Temat: "Lopinavir" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: A comparison of the long-term durability of nevirapine, efavirenz and lopinavir in routine clinical practice in Europe: a EuroSIDA study.
Autorzy:: Reekie J; Research Department of Infection & Population Health, University College London Medical School, Royal Free Campus, London, UK. />Reiss P
Ledergerber B
Sedlacek D
Parczewski M
Gatell J
Katlama C
Fätkenheuer G
Lundgren JD
Mocroft A; Pokaż więcej
Corporate Authors:: EuroSIDA study group
Źródło:: HIV medicine [HIV Med] 2011 May; Vol. 12 (5), pp. 259-68. Date of Electronic Publication: 2010 Aug 31.
Typ publikacji:: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Benzoxazines/*therapeutic use
HIV Infections/*drug therapy
HIV Protease Inhibitors/*therapeutic use
Nevirapine/*therapeutic use
Pyrimidinones/*therapeutic use
Reverse Transcriptase Inhibitors/*therapeutic use
Alkynes ; Argentina/epidemiology ; Benzoxazines/adverse effects ; Cyclopropanes ; Drug Administration Schedule ; Drug Resistance ; Drug Therapy, Combination ; Europe/epidemiology ; Female ; HIV Infections/epidemiology ; HIV Infections/virology ; HIV-1 ; Humans ; Israel/epidemiology ; Lopinavir ; Male ; Nevirapine/adverse effects ; Prospective Studies ; Pyrimidinones/adverse effects ; Treatment Outcome ; Viral Load

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Skocz do pozycji: 2.

Tytuł:: Cost-effectiveness of atazanavir/ritonavir compared with lopinavir/ritonavir in treatment-naïve human immunodeficiency virus-1 patients in Sweden.
Autorzy:: Thuresson PO; Pharmerit BV, Rotterdam, Netherlands. />Heeg B
Lescrauwaet B
Sennfält K
Alaeus A
Neubauer A; Pokaż więcej
Źródło:: Scandinavian journal of infectious diseases [Scand J Infect Dis] 2011 Apr; Vol. 43 (4), pp. 304-12. Date of Electronic Publication: 2011 Jan 13.
Typ publikacji:: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Anti-HIV Agents/*administration & dosage
Antiretroviral Therapy, Highly Active/*methods
HIV Infections/*drug therapy
HIV-1/*isolation & purification
Oligopeptides/*administration & dosage
Pyridines/*administration & dosage
Pyrimidinones/*administration & dosage
Ritonavir/*administration & dosage
Adult ; Anti-HIV Agents/economics ; Antiretroviral Therapy, Highly Active/economics ; Atazanavir Sulfate ; Clinical Trials as Topic ; Cost-Benefit Analysis ; HIV Infections/virology ; Humans ; Lopinavir ; Models, Statistical ; Oligopeptides/economics ; Pyridines/economics ; Pyrimidinones/economics ; Quality-Adjusted Life Years ; Ritonavir/economics ; Sweden

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Skocz do pozycji: 3.

Tytuł:: High efficacy of lopinavir/r-based second-line antiretroviral treatment after 24 months of follow up at ESTHER/Calmette Hospital in Phnom Penh, Cambodia.
Autorzy:: Ferradini L; Family Health International, Phnom Penh, Cambodia.
Ouk V
Segeral O
Nouhin J
Dulioust A
Hak C
Fournier I
Lerolle N
Ngin S
Mean CV
Delfraissy JF
Nerrienet E; Pokaż więcej
Źródło:: Journal of the International AIDS Society [J Int AIDS Soc] 2011 Mar 26; Vol. 14, pp. 14. Date of Electronic Publication: 2011 Mar 26.
Typ publikacji:: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Anti-HIV Agents/*therapeutic use
HIV Infections/*drug therapy
Pyrimidinones/*therapeutic use
Adult ; Antiretroviral Therapy, Highly Active ; CD4 Lymphocyte Count ; CD4-Positive T-Lymphocytes/immunology ; Cambodia ; Cohort Studies ; Female ; Follow-Up Studies ; HIV Infections/immunology ; HIV Infections/virology ; HIV-1/classification ; HIV-1/isolation & purification ; HIV-1/metabolism ; Humans ; Lopinavir ; Male ; Middle Aged ; Treatment Outcome ; Viral Load/drug effects

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Skocz do pozycji: 4.

Tytuł:: The HIV protease inhibitor lopinavir/ritonavir (Kaletra) alters the growth, differentiation and proliferation of primary gingival epithelium.
Autorzy:: Israr M; Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Mitchell D
Alam S
Dinello D
Kishel JJ
Meyers C; Pokaż więcej
Źródło:: HIV medicine [HIV Med] 2011 Mar; Vol. 12 (3), pp. 145-56. Date of Electronic Publication: 2010 Aug 15.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Gingiva/*drug effects
HIV Protease Inhibitors/*pharmacology
Keratinocytes/*drug effects
Pyrimidinones/*pharmacology
Ritonavir/*pharmacology
Cell Differentiation/drug effects ; Cell Proliferation/drug effects ; Cells, Cultured ; Dose-Response Relationship, Drug ; Drug Combinations ; Epithelial Cells/drug effects ; Epithelium/drug effects ; Gingiva/cytology ; Humans ; Lopinavir ; Microscopy, Electron, Transmission

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Skocz do pozycji: 5.

Tytuł:: Therapeutic drug monitoring of lopinavir/ritonavir in pregnancy.
Autorzy:: Lambert JS; The Rotunda Hospital, Dublin, Ireland.
Else LJ
Jackson V
Breiden J
Gibbons S
Dickinson L
Back DJ
Brennan M
Connor EO
Boyle N
Fleming C
Coulter-Smith S
Khoo SH; Pokaż więcej
Źródło:: HIV medicine [HIV Med] 2011 Mar; Vol. 12 (3), pp. 166-73. Date of Electronic Publication: 2010 Aug 18.
Typ publikacji:: Clinical Trial; Journal Article
MeSH Terms:: HIV-1*
Anti-HIV Agents/*blood
HIV Infections/*drug therapy
Pregnancy Complications, Infectious/*drug therapy
Pyrimidinones/*blood
Ritonavir/*blood
Adult ; Anti-HIV Agents/pharmacokinetics ; Anti-HIV Agents/therapeutic use ; Chromatography, High Pressure Liquid ; Drug Monitoring ; Female ; HIV Infections/blood ; Humans ; Lopinavir ; Pregnancy ; Pregnancy Complications, Infectious/blood ; Pyrimidinones/pharmacokinetics ; Pyrimidinones/therapeutic use ; Ritonavir/pharmacokinetics ; Ritonavir/therapeutic use ; Young Adult

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Skocz do pozycji: 6.

Tytuł:: Patent watch: Indian patent office rejects HIV drug formulation patent.
Autorzy:: Harrison C; Pokaż więcej
Źródło:: Nature reviews. Drug discovery [Nat Rev Drug Discov] 2011 Feb; Vol. 10 (2), pp. 88.
Typ publikacji:: Wiadomości
MeSH Terms:: Anti-HIV Agents/*therapeutic use
HIV Infections/*drug therapy
Patents as Topic/*legislation & jurisprudence
Pyrimidinones/*therapeutic use
Anti-HIV Agents/chemistry ; Chemistry, Pharmaceutical ; HIV Infections/epidemiology ; Humans ; India ; Lopinavir ; Pyrimidinones/chemistry

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Skocz do pozycji: 7.

Tytuł:: Ultrafast and high-throughput mass spectrometric assay for therapeutic drug monitoring of antiretroviral drugs in pediatric HIV-1 infection applying dried blood spots.
Autorzy:: Meesters RJ; Department of Neurology, Laboratory of Neuro-Oncology and Clinical and Cancer Proteomics, University Medical Center Rotterdam (Erasmus MC), Dr. Molewaterplein 50, Room Ee-1981, 3015 GE Rotterdam, The Netherlands. />van Kampen JJ
Reedijk ML
Scheuer RD
Dekker LJ
Burger DM
Hartwig NG
Osterhaus AD
Luider TM
Gruters RA; Pokaż więcej
Źródło:: Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2010 Sep; Vol. 398 (1), pp. 319-28. Date of Electronic Publication: 2010 Jul 15.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization*
Drug Monitoring/*methods
HIV Infections/*blood
HIV Infections/*drug therapy
HIV Protease Inhibitors/*blood
Pyrimidinones/*blood
Ritonavir/*blood
Blood Specimen Collection ; Case-Control Studies ; Child ; Chromatography, High Pressure Liquid ; HIV-1/isolation & purification ; Humans ; Lopinavir

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Skocz do pozycji: 8.

Tytuł:: Effects of cytochrome P450 3A (CYP3A) and the drug transporters P-glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) on the pharmacokinetics of lopinavir.
Autorzy:: van Waterschoot RA; Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
ter Heine R
Wagenaar E
van der Kruijssen CM
Rooswinkel RW
Huitema AD
Beijnen JH
Schinkel AH; Pokaż więcej
Źródło:: British journal of pharmacology [Br J Pharmacol] 2010 Jul; Vol. 160 (5), pp. 1224-33.
Typ publikacji:: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: ATP Binding Cassette Transporter, Subfamily B, Member 1/*metabolism
Cytochrome P-450 CYP3A/*drug effects
HIV Protease Inhibitors/*pharmacokinetics
Multidrug Resistance-Associated Proteins/*metabolism
Pyrimidinones/*pharmacokinetics
ATP Binding Cassette Transporter, Subfamily B, Member 1/genetics ; Animals ; Biological Availability ; Cytochrome P-450 CYP3A/genetics ; Dogs ; Drug Interactions ; Humans ; Intestinal Mucosa/metabolism ; Intestines/enzymology ; Liver/enzymology ; Liver/metabolism ; Lopinavir ; Male ; Mice ; Mice, Inbred Strains ; Mice, Transgenic ; Multidrug Resistance-Associated Protein 2 ; Multidrug Resistance-Associated Proteins/genetics ; Ritonavir/pharmacology

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Skocz do pozycji: 9.

Tytuł:: Lopinavir protein binding in HIV-1-infected pregnant women.
Autorzy:: Aweeka FT; Drug Research Unit, University of California, San Francisco, CA 94143-0622, USA. />Stek A
Best BM
Hu C
Holland D
Hermes A
Burchett SK
Read J
Mirochnick M
Capparelli EV; Pokaż więcej
Corporate Authors:: International Maternal Pediatric Adolescent AIDS Clinical Trials Group (IMPAACT) P1026s Protocol Team
Źródło:: HIV medicine [HIV Med] 2010 Apr; Vol. 11 (4), pp. 232-8. Date of Electronic Publication: 2009 Dec 03.
Typ publikacji:: Journal Article; Multicenter Study; Research Support, N.I.H., Extramural
MeSH Terms:: HIV-1*
Acute-Phase Proteins/*metabolism
HIV Infections/*drug therapy
HIV Protease Inhibitors/*metabolism
Pregnancy Complications, Infectious/*drug therapy
Pyrimidinones/*metabolism
Adolescent ; Adult ; Antiretroviral Therapy, Highly Active ; Drug Therapy, Combination ; Female ; HIV Infections/metabolism ; HIV Protease Inhibitors/administration & dosage ; Humans ; Lopinavir ; Pregnancy ; Pregnancy Complications, Infectious/metabolism ; Pregnancy Trimester, Third ; Prospective Studies ; Protein Binding ; Pyrimidinones/administration & dosage ; Ritonavir/administration & dosage ; Young Adult

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Skocz do pozycji: 10.

Tytuł:: Long-term (96-week) follow-up of antiretroviral-naïve HIV-infected patients treated with first-line lopinavir/ritonavir monotherapy in the MONARK trial.
Autorzy:: Ghosn J; Department of Internal Medicine and Infectious Diseases, AP-HP, Bicêtre University Hospital, Le Kremlin-Bicêtre Cedex, France. />Flandre P
Cohen-Codar I
Girard PM
Chaix ML
Raffi F
Dellamonica P
Ngovan P
Norton M
Delfraissy JF; Pokaż więcej
Corporate Authors:: MONARK Study Group
Źródło:: HIV medicine [HIV Med] 2010 Feb; Vol. 11 (2), pp. 137-42. Date of Electronic Publication: 2009 Aug 13.
Typ publikacji:: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:: HIV-1*/drug effects
HIV-1*/genetics
HIV Infections/*drug therapy
HIV Protease Inhibitors/*therapeutic use
Pyrimidinones/*therapeutic use
Ritonavir/*therapeutic use
Antiretroviral Therapy, Highly Active/methods ; Drug Administration Schedule ; Drug Resistance, Viral/genetics ; Drug Therapy, Combination ; Follow-Up Studies ; HIV Infections/virology ; Humans ; Intention to Treat Analysis ; Lamivudine/therapeutic use ; Lopinavir ; Male ; Medication Adherence ; RNA, Viral/blood ; RNA, Viral/genetics ; Reverse Transcriptase Inhibitors/therapeutic use ; Treatment Outcome ; Zidovudine/therapeutic use

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Skocz do pozycji: 11.

Tytuł:: Bilateral pedal edema in an HIV patient: Lopinavir/Ritonavir-containing treatment regimen as a potential cause?
Autorzy:: Shihab HM; Infectious Diseases Institute, Makerere University, Kampala, Uganda. />Lutwama F
Piloya T
Castelnuovo B
Kambugu AD
Colebunders R; Pokaż więcej
Źródło:: Journal of infection in developing countries [J Infect Dev Ctries] 2009 Jun 01; Vol. 3 (5), pp. 405-7. Date of Electronic Publication: 2009 Jun 01.
Typ publikacji:: Case Reports; Journal Article
MeSH Terms:: Anti-HIV Agents/*adverse effects
Edema/*pathology
HIV Infections/*complications
HIV Infections/*drug therapy
Leg/*pathology
Pyrimidinones/*adverse effects
Ritonavir/*adverse effects
Humans ; Lopinavir ; Male ; Middle Aged ; Uganda

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Skocz do pozycji: 12.

Tytuł:: Drug-resistant molecular mechanism of CRF01_AE HIV-1 protease due to V82F mutation.
Autorzy:: Liu X; Department of Bioscience and Biotechnology, School of Environmental and Biological Science and Technology, Dalian University of Technology, Dalian 116024, People's Republic of China. />Xiu Z
Hao C; Pokaż więcej
Źródło:: Journal of computer-aided molecular design [J Comput Aided Mol Des] 2009 May; Vol. 23 (5), pp. 261-72. Date of Electronic Publication: 2009 Feb 15.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: HIV Protease/*genetics
HIV Protease/*metabolism
HIV Protease Inhibitors/*pharmacology
HIV-1/*drug effects
Nelfinavir/*pharmacology
Pyrimidinones/*pharmacology
Amino Acid Sequence ; Amino Acid Substitution ; Catalytic Domain ; Computer Simulation ; Drug Design ; Drug Resistance, Viral ; HIV Protease Inhibitors/metabolism ; HIV-1/genetics ; Humans ; Lopinavir ; Models, Molecular ; Molecular Sequence Data ; Mutation ; Nelfinavir/metabolism ; Protein Binding ; Protein Conformation ; Pyrimidinones/metabolism ; Thermodynamics

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Skocz do pozycji: 13.

Tytuł:: Antiviral activity and safety of aplaviroc, a CCR5 antagonist, in combination with lopinavir/ritonavir in HIV-infected, therapy-naïve patients: results of the EPIC study (CCR100136).
Autorzy:: Yeni P; University Hospital Bichat, Paris, France.
Lamarca A
Berger D
Cimoch P
Lazzarin A
Salvato P
Smaill FM
Teofilo E
Madison SJ
Nichols WG
Adkison KK
Bonny T
Millard J
McCarty D; Pokaż więcej
Corporate Authors:: EPIC (CCR100136) study team
Źródło:: HIV medicine [HIV Med] 2009 Feb; Vol. 10 (2), pp. 116-24.
Typ publikacji:: Clinical Trial, Phase II; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms:: HIV-1*/immunology
Benzoates/*toxicity
HIV Infections/*drug therapy
HIV Protease Inhibitors/*therapeutic use
Piperazines/*toxicity
Pyrimidinones/*therapeutic use
Ritonavir/*therapeutic use
Spiro Compounds/*toxicity
Adult ; Aged ; Benzoates/pharmacokinetics ; Diketopiperazines ; Drug Administration Schedule ; Drug Therapy, Combination ; Female ; HIV Infections/immunology ; HIV Infections/virology ; HIV Protease Inhibitors/pharmacokinetics ; Humans ; Lopinavir ; Male ; Middle Aged ; Piperazines/pharmacokinetics ; Pyrimidinones/pharmacokinetics ; RNA, Viral/immunology ; Receptors, CCR5/therapeutic use ; Ritonavir/pharmacokinetics ; Spiro Compounds/pharmacokinetics ; Young Adult

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Skocz do pozycji: 14.

Tytuł:: Cultured CD4T cells and primary human lymphocytes express hOATPs: intracellular accumulation of saquinavir and lopinavir.
Autorzy:: Janneh O; School of Biomedical Sciences, University of Ulster, Coleraine, County Londonderry, UK. />Hartkoorn RC
Jones E
Owen A
Ward SA
Davey R
Back DJ
Khoo SH; Pokaż więcej
Źródło:: British journal of pharmacology [Br J Pharmacol] 2008 Nov; Vol. 155 (6), pp. 875-83. Date of Electronic Publication: 2008 Aug 18.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: CD4-Positive T-Lymphocytes/*metabolism
Lymphocytes/*metabolism
Multidrug Resistance-Associated Proteins/*metabolism
Pyrimidinones/*metabolism
Saquinavir/*metabolism
Cells, Cultured ; HIV Protease Inhibitors/metabolism ; Humans ; Lopinavir