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Tytuł :
Prognostic value of TP53 co-mutation status combined with EGFR mutation in patients with lung adenocarcinoma.
Autorzy :
Wang F; Department of Oncology, the Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Nangang District, 150086, Harbin, Heilongjiang, People's Republic of China.
Zhao N; Department of Oncology, the Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Nangang District, 150086, Harbin, Heilongjiang, People's Republic of China.
Gao G; Department of Thoracic Oncology, Cancer Center, West China Hospital, Chengdu, 610041, Sichuan Province, People's Republic of China.
Deng HB; Dental Hospital, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Road, Nangang District, 150001, Harbin, Heilongjiang, People's Republic of China.
Wang ZH; Department of Oncology, the Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Nangang District, 150086, Harbin, Heilongjiang, People's Republic of China.
Deng LL; Department of Oncology, the Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Nangang District, 150086, Harbin, Heilongjiang, People's Republic of China. .
Yang Y; Department of Oncology, the Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Nangang District, 150086, Harbin, Heilongjiang, People's Republic of China. .
Lu C; Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, 201318, People's Republic of China. .
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Źródło :
Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2020 Nov; Vol. 146 (11), pp. 2851-2859. Date of Electronic Publication: 2020 Aug 02.
Typ publikacji :
Journal Article
MeSH Terms :
Adenocarcinoma of Lung/*genetics
Lung Neoplasms/*genetics
Tumor Suppressor Protein p53/*genetics
Adenocarcinoma of Lung/mortality ; Adult ; Aged ; Aged, 80 and over ; ErbB Receptors/genetics ; Female ; Genes, erbB-1 ; Humans ; Lung Neoplasms/mortality ; Male ; Middle Aged ; Mutation ; Prognosis ; Retrospective Studies ; Survival Analysis
Czasopismo naukowe
Tytuł :
Applied electric fields suppress osimertinib-induced cytotoxicity via inhibiting FOXO3a nuclear translocation through AKT activation.
Autorzy :
Li L; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
Hu C; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
Lu C; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
Zhang K; Department of Clinical Laboratory, Daping Hospital, Army Medical University, Chongqing, China.
Han R; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
Lin C; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
Zhao S; School of Life Sciences, Yunnan Normal University, Kunming, China.
A C; School of Life Sciences, Yunnan Normal University, Kunming, China.
Cheng C; OrigiMed Co. Ltd, Shanghai, China.
Zhao M; Department of Dermatology, Department of Ophthalmology, Institute for Regenerative Cures, University of California, Davis, CA, USA.
He Y; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
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Źródło :
Carcinogenesis [Carcinogenesis] 2020 Jul 10; Vol. 41 (5), pp. 600-610.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acrylamides/*pharmacology
Aniline Compounds/*pharmacology
Carcinoma, Non-Small-Cell Lung/*therapy
Cell Nucleus/*metabolism
Electric Stimulation Therapy/*methods
Forkhead Box Protein O3/*metabolism
Lung Neoplasms/*therapy
Proto-Oncogene Proteins c-akt/*metabolism
Antineoplastic Agents/pharmacology ; Apoptosis ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Carcinoma, Non-Small-Cell Lung/chemically induced ; Carcinoma, Non-Small-Cell Lung/metabolism ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Proliferation ; Forkhead Box Protein O3/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Lung Neoplasms/chemically induced ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Protein Transport ; Proto-Oncogene Proteins c-akt/genetics ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
IL-6 promotes metastasis of non-small-cell lung cancer by up-regulating TIM-4 via NF-κB.
Autorzy :
Liu W; Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, Shandong Provincial Key Laboratory of Infection & Immunology, School of Basic Medical Sciences, Shandong University, Jinan, Shandong, China.
Wang H; Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, Shandong Provincial Key Laboratory of Infection & Immunology, School of Basic Medical Sciences, Shandong University, Jinan, Shandong, China.
Bai F; Laboratory for Tissue Engineering and Regeneration, School of Stomatology, Shandong University, Jinan, Shandong, China.
Ding L; Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, Shandong Provincial Key Laboratory of Infection & Immunology, School of Basic Medical Sciences, Shandong University, Jinan, Shandong, China.
Huang Y; Cell and Molecular Biology Laboratory, Zhoushan Hospital, Zhoushan, Zhejiang, China.
Lu C; Cell and Molecular Biology Laboratory, Zhoushan Hospital, Zhoushan, Zhejiang, China.
Chen S; Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, Shandong Provincial Key Laboratory of Infection & Immunology, School of Basic Medical Sciences, Shandong University, Jinan, Shandong, China.
Li C; Department of Anatomy and Histoembryology, School of Basic Medical Sciences, Shandong University, Jinan, Shandong, China.
Yue X; Department of Cell Biology, School of Basic Medical Sciences, Shandong University, Jinan, Shandong, China.
Liang X; Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, Shandong Provincial Key Laboratory of Infection & Immunology, School of Basic Medical Sciences, Shandong University, Jinan, Shandong, China.
Ma C; Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, Shandong Provincial Key Laboratory of Infection & Immunology, School of Basic Medical Sciences, Shandong University, Jinan, Shandong, China.
Xu L; Cell and Molecular Biology Laboratory, Zhoushan Hospital, Zhoushan, Zhejiang, China.
Gao L; Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, Shandong Provincial Key Laboratory of Infection & Immunology, School of Basic Medical Sciences, Shandong University, Jinan, Shandong, China.
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Źródło :
Cell proliferation [Cell Prolif] 2020 Mar; Vol. 53 (3), pp. e12776. Date of Electronic Publication: 2020 Feb 05.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Non-Small-Cell Lung/*immunology
Interleukin-6/*immunology
Lung Neoplasms/*immunology
Membrane Proteins/*genetics
NF-kappa B/*immunology
A549 Cells ; Animals ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; Epithelial-Mesenchymal Transition ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Interleukin-6/genetics ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Male ; Membrane Proteins/immunology ; Mice, Inbred BALB C ; Mice, Nude ; Middle Aged ; Neoplasm Invasiveness/genetics ; Neoplasm Invasiveness/immunology ; Neoplasm Invasiveness/pathology ; Up-Regulation
Czasopismo naukowe
Tytuł :
Sesamin suppresses NSCLC cell proliferation and induces apoptosis via Akt/p53 pathway.
Autorzy :
Chen Y; Department of Clinical Pharmacy, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangzhou key laboratory of construction and application of new drug screening model systems, Guangdong Pharmaceutical University, Guangzhou 510006, China; Key Laboratory of New Drug Discovery and Evaluation of ordinary universities of Guangdong province, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Li H; Department of Clinical Pharmacy, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangzhou key laboratory of construction and application of new drug screening model systems, Guangdong Pharmaceutical University, Guangzhou 510006, China; Key Laboratory of New Drug Discovery and Evaluation of ordinary universities of Guangdong province, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Zhang W; Department of Clinical Pharmacy, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangzhou key laboratory of construction and application of new drug screening model systems, Guangdong Pharmaceutical University, Guangzhou 510006, China; Key Laboratory of New Drug Discovery and Evaluation of ordinary universities of Guangdong province, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Qi W; Department of Clinical Pharmacy, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangzhou key laboratory of construction and application of new drug screening model systems, Guangdong Pharmaceutical University, Guangzhou 510006, China; Key Laboratory of New Drug Discovery and Evaluation of ordinary universities of Guangdong province, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Lu C; Department of Clinical Pharmacy, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangzhou key laboratory of construction and application of new drug screening model systems, Guangdong Pharmaceutical University, Guangzhou 510006, China; Key Laboratory of New Drug Discovery and Evaluation of ordinary universities of Guangdong province, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Huang H; Department of Clinical Pharmacy, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangzhou key laboratory of construction and application of new drug screening model systems, Guangdong Pharmaceutical University, Guangzhou 510006, China; Key Laboratory of New Drug Discovery and Evaluation of ordinary universities of Guangdong province, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Yang Z; Department of Clinical Pharmacy, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangzhou key laboratory of construction and application of new drug screening model systems, Guangdong Pharmaceutical University, Guangzhou 510006, China; Key Laboratory of New Drug Discovery and Evaluation of ordinary universities of Guangdong province, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Liu B; Department of Clinical Pharmacy, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangzhou key laboratory of construction and application of new drug screening model systems, Guangdong Pharmaceutical University, Guangzhou 510006, China; Key Laboratory of New Drug Discovery and Evaluation of ordinary universities of Guangdong province, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangdong Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou 510006, China. Electronic address: .
Zhang L; Guangzhou key laboratory of construction and application of new drug screening model systems, Guangdong Pharmaceutical University, Guangzhou 510006, China; Key Laboratory of New Drug Discovery and Evaluation of ordinary universities of Guangdong province, Guangdong Pharmaceutical University, Guangzhou 510006, China; The Center for Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou 510006, China. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2020 Jan 15; Vol. 387, pp. 114848. Date of Electronic Publication: 2019 Dec 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*drug effects
Carcinoma, Non-Small-Cell Lung/*drug therapy
Dioxoles/*pharmacology
Lignans/*pharmacology
Lung Neoplasms/*drug therapy
Signal Transduction/*drug effects
Animals ; Benzothiazoles/pharmacology ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Chromones/pharmacology ; Dioxoles/therapeutic use ; Female ; G1 Phase Cell Cycle Checkpoints/drug effects ; Humans ; Lignans/therapeutic use ; Lung Neoplasms/pathology ; Mice ; Morpholines/pharmacology ; Proto-Oncogene Proteins c-akt/antagonists & inhibitors ; Proto-Oncogene Proteins c-akt/metabolism ; Toluene/analogs & derivatives ; Toluene/pharmacology ; Tumor Suppressor Protein p53/antagonists & inhibitors ; Tumor Suppressor Protein p53/metabolism ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Metformin-sensitized NSCLC cells to osimertinib via AMPK-dependent autophagy inhibition.
Autorzy :
Chen H; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
Lin C; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
Lu C; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
Wang Y; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
Han R; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
Li L; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
Hao S; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
He Y; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
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Źródło :
The clinical respiratory journal [Clin Respir J] 2019 Dec; Vol. 13 (12), pp. 781-790. Date of Electronic Publication: 2019 Oct 07.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
AMP-Activated Protein Kinases/*drug effects
Autophagy/*drug effects
Carcinoma, Non-Small-Cell Lung/*drug therapy
ErbB Receptors/*antagonists & inhibitors
Lung Neoplasms/*drug therapy
AMP-Activated Protein Kinases/metabolism ; Acrylamides/therapeutic use ; Aniline Compounds/therapeutic use ; Carcinoma, Non-Small-Cell Lung/metabolism ; ErbB Receptors/genetics ; Humans ; Hypoglycemic Agents/pharmacology ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Metformin/pharmacology ; Mutation ; Phosphorylation/drug effects ; Protein Kinase Inhibitors/therapeutic use ; Sensitivity and Specificity
Czasopismo naukowe
Tytuł :
Immunomodulatory Protein from Nectria haematococca Induces Apoptosis in Lung Cancer Cells via the P53 Pathway.
Autorzy :
Wang JJ; Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, No. 2 Yuan Ming Yuan West Road, Beijing 100193, China. .
Wang Y; Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, No. 2 Yuan Ming Yuan West Road, Beijing 100193, China. .
Hou L; Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, No. 2 Yuan Ming Yuan West Road, Beijing 100193, China. .
Xin F; Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, No. 2 Yuan Ming Yuan West Road, Beijing 100193, China. .
Fan B; Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, No. 2 Yuan Ming Yuan West Road, Beijing 100193, China. .
Lu C; Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, No. 2 Yuan Ming Yuan West Road, Beijing 100193, China. .
Zhang L; Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, No. 2 Yuan Ming Yuan West Road, Beijing 100193, China. .
Wang F; Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, No. 2 Yuan Ming Yuan West Road, Beijing 100193, China. .
Li S; Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, No. 2 Yuan Ming Yuan West Road, Beijing 100193, China. .
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2019 Oct 28; Vol. 20 (21). Date of Electronic Publication: 2019 Oct 28.
Typ publikacji :
Journal Article
MeSH Terms :
Nectria*
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Fungal Proteins/*pharmacology
Lung Neoplasms/*drug therapy
Lung Neoplasms/*metabolism
Tumor Suppressor Protein p53/*metabolism
A549 Cells ; Antineoplastic Agents/therapeutic use ; Biosynthetic Pathways ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Fungal Proteins/metabolism ; Fungal Proteins/therapeutic use ; HEK293 Cells ; Humans ; Phosphatidylinositol 3-Kinases/metabolism ; Proteomics ; Signal Transduction/drug effects ; Tumor Suppressor Protein p53/genetics
Czasopismo naukowe
Tytuł :
Phase II Trial of Cediranib in Combination With Cisplatin and Pemetrexed in Chemotherapy-Naïve Patients With Unresectable Malignant Pleural Mesothelioma (SWOG S0905).
Autorzy :
Tsao AS; The University of Texas MD Anderson Cancer Center, Houston, TX.
Miao J; SWOG Statistical Center, Seattle, WA.
Wistuba II; The University of Texas MD Anderson Cancer Center, Houston, TX.
Vogelzang NJ; US Oncology Comprehensive Cancer Centers of Nevada, Las Vegas, NV.
Heymach JV; The University of Texas MD Anderson Cancer Center, Houston, TX.
Fossella FV; The University of Texas MD Anderson Cancer Center, Houston, TX.
Lu C; The University of Texas MD Anderson Cancer Center, Houston, TX.
Velasco MR; Cancer Care Specialists of Illinois, Decatur, IL.
Box-Noriega B; Kaiser Permanente, Fresno, CA.
Hueftle JG; Montana Cancer Consortium, Billings, MT.
Gadgeel S; University of Michigan, Ann Arbor, MI.
Redman MW; SWOG Statistical Center, Seattle, WA.
Gandara DR; University of California Davis Cancer Center, Sacramento, CA.
Kelly K; University of California Davis Cancer Center, Sacramento, CA.
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Źródło :
Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2019 Oct 01; Vol. 37 (28), pp. 2537-2547. Date of Electronic Publication: 2019 Aug 06.
Typ publikacji :
Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Cisplatin/*therapeutic use
Lung Neoplasms/*drug therapy
Mesothelioma/*drug therapy
Pemetrexed/*therapeutic use
Pleural Neoplasms/*drug therapy
Quinazolines/*therapeutic use
Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Cisplatin/pharmacology ; Female ; Humans ; Lung Neoplasms/mortality ; Male ; Mesothelioma/mortality ; Middle Aged ; Pemetrexed/pharmacology ; Pleural Neoplasms/mortality ; Progression-Free Survival ; Quinazolines/pharmacology
SCR Disease Name :
Mesothelioma, Malignant
Czasopismo naukowe
Tytuł :
Downregulation of miR-218 by nicotine promotes cell proliferation through targeting CDK6 in non-small cell lung cancer.
Autorzy :
Liu Z; The Eighth Medical Center, Chinese PLA General Hospital (The 309th Hospital of PLA), Beijing, China.
Lu C; The Eighth Medical Center, Chinese PLA General Hospital (The 309th Hospital of PLA), Beijing, China.
Zhao G; The Eighth Medical Center, Chinese PLA General Hospital (The 309th Hospital of PLA), Beijing, China.
Han X; The Eighth Medical Center, Chinese PLA General Hospital (The 309th Hospital of PLA), Beijing, China.
Dong K; The Eighth Medical Center, Chinese PLA General Hospital (The 309th Hospital of PLA), Beijing, China.
Wang C; Department of Clinical Liboratory, The First Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang, China.
Guan JZ; The Eighth Medical Center, Chinese PLA General Hospital (The 309th Hospital of PLA), Beijing, China.
Wang Z; The Eighth Medical Center, Chinese PLA General Hospital (The 309th Hospital of PLA), Beijing, China.
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Źródło :
Journal of cellular biochemistry [J Cell Biochem] 2019 Oct; Vol. 120 (10), pp. 18370-18377. Date of Electronic Publication: 2019 Jun 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinoma, Non-Small-Cell Lung/*genetics
Cell Proliferation/*drug effects
Cell Proliferation/*genetics
Lung Neoplasms/*genetics
Nicotine/*pharmacology
Aged ; Blotting, Western ; Carcinoma, Non-Small-Cell Lung/metabolism ; Cyclin-Dependent Kinase 6/genetics ; Cyclin-Dependent Kinase 6/metabolism ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; Lung Neoplasms/metabolism ; Male ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Middle Aged
Czasopismo naukowe
Tytuł :
A large cohort study identifying a novel prognosis prediction model for lung adenocarcinoma through machine learning strategies.
Autorzy :
Li Y; Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, People's Republic of China.
Ge D; Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, People's Republic of China.
Gu J; Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, People's Republic of China.
Xu F; Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, People's Republic of China.
Zhu Q; Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, People's Republic of China.
Lu C; Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, People's Republic of China. lu..
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Źródło :
BMC cancer [BMC Cancer] 2019 Sep 05; Vol. 19 (1), pp. 886. Date of Electronic Publication: 2019 Sep 05.
Typ publikacji :
Journal Article
MeSH Terms :
Machine Learning*
Adenocarcinoma of Lung/*genetics
Adenocarcinoma of Lung/*pathology
Lung Neoplasms/*genetics
Lung Neoplasms/*pathology
Adenocarcinoma of Lung/mortality ; Aged ; Biomarkers, Tumor/genetics ; Databases, Genetic ; Disease Progression ; Disease-Free Survival ; Female ; Follow-Up Studies ; Gene Expression Regulation, Neoplastic ; Genes, Neoplasm/genetics ; Humans ; Kaplan-Meier Estimate ; Lung Neoplasms/mortality ; Male ; Middle Aged ; Multivariate Analysis ; Prognosis ; Proportional Hazards Models ; Survival Rate ; Transcriptome/genetics
Czasopismo naukowe
Tytuł :
Differentiated super-enhancers in lung cancer cells.
Autorzy :
Li X; Department of Cardiothoracic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China.
Lu C; Department of Cardiothoracic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China.
Lu Q; Department of Cardiothoracic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China.
Li C; Department of Cardiothoracic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China.
Zhu J; Department of Cardiothoracic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China.
Zhao T; Department of Cardiothoracic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China.
Chen H; Department of Cardiothoracic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China. .
Jin H; Department of Cardiothoracic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China. .
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Źródło :
Science China. Life sciences [Sci China Life Sci] 2019 Sep; Vol. 62 (9), pp. 1218-1228. Date of Electronic Publication: 2019 Jan 09.
Typ publikacji :
Journal Article
MeSH Terms :
Enhancer Elements, Genetic/*genetics
Lung Neoplasms/*metabolism
Transcription Factors/*genetics
Transcription Factors/*metabolism
Cell Differentiation ; Cell Line ; Databases, Nucleic Acid ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; Wnt Proteins/genetics ; Wnt Proteins/metabolism
Czasopismo naukowe
Tytuł :
Hypofractionated EGFR tyrosine kinase inhibitor limits tumor relapse through triggering innate and adaptive immunity.
Autorzy :
Liu Z; Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75235, USA.
Han C; Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75235, USA.
Dong C; Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75235, USA.
Shen A; Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75235, USA.
Hsu E; Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75235, USA.; Department of Immunology, UT Southwestern Medical Center, Dallas, TX 75235, USA.
Ren Z; Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75235, USA.
Lu C; Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75235, USA.
Liu L; Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75235, USA.
Zhang A; Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75235, USA.
Timmerman C; Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75235, USA.; Department of Immunology, UT Southwestern Medical Center, Dallas, TX 75235, USA.
Pu Y; Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75235, USA.
Wang Y; Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75235, USA.
Chen M; Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75235, USA.
Qiao J; Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75235, USA.
Fu YX; Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75235, USA. .; Department of Immunology, UT Southwestern Medical Center, Dallas, TX 75235, USA.
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Źródło :
Science immunology [Sci Immunol] 2019 Aug 09; Vol. 4 (38).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptive Immunity/*drug effects
Antineoplastic Agents/*pharmacology
Carcinoma, Non-Small-Cell Lung/*drug therapy
ErbB Receptors/*antagonists & inhibitors
Immunity, Innate/*drug effects
Lung Neoplasms/*drug therapy
Protein Kinase Inhibitors/*pharmacology
Animals ; Antibodies/drug effects ; Antibodies/immunology ; Antineoplastic Agents/chemistry ; Carcinoma, Non-Small-Cell Lung/immunology ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Line, Tumor ; ErbB Receptors/metabolism ; Female ; Lung Neoplasms/immunology ; Lung Neoplasms/pathology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Inbred NOD ; Mice, Knockout ; Mice, SCID ; Mice, Transgenic ; Protein Kinase Inhibitors/chemistry
Czasopismo naukowe
Tytuł :
Prophylactic octreotide does not reduce the incidence of postoperative chylothorax following lobectomy: Results from a retrospective study.
Autorzy :
Zhang C; Department of Thoracic Surgery, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Shaoxing.
Zhang H; Department of Thoracic Surgery, Xuzhou Central Hospital Affiliated to Southeast University, Xuzhou, China.
Wu W; Department of Thoracic Surgery, Xuzhou Central Hospital Affiliated to Southeast University, Xuzhou, China.
Liu D; Department of Thoracic Surgery, Xuzhou Central Hospital Affiliated to Southeast University, Xuzhou, China.
Yang D; Department of Thoracic Surgery, Xuzhou Central Hospital Affiliated to Southeast University, Xuzhou, China.
Zhang M; Department of Thoracic Surgery, Xuzhou Central Hospital Affiliated to Southeast University, Xuzhou, China.
Lu C; Department of Thoracic Surgery, Xuzhou Central Hospital Affiliated to Southeast University, Xuzhou, China.
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Źródło :
Medicine [Medicine (Baltimore)] 2019 Jul; Vol. 98 (29), pp. e16599.
Typ publikacji :
Journal Article; Observational Study
MeSH Terms :
Antineoplastic Agents, Hormonal/*therapeutic use
Chylothorax/*prevention & control
Lung Neoplasms/*drug therapy
Lung Neoplasms/*surgery
Octreotide/*therapeutic use
Pneumonectomy/*adverse effects
Adult ; Aged ; Aged, 80 and over ; Chest Tubes ; Chylothorax/etiology ; Diet, Fat-Restricted ; Female ; Humans ; Logistic Models ; Male ; Middle Aged ; Patient Readmission ; Pleural Effusion ; Postoperative Complications/prevention & control ; Retrospective Studies ; Risk Factors ; Time Factors
Czasopismo naukowe
Tytuł :
Protective autophagy decreases osimertinib cytotoxicity through regulation of stem cell-like properties in lung cancer.
Autorzy :
Li L; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Wang Y; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Jiao L; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Lin C; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Lu C; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Zhang K; Department of Clinical Laboratory, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Hu C; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Ye J; Burning Rock Biotech, Guangzhou, 510300, China.
Zhang D; The Research and Development Institute of Precision Medicine, 3D Medicine Inc., Shanghai, 201114, China.
Wu H; OrigiMed Co. Ltd, Shanghai, 201114, China.
Feng M; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, 400042, China.
He Y; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, 400042, China. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2019 Jun 28; Vol. 452, pp. 191-202. Date of Electronic Publication: 2019 Mar 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Acrylamides/*pharmacology
Aniline Compounds/*pharmacology
Antineoplastic Agents/*pharmacology
Autophagy/*drug effects
Carcinoma, Non-Small-Cell Lung/*drug therapy
Lung Neoplasms/*drug therapy
Protein Kinase Inhibitors/*pharmacology
Aldehyde Dehydrogenase 1/biosynthesis ; Animals ; Beclin-1/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Line, Tumor ; Chloroquine/pharmacology ; Drug Resistance, Neoplasm/genetics ; ErbB Receptors/genetics ; Female ; Humans ; Lung Neoplasms/pathology ; Mice ; Mice, Inbred BALB C ; RNA Interference ; RNA, Small Interfering/genetics ; Retinal Dehydrogenase/biosynthesis ; SOXB1 Transcription Factors/biosynthesis ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
ROR1-CAVIN3 interaction required for caveolae-dependent endocytosis and pro-survival signaling in lung adenocarcinoma.
Autorzy :
Yamaguchi T; Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan.; Department of Cancer Biology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, 860-8556, Japan.; Center for Metabolic Regulation of Healthy Aging, Kumamoto University, Kumamoto, 860-8556, Japan.
Hayashi M; Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan.
Ida L; Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan.
Yamamoto M; Department of Cancer Biology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, 860-8556, Japan.; Center for Metabolic Regulation of Healthy Aging, Kumamoto University, Kumamoto, 860-8556, Japan.
Lu C; Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan.
Kajino T; Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan.; Division of Molecular Therapeutics, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya, 464-8681, Japan.
Cheng J; Department of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan.
Nakatochi M; Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, 466-8550, Japan.
Isomura H; Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan.; Division of Molecular Therapeutics, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya, 464-8681, Japan.
Yamazaki M; Department of Cancer Biology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, 860-8556, Japan.
Suzuki M; Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan.
Fujimoto T; Department of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan.
Takahashi T; Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan. .; Aichi Cancer Center, 1-1Kanokoden, Chikusa-ku, Nagoya, 464-8681, Japan. .
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Źródło :
Oncogene [Oncogene] 2019 Jun; Vol. 38 (26), pp. 5142-5157. Date of Electronic Publication: 2019 Mar 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Endocytosis*/genetics
Adenocarcinoma of Lung/*pathology
Caveolae/*physiology
Intracellular Signaling Peptides and Proteins/*metabolism
Lung Neoplasms/*pathology
Receptor Tyrosine Kinase-like Orphan Receptors/*metabolism
Adenocarcinoma of Lung/genetics ; Adenocarcinoma of Lung/metabolism ; Animals ; COS Cells ; Caveolae/metabolism ; Cell Survival/genetics ; Cells, Cultured ; Chlorocebus aethiops ; HEK293 Cells ; HeLa Cells ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Protein Binding/physiology ; Sf9 Cells ; Signal Transduction/genetics ; Spodoptera
Czasopismo naukowe
Tytuł :
Spatial Architecture and Arrangement of Tumor-Infiltrating Lymphocytes for Predicting Likelihood of Recurrence in Early-Stage Non-Small Cell Lung Cancer.
Autorzy :
Corredor G; Center for Computational Imaging and Personalized Diagnostics, Case Western Reserve University, Cleveland, Ohio.; Computer Imaging and Medical Applications Laboratory, Universidad Nacional de Colombia, Bogotá, Colombia.
Wang X; Center for Computational Imaging and Personalized Diagnostics, Case Western Reserve University, Cleveland, Ohio.
Zhou Y; Center for Computational Imaging and Personalized Diagnostics, Case Western Reserve University, Cleveland, Ohio.
Lu C; Center for Computational Imaging and Personalized Diagnostics, Case Western Reserve University, Cleveland, Ohio.
Fu P; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio.
Syrigos K; Department of Medicine, University of Athens, Sotiria General Hospital, Athens, Greece.
Rimm DL; Department of Pathology, Yale University School of Medicine, New Haven, Connecticut.
Yang M; Department of Pathology-Anatomic, University Hospitals, Cleveland, Ohio.
Romero E; Computer Imaging and Medical Applications Laboratory, Universidad Nacional de Colombia, Bogotá, Colombia.
Schalper KA; Department of Pathology, Yale University School of Medicine, New Haven, Connecticut.
Velcheti V; Hematology and Medical Oncology Department, Cleveland Clinic, Cleveland, Ohio.
Madabhushi A; Center for Computational Imaging and Personalized Diagnostics, Case Western Reserve University, Cleveland, Ohio. .
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Źródło :
Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2019 Mar 01; Vol. 25 (5), pp. 1526-1534. Date of Electronic Publication: 2018 Sep 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Carcinoma, Non-Small-Cell Lung/*immunology
Carcinoma, Non-Small-Cell Lung/*pathology
Lung Neoplasms/*immunology
Lung Neoplasms/*pathology
Lymphocytes, Tumor-Infiltrating/*immunology
Lymphocytes, Tumor-Infiltrating/*pathology
Aged ; Carcinoma, Non-Small-Cell Lung/mortality ; Female ; Humans ; Lung Neoplasms/mortality ; Lymphocytes, Tumor-Infiltrating/metabolism ; Male ; Middle Aged ; Neoplasm Metastasis ; Neoplasm Staging ; Prognosis ; Proportional Hazards Models ; Recurrence
Czasopismo naukowe
Tytuł :
Ubiquitin-protein ligase E3C maintains non-small-cell lung cancer stemness by targeting AHNAK-p53 complex.
Autorzy :
Gu J; Department of Thoracic Surgery, The Affiliated Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China; Key Laboratory of Medical Epigenetics and Metabolism, Institute of Biomedical Sciences, and Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, PR China.
Mao W; Department of Thoracic Surgery, The Affiliated Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China; Key Laboratory of Medical Epigenetics and Metabolism, Institute of Biomedical Sciences, and Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, PR China.
Ren W; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, PR China.
Xu F; Department of Thoracic Surgery, The Affiliated Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China.
Zhu Q; Department of Thoracic Surgery, The Affiliated Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China.
Lu C; Department of Thoracic Surgery, The Affiliated Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China.
Lin Z; Department of Thoracic Surgery, The Affiliated Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China.
Zhang Z; Department of Thoracic Surgery, Shanghai XuHui District Central Hospital, Shanghai, 200031, PR China.
Chu Y; Key Laboratory of Medical Epigenetics and Metabolism, Institute of Biomedical Sciences, and Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, PR China.
Liu R; Key Laboratory of Medical Epigenetics and Metabolism, Institute of Biomedical Sciences, and Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, PR China. Electronic address: .
Ge D; Department of Thoracic Surgery, The Affiliated Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2019 Feb 28; Vol. 443, pp. 125-134. Date of Electronic Publication: 2018 Nov 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinoma, Non-Small-Cell Lung/*metabolism
Lung Neoplasms/*metabolism
Membrane Proteins/*metabolism
Neoplasm Proteins/*metabolism
Neoplastic Stem Cells/*metabolism
Tumor Suppressor Protein p53/*metabolism
Ubiquitin-Protein Ligases/*metabolism
A549 Cells ; Carcinoma, Non-Small-Cell Lung/genetics ; Cell Line, Tumor ; Female ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Humans ; Lung Neoplasms/genetics ; Lymphatic Metastasis ; Male ; Membrane Proteins/chemistry ; Neoplasm Proteins/chemistry ; Promoter Regions, Genetic ; Proteolysis ; Survival Analysis ; Tumor Burden ; Ubiquitin-Protein Ligases/genetics ; Ubiquitination
Czasopismo naukowe
Tytuł :
Extracellular vesicles secreted by hypoxia pre-challenged mesenchymal stem cells promote non-small cell lung cancer cell growth and mobility as well as macrophage M2 polarization via miR-21-5p delivery.
Autorzy :
Ren W; Medical Examination Center, Luoyang Central Hospital, Zhengzhou University, No.288, Middle Zhongzhou Rd, Xigong District, Luoyang, 471009, China. .
Hou J; Department of Oncology, Zhengzhou Central Hospital, Zhengzhou, Henan, China.
Yang C; Department of Oncology, Kaifeng Central Hospital, Kaifeng, 475000, China.
Wang H; Imaging Department of Luoyang Orthopedic-traumatological Hospital, Luoyang, 471000, China.
Wu S; Department of Anesthesiology, Luoyang Central Hospital, Zhengzhou University, Luoyang, 471009, China.
Wu Y; Medical Examination Center, Luoyang Central Hospital, Zhengzhou University, No.288, Middle Zhongzhou Rd, Xigong District, Luoyang, 471009, China.
Zhao X; Medical Examination Center, Luoyang Central Hospital, Zhengzhou University, No.288, Middle Zhongzhou Rd, Xigong District, Luoyang, 471009, China.
Lu C; Department of Oncology, Zhengzhou Central Hospital, Zhengzhou, Henan, China.
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Źródło :
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2019 Feb 08; Vol. 38 (1), pp. 62. Date of Electronic Publication: 2019 Feb 08.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Non-Small-Cell Lung/*genetics
Extracellular Vesicles/*metabolism
Lung Neoplasms/*genetics
Macrophages/*metabolism
Mesenchymal Stem Cells/*metabolism
MicroRNAs/*metabolism
Animals ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Hypoxia ; Cell Proliferation ; Humans ; Lung Neoplasms/pathology ; Mice
Czasopismo naukowe
Tytuł :
Differential molecular markers of primary lung tumors and metastatic sites indicate different possible treatment selections in patients with metastatic lung adenocarcinoma.
Autorzy :
Deng LL; Department of Oncology, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Nangang District, Harbin, 150086, Heilongjiang, People's Republic of China.
Deng HB; Dental Hospital, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Road, Nangang District, Harbin, 150001, Heilongjiang, People's Republic of China.
Lu CL; Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University, 157 Baojian Road, Harbin, 150081, Heilongjiang, People's Republic of China.
Gao G; Department of Oncology, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Nangang District, Harbin, 150086, Heilongjiang, People's Republic of China.
Wang F; Department of Oncology, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Nangang District, Harbin, 150086, Heilongjiang, People's Republic of China.
Yang Y; Department of Oncology, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Nangang District, Harbin, 150086, Heilongjiang, People's Republic of China. .
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Źródło :
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico [Clin Transl Oncol] 2019 Feb; Vol. 21 (2), pp. 197-205. Date of Electronic Publication: 2018 Jun 11.
Typ publikacji :
Journal Article
MeSH Terms :
Adenocarcinoma of Lung/*secondary
Biomarkers, Tumor/*analysis
Lung Neoplasms/*pathology
Neoplasm Metastasis/*pathology
Adenocarcinoma of Lung/genetics ; Adult ; Aged ; Female ; Humans ; Lung Neoplasms/genetics ; Male ; Middle Aged ; Molecular Targeted Therapy ; Neoplasm Metastasis/genetics
Czasopismo naukowe
Tytuł :
Prognostic factors and outcome of surgically treated patients with brain metastases of non-small cell lung cancer.
Autorzy :
She C; Department of Neurosurgery and Neuro-Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.
Wang R; Department of Neurology, The Second Hospital of Tianjin Medical University, Tianjin, China.
Lu C; Ultrasound Department, Binzhou People's Hospital, Binzhou, China.
Sun Z; Department of Neurosurgery and Neuro-Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.
Li P; Department of Neurosurgery and Neuro-Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.
Yin Q; Department of Neurosurgery and Neuro-Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.
Liu Q; Department of Neurosurgery and Neuro-Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.
Wang P; Department of Neurosurgery and Neuro-Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.
Li W; Department of Neurosurgery and Neuro-Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.
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Źródło :
Thoracic cancer [Thorac Cancer] 2019 Feb; Vol. 10 (2), pp. 137-142. Date of Electronic Publication: 2018 Nov 28.
Typ publikacji :
Clinical Trial; Journal Article
MeSH Terms :
Adenocarcinoma of Lung/*mortality
Brain Neoplasms/*mortality
Carcinoma, Non-Small-Cell Lung/*mortality
Carcinoma, Squamous Cell/*mortality
Lung Neoplasms/*mortality
Pneumonectomy/*mortality
Adenocarcinoma of Lung/pathology ; Adenocarcinoma of Lung/surgery ; Adult ; Aged ; Aged, 80 and over ; Brain Neoplasms/secondary ; Brain Neoplasms/surgery ; Carcinoma, Non-Small-Cell Lung/pathology ; Carcinoma, Non-Small-Cell Lung/surgery ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/surgery ; Female ; Follow-Up Studies ; Humans ; Lung Neoplasms/pathology ; Lung Neoplasms/surgery ; Male ; Middle Aged ; Prognosis ; Retrospective Studies ; Survival Rate
Czasopismo naukowe
Tytuł :
Calpain-2 Enhances Non-Small Cell Lung Cancer Progression and Chemoresistance to Paclitaxel via EGFR-pAKT Pathway.
Autorzy :
Xu F; Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.
Gu J; Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.
Lu C; Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.
Mao W; Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.
Wang L; Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.
Zhu Q; Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.
Liu Z; Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.
Chu Y; Department of Immunology, Fudan University, Shanghai, P.R. China.
Liu R; Department of Immunology, Fudan University, Shanghai, P.R. China.
Ge D; Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.
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Źródło :
International journal of biological sciences [Int J Biol Sci] 2019 Jan 06; Vol. 15 (1), pp. 127-137. Date of Electronic Publication: 2019 Jan 06 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Calpain/*metabolism
Carcinoma, Non-Small-Cell Lung/*metabolism
Gene Expression Regulation, Neoplastic/*genetics
Lung Neoplasms/*metabolism
Paclitaxel/*pharmacology
Animals ; Apoptosis/drug effects ; Apoptosis/genetics ; Calpain/genetics ; Carcinoma, Non-Small-Cell Lung/genetics ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Movement/genetics ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Drug Resistance, Neoplasm/drug effects ; Drug Resistance, Neoplasm/genetics ; ErbB Receptors/genetics ; ErbB Receptors/metabolism ; Female ; Flow Cytometry ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Immunohistochemistry ; Lung Neoplasms/genetics ; Male ; Mice, Nude ; Tissue Array Analysis
Czasopismo naukowe

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