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Wyszukujesz frazę ""Loss of Heterozygosity"" wg kryterium: Temat


Tytuł :
Variable Spontaneous Mutation and Loss of Heterozygosity among Heterozygous Genomes in Yeast.
Autorzy :
Nguyen DT; Department of Biological Sciences, Wayne State University, Detroit, MI.
Wu B; Department of Biological Sciences, Wayne State University, Detroit, MI.
Long H; Institute of Evolution and Marine Biodiversity, KLMME, Ocean University of China, Qingdao, Shandong Province, China.
Zhang N; Department of Biological Sciences, Wayne State University, Detroit, MI.
Patterson C; Department of Biology, Indiana University, Bloomington, IN.
Simpson S; University of New Hampshire, Durham, NH.
Morris K; University of New Hampshire, Durham, NH.
Thomas WK; University of New Hampshire, Durham, NH.
Lynch M; Center for Mechanisms of Evolution, The Biodesign Institute, Arizona State University, Tempe, AZ.
Hao W; Department of Biological Sciences, Wayne State University, Detroit, MI.
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Źródło :
Molecular biology and evolution [Mol Biol Evol] 2020 Nov 01; Vol. 37 (11), pp. 3118-3130.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Genome, Fungal*
Loss of Heterozygosity*
Mutation Rate*
Hanseniaspora/*genetics
Mutation Accumulation
Czasopismo naukowe
Tytuł :
Loss of Wild-Type CDKN2A Is an Early Event in the Development of Melanoma in FAMMM Syndrome.
Autorzy :
Christodoulou E; Department of Dermatology, LUMC, Leiden, the Netherlands.
Nell RJ; Department of Ophthalmology, LUMC, Leiden, the Netherlands.
Verdijk RM; Department of Pathology, LUMC, Leiden, the Netherlands; Department of Pathology, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands.
Gruis NA; Department of Dermatology, LUMC, Leiden, the Netherlands.
van der Velden PA; Department of Ophthalmology, LUMC, Leiden, the Netherlands.
van Doorn R; Department of Dermatology, LUMC, Leiden, the Netherlands. Electronic address: .
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Źródło :
The Journal of investigative dermatology [J Invest Dermatol] 2020 Nov; Vol. 140 (11), pp. 2298-2301.e3. Date of Electronic Publication: 2020 Mar 28.
Typ publikacji :
Letter; Research Support, Non-U.S. Gov't
MeSH Terms :
Loss of Heterozygosity*
Cyclin-Dependent Kinase Inhibitor p16/*genetics
Dysplastic Nevus Syndrome/*genetics
Melanoma/*etiology
Humans ; Melanoma/genetics ; Melanoma/pathology ; Polymorphism, Single Nucleotide
Raport
Tytuł :
Cells with loss-of-heterozygosity after exposure to ionizing radiation in Drosophila are culled by p53-dependent and p53-independent mechanisms.
Autorzy :
Brown J; Department of Molecular, Cellular and Developmental Biology, 347 UCB, University of Colorado, Boulder, CO, United States of America.
Bush I; Department of Molecular, Cellular and Developmental Biology, 347 UCB, University of Colorado, Boulder, CO, United States of America.
Bozon J; Department of Molecular, Cellular and Developmental Biology, 347 UCB, University of Colorado, Boulder, CO, United States of America.
Su TT; Department of Molecular, Cellular and Developmental Biology, 347 UCB, University of Colorado, Boulder, CO, United States of America.
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Źródło :
PLoS genetics [PLoS Genet] 2020 Oct 19; Vol. 16 (10), pp. e1009056. Date of Electronic Publication: 2020 Oct 19 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Drosophila Proteins/*genetics
Drosophila melanogaster/*genetics
Loss of Heterozygosity/*genetics
Transcription Factors/*genetics
Tumor Suppressor Protein p53/*genetics
Alleles ; Animals ; Chromosome Aberrations/radiation effects ; Heterozygote ; Loss of Heterozygosity/radiation effects ; Mutation/genetics ; Radiation, Ionizing
Czasopismo naukowe
Tytuł :
Chromosome 3p loss of heterozygosity and reduced expression of H3K36me3 correlate with longer relapse-free survival in sacral conventional chordoma.
Autorzy :
Zhu GG; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA; Department of Pathology, Cooper University Hospital, Cooper Medical School of Rowan University, Camden, NJ, 08003, USA.
Ramirez D; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA; Department of Pathology, Northwell Health, Great Neck, NY, 11021, USA.
Chen W; Department of Pathology, Washington DC VA Medical Center, Washington, DC, 20422, USA.
Lu C; Department of Genetics & Development, Columbia University Medical Center, New York, NY, 10032, USA.
Wang L; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
Frosina D; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Jungbluth A; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Ntiamoah P; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Nafa K; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Boland PJ; Orthopaedic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Hameed MR; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA. Electronic address: .
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Źródło :
Human pathology [Hum Pathol] 2020 Oct; Vol. 104, pp. 73-83. Date of Electronic Publication: 2020 Aug 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Chromosomes, Human, Pair 3*
DNA Methylation*
Loss of Heterozygosity*
Biomarkers, Tumor/*genetics
Chordoma/*genetics
Histone-Lysine N-Methyltransferase/*genetics
Sacrum/*pathology
Spinal Cord Neoplasms/*genetics
Adult ; Aged ; Aged, 80 and over ; Chordoma/mortality ; Chordoma/pathology ; Chordoma/therapy ; Disease Progression ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Recurrence, Local ; Polymorphism, Single Nucleotide ; Progression-Free Survival ; Spinal Cord Neoplasms/mortality ; Spinal Cord Neoplasms/pathology ; Spinal Cord Neoplasms/therapy ; Time Factors ; Treatment Outcome ; Young Adult
Czasopismo naukowe
Tytuł :
Immune escape by loss of heterozygosis of HLA genes facilitated the transmission of diffuse large B cell lymphoma from mother to offspring.
Autorzy :
Goto H; Department of Pediatrics, Oita University Faculty of Medicine, Oita, Japan.; Division of General Pediatrics and Emergency Medicine, Department of Pediatrics, Oita University Faculty of Medicine, Oita, Japan.
Hirano N; Department of Pediatrics, Oita University Faculty of Medicine, Oita, Japan.
Inoue M; Department of Pediatrics, Oita University Faculty of Medicine, Oita, Japan.
Takano K; Department of Medical Oncology and Hematology, Oita University Faculty of Medicine, Oita, Japan.
Ogata M; Department of Hematology, Oita University Hospital, Oita, Japan.
Kishida T; Department of Forensic Medicine, Oita University Faculty of Medicine, Oita, Japan.
Arakane M; Department of Diagnostic Pathology, Oita University Faculty of Medicine, Oita, Japan.
Daa T; Department of Diagnostic Pathology, Oita University Faculty of Medicine, Oita, Japan.
Nishida Y; Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, Oita, Japan.
Suenobu S; Department of Pediatrics, Oita University Faculty of Medicine, Oita, Japan.; Division of General Pediatrics and Emergency Medicine, Department of Pediatrics, Oita University Faculty of Medicine, Oita, Japan.
Ihara K; Department of Pediatrics, Oita University Faculty of Medicine, Oita, Japan.
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Źródło :
British journal of haematology [Br J Haematol] 2020 Jun; Vol. 189 (6), pp. e234-e237. Date of Electronic Publication: 2020 Apr 17.
Typ publikacji :
Case Reports; Letter; Research Support, Non-U.S. Gov't
MeSH Terms :
Cord Blood Stem Cell Transplantation*
Loss of Heterozygosity*
Lymphoma, Large B-Cell, Diffuse*/genetics
Lymphoma, Large B-Cell, Diffuse*/metabolism
Lymphoma, Large B-Cell, Diffuse*/pathology
Lymphoma, Large B-Cell, Diffuse*/therapy
Maternal-Fetal Exchange*
HLA Antigens/*genetics
Adult ; Allografts ; Female ; Humans ; Infant, Newborn ; Pregnancy ; Pregnancy Complications, Neoplastic/genetics ; Pregnancy Complications, Neoplastic/metabolism ; Pregnancy Complications, Neoplastic/pathology ; Pregnancy Complications, Neoplastic/therapy
Raport
Tytuł :
Loss of heterozygosity of essential genes represents a widespread class of potential cancer vulnerabilities.
Autorzy :
Nichols CA; Departments of Cancer Biology, Boston, MA, USA.; Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, 02215, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
Gibson WJ; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Brown MS; Departments of Cancer Biology, Boston, MA, USA.; Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, 02215, USA.
Kosmicki JA; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA.; Program in Bioinformatics and Integrative Genomics, Harvard University, Cambridge, MA, 02138, USA.
Busanovich JP; Departments of Cancer Biology, Boston, MA, USA.; Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, 02215, USA.
Wei H; Departments of Cancer Biology, Boston, MA, USA.; Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, 02215, USA.
Urbanski LM; Departments of Cancer Biology, Boston, MA, USA.; Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, 02215, USA.
Curimjee N; Departments of Cancer Biology, Boston, MA, USA.; Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, 02215, USA.
Berger AC; Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, 02215, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
Gao GF; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
Cherniack AD; Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, 02215, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
Dhe-Paganon S; Departments of Cancer Biology, Boston, MA, USA.; Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA.
Paolella BR; Departments of Cancer Biology, Boston, MA, USA. .; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA. .
Beroukhim R; Departments of Cancer Biology, Boston, MA, USA. .; Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, 02215, USA. .; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA. .; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 May 20; Vol. 11 (1), pp. 2517. Date of Electronic Publication: 2020 May 20.
Typ publikacji :
Journal Article
MeSH Terms :
Genes, Essential*
Loss of Heterozygosity*
Neoplasms/*genetics
Alleles ; Cell Proliferation ; DNA Primase/genetics ; Exosome Multienzyme Ribonuclease Complex/genetics ; Humans ; Models, Genetic ; Neoplasms/physiopathology ; RNA-Binding Proteins/genetics
Czasopismo naukowe
Tytuł :
Heterozygous loss of Rbm24 in the adult mouse heart increases sarcomere slack length but does not affect function.
Autorzy :
de Groot NE; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, location AMC, Amsterdam, The Netherlands.
van den Hoogenhof MMG; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, location AMC, Amsterdam, The Netherlands.
Najafi A; Department of Physiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, location VUmc, Amsterdam, The Netherlands.
van der Made I; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, location AMC, Amsterdam, The Netherlands.
van der Velden J; Department of Physiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, location VUmc, Amsterdam, The Netherlands.
Beqqali A; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, location AMC, Amsterdam, The Netherlands.
Pinto YM; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, location AMC, Amsterdam, The Netherlands.
Creemers EE; Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, location AMC, Amsterdam, The Netherlands. .
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Źródło :
Scientific reports [Sci Rep] 2020 May 06; Vol. 10 (1), pp. 7687. Date of Electronic Publication: 2020 May 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Loss of Heterozygosity*
Myocardium/*metabolism
RNA-Binding Proteins/*genetics
Sarcomeres/*metabolism
Animals ; Biomarkers ; Cell Membrane/metabolism ; Cell Membrane Permeability ; Disease Models, Animal ; Echocardiography ; Heart Diseases/diagnostic imaging ; Heart Diseases/genetics ; Heart Diseases/metabolism ; Immunohistochemistry ; Isometric Contraction ; Mice ; Mice, Knockout ; Myocytes, Cardiac/metabolism ; RNA-Binding Proteins/metabolism ; Sarcomeres/ultrastructure
Czasopismo naukowe
Tytuł :
Identification of a minimal region of loss on chromosome 6q27 associated with poor survival of high-risk neuroblastoma patients.
Autorzy :
Ognibene M; Laboratorio Cellule Staminali Post Natali e Terapie Cellulari, IRCCS Istituto Gaslini, Genova, Italy.
Morini M; Laboratorio di Biologia Molecolare, IRCCS Istituto Gaslini, Genova, Italy.
Garaventa A; Dipartimento di Emato-oncologia, IRCCS Istituto Gaslini, Genova, Italy.
Podestà M; Laboratorio Cellule Staminali Post Natali e Terapie Cellulari, IRCCS Istituto Gaslini, Genova, Italy.
Pezzolo A; Laboratorio Cellule Staminali Post Natali e Terapie Cellulari, IRCCS Istituto Gaslini, Genova, Italy.
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Źródło :
Cancer biology & therapy [Cancer Biol Ther] 2020 May 03; Vol. 21 (5), pp. 391-399. Date of Electronic Publication: 2020 Jan 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Genes, Tumor Suppressor*
Loss of Heterozygosity*
Chromosome Mapping/*methods
Chromosomes, Human, Pair 6/*genetics
Comparative Genomic Hybridization/*methods
Neuroblastoma/*mortality
Adolescent ; Adult ; Aged ; Child ; Cohort Studies ; Databases, Genetic/statistics & numerical data ; Humans ; Middle Aged ; Neuroblastoma/genetics ; Neuroblastoma/pathology ; Survival Rate ; Young Adult
Czasopismo naukowe
Tytuł :
Involvement of Rev1 in alkylating agent-induced loss of heterozygosity in Oryzias latipes.
Autorzy :
Fujikawa Y; Radioisotope Research Center, Institute for Radiation Research, Osaka University, Suita, Japan.; Radiation Biology and Medical Genetics, Department of Genome Biology, Graduate School of Medicine, Osaka University, Suita, Japan.; Japan Society for the Promotion of Science Research Fellow, Tokyo, Japan.
Ishikawa-Fujiwara T; Radioisotope Research Center, Institute for Radiation Research, Osaka University, Suita, Japan.; Radiation Biology and Medical Genetics, Department of Genome Biology, Graduate School of Medicine, Osaka University, Suita, Japan.
Kuo T; RWBC-OIL, AIST, Tokyo, Japan.
Shinkai N; Artificial Intelligence Research Center (AIRC), AIST, Tokyo, Japan.; Cancer Translational Research Team, RIKEN Center for Advanced Intelligence Project, Tokyo, Japan.; Division of Molecular Modification and Cancer Biology, National Cancer Center Research Institute, Tokyo, Japan.
Shoji T; Artificial Intelligence Research Center (AIRC), AIST, Tokyo, Japan.; Humanome Lab., Inc., Tokyo, Japan.
Kawasaki T; Functional Biomolecular Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ikeda, Japan.
Kamei Y; Spectrography and Bioimaging Facility, National Institute for Basic Biology, Okazaki, Japan.
Sakuraba Y; Genomic Sciences Center (GSC), RIKEN Yokohama Institute, Yokohama, Japan.
Sato A; Department of Pathology, Hyogo College of Medicine, Nishinomiya, Japan.
Kinoshita M; Division of Applied Bioscience, Graduate School of Agriculture, Kyoto University, Kyoto, Japan.
Gondo Y; Genomic Sciences Center (GSC), RIKEN Yokohama Institute, Yokohama, Japan.
Yuba S; Functional Biomolecular Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ikeda, Japan.
Tsujimura T; Department of Pathology, Hyogo College of Medicine, Nishinomiya, Japan.
Sese J; RWBC-OIL, AIST, Tokyo, Japan.; Artificial Intelligence Research Center (AIRC), AIST, Tokyo, Japan.; Humanome Lab., Inc., Tokyo, Japan.
Todo T; Radioisotope Research Center, Institute for Radiation Research, Osaka University, Suita, Japan.; Radiation Biology and Medical Genetics, Department of Genome Biology, Graduate School of Medicine, Osaka University, Suita, Japan.
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Źródło :
Genes to cells : devoted to molecular & cellular mechanisms [Genes Cells] 2020 Feb; Vol. 25 (2), pp. 124-138. Date of Electronic Publication: 2020 Feb 05.
Typ publikacji :
Journal Article
MeSH Terms :
Loss of Heterozygosity*
Nucleotidyltransferases/*genetics
Nucleotidyltransferases/*metabolism
Oryzias/*genetics
Animals ; Animals, Genetically Modified ; Carcinogenesis ; Cell Line ; DNA Damage ; DNA Repair ; DNA Replication ; DNA-Directed DNA Polymerase ; Female ; Gene Expression Regulation ; Liver/pathology ; Male ; Mutagenesis ; Mutation ; Recombinant Proteins ; Transcriptome
Czasopismo naukowe
Tytuł :
Molecular Characteristics of Lymphocyte-predominant Triple-negative Breast Cancer.
Autorzy :
Sasaki R; Department of Breast Oncology, Juntendo University School of Medicine, Tokyo, Japan.
Horimoto Y; Department of Breast Oncology, Juntendo University School of Medicine, Tokyo, Japan; .; Department of Human Pathology, Juntendo University School of Medicine, Tokyo, Japan.
Yanai Y; Department of Human Pathology, Juntendo University School of Medicine, Tokyo, Japan.
Kurisaki-Arakawa A; Department of Human Pathology, Juntendo University School of Medicine, Tokyo, Japan.
Arakawa A; Department of Human Pathology, Juntendo University School of Medicine, Tokyo, Japan.
Nakai K; Department of Breast Oncology, Juntendo University School of Medicine, Tokyo, Japan.
Saito M; Department of Breast Oncology, Juntendo University School of Medicine, Tokyo, Japan.
Saito T; Department of Human Pathology, Juntendo University School of Medicine, Tokyo, Japan.
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Źródło :
Anticancer research [Anticancer Res] 2021 Apr; Vol. 41 (4), pp. 2133-2140.
Typ publikacji :
Journal Article
MeSH Terms :
Biomarkers, Tumor/*genetics
Lymphocytes, Tumor-Infiltrating/*metabolism
Triple Negative Breast Neoplasms/*diagnosis
Triple Negative Breast Neoplasms/*genetics
Adult ; Aged ; Aged, 80 and over ; B7-H1 Antigen/genetics ; B7-H1 Antigen/metabolism ; Biomarkers, Pharmacological/analysis ; Biomarkers, Pharmacological/metabolism ; Biomarkers, Tumor/analysis ; Biomarkers, Tumor/metabolism ; DNA Copy Number Variations ; DNA Mutational Analysis/methods ; Gene Expression Regulation, Neoplastic ; High-Throughput Nucleotide Sequencing ; Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Loss of Heterozygosity ; Lymphocyte Count ; Lymphocytes/metabolism ; Lymphocytes/pathology ; Lymphocytes, Tumor-Infiltrating/pathology ; Middle Aged ; Mutation ; PTEN Phosphohydrolase/genetics ; PTEN Phosphohydrolase/metabolism ; Polymorphism, Single Nucleotide ; Prognosis ; Transcriptome ; Treatment Outcome ; Triple Negative Breast Neoplasms/drug therapy ; Triple Negative Breast Neoplasms/metabolism
Czasopismo naukowe
Tytuł :
Molecular and clinicopathological features of appendiceal mucinous neoplasms.
Autorzy :
Yanai Y; Department of Human Pathology, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-Ku, Tokyo, 113-8421, Japan.
Saito T; Department of Human Pathology, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-Ku, Tokyo, 113-8421, Japan. .; Intractable Disease Research Center, Graduate School of Medicine, Juntendo University, Tokyo, 113-8421, Japan. .
Hayashi T; Department of Human Pathology, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-Ku, Tokyo, 113-8421, Japan.
Akazawa Y; Department of Gastroenterology, Graduate School of Medicine, Juntendo University, Tokyo, 113-8421, Japan.
Yatagai N; Department of Gastroenterology, Graduate School of Medicine, Juntendo University, Tokyo, 113-8421, Japan.
Tsuyama S; Department of Human Pathology, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-Ku, Tokyo, 113-8421, Japan.
Tomita S; Department of Pathology, Juntendo University Urayasu Hospital, Urayasu, Chiba, 279-0021, Japan.
Hirai S; Department of Pathology, Juntendo University Tokyo Koto Geriatric Medical center, Tokyo, 136-0075, Japan.
Ogura K; Department of Pathology, Juntendo University Nerima Hospital, Tokyo, 177-8521, Japan.
Matsumoto T; Department of Pathology, Juntendo University Nerima Hospital, Tokyo, 177-8521, Japan.
Wada R; Department of Pathology, Juntendo University Shizuoka Hospital, Shizuoka, 410-2295, Japan.
Yao T; Department of Human Pathology, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-Ku, Tokyo, 113-8421, Japan.
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Źródło :
Virchows Archiv : an international journal of pathology [Virchows Arch] 2021 Mar; Vol. 478 (3), pp. 413-426. Date of Electronic Publication: 2020 Aug 21.
Typ publikacji :
Comparative Study; Journal Article; Multicenter Study
MeSH Terms :
Mutation*
Adenocarcinoma, Mucinous/*genetics
Appendiceal Neoplasms/*genetics
Biomarkers, Tumor/*genetics
Adenocarcinoma, Mucinous/chemistry ; Adenocarcinoma, Mucinous/pathology ; Adenocarcinoma, Mucinous/surgery ; Adult ; Aged ; Aged, 80 and over ; Appendiceal Neoplasms/chemistry ; Appendiceal Neoplasms/pathology ; Appendiceal Neoplasms/surgery ; Biomarkers, Tumor/analysis ; Chromogranins/genetics ; DNA Mutational Analysis ; Female ; GTP-Binding Protein alpha Subunits, Gs/genetics ; High-Throughput Nucleotide Sequencing ; Humans ; Immunohistochemistry ; Loss of Heterozygosity ; Male ; Middle Aged ; Neoplasm Grading ; Neoplasm Staging ; Proto-Oncogene Proteins p21(ras)/genetics ; Tokyo ; Tumor Suppressor Protein p53/genetics ; Ubiquitin-Protein Ligases/genetics ; Young Adult
Czasopismo naukowe
Tytuł :
The implications of BRCA loss of heterozygosity (LOH) and deficient mismatch repair gene (dMMR) expression in the breast cancer of a patient with both inherited breast and ovarian cancer syndrome (BRCA2) and Lynch syndrome (MLH1).
Autorzy :
Sorscher S; Oncology Division, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC, 27157, USA. .
Ansley K; Oncology Division, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC, 27157, USA.
Delaney SD; Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC, 27157, USA.
Ramkissoon S; Foundation Medicine, Inc, Cambridge, MA, 02141, USA.; Wake Forest Comprehensive Cancer Center and Department of Pathology, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA.
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Źródło :
Breast cancer research and treatment [Breast Cancer Res Treat] 2020 Apr; Vol. 180 (2), pp. 511-514. Date of Electronic Publication: 2020 Feb 10.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Germ-Line Mutation*
Loss of Heterozygosity*
BRCA2 Protein/*genetics
Breast Neoplasms/*pathology
Colorectal Neoplasms, Hereditary Nonpolyposis/*pathology
MutL Protein Homolog 1/*genetics
Ovarian Neoplasms/*pathology
Breast Neoplasms/genetics ; Colorectal Neoplasms, Hereditary Nonpolyposis/genetics ; Female ; Genetic Predisposition to Disease ; Humans ; Immunotherapy/methods ; Middle Aged ; Molecular Targeted Therapy/methods ; Ovarian Neoplasms/genetics ; Prognosis
SCR Disease Name :
Breast Cancer, Familial
Czasopismo naukowe
Tytuł :
Comprehensive analysis of somatic copy number alterations in clear cell renal cell carcinoma.
Autorzy :
Tsuyukubo T; Department of Molecular Diagnostic Pathology, School of Medicine, Iwate Medical University, Morioka, Japan.; Department of Urology, School of Medicine, Iwate Medical University, Morioka, Japan.
Ishida K; Department of Molecular Diagnostic Pathology, School of Medicine, Iwate Medical University, Morioka, Japan.
Osakabe M; Department of Molecular Diagnostic Pathology, School of Medicine, Iwate Medical University, Morioka, Japan.
Shiomi E; Department of Molecular Diagnostic Pathology, School of Medicine, Iwate Medical University, Morioka, Japan.; Department of Urology, School of Medicine, Iwate Medical University, Morioka, Japan.
Kato R; Department of Urology, School of Medicine, Iwate Medical University, Morioka, Japan.
Takata R; Department of Urology, School of Medicine, Iwate Medical University, Morioka, Japan.
Obara W; Department of Urology, School of Medicine, Iwate Medical University, Morioka, Japan.
Sugai T; Department of Molecular Diagnostic Pathology, School of Medicine, Iwate Medical University, Morioka, Japan.
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Źródło :
Molecular carcinogenesis [Mol Carcinog] 2020 Apr; Vol. 59 (4), pp. 412-424. Date of Electronic Publication: 2020 Feb 10.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Copy Number Variations*
Loss of Heterozygosity*
Mutation*
Carcinoma, Renal Cell/*genetics
Kidney Neoplasms/*genetics
Adult ; Aged ; Aged, 80 and over ; Carcinoma, Renal Cell/pathology ; Cluster Analysis ; Cohort Studies ; Female ; Humans ; Kaplan-Meier Estimate ; Kidney Neoplasms/pathology ; Male ; Middle Aged ; Multivariate Analysis ; Polymorphism, Single Nucleotide ; Prognosis
Czasopismo naukowe
Tytuł :
Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy.
Autorzy :
Rendo V; Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, SE-75185, Uppsala, Sweden.; Dana-Farber Cancer Institute, 450 Brookline Ave, 02115, Boston, MA, USA.
Stoimenov I; Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, SE-75185, Uppsala, Sweden.
Mateus A; Uppsala Drug Optimization and Pharmaceutical Profiling Facility (UDOPP), SciLifeLab Chemical Biology Consortium Sweden (CBCS), Department of Pharmacy, Uppsala University, 75123, Uppsala, Sweden.
Sjöberg E; Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, SE-75185, Uppsala, Sweden.
Svensson R; Uppsala Drug Optimization and Pharmaceutical Profiling Facility (UDOPP), SciLifeLab Chemical Biology Consortium Sweden (CBCS), Department of Pharmacy, Uppsala University, 75123, Uppsala, Sweden.; SciLifeLab Drug Discovery and Development Platform, ADME of Therapeutics facility (UDOPP), Department of Pharmacy, Uppsala University, 75123, Uppsala, Sweden.
Gustavsson AL; Chemical Biology Consortium Sweden, Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medicinal Biochemistry and Biophysics, Karolinska Institute, 17177, Solna, Sweden.
Johansson L; Chemical Biology Consortium Sweden, Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medicinal Biochemistry and Biophysics, Karolinska Institute, 17177, Solna, Sweden.
Ng A; Temasek Life Sciences Laboratory, 1 Research Link, NUS, 117604, Singapore, Singapore.
OʼBrien C; Dana-Farber Cancer Institute, 450 Brookline Ave, 02115, Boston, MA, USA.
Giannakis M; Dana-Farber Cancer Institute, 450 Brookline Ave, 02115, Boston, MA, USA.
Artursson P; Uppsala Drug Optimization and Pharmaceutical Profiling Facility (UDOPP), SciLifeLab Chemical Biology Consortium Sweden (CBCS), Department of Pharmacy, Uppsala University, 75123, Uppsala, Sweden.; SciLifeLab Drug Discovery and Development Platform, ADME of Therapeutics facility (UDOPP), Department of Pharmacy, Uppsala University, 75123, Uppsala, Sweden.
Nygren P; Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, SE-75185, Uppsala, Sweden.
Cheong I; Temasek Life Sciences Laboratory, 1 Research Link, NUS, 117604, Singapore, Singapore.
Sjöblom T; Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, SE-75185, Uppsala, Sweden. .
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Źródło :
Nature communications [Nat Commun] 2020 Mar 11; Vol. 11 (1), pp. 1308. Date of Electronic Publication: 2020 Mar 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Loss of Heterozygosity*
Antineoplastic Agents/*pharmacology
Arylamine N-Acetyltransferase/*genetics
Colorectal Neoplasms/*drug therapy
Protein Kinase Inhibitors/*pharmacology
Alleles ; Animals ; Antineoplastic Agents/therapeutic use ; Arylamine N-Acetyltransferase/metabolism ; Bystander Effect/genetics ; Case-Control Studies ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Dose-Response Relationship, Drug ; Female ; HCT116 Cells ; Humans ; Isoenzymes/metabolism ; Mice ; Mice, Nude ; Polymorphism, Genetic ; Protein Kinase Inhibitors/therapeutic use ; Small Molecule Libraries ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Epigenetic loss of heterozygosity of Apc and an inflammation-associated mutational signature detected in Lrig1 -driven murine colonic adenomas.
Autorzy :
Preston JL; Institute of Molecular Biology, University of Oregon, Eugene, OR, 97403, USA. .
Stiffler N; Institute of Molecular Biology, University of Oregon, Eugene, OR, 97403, USA.
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Źródło :
BMC cancer [BMC Cancer] 2020 Feb 14; Vol. 20 (1), pp. 126. Date of Electronic Publication: 2020 Feb 14.
Typ publikacji :
Journal Article
MeSH Terms :
Epigenesis, Genetic*
Genes, APC*
Loss of Heterozygosity*
Mutation*
Colonic Neoplasms/*genetics
Membrane Glycoproteins/*genetics
Nerve Tissue Proteins/*genetics
Animals ; Cell Transformation, Neoplastic/genetics ; Disease Models, Animal ; Exome ; Gene Expression Profiling ; Gene Silencing ; Humans ; Mice ; Transcriptome
Czasopismo naukowe
Tytuł :
Hypermethylation of FOXA1 and allelic loss of PTEN drive squamous differentiation and promote heterogeneity in bladder cancer.
Autorzy :
Osei-Amponsa V; Department of Pathology and Laboratory Medicine, The Pennsylvania State University, College of Medicine, Hershey, PA, USA.
Buckwalter JM; Department of Pathology and Laboratory Medicine, The Pennsylvania State University, College of Medicine, Hershey, PA, USA.; Department of Surgery, Division of Urology, The Pennsylvania State University, College of Medicine, Hershey, PA, USA.
Shuman L; Department of Pathology and Laboratory Medicine, The Pennsylvania State University, College of Medicine, Hershey, PA, USA.; Department of Surgery, Division of Urology, The Pennsylvania State University, College of Medicine, Hershey, PA, USA.
Zheng Z; Department of Pathology and Laboratory Medicine, The Pennsylvania State University, College of Medicine, Hershey, PA, USA.
Yamashita H; Department of Pathology and Laboratory Medicine, The Pennsylvania State University, College of Medicine, Hershey, PA, USA.; Department of Surgery, Division of Urology, The Pennsylvania State University, College of Medicine, Hershey, PA, USA.
Walter V; Department of Public Health Sciences, The Pennsylvania State University, College of Medicine, Hershey, PA, USA.
Wildermuth T; Department of Pathology and Laboratory Medicine, The Pennsylvania State University, College of Medicine, Hershey, PA, USA.; Department of Surgery, Division of Urology, The Pennsylvania State University, College of Medicine, Hershey, PA, USA.
Ellis-Mohl J; Department of Pathology and Laboratory Medicine, The Pennsylvania State University, College of Medicine, Hershey, PA, USA.; Department of Surgery, Division of Urology, The Pennsylvania State University, College of Medicine, Hershey, PA, USA.
Liu C; Department of Urology, Columbia University, New York, NY, USA.
Warrick JI; Department of Pathology and Laboratory Medicine, The Pennsylvania State University, College of Medicine, Hershey, PA, USA.; Department of Surgery, Division of Urology, The Pennsylvania State University, College of Medicine, Hershey, PA, USA.
Shantz LM; Department of Cellular and Molecular Physiology, The Pennsylvania State University, College of Medicine, Hershey, PA, USA.
Feehan RP; Department of Cellular and Molecular Physiology, The Pennsylvania State University, College of Medicine, Hershey, PA, USA.
Al-Ahmadie H; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Mendelsohn C; Department of Urology, Columbia University, New York, NY, USA.
Raman JD; Department of Pathology and Laboratory Medicine, The Pennsylvania State University, College of Medicine, Hershey, PA, USA.; Department of Surgery, Division of Urology, The Pennsylvania State University, College of Medicine, Hershey, PA, USA.
Kaestner KH; Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA.
Wu XR; Departments of Urology and Pathology, New York University School of Medicine, New York, NY, USA.; Veterans Affairs New York Harbor Healthcare System, Manhattan Campus, New York, NY, USA.
DeGraff DJ; Department of Pathology and Laboratory Medicine, The Pennsylvania State University, College of Medicine, Hershey, PA, USA. .; Department of Surgery, Division of Urology, The Pennsylvania State University, College of Medicine, Hershey, PA, USA. .
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Źródło :
Oncogene [Oncogene] 2020 Feb; Vol. 39 (6), pp. 1302-1317. Date of Electronic Publication: 2019 Oct 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Differentiation*
DNA Methylation*
Loss of Heterozygosity*
Carcinoma, Squamous Cell/*pathology
Hepatocyte Nuclear Factor 3-alpha/*genetics
PTEN Phosphohydrolase/*genetics
Urinary Bladder Neoplasms/*pathology
Animals ; Apoptosis ; Biomarkers, Tumor ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/metabolism ; Cell Proliferation ; Female ; Gene Expression Regulation, Neoplastic ; Hepatocyte Nuclear Factor 3-alpha/metabolism ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Muscle Neoplasms/genetics ; Muscle Neoplasms/metabolism ; Muscle Neoplasms/pathology ; PTEN Phosphohydrolase/metabolism ; Prognosis ; Tumor Cells, Cultured ; Urinary Bladder Neoplasms/genetics ; Urinary Bladder Neoplasms/metabolism
Czasopismo naukowe
Tytuł :
Detection of Loss of Heterozygosity in Tk-Deficient Mutants from L5178Y Tk -3.7.2C Mouse Lymphoma Cells.
Autorzy :
Guo X; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Jefferson, AR, USA.
Chen Y; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Jefferson, AR, USA.
Moore MM; Ramboll, US Corporation, Little Rock, AR, USA.
Mei N; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2020; Vol. 2102, pp. 251-270.
Typ publikacji :
Journal Article
MeSH Terms :
Loss of Heterozygosity*
Chromosomes, Human, Pair 11/*genetics
Lymphoma/*genetics
Mutagenicity Tests/*methods
Thymidine Kinase/*genetics
Alleles ; Animals ; Chromosome Aberrations ; DNA/isolation & purification ; Heterozygote ; Humans ; Mice ; Microsatellite Repeats/genetics ; Mutation ; Polymerase Chain Reaction ; Thymidine Kinase/metabolism ; Workflow
Czasopismo naukowe
Tytuł :
Detection of Loss of Heterozygosity in cfDNA of Advanced EGFR - or KRAS -Mutated Non-Small-Cell Lung Cancer Patients.
Autorzy :
Boldrin E; Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV-IRCCS, Via Gattamelata 64, 35128 Padova, Italy.
Nardo G; Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV-IRCCS, Via Gattamelata 64, 35128 Padova, Italy.
Zulato E; Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV-IRCCS, Via Gattamelata 64, 35128 Padova, Italy.
Bonanno L; Medical Oncology 2, Istituto Oncologico Veneto IOV-IRCCS, Via Gattamelata 64, 35128 Padova, Italy.
Polo V; Medical Oncology, Azienda ULSS 2, 31100 Treviso, Italy.
Frega S; Medical Oncology 2, Istituto Oncologico Veneto IOV-IRCCS, Via Gattamelata 64, 35128 Padova, Italy.
Pavan A; Medical Oncology 2, Istituto Oncologico Veneto IOV-IRCCS, Via Gattamelata 64, 35128 Padova, Italy.
Indraccolo S; Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV-IRCCS, Via Gattamelata 64, 35128 Padova, Italy.
Saggioro D; Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV-IRCCS, Via Gattamelata 64, 35128 Padova, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2019 Dec 20; Vol. 21 (1). Date of Electronic Publication: 2019 Dec 20.
Typ publikacji :
Journal Article
MeSH Terms :
Loss of Heterozygosity*
Carcinoma, Non-Small-Cell Lung/*genetics
Cell-Free Nucleic Acids/*genetics
Lung Neoplasms/*genetics
Proto-Oncogene Proteins p21(ras)/*genetics
Aged ; Aged, 80 and over ; Carcinoma, Non-Small-Cell Lung/pathology ; ErbB Receptors/genetics ; Female ; Humans ; Lung Neoplasms/pathology ; Male ; Middle Aged ; Mutation ; Pilot Projects
Czasopismo naukowe
Tytuł :
Microsatellite instability profiling in Egyptian bladder cancer patients: A pilot study.
Autorzy :
Zekri AN; Molecular Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt. Electronic address: .
Khaled HM; Medical Oncology, National Cancer Institute, Cairo University, Cairo, Egypt. Electronic address: .
Mohammed MB; Molecular Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt. Electronic address: .
Diab FM; Zoology Department, Faculty of Science, Cairo University, Giza, Egypt.
Abdellateif MS; Medical Biochemistry and Molecular Biology, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt.
El Deeb S; Zoology Department, Faculty of Science, Cairo University, Giza, Egypt.
Badr AM; Zoology Department, Faculty of Science, Cairo University, Giza, Egypt.
Mohanad M; Biochemistry Department, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, 6th of October, Egypt.
Abdallah SO; Inorganic Chemistry, Faculty of Science, Cairo University, Giza, Egypt. Electronic address: .
Bahnassy AA; Pathology Department, National Cancer Institute, Cairo University, Cairo, Egypt.
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Źródło :
Current problems in cancer [Curr Probl Cancer] 2019 Dec; Vol. 43 (6), pp. 100472. Date of Electronic Publication: 2019 Mar 26.
Typ publikacji :
Journal Article
MeSH Terms :
Loss of Heterozygosity*
Microsatellite Instability*
Biomarkers, Tumor/*genetics
Urinary Bladder Neoplasms/*diagnosis
Adult ; Aged ; Aged, 80 and over ; Egypt ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Pilot Projects ; Prognosis ; Retrospective Studies ; Urinary Bladder Neoplasms/genetics
Czasopismo naukowe
Tytuł :
Interhomolog Homologous Recombination in Mouse Embryonic Stem Cells.
Autorzy :
Vanoli F; Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Prakash R; Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
White T; Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Jasin M; Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2153, pp. 127-143.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Breaks, Double-Stranded*
Recombinational DNA Repair*
Mouse Embryonic Stem Cells/*cytology
Animals ; Cell Line ; Loss of Heterozygosity ; Mice ; Mouse Embryonic Stem Cells/chemistry ; RecQ Helicases/metabolism
Czasopismo naukowe

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