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Tytuł:
Correlation of distribution characteristics and dynamic changes of gut microbiota with the efficacy of immunotherapy in EGFR-mutated non-small cell lung cancer.
Autorzy:
Luo WC; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Mei SQ; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Huang ZJ; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Chen ZH; Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Zhang YC; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Yang MY; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.; School of Medicine, South China University of Technology, Guangzhou, China.
Liu JQ; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Xu JY; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Yang XR; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.; School of Medicine, South China University of Technology, Guangzhou, China.
Zhong RW; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.; School of Medicine, South China University of Technology, Guangzhou, China.
Tang LB; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.; School of Medicine, South China University of Technology, Guangzhou, China.
Yin LX; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Deng Y; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Peng YL; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.; School of Medicine, South China University of Technology, Guangzhou, China.
Lu C; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Chen BL; Xiamen Treatgut Biotechnology Co., Ltd, Xiamen, China.
Ke DX; Xiamen Treatgut Medical Laboratory Co., Ltd, Xiamen, China.
Tu HY; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Yang JJ; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Xu CR; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Wu YL; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.; Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Zhou Q; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China. .
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Źródło:
Journal of translational medicine [J Transl Med] 2024 Apr 02; Vol. 22 (1), pp. 326. Date of Electronic Publication: 2024 Apr 02.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Non-Small-Cell Lung*/therapy
Carcinoma, Non-Small-Cell Lung*/drug therapy
Lung Neoplasms*/therapy
Lung Neoplasms*/drug therapy
Gastrointestinal Microbiome*
Humans ; Immunotherapy ; ErbB Receptors/genetics ; Anti-Bacterial Agents/therapeutic use
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Predictive value of early kinetics of ctDNA combined with cfDNA and serum CEA for EGFR-TKI treatment in advanced non-small cell lung cancer.
Autorzy:
Zheng J; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.; School of Medicine, Chongqing University, Chongqing, China.
Wang Y; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
Hu C; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
Zhu M; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
Ii J; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
Lin C; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
Lu C; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
Dou Y; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
Zhao C; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
Zhang Y; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
Wu D; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
Li L; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
Tang H; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
He T; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
Pan C; Burning Rock Biotech, Guangzhou, China.
Han R; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
He Y; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.; School of Medicine, Chongqing University, Chongqing, China.
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Źródło:
Thoracic cancer [Thorac Cancer] 2022 Nov; Vol. 13 (22), pp. 3162-3173. Date of Electronic Publication: 2022 Oct 04.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Carcinoma, Non-Small-Cell Lung*/drug therapy
Carcinoma, Non-Small-Cell Lung*/genetics
Circulating Tumor DNA*/genetics
Cell-Free Nucleic Acids*
Lung Neoplasms*/drug therapy
Lung Neoplasms*/genetics
Humans ; Carcinoembryonic Antigen ; ErbB Receptors/genetics ; Retrospective Studies ; Mutation ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Ibrutinib reverses IL-6-induced osimertinib resistance through inhibition of Laminin α5/FAK signaling.
Autorzy:
Li L; Department of Respiratory Medicine, Daping Hospital, Third Military Medical University (Army Medical University), Chongqing, 400042, China. .
Li Z; Department of Respiratory Medicine, Daping Hospital, Third Military Medical University (Army Medical University), Chongqing, 400042, China.
Lu C; Department of Respiratory Medicine, Daping Hospital, Third Military Medical University (Army Medical University), Chongqing, 400042, China.
Li J; Department of Respiratory Medicine, Daping Hospital, Third Military Medical University (Army Medical University), Chongqing, 400042, China.
Zhang K; Department of Clinical Laboratory, Daping Hospital, Third Military Medical University (Army Medical University), Chongqing, 400042, China.
Lin C; Department of Respiratory Medicine, Daping Hospital, Third Military Medical University (Army Medical University), Chongqing, 400042, China.
Tang X; Department of Respiratory Medicine, Daping Hospital, Third Military Medical University (Army Medical University), Chongqing, 400042, China.
Liu Z; Department of Respiratory Medicine, Daping Hospital, Third Military Medical University (Army Medical University), Chongqing, 400042, China.
Zhang Y; Department of Respiratory Medicine, Daping Hospital, Third Military Medical University (Army Medical University), Chongqing, 400042, China.
Han R; Department of Respiratory Medicine, Daping Hospital, Third Military Medical University (Army Medical University), Chongqing, 400042, China.
Wang Y; Department of Respiratory Medicine, Daping Hospital, Third Military Medical University (Army Medical University), Chongqing, 400042, China.
Feng M; Department of Respiratory Medicine, Daping Hospital, Third Military Medical University (Army Medical University), Chongqing, 400042, China.
Zhuang Y; National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy and Laboratory Medicine, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Hu C; Department of Respiratory Medicine, Daping Hospital, Third Military Medical University (Army Medical University), Chongqing, 400042, China. .
He Y; Department of Respiratory Medicine, Daping Hospital, Third Military Medical University (Army Medical University), Chongqing, 400042, China. .
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Źródło:
Communications biology [Commun Biol] 2022 Feb 23; Vol. 5 (1), pp. 155. Date of Electronic Publication: 2022 Feb 23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Carcinoma, Non-Small-Cell Lung*/drug therapy
Carcinoma, Non-Small-Cell Lung*/genetics
Carcinoma, Non-Small-Cell Lung*/pathology
Interleukin-6*/blood
Laminin*/metabolism
Lung Neoplasms*/drug therapy
Lung Neoplasms*/genetics
Lung Neoplasms*/pathology
Acrylamides ; Adenine/analogs & derivatives ; Aniline Compounds/pharmacology ; Drug Resistance, Neoplasm ; ErbB Receptors/genetics ; ErbB Receptors/metabolism ; Focal Adhesion Kinase 1/genetics ; Focal Adhesion Kinase 1/metabolism ; Focal Adhesion Protein-Tyrosine Kinases/genetics ; Humans ; Mutation ; Piperidines
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Hexokinases II-mediated glycolysis governs susceptibility to crizotinib in ALK-positive non-small cell lung cancer.
Autorzy:
Lin C; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
Chen H; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
Han R; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
Li L; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
Lu C; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
Hao S; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
Wang Y; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
He Y; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
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Źródło:
Thoracic cancer [Thorac Cancer] 2021 Dec; Vol. 12 (23), pp. 3184-3193. Date of Electronic Publication: 2021 Nov 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Carcinoma, Non-Small-Cell Lung/*drug therapy
Crizotinib/*pharmacology
Deoxyglucose/*pharmacology
Glycolysis/*drug effects
Hexokinase/*metabolism
Lung Neoplasms/*drug therapy
Anaplastic Lymphoma Kinase/genetics ; Antimetabolites/pharmacology ; Carcinoma, Non-Small-Cell Lung/enzymology ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Line, Tumor ; Humans ; Lung Neoplasms/enzymology ; Lung Neoplasms/pathology ; Neoplasm Invasiveness ; Protein Kinase Inhibitors/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
E3 ubiquitin ligase HECW1 promotes the metastasis of non-small cell lung cancer cells through mediating the ubiquitination of Smad4.
Autorzy:
Lu C; Department of Thoracic Surgery, The First Affiliated Hospital of Anhui Medical University, No.218 Jixi Road, Shushan District, Hefei 230022, Anhui, China.
Ning G; Department of Thoracic Surgery, The First Affiliated Hospital of Anhui Medical University, No.218 Jixi Road, Shushan District, Hefei 230022, Anhui, China.
Si P; Department of Thoracic Surgery, The First Affiliated Hospital of Anhui Medical University, No.218 Jixi Road, Shushan District, Hefei 230022, Anhui, China.
Zhang C; Department of Thoracic Surgery, The First Affiliated Hospital of Anhui Medical University, No.218 Jixi Road, Shushan District, Hefei 230022, Anhui, China.
Liu W; Department of Thoracic Surgery, The First Affiliated Hospital of Anhui Medical University, No.218 Jixi Road, Shushan District, Hefei 230022, Anhui, China.
Ge W; Department of Thoracic Surgery, The First Affiliated Hospital of Anhui Medical University, No.218 Jixi Road, Shushan District, Hefei 230022, Anhui, China.
Cui K; Department of Thoracic Surgery, The First Affiliated Hospital of Anhui Medical University, No.218 Jixi Road, Shushan District, Hefei 230022, Anhui, China.
Zhang R; Department of Thoracic Surgery, The First Affiliated Hospital of Anhui Medical University, No.218 Jixi Road, Shushan District, Hefei 230022, Anhui, China.
Ge S; Department of Cardiovascular Surgery, The First Affiliated Hospital of Anhui Medical University, No.218 Jixi Road, Shushan District, Hefei 230022, Anhui, China.
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Źródło:
Biochemistry and cell biology = Biochimie et biologie cellulaire [Biochem Cell Biol] 2021 Oct; Vol. 99 (5), pp. 675-681. Date of Electronic Publication: 2021 Feb 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Carcinoma, Non-Small-Cell Lung/*metabolism
Lung Neoplasms/*metabolism
Nerve Tissue Proteins/*metabolism
Smad4 Protein/*metabolism
Ubiquitin-Protein Ligases/*metabolism
Carcinoma, Non-Small-Cell Lung/pathology ; Cell Line, Tumor ; Humans ; Lung Neoplasms/pathology ; Nerve Tissue Proteins/genetics ; Smad4 Protein/genetics ; Ubiquitin-Protein Ligases/genetics ; Ubiquitination
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Ceramide synthases: insights into the expression and prognosis of lung cancer.
Autorzy:
Qian H; Department of Respiratory, The First Hospital of Jiaxing, Affiliated Hospital of Jiaxing University.
Deng J; Department of Respiratory, The First Hospital of Jiaxing, Affiliated Hospital of Jiaxing University.
Lu C; Department of Cardiothoracic Surgery, The First Hospital of Jiaxing, Affiliated Hospital of Jiaxing University.
Hou G; Department of Oncology, Affiliated Hospital of Jiaxing University, The First Hospital of Jiaxing, Jiaxing, Zhejiang, P.R. China.
Zhang H; Department of Respiratory, The First Hospital of Jiaxing, Affiliated Hospital of Jiaxing University.
Zhang M; Department of Respiratory, The First Hospital of Jiaxing, Affiliated Hospital of Jiaxing University.
Fang Z; Department of Respiratory, The First Hospital of Jiaxing, Affiliated Hospital of Jiaxing University.
Lv XD; Department of Respiratory, The First Hospital of Jiaxing, Affiliated Hospital of Jiaxing University.
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Źródło:
Experimental lung research [Exp Lung Res] 2021 Feb; Vol. 47 (1), pp. 37-53. Date of Electronic Publication: 2020 Nov 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Carcinoma, Non-Small-Cell Lung*/genetics
Lung Neoplasms*/genetics
Animals ; Apoptosis ; Ceramides ; Humans ; Prognosis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Association of genetic and immuno-characteristics with clinical outcomes in patients with RET-rearranged non-small cell lung cancer: a retrospective multicenter study.
Autorzy:
Lu C; The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China.; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Dong XR; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Zhao J; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department I of Thoracic Oncology, Peking University Cancer Hospital & Institute, Beijing, China.
Zhang XC; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Chen HJ; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Zhou Q; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Tu HY; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Ai XH; Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.
Chen XF; Oncology Department, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
An GL; Department of Clinical Oncology, Shaanxi Provincial People's Hospital, Xi'an, China.
Bai J; Department of Clinical Oncology, Shaanxi Provincial People's Hospital, Xi'an, China.
Shan JL; Daping Hospital, Army medical center of PLA, Chongqing, China.
Wang YN; Department of Oncology, The First Affiliated Hospital of Zhejiang University, Hangzhou, China.
Yang SY; The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Liu X; Department of Cardiothoracic Surgery, The Second Affiliated Hospital, University of South China, Hengyang, China.
Zhuang W; Fujian Provincial Cancer Hospital, Fuzhou, China.
Wu HT; Department of Oncology, Zhongshan Hospital, Xiamen University, Xiamen, China.
Zhu B; Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
Xia XF; Geneplus-Beijing Institute, Beijing, China.
Chen RR; Geneplus-Beijing Institute, Beijing, China.
Gu DJ; Geneplus-Beijing Institute, Beijing, China.
Xu HM; Geneplus-Beijing Institute, Beijing, China.
Wu YL; The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China. .; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China. .
Yang JJ; The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China. .; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China. .
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Źródło:
Journal of hematology & oncology [J Hematol Oncol] 2020 Apr 15; Vol. 13 (1), pp. 37. Date of Electronic Publication: 2020 Apr 15.
Typ publikacji:
Journal Article; Multicenter Study; Observational Study; Research Support, Non-U.S. Gov't
MeSH Terms:
Carcinoma, Non-Small-Cell Lung/*genetics
Lung Neoplasms/*genetics
Proto-Oncogene Proteins c-ret/*genetics
Adult ; Aged ; Aged, 80 and over ; B7-H1 Antigen/genetics ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/epidemiology ; Female ; Gene Rearrangement ; Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Lung Neoplasms/drug therapy ; Lung Neoplasms/epidemiology ; Male ; Middle Aged ; Mutation ; Retrospective Studies ; Survival Analysis ; Tumor Suppressor Protein p53/genetics ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
IL-6 promotes metastasis of non-small-cell lung cancer by up-regulating TIM-4 via NF-κB.
Autorzy:
Liu W; Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, Shandong Provincial Key Laboratory of Infection & Immunology, School of Basic Medical Sciences, Shandong University, Jinan, Shandong, China.
Wang H; Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, Shandong Provincial Key Laboratory of Infection & Immunology, School of Basic Medical Sciences, Shandong University, Jinan, Shandong, China.
Bai F; Laboratory for Tissue Engineering and Regeneration, School of Stomatology, Shandong University, Jinan, Shandong, China.
Ding L; Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, Shandong Provincial Key Laboratory of Infection & Immunology, School of Basic Medical Sciences, Shandong University, Jinan, Shandong, China.
Huang Y; Cell and Molecular Biology Laboratory, Zhoushan Hospital, Zhoushan, Zhejiang, China.
Lu C; Cell and Molecular Biology Laboratory, Zhoushan Hospital, Zhoushan, Zhejiang, China.
Chen S; Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, Shandong Provincial Key Laboratory of Infection & Immunology, School of Basic Medical Sciences, Shandong University, Jinan, Shandong, China.
Li C; Department of Anatomy and Histoembryology, School of Basic Medical Sciences, Shandong University, Jinan, Shandong, China.
Yue X; Department of Cell Biology, School of Basic Medical Sciences, Shandong University, Jinan, Shandong, China.
Liang X; Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, Shandong Provincial Key Laboratory of Infection & Immunology, School of Basic Medical Sciences, Shandong University, Jinan, Shandong, China.
Ma C; Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, Shandong Provincial Key Laboratory of Infection & Immunology, School of Basic Medical Sciences, Shandong University, Jinan, Shandong, China.
Xu L; Cell and Molecular Biology Laboratory, Zhoushan Hospital, Zhoushan, Zhejiang, China.
Gao L; Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, Shandong Provincial Key Laboratory of Infection & Immunology, School of Basic Medical Sciences, Shandong University, Jinan, Shandong, China.
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Źródło:
Cell proliferation [Cell Prolif] 2020 Mar; Vol. 53 (3), pp. e12776. Date of Electronic Publication: 2020 Feb 05.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Non-Small-Cell Lung/*immunology
Interleukin-6/*immunology
Lung Neoplasms/*immunology
Membrane Proteins/*genetics
NF-kappa B/*immunology
A549 Cells ; Animals ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; Epithelial-Mesenchymal Transition ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Interleukin-6/genetics ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Male ; Membrane Proteins/immunology ; Mice, Inbred BALB C ; Mice, Nude ; Middle Aged ; Neoplasm Invasiveness/genetics ; Neoplasm Invasiveness/immunology ; Neoplasm Invasiveness/pathology ; Up-Regulation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Metformin-sensitized NSCLC cells to osimertinib via AMPK-dependent autophagy inhibition.
Autorzy:
Chen H; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
Lin C; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
Lu C; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
Wang Y; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
Han R; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
Li L; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
Hao S; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
He Y; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.
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Źródło:
The clinical respiratory journal [Clin Respir J] 2019 Dec; Vol. 13 (12), pp. 781-790. Date of Electronic Publication: 2019 Oct 07.
Typ publikacji:
Comparative Study; Journal Article
MeSH Terms:
AMP-Activated Protein Kinases/*drug effects
Autophagy/*drug effects
Carcinoma, Non-Small-Cell Lung/*drug therapy
ErbB Receptors/*antagonists & inhibitors
Lung Neoplasms/*drug therapy
AMP-Activated Protein Kinases/metabolism ; Acrylamides/therapeutic use ; Aniline Compounds/therapeutic use ; Carcinoma, Non-Small-Cell Lung/metabolism ; ErbB Receptors/genetics ; Humans ; Hypoglycemic Agents/pharmacology ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Metformin/pharmacology ; Mutation ; Phosphorylation/drug effects ; Protein Kinase Inhibitors/therapeutic use ; Sensitivity and Specificity
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Extracellular vesicles secreted by hypoxia pre-challenged mesenchymal stem cells promote non-small cell lung cancer cell growth and mobility as well as macrophage M2 polarization via miR-21-5p delivery.
Autorzy:
Ren W; Medical Examination Center, Luoyang Central Hospital, Zhengzhou University, No.288, Middle Zhongzhou Rd, Xigong District, Luoyang, 471009, China. .
Hou J; Department of Oncology, Zhengzhou Central Hospital, Zhengzhou, Henan, China.
Yang C; Department of Oncology, Kaifeng Central Hospital, Kaifeng, 475000, China.
Wang H; Imaging Department of Luoyang Orthopedic-traumatological Hospital, Luoyang, 471000, China.
Wu S; Department of Anesthesiology, Luoyang Central Hospital, Zhengzhou University, Luoyang, 471009, China.
Wu Y; Medical Examination Center, Luoyang Central Hospital, Zhengzhou University, No.288, Middle Zhongzhou Rd, Xigong District, Luoyang, 471009, China.
Zhao X; Medical Examination Center, Luoyang Central Hospital, Zhengzhou University, No.288, Middle Zhongzhou Rd, Xigong District, Luoyang, 471009, China.
Lu C; Department of Oncology, Zhengzhou Central Hospital, Zhengzhou, Henan, China.
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Źródło:
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2019 Feb 08; Vol. 38 (1), pp. 62. Date of Electronic Publication: 2019 Feb 08.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Non-Small-Cell Lung/*genetics
Extracellular Vesicles/*metabolism
Lung Neoplasms/*genetics
Macrophages/*metabolism
Mesenchymal Stem Cells/*metabolism
MicroRNAs/*metabolism
Animals ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Hypoxia ; Cell Proliferation ; Humans ; Lung Neoplasms/pathology ; Mice
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Prognostic factors and outcome of surgically treated patients with brain metastases of non-small cell lung cancer.
Autorzy:
She C; Department of Neurosurgery and Neuro-Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.
Wang R; Department of Neurology, The Second Hospital of Tianjin Medical University, Tianjin, China.
Lu C; Ultrasound Department, Binzhou People's Hospital, Binzhou, China.
Sun Z; Department of Neurosurgery and Neuro-Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.
Li P; Department of Neurosurgery and Neuro-Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.
Yin Q; Department of Neurosurgery and Neuro-Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.
Liu Q; Department of Neurosurgery and Neuro-Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.
Wang P; Department of Neurosurgery and Neuro-Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.
Li W; Department of Neurosurgery and Neuro-Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.
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Źródło:
Thoracic cancer [Thorac Cancer] 2019 Feb; Vol. 10 (2), pp. 137-142. Date of Electronic Publication: 2018 Nov 28.
Typ publikacji:
Clinical Trial; Journal Article
MeSH Terms:
Adenocarcinoma of Lung/*mortality
Brain Neoplasms/*mortality
Carcinoma, Non-Small-Cell Lung/*mortality
Carcinoma, Squamous Cell/*mortality
Lung Neoplasms/*mortality
Pneumonectomy/*mortality
Adenocarcinoma of Lung/pathology ; Adenocarcinoma of Lung/surgery ; Adult ; Aged ; Aged, 80 and over ; Brain Neoplasms/secondary ; Brain Neoplasms/surgery ; Carcinoma, Non-Small-Cell Lung/pathology ; Carcinoma, Non-Small-Cell Lung/surgery ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/surgery ; Female ; Follow-Up Studies ; Humans ; Lung Neoplasms/pathology ; Lung Neoplasms/surgery ; Male ; Middle Aged ; Prognosis ; Retrospective Studies ; Survival Rate
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Establishment of patient-derived tumor spheroids for non-small cell lung cancer.
Autorzy:
Zhang Z; Department of Respiration, The Second Affiliated Hospital of Soochow University, Suzhou, P.R. China.
Wang H; Invitrocue Biomedical Service Suzhou, Suzhou, P.R. China.
Ding Q; Department of Thoracic & Cardiac Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, P.R. China.
Xing Y; Department of Respiration, The Second Affiliated Hospital of Soochow University, Suzhou, P.R. China.
Xu Z; Department of Thoracic & Cardiac Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, P.R. China.
Lu C; Invitrocue Biomedical Service Suzhou, Suzhou, P.R. China.
Luo D; Invitrocue Biomedical Service Suzhou, Suzhou, P.R. China.
Xu L; Department of Pathology, The Second Affiliated Hospital of Soochow University, Suzhou, P.R. China.
Xia W; Department of Pathology, The Second Affiliated Hospital of Soochow University, Suzhou, P.R. China.
Zhou C; Department of Medical Oncology, Shanghai Pulmonary Hospital, Thoracic Cancer Institute, Tongji University School of Medicine, Shanghai, P.R. China.
Shi M; Department of Respiration, The Second Affiliated Hospital of Soochow University, Suzhou, P.R. China.
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Źródło:
PloS one [PLoS One] 2018 Mar 15; Vol. 13 (3), pp. e0194016. Date of Electronic Publication: 2018 Mar 15 (Print Publication: 2018).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Carcinoma, Non-Small-Cell Lung/*pathology
Lung Neoplasms/*pathology
Spheroids, Cellular/*pathology
Carcinoma, Non-Small-Cell Lung/metabolism ; Cell Culture Techniques/methods ; Cell Line, Tumor ; Humans ; Ki-67 Antigen/metabolism ; Lung Neoplasms/metabolism ; Spheroids, Cellular/metabolism ; Thyroid Nuclear Factor 1/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
[Effect and mechanism of silibinin on the inhibition of ALK positive NSCLC cells by sensitizing crizotinib].
Autorzy:
Lin CC; Department of Respiratory, Daping Hospital, the Third Military Medical University, Chongqing 400042, China.
Lu CH; Department of Respiratory, Daping Hospital, the Third Military Medical University, Chongqing 400042, China.
Pan YH; Department of Respiratory, Daping Hospital, the Third Military Medical University, Chongqing 400042, China.
Jiao L; Department of Respiratory, Daping Hospital, the Third Military Medical University, Chongqing 400042, China.
Chen HY; Department of Respiratory, Daping Hospital, the Third Military Medical University, Chongqing 400042, China.
Li L; Department of Respiratory, Daping Hospital, the Third Military Medical University, Chongqing 400042, China.
He Y; Department of Respiratory, Daping Hospital, the Third Military Medical University, Chongqing 400042, China.
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Źródło:
Zhonghua zhong liu za zhi [Chinese journal of oncology] [Zhonghua Zhong Liu Za Zhi] 2017 Sep 23; Vol. 39 (9), pp. 650-656.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents, Phytogenic/*pharmacology
Carcinoma, Non-Small-Cell Lung/*drug therapy
Lung Neoplasms/*drug therapy
Silybin/*pharmacology
Anaplastic Lymphoma Kinase/analysis ; Animals ; Cadherins/analysis ; Carcinoma, Non-Small-Cell Lung/enzymology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Crizotinib/pharmacology ; Epithelial-Mesenchymal Transition ; Formazans ; Lung Neoplasms/enzymology ; Mice ; Mice, Nude ; Protein Kinase Inhibitors/pharmacology ; Tetrazolium Salts ; Tumor Stem Cell Assay ; Vimentin/analysis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Wnt signaling pathway pharmacogenetics in non-small cell lung cancer.
Autorzy:
Stewart DJ; Division of Medical Oncology, University of Ottawa, The Ottawa Hospital, Ottawa, ON, Canada.
Chang DW; Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Ye Y; Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Spitz M; Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Lu C; Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Shu X; Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Wampfler JA; Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, USA.
Marks RS; Department of Medical Oncology, Mayo Clinic College of Medicine, Rochester, MN, USA.
Garces YI; Department of Radiation Oncology, Mayo Clinic College of Medicine, Rochester, MN, USA.
Yang P; Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, USA.
Wu X; Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
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Źródło:
The pharmacogenomics journal [Pharmacogenomics J] 2014 Dec; Vol. 14 (6), pp. 509-22. Date of Electronic Publication: 2014 Jul 01.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Carcinoma, Non-Small-Cell Lung/*genetics
Lung Neoplasms/*genetics
Wnt Proteins/*metabolism
Wnt Signaling Pathway/*genetics
Adult ; Aged ; Aged, 80 and over ; Carcinoma, Non-Small-Cell Lung/diagnosis ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/metabolism ; Cohort Studies ; Female ; Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/drug therapy ; Lung Neoplasms/metabolism ; Male ; Middle Aged ; Multivariate Analysis ; Wnt Proteins/antagonists & inhibitors ; Wnt Signaling Pathway/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Association between MGMT promoter methylation and non-small cell lung cancer: a meta-analysis.
Autorzy:
Gu C; Department of Epidemiology and Biostatistics and the Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Lu J
Cui T
Lu C
Shi H
Xu W
Yuan X
Yang X
Huang Y
Lu M
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Źródło:
PloS one [PLoS One] 2013 Sep 26; Vol. 8 (9), pp. e72633. Date of Electronic Publication: 2013 Sep 26 (Print Publication: 2013).
Typ publikacji:
Journal Article; Meta-Analysis
MeSH Terms:
DNA Methylation*
Promoter Regions, Genetic*
Carcinoma, Non-Small-Cell Lung/*genetics
Lung Neoplasms/*genetics
Case-Control Studies ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
TGFβ1 Polymorphisms Predict Distant Metastasis-Free Survival in Patients with Inoperable Non-Small-Cell Lung Cancer after Definitive Radiotherapy.
Autorzy:
Yuan X; Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Wei Q
Komaki R
Liu Z
Yang J
Tucker SL
Xu T
Heymach JV
Lu C
Cox JD
Liao Z
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Źródło:
PloS one [PLoS One] 2013 Jun 19; Vol. 8 (6), pp. e65659. Date of Electronic Publication: 2013 Jun 19 (Print Publication: 2013).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Polymorphism, Single Nucleotide*
Carcinoma, Non-Small-Cell Lung/*radiotherapy
Lung Neoplasms/*genetics
Transforming Growth Factor beta1/*genetics
A549 Cells ; Adult ; Aged ; Aged, 80 and over ; Carcinoma, Non-Small-Cell Lung/genetics ; Cell Line, Tumor ; Cell Movement ; Disease-Free Survival ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Metastasis ; Prognosis ; Prospective Studies ; Survival Analysis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Initial medical attention on patients with early-stage non-small cell lung cancer.
Autorzy:
Chen X; Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America. />Gorlov IP
Ying J
Merriman KW
Kimmel M
Lu C
Reyes-Gibby CC
Gorlova OY
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Źródło:
PloS one [PLoS One] 2012; Vol. 7 (3), pp. e32644. Date of Electronic Publication: 2012 Mar 07.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Carcinoma, Non-Small-Cell Lung/*diagnosis
Lung Neoplasms/*diagnosis
Aged ; Aged, 80 and over ; Carcinoma, Non-Small-Cell Lung/mortality ; Female ; Humans ; Lung Neoplasms/mortality ; Male ; Middle Aged ; Neoplasm Staging ; Prognosis ; Registries ; Retrospective Studies ; Tumor Burden
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Genetic variations in the regulator of G-protein signaling genes are associated with survival in late-stage non-small cell lung cancer.
Autorzy:
Dai J; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.
Gu J
Lu C
Lin J
Stewart D
Chang D
Roth JA
Wu X
Pokaż więcej
Źródło:
PloS one [PLoS One] 2011; Vol. 6 (6), pp. e21120. Date of Electronic Publication: 2011 Jun 17.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Genetic Variation*
Survival Analysis*
Carcinoma, Non-Small-Cell Lung/*pathology
GTP-Binding Proteins/*metabolism
Lung Neoplasms/*pathology
Signal Transduction/*genetics
Aged ; Antineoplastic Agents/therapeutic use ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/metabolism ; Carcinoma, Non-Small-Cell Lung/therapy ; Combined Modality Therapy ; Female ; Genotype ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Lung Neoplasms/therapy ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Radiotherapy
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.
Autorzy:
Hildebrandt MA; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.
Komaki R
Liao Z
Gu J
Chang JY
Ye Y
Lu C
Stewart DJ
Minna JD
Roth JA
Lippman SM
Cox JD
Hong WK
Spitz MR
Wu X
Pokaż więcej
Źródło:
PloS one [PLoS One] 2010 Aug 25; Vol. 5 (8), pp. e12402. Date of Electronic Publication: 2010 Aug 25.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Polymorphism, Single Nucleotide*
Carcinoma, Non-Small-Cell Lung/*genetics
Carcinoma, Non-Small-Cell Lung/*radiotherapy
Inflammation/*genetics
Lung Neoplasms/*genetics
Lung Neoplasms/*radiotherapy
Radiation Injuries/*genetics
Alleles ; Esophagitis/etiology ; Esophagitis/genetics ; Female ; Genetic Predisposition to Disease ; Humans ; Male ; Middle Aged ; Radiation Injuries/etiology ; Radiation Pneumonitis/etiology ; Radiation Pneumonitis/genetics ; Survival Analysis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Expression of methylation-related genes is associated with overall survival in patients with non-small cell lung cancer.
Autorzy:
Xing J; Department of Epidemiology, Unit 1340, The University of Texas MD Anderson Cancer Center, 1155 Pressler Boulevard, Houston, TX 77030, USA.
Stewart DJ
Gu J
Lu C
Spitz MR
Wu X
Pokaż więcej
Źródło:
British journal of cancer [Br J Cancer] 2008 May 20; Vol. 98 (10), pp. 1716-22. Date of Electronic Publication: 2008 Apr 15.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
DNA Methylation*
Carcinoma, Non-Small-Cell Lung/*genetics
Carcinoma, Non-Small-Cell Lung/*mortality
DNA (Cytosine-5-)-Methyltransferases/*genetics
DNA-Binding Proteins/*genetics
Lung Neoplasms/*genetics
Lung Neoplasms/*mortality
Adult ; Aged ; Carcinoma, Non-Small-Cell Lung/metabolism ; DNA (Cytosine-5-)-Methyltransferase 1 ; DNA (Cytosine-5-)-Methyltransferases/metabolism ; DNA, Neoplasm/metabolism ; DNA-Binding Proteins/metabolism ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Kaplan-Meier Estimate ; Lung Neoplasms/metabolism ; Male ; Middle Aged ; Multivariate Analysis ; Polymerase Chain Reaction ; Predictive Value of Tests ; Prognosis ; Proportional Hazards Models ; RNA, Messenger/metabolism ; Survival Analysis ; Texas/epidemiology ; DNA Methyltransferase 3B
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 39

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