metabolomic Society [Metabolomics] 2020 Oct 21; Vol. 16 (11), pp. 116. Date of Electronic Publication: 2020 Oct 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Czasopismo naukowe
Tytuł :
Mycobacterium tuberculosis curli pili (MTP) deficiency is associated with alterations in cell wall biogenesis, fatty acid metabolism and amino acid synthesis.
Autorzy :
Ashokcoomar S; Discipline of Medical Microbiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, 1st Floor Doris Duke Medical Research Institute, Congella, Private Bag 7, Durban, 4013, South Africa.
Reedoy KS; Discipline of Medical Microbiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, 1st Floor Doris Duke Medical Research Institute, Congella, Private Bag 7, Durban, 4013, South Africa.
Senzani S; Discipline of Medical Microbiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, 1st Floor Doris Duke Medical Research Institute, Congella, Private Bag 7, Durban, 4013, South Africa.
Loots DT; Human Metabolomics, North-West University, Private Bag x6001, Box 269, Potchefstroom, 2531, South Africa.
Beukes D; Human Metabolomics, North-West University, Private Bag x6001, Box 269, Potchefstroom, 2531, South Africa.
van Reenen M; Human Metabolomics, North-West University, Private Bag x6001, Box 269, Potchefstroom, 2531, South Africa.
Pillay B; Discipline of Microbiology, School of Life Sciences, College of Agriculture, Engineering and Science, University of KwaZulu-Natal, Westville Campus, Private Bag X54001, Durban, 4000, South Africa.
Pillay M; Discipline of Medical Microbiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, 1st Floor Doris Duke Medical Research Institute, Congella, Private Bag 7, Durban, 4013, South Africa. .
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Źródło :
Metabolomics : Official journal of the Metabolomic Society [Metabolomics] 2020 Sep 10; Vol. 16 (9), pp. 97. Date of Electronic Publication: 2020 Sep 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Czasopismo naukowe
Tytuł :
The unaided recovery of marathon-induced serum metabolome alterations.
Autorzy :
Stander Z; Human Metabolomics, Faculty of Natural and Agricultural Sciences, North-West University, Potchefstroom, 2531, South Africa.
Luies L; Human Metabolomics, Faculty of Natural and Agricultural Sciences, North-West University, Potchefstroom, 2531, South Africa.
Mienie LJ; Human Metabolomics, Faculty of Natural and Agricultural Sciences, North-West University, Potchefstroom, 2531, South Africa.
Van Reenen M; Human Metabolomics, Faculty of Natural and Agricultural Sciences, North-West University, Potchefstroom, 2531, South Africa.
Howatson G; Department of Sport, Exercise and Rehabilitation, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, NE1 8ST, UK.; Water Research Group, School of Environmental Sciences and Development, North-West University, Potchefstroom, 2531, South Africa.
Keane KM; Department of Sport, Exercise and Rehabilitation, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, NE1 8ST, UK.
Clifford T; Human Nutrition Research Centre, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.; School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.
Stevenson EJ; Human Nutrition Research Centre, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.
Loots DT; Human Metabolomics, Faculty of Natural and Agricultural Sciences, North-West University, Potchefstroom, 2531, South Africa. dutoit.loots@nwu.ac.za.; North-West University, Private Bag X6001, Box 269, Potchefstroom CampusPotchefstroom, 2520, South Africa. dutoit.loots@nwu.ac.za.
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Źródło :
Scientific reports [Sci Rep] 2020 Jul 06; Vol. 10 (1), pp. 11060. Date of Electronic Publication: 2020 Jul 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Athletic Performance/*physiology
Metabolome/*physiology
Physical Endurance/*physiology
Running/*physiology
Adult ; Amino Acids/metabolism ; Carbohydrate Metabolism ; Citric Acid Cycle ; Female ; Gas Chromatography-Mass Spectrometry ; Humans ; Ketones/metabolism ; Lipid Metabolism ; Male ; Metabolomics/methods ; Metabolomics/statistics & numerical data ; Middle Aged ; Multivariate Analysis ; Time Factors
Czasopismo naukowe
Tytuł :
Serum Metabolome Changes in Relation to Prothrombotic State Induced by Combined Oral Contraceptives with Drospirenone and Ethinylestradiol.
Autorzy :
Swanepoel AC; Department of Physiology and Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Bester J; Department of Physiology and Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Emmerson O; Department of Physiology and Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Soma P; Department of Anatomy, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Beukes D; Human Metabolomics, North-West University, Potchefstroom, South Africa.
van Reenen M; Human Metabolomics, North-West University, Potchefstroom, South Africa.
Loots DT; Human Metabolomics, North-West University, Potchefstroom, South Africa.
du Preez I; Human Metabolomics, North-West University, Potchefstroom, South Africa.
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Źródło :
Omics : a journal of integrative biology [OMICS] 2020 Jul; Vol. 24 (7), pp. 404-414. Date of Electronic Publication: 2020 May 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Czasopismo naukowe
Tytuł :
Potential anti-TB investigational compounds and drugs with repurposing potential in TB therapy: a conspectus.
Autorzy :
Adeniji AA; Faculty of Natural and Agricultural Science, North-West University, Human Metabolomics Private Bag X6001, Box 269, Potchefstroom, 2531, South Africa.
Knoll KE; Faculty of Natural and Agricultural Science, North-West University, Human Metabolomics Private Bag X6001, Box 269, Potchefstroom, 2531, South Africa.
Loots DT; Faculty of Natural and Agricultural Science, North-West University, Human Metabolomics Private Bag X6001, Box 269, Potchefstroom, 2531, South Africa. dutoit.loots@nwu.ac.za.
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Źródło :
Applied microbiology and biotechnology [Appl Microbiol Biotechnol] 2020 Jul; Vol. 104 (13), pp. 5633-5662. Date of Electronic Publication: 2020 May 05.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Repositioning*/trends
Antitubercular Agents/*pharmacology
Antitubercular Agents/*therapeutic use
Mycobacterium tuberculosis/*drug effects
Tuberculosis, Multidrug-Resistant/*drug therapy
Adjuvants, Pharmaceutic/chemistry ; Adjuvants, Pharmaceutic/pharmacology ; Adjuvants, Pharmaceutic/therapeutic use ; Animals ; Antitubercular Agents/chemistry ; Drug Evaluation, Preclinical ; Drug Therapy, Combination/trends ; Humans ; Prodrugs/chemistry ; Prodrugs/pharmacology ; Prodrugs/therapeutic use
Czasopismo naukowe
Tytuł :
Overview of Brain-to-Gut Axis Exposed to Chronic CNS Bacterial Infection(s) and a Predictive Urinary Metabolic Profile of a Brain Infected by Mycobacterium tuberculosis .
Autorzy :
Isaiah S; Human Metabolomics, Faculty of Natural and Agricultural Sciences, North-West University, Potchefstroom, South Africa.
Loots DT; Human Metabolomics, Faculty of Natural and Agricultural Sciences, North-West University, Potchefstroom, South Africa.
Solomons R; Department of Pediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.
van der Kuip M; Pediatric Infectious Diseases and Immunology, Amsterdam University Medical Center, Academic Medical Center, Emma Children's Hospital, Amsterdam, Netherlands.
Tutu Van Furth AM; Pediatric Infectious Diseases and Immunology, Amsterdam University Medical Center, Academic Medical Center, Emma Children's Hospital, Amsterdam, Netherlands.
Mason S; Human Metabolomics, Faculty of Natural and Agricultural Sciences, North-West University, Potchefstroom, South Africa.
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Źródło :
Frontiers in neuroscience [Front Neurosci] 2020 Apr 21; Vol. 14, pp. 296. Date of Electronic Publication: 2020 Apr 21 (Print Publication: 2020).
Typ publikacji :
Journal Article; Review
Czasopismo naukowe
Tytuł :
Metabolomics describes previously unknown toxicity mechanisms of isoniazid and rifampicin.
Autorzy :
Combrink M; Human Metabolomics, North-West University (Potchefstroom Campus), Private Bag x6001, Box 269, Potchefstroom, 2531, South Africa.
Loots DT; Human Metabolomics, North-West University (Potchefstroom Campus), Private Bag x6001, Box 269, Potchefstroom, 2531, South Africa.
du Preez I; Human Metabolomics, North-West University (Potchefstroom Campus), Private Bag x6001, Box 269, Potchefstroom, 2531, South Africa. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2020 Apr 01; Vol. 322, pp. 104-110. Date of Electronic Publication: 2020 Jan 22.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antitubercular Agents/*toxicity
Drug-Related Side Effects and Adverse Reactions/*etiology
Isoniazid/*toxicity
Metabolomics/*methods
Rifampin/*toxicity
Toxicity Tests/*methods
Animals ; Antitubercular Agents/metabolism ; Biomarkers/metabolism ; Biotransformation ; Drug-Related Side Effects and Adverse Reactions/diagnosis ; Drug-Related Side Effects and Adverse Reactions/metabolism ; Humans ; Isoniazid/metabolism ; Rifampin/metabolism ; Risk Assessment
Czasopismo naukowe
Tytuł :
Tween 80 induces a carbon flux rerouting in Mycobacterium tuberculosis.
Autorzy :
Pietersen RD; DST-NRF Centre of Excellence for Biomedical Tuberculosis Research, SA MRC Centre for TB Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa. Electronic address: .
du Preez I; Human Metabolomics, North-West University, Potchefstroom, South Africa. Electronic address: .
Loots DT; Human Metabolomics, North-West University, Potchefstroom, South Africa. Electronic address: dutoit.loots@nwu.ac.za.
van Reenen M; Human Metabolomics, North-West University, Potchefstroom, South Africa. Electronic address: .
Beukes D; Human Metabolomics, North-West University, Potchefstroom, South Africa. Electronic address: .
Leisching G; DST-NRF Centre of Excellence for Biomedical Tuberculosis Research, SA MRC Centre for TB Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa. Electronic address: .
Baker B; DST-NRF Centre of Excellence for Biomedical Tuberculosis Research, SA MRC Centre for TB Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa. Electronic address: .
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Źródło :
Journal of microbiological methods [J Microbiol Methods] 2020 Mar; Vol. 170, pp. 105795. Date of Electronic Publication: 2019 Nov 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Czasopismo naukowe
Tytuł :
Metabolomic applications for understanding complex tripartite plant-microbes interactions: Strategies and perspectives.
Autorzy :
Adeniji AA; Faculty of Natural and Agricultural Science, North-West University, Human Metabolomics Private Bag X6001, Box 269, Potchefstroom, 2531, South Africa.
Babalola OO; Faculty of Natural and Agricultural Science, North-West University, Food Security and Safety Private Bag X2046, Mmabatho, 2735, South Africa.
Loots DT; Faculty of Natural and Agricultural Science, North-West University, Human Metabolomics Private Bag X6001, Box 269, Potchefstroom, 2531, South Africa.
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Źródło :
Biotechnology reports (Amsterdam, Netherlands) [Biotechnol Rep (Amst)] 2020 Feb 01; Vol. 25, pp. e00425. Date of Electronic Publication: 2020 Feb 01 (Print Publication: 2020).
Typ publikacji :
Journal Article; Review
Czasopismo naukowe
Tytuł :
Time-Dependent Changes in Urinary Metabolome Before and After Intensive Phase Tuberculosis Therapy: A Pharmacometabolomics Study.
Autorzy :
Combrink M; Human Metabolomics, North-West University, Potchefstroom, South Africa.
du Preez I; Human Metabolomics, North-West University, Potchefstroom, South Africa.
Ronacher K; Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, DST/NRF Centre of Excellence for Biomedical Tuberculosis Research/MRC Centre for Molecular and Cellular Biology, Stellenbosch University, Tygerberg, South Africa.; Mater Research Institute, The University of Queensland, Brisbane, Australia.
Walzl G; Mater Research Institute, The University of Queensland, Brisbane, Australia.
Loots DT; Human Metabolomics, North-West University, Potchefstroom, South Africa.
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Źródło :
Omics : a journal of integrative biology [OMICS] 2019 Nov; Vol. 23 (11), pp. 560-572. Date of Electronic Publication: 2019 Oct 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Biomarkers*
Metabolome*
Metabolomics*/methods
Metabolomics*/standards
Antitubercular Agents/*pharmacology
Tuberculosis/*drug therapy
Tuberculosis/*urine
Antitubercular Agents/therapeutic use ; Gas Chromatography-Mass Spectrometry ; Humans ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ; Tuberculosis/microbiology ; Urinalysis/methods
Czasopismo naukowe

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