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Tytuł:
Expression of DNA Helicase Genes Was Correlated with Homologous Recombination Deficiency in Breast Cancer.
Autorzy:
Long M; Department of Pathology, Peking University Cancer Hospital, Beijing, China.
Liu H; Department of Breast Surgery, Peking University People's Hospital, Beijing, China.
Wu J; Department of Breast Surgery, Peking University People's Hospital, Beijing, China.
Wang S; Department of Breast Surgery, Peking University People's Hospital, Beijing, China.
Liao X; Department of Breast Surgery, Peking University People's Hospital, Beijing, China.
Liu Y; Department of Pathology, Peking University Cancer Hospital, Beijing, China.
Hu T; Department of Breast Surgery, Peking University People's Hospital, Beijing, China.
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Źródło:
Computational and mathematical methods in medicine [Comput Math Methods Med] 2022 Jul 09; Vol. 2022, pp. 5508301. Date of Electronic Publication: 2022 Jul 09 (Print Publication: 2022).
Typ publikacji:
Journal Article
MeSH Terms:
Breast Neoplasms*/genetics
DNA Helicases/genetics ; Female ; Homologous Recombination ; Humans ; Loss of Heterozygosity ; Poly(ADP-ribose) Polymerase Inhibitors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Landscape of homologous recombination deficiencies in solid tumours: analyses of two independent genomic datasets.
Autorzy:
Lai Z; AstraZeneca, Waltham, MA, 02451, USA. .
Brosnan M; Foundation Medicine Inc., Cambridge, MA, USA.
Sokol ES; Foundation Medicine Inc., Cambridge, MA, USA.
Xie M; AstraZeneca, Waltham, MA, 02451, USA.
Dry JR; AstraZeneca, Waltham, MA, 02451, USA.; Present Address: Tempus Labs Inc., Boston, MA, USA.
Harrington EA; AstraZeneca, Cambridge, UK.
Barrett JC; AstraZeneca, Waltham, MA, 02451, USA.
Hodgson D; AstraZeneca, Waltham, MA, 02451, USA.
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Źródło:
BMC cancer [BMC Cancer] 2022 Jan 03; Vol. 22 (1), pp. 13. Date of Electronic Publication: 2022 Jan 03.
Typ publikacji:
Journal Article
MeSH Terms:
BRCA1 Protein/*genetics
BRCA2 Protein/*genetics
Breast Neoplasms/*genetics
Homologous Recombination/*genetics
Ovarian Neoplasms/*genetics
Databases, Genetic ; Datasets as Topic ; Female ; Genomics ; Germ-Line Mutation/genetics ; Humans ; Loss of Heterozygosity/genetics ; Mutation/genetics ; Recombinational DNA Repair/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Genetic and clinical landscape of breast cancers with germline BRCA1/2 variants.
Autorzy:
Inagaki-Kawata Y; Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan.; Department of Breast Surgery, Kyoto University, Kyoto, Japan.
Yoshida K; Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan.
Kawaguchi-Sakita N; Department of Clinical Oncology, Kyoto University Hospital, Kyoto, Japan.
Kawashima M; Department of Breast Surgery, Kyoto University, Kyoto, Japan.
Nishimura T; Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan.; Department of Breast Surgery, Kyoto University, Kyoto, Japan.
Senda N; Department of Breast Surgery, Kyoto University, Kyoto, Japan.
Shiozawa Y; Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan.
Takeuchi Y; Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan.; Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan.; Department of Diagnostic Pathology, Kyoto University, Kyoto, Japan.
Inoue Y; Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan.
Sato-Otsubo A; Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan.
Fujii Y; Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan.
Nannya Y; Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan.
Suzuki E; Department of Breast Surgery, Kyoto University, Kyoto, Japan.
Takada M; Department of Breast Surgery, Kyoto University, Kyoto, Japan.
Tanaka H; Laboratory of Sequence Analysis, Human Genome Centre, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Shiraishi Y; Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Chiba K; Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Kataoka Y; Hospital Care Research Unit/Department of Respiratory Medicine, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan.
Torii M; Department of Breast Surgery, Japanese Red Cross Wakayama Medical Center, Wakayama, Japan.
Yoshibayashi H; Department of Breast Surgery, Japanese Red Cross Wakayama Medical Center, Wakayama, Japan.
Yamagami K; Department of Breast Surgery, Shinko Hospital, Kobe, Japan.
Okamura R; Department of Breast Surgery, Yamatotakada Municipal Hospital, Yamatotakada, Japan.
Moriguchi Y; Department of Breast Surgery, Kyoto City Hospital, Kyoto, Japan.
Kato H; Department of Breast Surgery, Kobe City Medical Center General Hospital, Kobe, Japan.
Tsuyuki S; Department of Breast Surgery, Osaka Red Cross Hospital, Osaka, Japan.
Yamauchi A; Department of Breast Surgery, Kitano Hospital, Osaka, Japan.
Suwa H; Department of Breast Surgery, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan.
Inamoto T; Tenri Health Care University, Tenri, Japan.
Miyano S; Laboratory of Sequence Analysis, Human Genome Centre, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Ogawa S; Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan. .; Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan. .; Department of Medicine, Centre for Haematology and Regenerative Medicine, Karolinska Institute, Stockholm, Sweden. .
Toi M; Department of Breast Surgery, Kyoto University, Kyoto, Japan. .
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Źródło:
Communications biology [Commun Biol] 2020 Oct 16; Vol. 3 (1), pp. 578. Date of Electronic Publication: 2020 Oct 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Germ-Line Mutation*
BRCA1 Protein/*genetics
Breast Neoplasms/*epidemiology
Breast Neoplasms/*genetics
Adult ; Aged ; Alleles ; BRCA2 Protein/genetics ; Biomarkers, Tumor ; Breast Neoplasms/diagnosis ; Female ; Gene Frequency ; Gene Silencing ; Genetic Association Studies ; Genetic Predisposition to Disease ; Humans ; Loss of Heterozygosity ; Middle Aged ; Neoplasm Grading ; Neoplasm Staging ; Prevalence ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Single-base LOH can be used as Specific Marker to Classify BRCAx Familial Breast Cancer into More Homogenous Subtypes.
Autorzy:
Downs B; Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska.
Xiao F; Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska.
Kim YC; Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska.
Chen PX; Department of Medicine, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska.
Huang D; Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska.
Fleissner EA; Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska.
Cowan K; Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska.
Wang SM; Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska.
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Źródło:
The breast journal [Breast J] 2017 Jul; Vol. 23 (4), pp. 479-481. Date of Electronic Publication: 2017 Jan 24.
Typ publikacji:
Letter; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Biomarkers*
Loss of Heterozygosity*
Breast Neoplasms/*genetics
Carcinoma, Ductal, Breast/*genetics
Carcinoma, Intraductal, Noninfiltrating/*genetics
Genetic Predisposition to Disease/*genetics
Adult ; Aged ; Female ; Genes, BRCA1 ; Genes, BRCA2 ; Humans ; Middle Aged
SCR Disease Name:
Breast Cancer, Familial
Raport
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Irradiation induces p53 loss of heterozygosity in breast cancer expressing mutant p53.
Autorzy:
Ghaleb A; 1Department of Pathology, Stony Brook University, Stony Brook, NY 11794-8691 USA.
Yallowitz A; 1Department of Pathology, Stony Brook University, Stony Brook, NY 11794-8691 USA.; 2Weill Cornell Medicine, 1300 York Avenue, LC-902, New York, NY 10065 USA.
Marchenko N; 1Department of Pathology, Stony Brook University, Stony Brook, NY 11794-8691 USA.
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Źródło:
Communications biology [Commun Biol] 2019 Nov 27; Vol. 2, pp. 436. Date of Electronic Publication: 2019 Nov 27 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Mutation*
Breast Neoplasms/*genetics
Gene Expression Regulation, Neoplastic/*radiation effects
Loss of Heterozygosity/*radiation effects
Tumor Suppressor Protein p53/*genetics
Animals ; Biomarkers, Tumor ; Breast Neoplasms/mortality ; Breast Neoplasms/pathology ; Breast Neoplasms/radiotherapy ; Cell Line, Tumor ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/radiation effects ; DNA Damage ; Disease Models, Animal ; Female ; Gamma Rays ; Genomic Instability ; Humans ; Immunohistochemistry ; Kaplan-Meier Estimate ; Mice ; Mice, Transgenic ; Neoplasm Staging ; Prognosis ; Treatment Outcome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Genetic features of metachronous esophageal cancer developed in Hodgkin's lymphoma or breast cancer long-term survivors: an exploratory study.
Autorzy:
Boldrin E; Immunology and Molecular Oncology, Veneto Institute of Oncology, IOV-IRCCS, Padova, Italy.
Rumiato E; Immunology and Molecular Oncology, Veneto Institute of Oncology, IOV-IRCCS, Padova, Italy.
Fassan M; Department of Medicine, Surgical Pathology and Cytopathology, University of Padova, Padova, Italy.
Cappellesso R; Department of Medicine, Surgical Pathology and Cytopathology, University of Padova, Padova, Italy.
Rugge M; Department of Medicine, Surgical Pathology and Cytopathology, University of Padova, Padova, Italy.
Chiarion-Sileni V; Medical Oncology, Veneto Institute of Oncology, IOV-IRCCS, Padova, Italy.
Ruol A; Department of Surgical Sciences, Oncology and Gastroenterology, University of Padova, Padova, Italy.
Alfieri R; Oncological Surgery, Veneto Institute of Oncology, IOV-IRCCS, Padova, Italy.
Cagol M; Oncological Surgery, Veneto Institute of Oncology, IOV-IRCCS, Padova, Italy.
Castoro C; Oncological Surgery, Veneto Institute of Oncology, IOV-IRCCS, Padova, Italy.
Amadori A; Immunology and Molecular Oncology, Veneto Institute of Oncology, IOV-IRCCS, Padova, Italy; Department of Surgical Sciences, Oncology and Gastroenterology, University of Padova, Padova, Italy.
Saggioro D; Immunology and Molecular Oncology, Veneto Institute of Oncology, IOV-IRCCS, Padova, Italy.
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Źródło:
PloS one [PLoS One] 2015 Jan 22; Vol. 10 (1), pp. e0117070. Date of Electronic Publication: 2015 Jan 22 (Print Publication: 2015).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Loss of Heterozygosity*
Microsatellite Repeats*
Survivors*
Adenocarcinoma/*genetics
Breast Neoplasms/*genetics
Carcinoma, Squamous Cell/*genetics
Esophageal Neoplasms/*genetics
Hodgkin Disease/*genetics
Neoplasms, Second Primary/*genetics
Adenocarcinoma/radiotherapy ; Adult ; Aged ; Breast Neoplasms/radiotherapy ; Carcinoma, Squamous Cell/radiotherapy ; Female ; Hodgkin Disease/radiotherapy ; Humans ; Male ; Middle Aged
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Exome sequencing of primary breast cancers with paired metastatic lesions reveals metastasis-enriched mutations in the A-kinase anchoring protein family (AKAPs).
Autorzy:
Kjällquist U; Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institute and University Hospital, Stockholm, Sweden. .; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden. .
Erlandsson R; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Tobin NP; Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institute and University Hospital, Stockholm, Sweden.
Alkodsi A; Research Programs Unit, Genome-Scale Biology and Medicum, University of Helsinki, Helsinki, Finland.
Ullah I; Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institute and University Hospital, Stockholm, Sweden.
Stålhammar G; Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institute and University Hospital, Stockholm, Sweden.
Karlsson E; Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institute and University Hospital, Stockholm, Sweden.
Hatschek T; Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institute and University Hospital, Stockholm, Sweden.
Hartman J; Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institute and University Hospital, Stockholm, Sweden.
Linnarsson S; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Bergh J; Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institute and University Hospital, Stockholm, Sweden.
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Źródło:
BMC cancer [BMC Cancer] 2018 Feb 12; Vol. 18 (1), pp. 174. Date of Electronic Publication: 2018 Feb 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Biomarkers, Tumor*
Multigene Family*
Mutation*
A Kinase Anchor Proteins/*genetics
Breast Neoplasms/*genetics
Breast Neoplasms/*pathology
A Kinase Anchor Proteins/metabolism ; Breast Neoplasms/metabolism ; Cohort Studies ; DNA Copy Number Variations ; Female ; Gene Expression Regulation, Neoplastic ; Genetic Association Studies ; Humans ; Loss of Heterozygosity ; Neoplasm Metastasis/genetics ; Neoplasm Staging ; Exome Sequencing
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Genome-wide analysis of loss of heterozygosity in breast infiltrating ductal carcinoma distant normal tissue highlights arm specific enrichment and expansion across tumor stages.
Autorzy:
Ruan X; Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America.
Liu H; Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America.
Boardman L; Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, United States of America.
Kocher JP; Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America.
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Źródło:
PloS one [PLoS One] 2014 Apr 18; Vol. 9 (4), pp. e95783. Date of Electronic Publication: 2014 Apr 18 (Print Publication: 2014).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Chromosomes, Human*
Genome-Wide Association Study*
Loss of Heterozygosity*
Breast Neoplasms/*genetics
Breast Neoplasms/*pathology
Carcinoma, Ductal, Breast/*genetics
Carcinoma, Ductal, Breast/*pathology
Chromosome Fragile Sites ; Chromosome Mapping ; Female ; High-Throughput Nucleotide Sequencing ; Humans ; Neoplasm Staging
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Androgen receptor CAG repeats, non-random X chromosome inactivation, and loss of heterozygosity at Xq25 in relation to breast cancer risk.
Autorzy:
Chen HT
Wu YC
Chen ST
Tsai HC
Chien YC; Department of Biology, National Changhua University of Education, No,1, Jin-De Road, 50058 Changhua City, Taiwan. .
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Źródło:
BMC cancer [BMC Cancer] 2014 Mar 01; Vol. 14, pp. 144. Date of Electronic Publication: 2014 Mar 01.
Typ publikacji:
Journal Article
MeSH Terms:
Genetic Predisposition to Disease*
Loss of Heterozygosity*
Trinucleotide Repeats*
X Chromosome Inactivation*
Breast Neoplasms/*genetics
Receptors, Androgen/*genetics
Adult ; Aged ; Alleles ; Breast Neoplasms/pathology ; Case-Control Studies ; Cluster Analysis ; Female ; Gene Frequency ; Humans ; Microsatellite Repeats ; Middle Aged ; Risk ; Taiwan
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
SYK allelic loss and the role of Syk-regulated genes in breast cancer survival.
Autorzy:
Blancato J; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, D. C., United States of America.
Graves A; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, D. C., United States of America.
Rashidi B; Department of Pathology, Georgetown University Medical Center, Washington, D. C., United States of America.
Moroni M; Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America.
Tchobe L; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, D. C., United States of America ; University of the District of Columbia/Lombardi Comprehensive Cancer Center Partnership, Washington, D. C., United States of America.
Ozdemirli M; Department of Pathology, Georgetown University Medical Center, Washington, D. C., United States of America.
Kallakury B; Department of Pathology, Georgetown University Medical Center, Washington, D. C., United States of America.
Makambi KH; Department of Biostatistics and Bioinformatics, Georgetown University Medical Center, Washington, D. C., United States of America.
Marian C; Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America ; Biochemistry Department, University of Medicine and Pharmacy, 'Victor Babes', Timisoara, Romania.
Mueller SC; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, D. C., United States of America.
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Źródło:
PloS one [PLoS One] 2014 Feb 11; Vol. 9 (2), pp. e87610. Date of Electronic Publication: 2014 Feb 11 (Print Publication: 2014).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Loss of Heterozygosity*
Breast Neoplasms/*genetics
Breast Neoplasms/*metabolism
Carcinoma, Ductal, Breast/*genetics
Carcinoma, Ductal, Breast/*metabolism
Intracellular Signaling Peptides and Proteins/*genetics
Protein-Tyrosine Kinases/*genetics
Breast Neoplasms/mortality ; Carcinoma, Ductal, Breast/mortality ; Chromosome Mapping ; DNA Methylation ; Female ; Gene Expression Regulation, Neoplastic ; Genomic Instability ; Humans ; In Situ Hybridization, Fluorescence ; Kaplan-Meier Estimate ; Neoplasm Invasiveness ; Prognosis ; Promoter Regions, Genetic ; Syk Kinase ; Treatment Outcome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
High incidence of microsatellite instability and loss of heterozygosity in three loci in breast cancer patients receiving chemotherapy: a prospective study.
Autorzy:
Kamat N; Department of Genetics, Microbiology and Toxicology, Stockholm University, Stockholm, Sweden.
Khidhir MA
Jaloudi M
Hussain S
Alashari MM
Al Qawasmeh KH
Rannug U
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Źródło:
BMC cancer [BMC Cancer] 2012 Aug 28; Vol. 12, pp. 373. Date of Electronic Publication: 2012 Aug 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Loss of Heterozygosity*
Microsatellite Instability*
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Breast Neoplasms/*drug therapy
Breast Neoplasms/*genetics
Adult ; Aged ; Chi-Square Distribution ; DNA Mismatch Repair ; Female ; Humans ; Immunohistochemistry ; Middle Aged ; Prospective Studies
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Intracystic papillary carcinoma of breast harbors significant genomic alteration compared with intracystic papilloma: genome-wide copy number and LOH analysis using high-density single-nucleotide polymorphism microarrays.
Autorzy:
Oikawa M
Nagayasu T
Yano H
Hayashi T
Abe K
Kinoshita A
Yoshiura K
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Źródło:
The breast journal [Breast J] 2011 Jul-Aug; Vol. 17 (4), pp. 427-30. Date of Electronic Publication: 2011 Jun 09.
Typ publikacji:
Comparative Study; Letter
MeSH Terms:
Gene Dosage*
Loss of Heterozygosity*
Polymorphism, Single Nucleotide*
Breast Neoplasms/*genetics
Carcinoma, Papillary/*genetics
Adult ; Aged ; Female ; Genome-Wide Association Study ; Humans ; Middle Aged ; Oligonucleotide Array Sequence Analysis
Raport
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Integration of transcript expression, copy number and LOH analysis of infiltrating ductal carcinoma of the breast.
Autorzy:
Hawthorn L; Medical College of Georgia Cancer Center, 1120 15th St, Augusta, GA 30912, USA. />Luce J
Stein L
Rothschild J
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Źródło:
BMC cancer [BMC Cancer] 2010 Aug 27; Vol. 10, pp. 460. Date of Electronic Publication: 2010 Aug 27.
Typ publikacji:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Chromosome Aberrations*
Gene Dosage*
Gene Expression Profiling*
Loss of Heterozygosity*
Breast/*pathology
Breast Neoplasms/*genetics
Carcinoma, Ductal, Breast/*genetics
Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Breast/metabolism ; Breast Neoplasms/pathology ; Carcinoma, Ductal, Breast/pathology ; Case-Control Studies ; Comparative Genomic Hybridization ; DNA, Neoplasm ; Female ; Humans ; Lymphatic Metastasis ; Oligonucleotide Array Sequence Analysis ; RNA, Messenger/genetics ; Reverse Transcriptase Polymerase Chain Reaction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
LOH at 1p31 (ARHI) and proliferation in lymph node-negative breast cancer.
Autorzy:
Janssen EA; Department of Pathology, Stavanger University Hospital, Stavanger, Norway.
Øvestad IT
Skaland I
Søiland H
Gudlaugsson E
Kjellevold KH
Nysted A
Søreide JA
Baak JP
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Źródło:
Cellular oncology : the official journal of the International Society for Cellular Oncology [Cell Oncol] 2009; Vol. 31 (5), pp. 335-43.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell Proliferation*
Chromosomes, Human, Pair 1*
Loss of Heterozygosity*
Breast Neoplasms/*genetics
Breast Neoplasms/*pathology
rho GTP-Binding Proteins/*genetics
Adult ; Aged ; Aged, 80 and over ; Breast Neoplasms/metabolism ; Female ; Histones/metabolism ; Humans ; Lymphatic Metastasis ; Middle Aged ; Phosphorylation ; Prognosis ; Survival Rate
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas.
Autorzy:
Qiu W; VBCRC Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia.
Hu M
Sridhar A
Opeskin K
Fox S
Shipitsin M
Trivett M
Thompson ER
Ramakrishna M
Gorringe KL
Polyak K
Haviv I
Campbell IG
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Źródło:
Nature genetics [Nat Genet] 2008 May; Vol. 40 (5), pp. 650-5. Date of Electronic Publication: 2008 Apr 13.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Loss of Heterozygosity*
Breast Neoplasms/*genetics
Breast Neoplasms/*pathology
Carcinoma/*genetics
Carcinoma/*pathology
Fibroblasts/*pathology
Ovarian Neoplasms/*genetics
Ovarian Neoplasms/*pathology
Chromosomes, Human, Pair 22/genetics ; Clone Cells/pathology ; Female ; Genome, Human ; Humans ; Microdissection ; Mutation ; Oligonucleotide Array Sequence Analysis ; Polymorphism, Single Nucleotide ; Stromal Cells/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
ATBF1 and NQO1 as candidate targets for allelic loss at chromosome arm 16q in breast cancer: absence of somatic ATBF1 mutations and no role for the C609T NQO1 polymorphism.
Autorzy:
Cleton-Jansen AM; Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands. />van Eijk R
Lombaerts M
Schmidt MK
Van't Veer LJ
Philippo K
Zimmerman RM
Peterse JL
Smit VT
van Wezel T
Cornelisse CJ
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Źródło:
BMC cancer [BMC Cancer] 2008 Apr 16; Vol. 8, pp. 105. Date of Electronic Publication: 2008 Apr 16.
Typ publikacji:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Chromosomes, Human, Pair 16*
Loss of Heterozygosity*
Polymorphism, Genetic*
Breast Neoplasms/*genetics
Homeodomain Proteins/*genetics
NAD(P)H Dehydrogenase (Quinone)/*genetics
DNA Mutational Analysis ; DNA, Neoplasm/genetics ; Down-Regulation ; Genes, Tumor Suppressor ; Humans ; Mutation ; Oligonucleotide Array Sequence Analysis ; RNA, Messenger/genetics ; RNA, Neoplasm/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Analysing multiple types of molecular profiles simultaneously: connecting the needles in the haystack.
Autorzy:
Menezes RX; Department of Epidemiology and Biostatistics, VU University Medical Center, De Boelelaan 1089a, HV Amsterdam, 1081, The Netherlands. .
Mohammadi L; Department of Statistics, Shiraz University, Shiraz, Iran. .
Goeman JJ; Biostatistics, Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands. .; Medical Statistics and Bioinformatics, Leiden University Medical Center, Nijmegen, The Netherlands. .
Boer JM; Department of Pediatric Oncology and Hematology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands. .; Netherlands Bioinformatics Centre, Nijmegen, The Netherlands. .
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Źródło:
BMC bioinformatics [BMC Bioinformatics] 2016 Feb 09; Vol. 17, pp. 77. Date of Electronic Publication: 2016 Feb 09.
Typ publikacji:
Journal Article
MeSH Terms:
Gene Expression Regulation*
Gene Regulatory Networks*
Transcriptome*
Breast Neoplasms/*genetics
Colonic Neoplasms/*genetics
Computational Biology/*methods
Computer Simulation ; DNA Methylation ; Female ; Gene Dosage ; Genotype ; Humans ; Loss of Heterozygosity ; Polymorphism, Single Nucleotide
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Integrative analysis of a cancer somatic mutome.
Autorzy:
Hernández P; Bioinformatics and Biostatistics Unit, and Translational Research Laboratory, Catalan Institute of Oncology, IDIBELL, L'Hospitalet, Barcelona, Spain. />Solé X
Valls J
Moreno V
Capellá G
Urruticoechea A
Pujana MA
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Źródło:
Molecular cancer [Mol Cancer] 2007 Feb 05; Vol. 6, pp. 13. Date of Electronic Publication: 2007 Feb 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Dosage*
Gene Expression Regulation, Neoplastic*
Loss of Heterozygosity*
Breast Neoplasms/*genetics
Carcinoma, Ductal, Breast/*genetics
Breast Neoplasms/classification ; Breast Neoplasms/metabolism ; Cluster Analysis ; Humans ; Models, Genetic ; Mutation ; Neoplasm Proteins/genetics ; Neoplasms ; Oligonucleotide Array Sequence Analysis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Genomic profiling of CHEK2*1100delC-mutated breast carcinomas.
Autorzy:
Massink MP; Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands. .
Kooi IE; Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands. .
Martens JW; Department of Medical Oncology, Erasmus MC Cancer Institute, Cancer Genomics Netherlands, Erasmus University Medical Center, Rotterdam, The Netherlands. .
Waisfisz Q; Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands. .
Meijers-Heijboer H; Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands. .
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Źródło:
BMC cancer [BMC Cancer] 2015 Nov 09; Vol. 15, pp. 877. Date of Electronic Publication: 2015 Nov 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Genetic Predisposition to Disease*
Breast Neoplasms/*genetics
Checkpoint Kinase 2/*genetics
Aged ; BRCA1 Protein/genetics ; BRCA2 Protein/genetics ; Breast Neoplasms/pathology ; DNA Copy Number Variations ; Female ; Genomics ; Humans ; Loss of Heterozygosity/genetics ; Middle Aged ; Netherlands ; Sequence Deletion
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Genomic landscapes of breast fibroepithelial tumors.
Autorzy:
Tan J; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore.; Division of Cancer and Stem Cell Biology, Duke-National University of Singapore Graduate Medical School, Singapore.
Ong CK; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore.; Division of Cancer and Stem Cell Biology, Duke-National University of Singapore Graduate Medical School, Singapore.
Lim WK; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore.; Division of Cancer and Stem Cell Biology, Duke-National University of Singapore Graduate Medical School, Singapore.
Ng CC; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore.; Division of Cancer and Stem Cell Biology, Duke-National University of Singapore Graduate Medical School, Singapore.
Thike AA; Department of Pathology, Singapore General Hospital, Singapore.
Ng LM; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
Rajasegaran V; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore.; Division of Cancer and Stem Cell Biology, Duke-National University of Singapore Graduate Medical School, Singapore.
Myint SS; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore.; Division of Cancer and Stem Cell Biology, Duke-National University of Singapore Graduate Medical School, Singapore.
Nagarajan S; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore.; Division of Cancer and Stem Cell Biology, Duke-National University of Singapore Graduate Medical School, Singapore.
Thangaraju S; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore.; Division of Cancer and Stem Cell Biology, Duke-National University of Singapore Graduate Medical School, Singapore.
Dey S; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
Nasir ND; Department of Pathology, Singapore General Hospital, Singapore.
Wijaya GC; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore.; Division of Cancer and Stem Cell Biology, Duke-National University of Singapore Graduate Medical School, Singapore.
Lim JQ; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore.; Division of Cancer and Stem Cell Biology, Duke-National University of Singapore Graduate Medical School, Singapore.
Huang D; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore.; Division of Cancer and Stem Cell Biology, Duke-National University of Singapore Graduate Medical School, Singapore.
Li Z; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore.; Division of Cancer and Stem Cell Biology, Duke-National University of Singapore Graduate Medical School, Singapore.
Wong BH; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore.
Chan JY; Department of Medical Oncology, National Cancer Centre Singapore, Singapore.
McPherson JR; Division of Cancer and Stem Cell Biology, Duke-National University of Singapore Graduate Medical School, Singapore.
Cutcutache I; Division of Cancer and Stem Cell Biology, Duke-National University of Singapore Graduate Medical School, Singapore.
Poore G; Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA.
Tay ST; Division of Cancer and Stem Cell Biology, Duke-National University of Singapore Graduate Medical School, Singapore.
Tan WJ; Department of Pathology, Singapore General Hospital, Singapore.
Putti TC; Department of Pathology, National University of Singapore Yong Loo Lin School of Medicine, Singapore.
Ahmad BS; Department of Surgery, National University Hospital, Singapore.
Iau P; Department of Surgery, National University Hospital, Singapore.
Chan CW; Department of Surgery, National University Hospital, Singapore.
Tang AP; Department of Surgery, National University Hospital, Singapore.
Yong WS; Department of Surgical Oncology, National Cancer Center Singapore, Singapore.; Department of General Surgery, Singapore General Hospital, Singapore.; SingHealth Duke-National University of Singapore Breast Centre, Singapore.
Madhukumar P; Department of Surgical Oncology, National Cancer Center Singapore, Singapore.; Department of General Surgery, Singapore General Hospital, Singapore.; SingHealth Duke-National University of Singapore Breast Centre, Singapore.
Ho GH; Department of Surgical Oncology, National Cancer Center Singapore, Singapore.; Department of General Surgery, Singapore General Hospital, Singapore.; SingHealth Duke-National University of Singapore Breast Centre, Singapore.
Tan VK; Department of Surgical Oncology, National Cancer Center Singapore, Singapore.; Department of General Surgery, Singapore General Hospital, Singapore.; SingHealth Duke-National University of Singapore Breast Centre, Singapore.
Wong CY; Department of Surgical Oncology, National Cancer Center Singapore, Singapore.; Department of General Surgery, Singapore General Hospital, Singapore.; SingHealth Duke-National University of Singapore Breast Centre, Singapore.
Hartman M; Department of Surgery, National University Hospital, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore, Singapore.; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Ong KW; Department of Surgical Oncology, National Cancer Center Singapore, Singapore.; Department of General Surgery, Singapore General Hospital, Singapore.; SingHealth Duke-National University of Singapore Breast Centre, Singapore.
Tan BK; Department of Surgical Oncology, National Cancer Center Singapore, Singapore.; Department of General Surgery, Singapore General Hospital, Singapore.; SingHealth Duke-National University of Singapore Breast Centre, Singapore.
Rozen SG; Division of Cancer and Stem Cell Biology, Duke-National University of Singapore Graduate Medical School, Singapore.
Tan P; Division of Cancer and Stem Cell Biology, Duke-National University of Singapore Graduate Medical School, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore.; Genome Institute of Singapore, Singapore.
Tan PH; Department of Pathology, Singapore General Hospital, Singapore.
Teh BT; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore.; Division of Cancer and Stem Cell Biology, Duke-National University of Singapore Graduate Medical School, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore.; Institute of Molecular and Cellular Biology, Singapore.
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Źródło:
Nature genetics [Nat Genet] 2015 Nov; Vol. 47 (11), pp. 1341-5. Date of Electronic Publication: 2015 Oct 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Mutation*
Breast Neoplasms/*genetics
Fibroadenoma/*genetics
Genetic Predisposition to Disease/*genetics
Genome-Wide Association Study/*methods
Phyllodes Tumor/*genetics
Adolescent ; Adult ; Aged ; Base Sequence ; Breast Neoplasms/metabolism ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Exome/genetics ; Female ; Fibroadenoma/metabolism ; Filamins/genetics ; Filamins/metabolism ; HEK293 Cells ; High-Throughput Nucleotide Sequencing/methods ; Humans ; Immunohistochemistry ; Loss of Heterozygosity ; Mediator Complex/genetics ; Mediator Complex/metabolism ; Middle Aged ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Phyllodes Tumor/metabolism ; Receptors, Retinoic Acid/genetics ; Receptors, Retinoic Acid/metabolism ; Retinoic Acid Receptor alpha ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 95

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