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Tytuł :
Protective effect of hyperoside on heart failure rats via attenuating myocardial apoptosis and inducing autophagy.
Autorzy :
Guo X; Heart Center, Qingdao Fuwai Cardiovascular Hospital, Qingdao, People's Republic of China.
Zhang Y; Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, People's Republic of China.
Lu C; Heart Center, Qingdao Fuwai Cardiovascular Hospital, Qingdao, People's Republic of China.
Qu F; Heart Center, Qingdao Fuwai Cardiovascular Hospital, Qingdao, People's Republic of China.
Jiang X; Heart Center, Qingdao Fuwai Cardiovascular Hospital, Qingdao, People's Republic of China.
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Źródło :
Bioscience, biotechnology, and biochemistry [Biosci Biotechnol Biochem] 2020 Apr; Vol. 84 (4), pp. 714-724. Date of Electronic Publication: 2019 Dec 04.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Autophagy/*drug effects
Cardiotonic Agents/*pharmacology
Heart Failure/*prevention & control
Myocardium/*pathology
Quercetin/*analogs & derivatives
Angiotensin II/pharmacology ; Animals ; Cells, Cultured ; Male ; Quercetin/pharmacology ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
ROS-mediated miR-21-5p regulates the proliferation and apoptosis of Cr(VI)-exposed L02 hepatocytes via targeting PDCD4.
Autorzy :
Zhang Y; School of Medicine, Hunan Normal University, Changsha, 410081, PR China; Department of Health Toxicology, Xiangya School of Public Health, Central South University, Changsha, 410078, PR China.
Xiao Y; Department of Health Toxicology, Xiangya School of Public Health, Central South University, Changsha, 410078, PR China.
Ma Y; Department of Health Toxicology, Xiangya School of Public Health, Central South University, Changsha, 410078, PR China.
Liang N; Department of Health Toxicology, Xiangya School of Public Health, Central South University, Changsha, 410078, PR China.
Liang Y; Department of Health Toxicology, Xiangya School of Public Health, Central South University, Changsha, 410078, PR China.
Lu C; Department of Health Toxicology, Xiangya School of Public Health, Central South University, Changsha, 410078, PR China.
Xiao F; Department of Health Toxicology, Xiangya School of Public Health, Central South University, Changsha, 410078, PR China. Electronic address: .
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Źródło :
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2020 Mar 15; Vol. 191, pp. 110160. Date of Electronic Publication: 2020 Jan 15.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Apoptosis Regulatory Proteins/*genetics
Cell Proliferation/*drug effects
Chromium/*toxicity
Hepatocytes/*drug effects
MicroRNAs/*genetics
RNA-Binding Proteins/*genetics
Reactive Oxygen Species/*metabolism
Apoptosis/genetics ; Cell Proliferation/genetics ; Gene Expression Regulation/drug effects ; Hepatocytes/metabolism ; Humans ; Mitochondria/metabolism ; Up-Regulation
Czasopismo naukowe
Tytuł :
(+)-Usnic Acid Induces ROS-dependent Apoptosis via Inhibition of Mitochondria Respiratory Chain Complexes and Nrf2 Expression in Lung Squamous Cell Carcinoma.
Autorzy :
Qi W; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.; Guangzhou Key Laboratory of Construction and Application of New Drug Screening Model Systems, Guangdong Pharmaceutical University, Guangzhou 510006, China.; Key Laboratory of New Drug Discovery and Evaluation of ordinary universities of Guangdong province, Guangdong Pharmaceutical University, Guangzhou 510006, China.; Guangdong Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Lu C; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.; Guangzhou Key Laboratory of Construction and Application of New Drug Screening Model Systems, Guangdong Pharmaceutical University, Guangzhou 510006, China.; Key Laboratory of New Drug Discovery and Evaluation of ordinary universities of Guangdong province, Guangdong Pharmaceutical University, Guangzhou 510006, China.; Guangdong Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Huang H; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.; Guangzhou Key Laboratory of Construction and Application of New Drug Screening Model Systems, Guangdong Pharmaceutical University, Guangzhou 510006, China.; Key Laboratory of New Drug Discovery and Evaluation of ordinary universities of Guangdong province, Guangdong Pharmaceutical University, Guangzhou 510006, China.; Guangdong Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Zhang W; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.; Guangzhou Key Laboratory of Construction and Application of New Drug Screening Model Systems, Guangdong Pharmaceutical University, Guangzhou 510006, China.; Key Laboratory of New Drug Discovery and Evaluation of ordinary universities of Guangdong province, Guangdong Pharmaceutical University, Guangzhou 510006, China.; Guangdong Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Song S; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Liu B; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.; Guangzhou Key Laboratory of Construction and Application of New Drug Screening Model Systems, Guangdong Pharmaceutical University, Guangzhou 510006, China.; Key Laboratory of New Drug Discovery and Evaluation of ordinary universities of Guangdong province, Guangdong Pharmaceutical University, Guangzhou 510006, China.; Guangdong Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou 510006, China.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Jan 29; Vol. 21 (3). Date of Electronic Publication: 2020 Jan 29.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Benzofurans/*pharmacology
Electron Transport Chain Complex Proteins/*metabolism
Mitochondria/*drug effects
NF-E2-Related Factor 2/*metabolism
Reactive Oxygen Species/*metabolism
Animals ; Antineoplastic Agents, Phytogenic/pharmacology ; Benzofurans/chemistry ; Benzofurans/therapeutic use ; Carcinoma, Squamous Cell/drug therapy ; Carcinoma, Squamous Cell/metabolism ; Carcinoma, Squamous Cell/pathology ; Cell Line, Tumor ; Electron Transport Chain Complex Proteins/antagonists & inhibitors ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Mice ; Mitochondria/metabolism ; NF-E2-Related Factor 2/antagonists & inhibitors ; Paclitaxel/pharmacology ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction/drug effects ; Transplantation, Heterologous
Czasopismo naukowe
Tytuł :
Sesamin suppresses NSCLC cell proliferation and induces apoptosis via Akt/p53 pathway.
Autorzy :
Chen Y; Department of Clinical Pharmacy, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangzhou key laboratory of construction and application of new drug screening model systems, Guangdong Pharmaceutical University, Guangzhou 510006, China; Key Laboratory of New Drug Discovery and Evaluation of ordinary universities of Guangdong province, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Li H; Department of Clinical Pharmacy, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangzhou key laboratory of construction and application of new drug screening model systems, Guangdong Pharmaceutical University, Guangzhou 510006, China; Key Laboratory of New Drug Discovery and Evaluation of ordinary universities of Guangdong province, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Zhang W; Department of Clinical Pharmacy, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangzhou key laboratory of construction and application of new drug screening model systems, Guangdong Pharmaceutical University, Guangzhou 510006, China; Key Laboratory of New Drug Discovery and Evaluation of ordinary universities of Guangdong province, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Qi W; Department of Clinical Pharmacy, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangzhou key laboratory of construction and application of new drug screening model systems, Guangdong Pharmaceutical University, Guangzhou 510006, China; Key Laboratory of New Drug Discovery and Evaluation of ordinary universities of Guangdong province, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Lu C; Department of Clinical Pharmacy, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangzhou key laboratory of construction and application of new drug screening model systems, Guangdong Pharmaceutical University, Guangzhou 510006, China; Key Laboratory of New Drug Discovery and Evaluation of ordinary universities of Guangdong province, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Huang H; Department of Clinical Pharmacy, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangzhou key laboratory of construction and application of new drug screening model systems, Guangdong Pharmaceutical University, Guangzhou 510006, China; Key Laboratory of New Drug Discovery and Evaluation of ordinary universities of Guangdong province, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Yang Z; Department of Clinical Pharmacy, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangzhou key laboratory of construction and application of new drug screening model systems, Guangdong Pharmaceutical University, Guangzhou 510006, China; Key Laboratory of New Drug Discovery and Evaluation of ordinary universities of Guangdong province, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Liu B; Department of Clinical Pharmacy, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangzhou key laboratory of construction and application of new drug screening model systems, Guangdong Pharmaceutical University, Guangzhou 510006, China; Key Laboratory of New Drug Discovery and Evaluation of ordinary universities of Guangdong province, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangdong Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou 510006, China. Electronic address: .
Zhang L; Guangzhou key laboratory of construction and application of new drug screening model systems, Guangdong Pharmaceutical University, Guangzhou 510006, China; Key Laboratory of New Drug Discovery and Evaluation of ordinary universities of Guangdong province, Guangdong Pharmaceutical University, Guangzhou 510006, China; The Center for Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou 510006, China. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2020 Jan 15; Vol. 387, pp. 114848. Date of Electronic Publication: 2019 Dec 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*drug effects
Carcinoma, Non-Small-Cell Lung/*drug therapy
Dioxoles/*pharmacology
Lignans/*pharmacology
Lung Neoplasms/*drug therapy
Signal Transduction/*drug effects
Animals ; Benzothiazoles/pharmacology ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Chromones/pharmacology ; Dioxoles/therapeutic use ; Female ; G1 Phase Cell Cycle Checkpoints/drug effects ; Humans ; Lignans/therapeutic use ; Lung Neoplasms/pathology ; Mice ; Morpholines/pharmacology ; Proto-Oncogene Proteins c-akt/antagonists & inhibitors ; Proto-Oncogene Proteins c-akt/metabolism ; Toluene/analogs & derivatives ; Toluene/pharmacology ; Tumor Suppressor Protein p53/antagonists & inhibitors ; Tumor Suppressor Protein p53/metabolism ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
LncRNA PART-1 targets TGFBR2/Smad3 to regulate cell viability and apoptosis of chondrocytes via acting as miR-590-3p sponge in osteoarthritis.
Autorzy :
Lu C; Department of Joint Surgery, Xi'an Honghui Hospital, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Li Z; Department of Emergency, the First Affiliated Hospital of Xi'an Medical University, Xi'an, China.
Hu S; Department of Joint Surgery, Xi'an Honghui Hospital, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Cai Y; Department of Joint Surgery, Xi'an Honghui Hospital, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Peng K; Department of Joint Surgery, Xi'an Honghui Hospital, Xi'an Jiaotong University Health Science Center, Xi'an, China.
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Źródło :
Journal of cellular and molecular medicine [J Cell Mol Med] 2019 Dec; Vol. 23 (12), pp. 8196-8205. Date of Electronic Publication: 2019 Oct 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*genetics
Chondrocytes/*metabolism
MicroRNAs/*genetics
Osteoarthritis/*genetics
RNA, Long Noncoding/*genetics
Receptor, Transforming Growth Factor-beta Type II/*genetics
Smad3 Protein/*genetics
Cell Line ; Cell Survival/genetics ; Chondrocytes/cytology ; Gene Expression Regulation ; Humans ; Osteoarthritis/metabolism ; Osteoarthritis/pathology ; RNA Interference ; RNA, Untranslated/genetics ; Receptor, Transforming Growth Factor-beta Type II/metabolism ; Signal Transduction/genetics ; Smad3 Protein/metabolism
Czasopismo naukowe
Tytuł :
Immunomodulatory Protein from Nectria haematococca Induces Apoptosis in Lung Cancer Cells via the P53 Pathway.
Autorzy :
Wang JJ; Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, No. 2 Yuan Ming Yuan West Road, Beijing 100193, China. .
Wang Y; Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, No. 2 Yuan Ming Yuan West Road, Beijing 100193, China. .
Hou L; Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, No. 2 Yuan Ming Yuan West Road, Beijing 100193, China. .
Xin F; Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, No. 2 Yuan Ming Yuan West Road, Beijing 100193, China. .
Fan B; Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, No. 2 Yuan Ming Yuan West Road, Beijing 100193, China. .
Lu C; Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, No. 2 Yuan Ming Yuan West Road, Beijing 100193, China. .
Zhang L; Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, No. 2 Yuan Ming Yuan West Road, Beijing 100193, China. .
Wang F; Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, No. 2 Yuan Ming Yuan West Road, Beijing 100193, China. .
Li S; Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, No. 2 Yuan Ming Yuan West Road, Beijing 100193, China. .
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2019 Oct 28; Vol. 20 (21). Date of Electronic Publication: 2019 Oct 28.
Typ publikacji :
Journal Article
MeSH Terms :
Nectria*
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Fungal Proteins/*pharmacology
Lung Neoplasms/*drug therapy
Lung Neoplasms/*metabolism
Tumor Suppressor Protein p53/*metabolism
A549 Cells ; Antineoplastic Agents/therapeutic use ; Biosynthetic Pathways ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Fungal Proteins/metabolism ; Fungal Proteins/therapeutic use ; HEK293 Cells ; Humans ; Phosphatidylinositol 3-Kinases/metabolism ; Proteomics ; Signal Transduction/drug effects ; Tumor Suppressor Protein p53/genetics
Czasopismo naukowe
Tytuł :
LncRNA TTN-AS1 regulates osteosarcoma cell apoptosis and drug resistance via the miR-134-5p/MBTD1 axis.
Autorzy :
Fu D; Children's Hospital of Shanghai, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Lu C; Department of Spinal Surgery, Changhai Hospital, Affiliated to Naval Military Medical University, Shanghai, China.
Qu X; The Department of Oral Maxillofacial and Head Neck Oncology in the Ninth Hospital Affiliated Shanghai Jiaotong University, Shanghai, China.
Li P; Children's Hospital of Shanghai, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Chen K; Hai'an People's Hospital, Hai'an, Nantong, Jiangsu, China.
Shan L; Department of Orthopedics, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhu X; Department of Orthopedics, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
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Źródło :
Aging [Aging (Albany NY)] 2019 Oct 10; Vol. 11 (19), pp. 8374-8385. Date of Electronic Publication: 2019 Oct 10.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*/drug effects
Apoptosis*/genetics
Osteosarcoma*/genetics
Osteosarcoma*/metabolism
Aging/*physiology
Chromosomal Proteins, Non-Histone/*genetics
MicroRNAs/*genetics
RNA, Long Noncoding/*genetics
Brain Neoplasms/genetics ; Brain Neoplasms/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Computational Biology ; Drug Resistance/genetics ; Gene Expression Regulation, Neoplastic ; Humans
Czasopismo naukowe
Tytuł :
Dracorhodin perchlorate induces apoptosis and G2/M cell cycle arrest in human esophageal squamous cell carcinoma through inhibition of the JAK2/STAT3 and AKT/FOXO3a pathways.
Autorzy :
Lu Z; Department of General Surgery, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China.
Lu C; Department of Respiratory Medicine, Third Hospital of Xi'an, Xi'an, Shaanxi 710082, P.R. China.
Li C; Department of Cardiovascular Medicine, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
Jiao Y; Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
Li Y; Department of Pathophysiology, College of Basic Medical Sciences, Jilin University, Changchun, Jilin 130021, P.R. China.
Zhang G; Department of Thoracic Surgery, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China.
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Źródło :
Molecular medicine reports [Mol Med Rep] 2019 Sep; Vol. 20 (3), pp. 2091-2100. Date of Electronic Publication: 2019 Jul 08.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Benzopyrans/*pharmacology
Esophageal Neoplasms/*drug therapy
Esophageal Squamous Cell Carcinoma/*drug therapy
Signal Transduction/*drug effects
Cell Line ; Cell Line, Tumor ; Esophageal Neoplasms/metabolism ; Esophageal Squamous Cell Carcinoma/metabolism ; Forkhead Box Protein O3/metabolism ; G2 Phase Cell Cycle Checkpoints/drug effects ; Humans ; Janus Kinase 2/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; STAT3 Transcription Factor/metabolism
Czasopismo naukowe
Tytuł :
Suppression of lncRNA RMRP ameliorates oxygen-glucose deprivation/re-oxygenation-induced neural cells injury by inhibiting autophagy and PI3K/Akt/mTOR-mediated apoptosis.
Autorzy :
Zhou Z; Department of Neurology, GuangDong Province Hospital Of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China.; Department of Neurology, Liuzhou Traditional Chinese Medical Hospital, The Third Affiliated Hospital of Guangxi University of Chinese Medicine, Liuzhou, China.
Xu H; Department of Neurology, Liuzhou Traditional Chinese Medical Hospital, The Third Affiliated Hospital of Guangxi University of Chinese Medicine, Liuzhou, China.
Liu B; Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Dun L; Department of Neurology, Liuzhou Traditional Chinese Medical Hospital, The Third Affiliated Hospital of Guangxi University of Chinese Medicine, Liuzhou, China.
Lu C; Department of Neurology, Liuzhou Traditional Chinese Medical Hospital, The Third Affiliated Hospital of Guangxi University of Chinese Medicine, Liuzhou, China.
Cai Y; Department of Neurology, GuangDong Province Hospital Of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China .
Wang H; Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China .
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Źródło :
Bioscience reports [Biosci Rep] 2019 Jun 25; Vol. 39 (6). Date of Electronic Publication: 2019 Jun 25 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*genetics
Autophagy/*genetics
RNA, Long Noncoding/*genetics
Reperfusion Injury/*genetics
Cell Cycle Checkpoints/genetics ; Cell Proliferation/genetics ; Gene Expression Regulation/genetics ; Gene Knockdown Techniques ; Glucose/metabolism ; Humans ; Neurons/metabolism ; Neurons/pathology ; Oxygen/metabolism ; Phosphatidylinositol 3-Kinases/genetics ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-bcl-2/genetics ; RNA, Long Noncoding/antagonists & inhibitors ; RNA, Small Interfering/genetics ; RNA-Binding Proteins/genetics ; Reperfusion Injury/metabolism ; Reperfusion Injury/pathology ; Signal Transduction ; TOR Serine-Threonine Kinases/genetics
Czasopismo naukowe
Tytuł :
Mechanisms underlying nickel nanoparticle induced reproductive toxicity and chemo-protective effects of vitamin C in male rats.
Autorzy :
Kong L; Key Laboratory of Environmental Medicine and Engineering, Ministry of Education; School of Public Health & Collaborative Innovation Center of Suzhou Nano Science and Technology, Southeast University, Nanjing 210009, PR China.
Hu W; Key Laboratory of Environmental Medicine and Engineering, Ministry of Education; School of Public Health & Collaborative Innovation Center of Suzhou Nano Science and Technology, Southeast University, Nanjing 210009, PR China.
Lu C; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 211166, PR China.
Cheng K; Zhongda Hospital, Southeast University, Nanjing 210009, Jiangsu, PR China. Electronic address: .
Tang M; Key Laboratory of Environmental Medicine and Engineering, Ministry of Education; School of Public Health & Collaborative Innovation Center of Suzhou Nano Science and Technology, Southeast University, Nanjing 210009, PR China. Electronic address: .
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Źródło :
Chemosphere [Chemosphere] 2019 Mar; Vol. 218, pp. 259-265. Date of Electronic Publication: 2018 Nov 20.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Ascorbic Acid/*pharmacology
Nanoparticles/*chemistry
Nickel/*toxicity
Reproduction/*drug effects
Animals ; Antioxidants/pharmacology ; Caspases/metabolism ; Drug Antagonism ; Male ; Nanoparticles/toxicity ; Oxidants/pharmacology ; Oxidative Stress/drug effects ; Rats ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł :
Testosterone induces renal tubular epithelial cell death through the HIF-1α/BNIP3 pathway.
Autorzy :
Peng Y; Department of Urology, Shanghai Changhai Hospital, Shanghai, 200433, China.
Fang Z; Department of Urology, Shanghai Changhai Hospital, Shanghai, 200433, China.
Liu M; Department of Urology, Shanghai Changhai Hospital, Shanghai, 200433, China.
Wang Z; Department of Urology, Shanghai Changhai Hospital, Shanghai, 200433, China.
Li L; Department of Urology, Shanghai Changhai Hospital, Shanghai, 200433, China.
Ming S; Department of Urology, Shanghai Changhai Hospital, Shanghai, 200433, China.
Lu C; Department of Urology, Shanghai Changhai Hospital, Shanghai, 200433, China.
Dong H; Department of Urology, Shanghai Changhai Hospital, Shanghai, 200433, China.
Zhang W; Department of Urology, Shanghai Changhai Hospital, Shanghai, 200433, China.
Wang Q; Department of Urology, Shanghai Changhai Hospital, Shanghai, 200433, China.
Shen R; Department of Urology, Shanghai Changhai Hospital, Shanghai, 200433, China.
Xie F; Department of Urology, Shanghai Changhai Hospital, Shanghai, 200433, China.
Zhang W; Department of Urology, Zhongshan Hospital, Fudan University; Shanghai Key Laboratory of Organ Transplantation, 180 Fenglin Road, Shanghai, 200032, China.
Yang C; Department of Urology, Zhongshan Hospital, Fudan University; Shanghai Key Laboratory of Organ Transplantation, 180 Fenglin Road, Shanghai, 200032, China. .; Zhangjiang Institute of Fudan University, Shanghai, 201203, China. .
Gao X; Department of Urology, Shanghai Changhai Hospital, Shanghai, 200433, China. .
Sun Y; Department of Urology, Shanghai Changhai Hospital, Shanghai, 200433, China. .
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Źródło :
Journal of translational medicine [J Transl Med] 2019 Feb 28; Vol. 17 (1), pp. 62. Date of Electronic Publication: 2019 Feb 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Epithelial Cells/*metabolism
Epithelial Cells/*pathology
Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism
Kidney Tubules/*pathology
Membrane Proteins/*metabolism
Mitochondrial Proteins/*metabolism
Proto-Oncogene Proteins/*metabolism
Testosterone/*metabolism
Adult ; Animals ; Base Sequence ; Caspases/metabolism ; Cell Line ; Female ; Healthy Volunteers ; Humans ; Kidney Calculi/blood ; Kidney Calculi/pathology ; Male ; Membrane Proteins/genetics ; Mice ; Mice, Inbred BALB C ; Middle Aged ; Mitochondria/metabolism ; Mitochondrial Proteins/genetics ; Necrosis ; Promoter Regions, Genetic/genetics ; Protein Binding ; Proto-Oncogene Proteins/genetics ; Receptors, Androgen/metabolism ; Signal Transduction ; Testosterone/blood
Czasopismo naukowe
Tytuł :
Aberrant expression of hsa_circ_0025036 in lung adenocarcinoma and its potential roles in regulating cell proliferation and apoptosis.
Autorzy :
Wu S; Department of Respiratory Medicine, The First Affiliated Hospital of Zhengzhou University, No. 1, Jianshe East Road, Zhengzhou, Henan 450052, P.R.China.
Li H; Department of Respiratory Medicine, The First Affiliated Hospital of Zhengzhou University, No. 1, Jianshe East Road, Zhengzhou, Henan 450052, P.R.China.
Lu C; Department of Respiratory Medicine, The First Affiliated Hospital of Zhengzhou University, No. 1, Jianshe East Road, Zhengzhou, Henan 450052, P.R.China.
Zhang F; Department of Respiratory Medicine, The First Affiliated Hospital of Zhengzhou University, No. 1, Jianshe East Road, Zhengzhou, Henan 450052, P.R.China.
Wang H; Department of Respiratory Medicine, The First Affiliated Hospital of Zhengzhou University, No. 1, Jianshe East Road, Zhengzhou, Henan 450052, P.R.China.
Lu X; Department of Respiratory Medicine, The First Affiliated Hospital of Zhengzhou University, No. 1, Jianshe East Road, Zhengzhou, Henan 450052, P.R.China.
Zhang G; Department of Respiratory Medicine, The First Affiliated Hospital of Zhengzhou University, No. 1, Jianshe East Road, Zhengzhou, Henan 450052, P.R.China.
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Źródło :
Biological chemistry [Biol Chem] 2018 Nov 27; Vol. 399 (12), pp. 1457-1467.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenocarcinoma of Lung/*metabolism
Apoptosis/*genetics
Lung Neoplasms/*metabolism
RNA/*metabolism
Adenocarcinoma of Lung/pathology ; Cell Proliferation/genetics ; Computational Biology ; Female ; Humans ; Lung Neoplasms/pathology ; Male ; MicroRNAs/pharmacology ; Middle Aged ; RNA/antagonists & inhibitors ; RNA/genetics ; RNA, Circular ; Reverse Transcriptase Polymerase Chain Reaction
Czasopismo naukowe
Tytuł :
Immunomodulatory drugs downregulate IKZF1 leading to expansion of hematopoietic progenitors with concomitant block of megakaryocytic maturation.
Autorzy :
Liu A; Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh School of Medicine and Cancer Institute, PA, USA.
Li S; Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh School of Medicine and Cancer Institute, PA, USA.; Division of Hematology/Oncology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Donnenberg V; Department of Surgery and Pharmaceutical Sciences, University of Pittsburgh School of Medicine and Cancer Institute, PA, USA.
Fu J; Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh School of Medicine and Cancer Institute, PA, USA.; Division of Hematology/Oncology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Gollin SM; Department of Human Genetics, University of Pittsburgh Graduate School of Public Health and Cancer Institute, and the University of Pittsburgh Cell Culture and Cytogenetics Facility, PA, USA.
Ma H; Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh School of Medicine and Cancer Institute, PA, USA.; Columbia Center for Translational Immunology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Lu C; Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh School of Medicine and Cancer Institute, PA, USA.; Columbia Center for Translational Immunology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Stolz DB; Department of Cell Biology and Physiology, University of Pittsburgh, PA, USA.
Mapara MY; Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh School of Medicine and Cancer Institute, PA, USA.; Division of Hematology/Oncology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Columbia Center for Translational Immunology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Monaghan SA; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Lentzsch S; Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh School of Medicine and Cancer Institute, PA, USA .; Division of Hematology/Oncology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
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Źródło :
Haematologica [Haematologica] 2018 Oct; Vol. 103 (10), pp. 1688-1697. Date of Electronic Publication: 2018 Jun 28.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Apoptosis/*drug effects
Down-Regulation/*drug effects
Hematopoietic Stem Cells/*metabolism
Ikaros Transcription Factor/*biosynthesis
Immunologic Factors/*pharmacology
Megakaryocytes/*metabolism
Female ; Hematopoietic Stem Cells/cytology ; Humans ; Male ; Megakaryocytes/cytology
Czasopismo naukowe
Tytuł :
Ischemia-reperfusion induces death receptor-independent necroptosis via calpain-STAT3 activation in a lung transplant setting.
Autorzy :
Kim H; Latner Thoracic Surgery Research Laboratories, Toronto General Hospital Research Institute, University Health Network , Toronto, Ontario , Canada.; Department of Physiology, Faculty of Medicine, University of Toronto , Toronto, Ontario , Canada.
Zamel R; Latner Thoracic Surgery Research Laboratories, Toronto General Hospital Research Institute, University Health Network , Toronto, Ontario , Canada.
Bai XH; Latner Thoracic Surgery Research Laboratories, Toronto General Hospital Research Institute, University Health Network , Toronto, Ontario , Canada.
Lu C; Latner Thoracic Surgery Research Laboratories, Toronto General Hospital Research Institute, University Health Network , Toronto, Ontario , Canada.
Keshavjee S; Latner Thoracic Surgery Research Laboratories, Toronto General Hospital Research Institute, University Health Network , Toronto, Ontario , Canada.
Keshavjee S; Latner Thoracic Surgery Research Laboratories, Toronto General Hospital Research Institute, University Health Network , Toronto, Ontario , Canada.; Institute of Medical Science, Faculty of Medicine, University of Toronto , Toronto, Ontario , Canada.; Department of Surgery, Faculty of Medicine, University of Toronto , Toronto, Ontario , Canada.
Liu M; Latner Thoracic Surgery Research Laboratories, Toronto General Hospital Research Institute, University Health Network , Toronto, Ontario , Canada.; Department of Physiology, Faculty of Medicine, University of Toronto , Toronto, Ontario , Canada.; Institute of Medical Science, Faculty of Medicine, University of Toronto , Toronto, Ontario , Canada.; Department of Surgery, Faculty of Medicine, University of Toronto , Toronto, Ontario , Canada.
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Źródło :
American journal of physiology. Lung cellular and molecular physiology 2018 Oct 01; Vol. 315 (4), pp. L595-L608. Date of Electronic Publication: 2018 Jul 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Necrosis*
Calpain/*metabolism
Lung Transplantation/*adverse effects
Receptor-Interacting Protein Serine-Threonine Kinases/*metabolism
Reperfusion Injury/*pathology
STAT3 Transcription Factor/*metabolism
Cells, Cultured ; Humans ; Imidazoles/metabolism ; Indoles/metabolism ; Leupeptins/metabolism ; Phosphorylation ; Primary Graft Dysfunction/etiology ; Primary Graft Dysfunction/metabolism ; Primary Graft Dysfunction/pathology ; Receptors, Death Domain/metabolism ; Reperfusion Injury/etiology ; Reperfusion Injury/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Alteration of Tumor Metabolism by CD4+ T Cells Leads to TNF-α-Dependent Intensification of Oxidative Stress and Tumor Cell Death.
Autorzy :
Habtetsion T; Georgia Cancer Center, Medical College of Georgia, Augusta University, 1120 15(th) Street, CN-4140, Augusta, GA 30912, USA.
Ding ZC; Georgia Cancer Center, Medical College of Georgia, Augusta University, 1120 15(th) Street, CN-4140, Augusta, GA 30912, USA.
Pi W; Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Li T; Department of Oncology and Surgery, General Hospital of Ningxia Medical University, 804 Shengli Road, Yinchuan, Ningxia Province 750004, PR China.
Lu C; Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Chen T; Georgia Cancer Center, Medical College of Georgia, Augusta University, 1120 15(th) Street, CN-4140, Augusta, GA 30912, USA.
Xi C; Georgia Cancer Center, Medical College of Georgia, Augusta University, 1120 15(th) Street, CN-4140, Augusta, GA 30912, USA; Molecular Chaperone Biology, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Spartz H; Department of Pathology, Section of Anatomic Pathology, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Liu K; Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Hao Z; Georgia Cancer Center, Medical College of Georgia, Augusta University, 1120 15(th) Street, CN-4140, Augusta, GA 30912, USA; Department of Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Mivechi N; Georgia Cancer Center, Medical College of Georgia, Augusta University, 1120 15(th) Street, CN-4140, Augusta, GA 30912, USA; Molecular Chaperone Biology, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Huo Y; Vascular Biology Center, Department of Cellular Biology and Anatomy, Augusta University, Augusta, GA, USA.
Blazar BR; Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN, USA.
Munn DH; Georgia Cancer Center, Medical College of Georgia, Augusta University, 1120 15(th) Street, CN-4140, Augusta, GA 30912, USA.
Zhou G; Georgia Cancer Center, Medical College of Georgia, Augusta University, 1120 15(th) Street, CN-4140, Augusta, GA 30912, USA; Department of Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA. Electronic address: .
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Źródło :
Cell metabolism [Cell Metab] 2018 Aug 07; Vol. 28 (2), pp. 228-242.e6. Date of Electronic Publication: 2018 Jun 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Colorectal Neoplasms*/drug therapy
Colorectal Neoplasms*/metabolism
Apoptosis/*drug effects
CD4-Positive T-Lymphocytes/*physiology
Immunotherapy, Adoptive/*methods
Oxidative Stress/*drug effects
Tumor Necrosis Factor-alpha/*metabolism
Animals ; Cell Line, Tumor ; Glutathione/metabolism ; Mice ; Mice, Inbred BALB C ; NADPH Oxidases/metabolism ; Reactive Oxygen Species/metabolism ; Signal Transduction/drug effects ; Xenograft Model Antitumor Assays/methods
Czasopismo naukowe
Tytuł :
Deacetylmycoepoxydiene is an agonist of Rac1, and simultaneously induces autophagy and apoptosis.
Autorzy :
Xie W; Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan, Shandong, 250120, People's Republic of China.; Institute of Biomedical Sciences, College of Life Sciences, Key Laboratory of Animal Resistance Biology of Shandong Province, Key Laboratory of Molecular and Nano Probes of the Ministry of Education, Shandong Normal University, No. 88 East Wenhua Road, Jinan, Shandong, 250014, People's Republic of China.
Zhang W; Key Laboratory of Biofuels, Shandong Provincial Key Laboratory of Energy Genetics, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, No. 189 Songling Road, Qingdao, Shandong, 266101, People's Republic of China.
Sun M; Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan, Shandong, 250120, People's Republic of China.
Lu C; Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan, Shandong, 250120, People's Republic of China.
Shen Y; Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan, Shandong, 250120, People's Republic of China. .; State Key Laboratory of Microbial Technology, Shandong University, Jinan, Shandong, 250100, People's Republic of China. .
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Źródło :
Applied microbiology and biotechnology [Appl Microbiol Biotechnol] 2018 Jul; Vol. 102 (14), pp. 5965-5975. Date of Electronic Publication: 2018 May 09.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Autophagy/*drug effects
Bridged Bicyclo Compounds, Heterocyclic/*pharmacology
Pyrones/*pharmacology
rac1 GTP-Binding Protein/*agonists
Carcinoma, Non-Small-Cell Lung/drug therapy ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Drug Delivery Systems ; Humans ; Inhibitory Concentration 50 ; Reactive Oxygen Species/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Renal denervation improves cardiac function by attenuating myocardiocyte apoptosis in dogs after myocardial infarction.
Autorzy :
Wang L; First Center Clinic College of Tianjin Medical University, Tianjin First Center Hospital, 24 Fukang Road, Nankai District, Tianjin, 300192, China.; Department of Cardiology, Tianjin First Center Hospital, Tianjin, China.
Song L; Department of Digestion, Tianjin First Center Hospital, Tianjin, China.
Li C; Department of Cardiology, Tianjin First Center Hospital, Tianjin, China.
Feng Q; First Center Clinic College of Tianjin Medical University, Tianjin First Center Hospital, 24 Fukang Road, Nankai District, Tianjin, 300192, China.
Xu M; First Center Clinic College of Tianjin Medical University, Tianjin First Center Hospital, 24 Fukang Road, Nankai District, Tianjin, 300192, China.
Li Z; First Center Clinic College of Tianjin Medical University, Tianjin First Center Hospital, 24 Fukang Road, Nankai District, Tianjin, 300192, China.
Lu C; Department of Cardiology, Tianjin First Center Hospital, Tianjin, China. .
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Źródło :
BMC cardiovascular disorders [BMC Cardiovasc Disord] 2018 May 08; Vol. 18 (1), pp. 86. Date of Electronic Publication: 2018 May 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Ventricular Function, Left*
Autonomic Denervation/*methods
Heart Failure/*surgery
Kidney/*blood supply
Myocardial Infarction/*surgery
Myocytes, Cardiac/*pathology
Renal Artery/*innervation
Animals ; Apoptosis Regulatory Proteins/genetics ; Apoptosis Regulatory Proteins/metabolism ; Creatinine/blood ; Disease Models, Animal ; Dogs ; Endoplasmic Reticulum Stress ; Female ; Fibrosis ; Heart Failure/metabolism ; Heart Failure/pathology ; Heart Failure/physiopathology ; Male ; Matrix Metalloproteinase 2/metabolism ; Matrix Metalloproteinase 9/metabolism ; Myocardial Infarction/metabolism ; Myocardial Infarction/pathology ; Myocardial Infarction/physiopathology ; Myocytes, Cardiac/metabolism ; Natriuretic Peptide, Brain/blood ; Peptide Fragments/blood ; Recovery of Function ; Stroke Volume ; Ventricular Pressure
Czasopismo naukowe
Tytuł :
Contrasting roles of H3K4me3 and H3K9me3 in regulation of apoptosis and gemcitabine resistance in human pancreatic cancer cells.
Autorzy :
Lu C; Department of Biochemistry and Molecular Biology, Medical College of Georgia, 1410 Laney Walker Blvd, Augusta, GA, 30912, USA. .; Georgia Cancer Center, Medical College of Georgia, Augusta, GA, 30912, USA. .; Charlie Norwood VA Medical Center, Augusta, GA, 30904, USA. .
Yang D; Department of Biochemistry and Molecular Biology, Medical College of Georgia, 1410 Laney Walker Blvd, Augusta, GA, 30912, USA.; Georgia Cancer Center, Medical College of Georgia, Augusta, GA, 30912, USA.; Charlie Norwood VA Medical Center, Augusta, GA, 30904, USA.
Sabbatini ME; Department of Biological Sciences, Augusta University, Augusta, GA, 30904, USA.
Colby AH; Ionic Pharmaceuticals, Brookline, MA, 02445, USA.; Department of Biomedical Engineering, Boston University, Boston, MA, 02215, USA.
Grinstaff MW; Department of Biomedical Engineering, Boston University, Boston, MA, 02215, USA.
Oberlies NH; Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC, 27402, USA.
Pearce C; Mycosynthetix, Inc, Hillsborough, NC, 27278, USA.
Liu K; Department of Biochemistry and Molecular Biology, Medical College of Georgia, 1410 Laney Walker Blvd, Augusta, GA, 30912, USA.; Georgia Cancer Center, Medical College of Georgia, Augusta, GA, 30912, USA.; Charlie Norwood VA Medical Center, Augusta, GA, 30904, USA.
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Źródło :
BMC cancer [BMC Cancer] 2018 Feb 06; Vol. 18 (1), pp. 149. Date of Electronic Publication: 2018 Feb 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Apoptosis/*drug effects
Deoxycytidine/*analogs & derivatives
Drug Resistance, Neoplasm/*drug effects
Histones/*metabolism
Lysine/*metabolism
Antimetabolites, Antineoplastic/pharmacology ; Apoptosis/genetics ; Apoptosis Regulatory Proteins/metabolism ; Carcinoma, Pancreatic Ductal/genetics ; Carcinoma, Pancreatic Ductal/metabolism ; Cell Line, Tumor ; Deoxycytidine/pharmacology ; Drug Resistance, Neoplasm/genetics ; Epigenesis, Genetic/drug effects ; Histone Methyltransferases ; Histone-Lysine N-Methyltransferase/antagonists & inhibitors ; Histone-Lysine N-Methyltransferase/metabolism ; Humans ; Indoles/pharmacology ; Methylation/drug effects ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/metabolism
Czasopismo naukowe
Tytuł :
Ergosterol Attenuates LPS-Induced Myocardial Injury by Modulating Oxidative Stress and Apoptosis in Rats.
Autorzy :
Xu J; Burn Wound Center, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Lin C; Burn Wound Center, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Wang T; Department of Infectious Internal Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Zhang P; Burn Wound Center, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Liu Z; Burn Wound Center, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Lu C; Burn Wound Center, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
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Źródło :
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology [Cell Physiol Biochem] 2018; Vol. 48 (2), pp. 583-592. Date of Electronic Publication: 2018 Jul 18.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Ergosterol/*pharmacology
Lipopolysaccharides/*toxicity
Oxidative Stress/*drug effects
Animals ; Apoptosis Regulatory Proteins/metabolism ; Cell Line ; Cell Survival/drug effects ; Creatine Kinase, MB Form/metabolism ; Ergosterol/chemistry ; Male ; Malondialdehyde/metabolism ; Myocardium/metabolism ; Myocardium/pathology ; Myocytes, Cardiac/cytology ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; NF-E2-Related Factor 2/antagonists & inhibitors ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; RNA Interference ; RNA, Small Interfering/metabolism ; Rats ; Rats, Sprague-Dawley ; Signal Transduction/drug effects ; Superoxide Dismutase/metabolism
Czasopismo naukowe
Tytuł :
Betulinic acid protects the neuronal damage in new born rats from isoflurane-induced apoptosis in the developing brain by blocking FASL-FAS signaling pathway.
Autorzy :
Wang D; Department of Anesthesiology, First Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang 154002, China.
Chen P; Department of Gynecology and Obstetrics, First Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang 154002, China.
Chen L; Department of Gynecology and Obstetrics, Jiamusi Central Hospital, Jiamusi, Heilongjiang 154002, China.
Zeng F; Department of Anesthesiology, First Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang 154002, China.
Zang R; Department of Anesthesiology, First Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang 154002, China.
Liu H; Department of Anesthesiology, First Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang 154002, China.
Lu C; Pharmacological Division of Basic Medical College, Jiamusi University, Jiamusi, Heilongjiang 154002, China. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2017 Nov; Vol. 95, pp. 1631-1635. Date of Electronic Publication: 2017 Oct 06.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Fas Ligand Protein/*drug effects
Neuroprotective Agents/*pharmacology
Triterpenes/*pharmacology
Animals ; Animals, Newborn ; Brain/drug effects ; Brain/pathology ; Cytokines/metabolism ; Female ; In Situ Nick-End Labeling ; Isoflurane/toxicity ; Maze Learning/drug effects ; Mice ; Neurons/drug effects ; Oxidative Stress/drug effects ; Rats ; Signal Transduction/drug effects
Czasopismo naukowe

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