- Tytuł:
-
(+)-Usnic Acid Induces ROS-dependent
Apoptosis via Inhibition ofMitochondria Respiratory Chain Complexes and Nrf2 Expression in Lung Squamous Cell Carcinoma. - Autorzy:
- Źródło:
- International journal of molecular sciences [Int J Mol Sci] 2020 Jan 29; Vol. 21 (3). Date of Electronic Publication: 2020 Jan 29.
- Typ publikacji:
- Journal Article
- MeSH Terms:
-
Apoptosis /*drug effects
Benzofurans/*pharmacology
Electron Transport Chain Complex Proteins/*metabolismMitochondria /*drug effects
NF-E2-Related Factor 2/*metabolism
Reactive Oxygen Species/*metabolism
Animals ; Antineoplastic Agents, Phytogenic/pharmacology ; Benzofurans/chemistry ; Benzofurans/therapeutic use ; Carcinoma, Squamous Cell/drug therapy ; Carcinoma, Squamous Cell/metabolism ; Carcinoma, Squamous Cell/pathology ; Cell Line, Tumor ; Electron Transport Chain Complex Proteins/antagonists & inhibitors ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Mice ;Mitochondria /metabolism ; NF-E2-Related Factor 2/antagonists & inhibitors ; Paclitaxel/pharmacology ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteinsc -akt/metabolism ; Signal Transduction/drug effects ; Transplantation, Heterologous
Czasopismo naukowe