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Wyświetlanie 1-20 z 83
Tytuł:
Novel ALK inhibitor AZD3463 inhibits neuroblastoma growth by overcoming crizotinib resistance and inducing apoptosis.
Autorzy:
Wang Y; Department of Microbiology, Peking University Health Science Center, Beijing 100191, China.; Texas Children's Cancer Center, Department of Pediatrics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Wang L; Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.; Department of Acupuncture, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China.
Guan S; Texas Children's Cancer Center, Department of Pediatrics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Cao W; Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.; Department of Medical Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, China.
Wang H; Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.; Department of Hepatopancreatobiliary Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, China.
Chen Z; Texas Children's Cancer Center, Department of Pediatrics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Zhao Y; Texas Children's Cancer Center, Department of Pediatrics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Yu Y; Texas Children's Cancer Center, Department of Pediatrics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Zhang H; Texas Children's Cancer Center, Department of Pediatrics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Pang JC; Texas Children's Cancer Center, Department of Pediatrics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Huang SL; Texas Children's Cancer Center, Department of Pediatrics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Akiyama Y; Texas Children's Cancer Center, Department of Pediatrics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Yang Y; Texas Children's Cancer Center, Department of Pediatrics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Sun W; Division of Pediatric Surgery, Michael E. DeBakey Department of Pediatric Surgery, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Xu X; Texas Children's Cancer Center, Department of Pediatrics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Shi Y; Division of Pediatric Surgery, Michael E. DeBakey Department of Pediatric Surgery, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Zhang H; Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Kim ES; Division of Pediatric Surgery, Michael E. DeBakey Department of Pediatric Surgery, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Muscal JA; Texas Children's Cancer Center, Department of Pediatrics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Lu F; Department of Microbiology, Peking University Health Science Center, Beijing 100191, China.
Yang J; Texas Children's Cancer Center, Department of Pediatrics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA.
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Źródło:
Scientific reports [Sci Rep] 2016 Jan 20; Vol. 6, pp. 19423. Date of Electronic Publication: 2016 Jan 20.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Drug Resistance, Neoplasm*/genetics
Apoptosis/*drug effects
Neuroblastoma/*metabolism
Protein Kinase Inhibitors/*pharmacology
Pyrazoles/*pharmacology
Pyridines/*pharmacology
Receptor Protein-Tyrosine Kinases/*antagonists & inhibitors
Anaplastic Lymphoma Kinase ; Animals ; Autophagy/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Crizotinib ; Disease Models, Animal ; Female ; Humans ; Mice ; Mutation ; Neuroblastoma/drug therapy ; Neuroblastoma/pathology ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphorylation ; Proto-Oncogene Proteins c-akt/metabolism ; Receptor Protein-Tyrosine Kinases/genetics ; Signal Transduction/drug effects ; TOR Serine-Threonine Kinases/metabolism ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Transcription factor myocyte enhancer factor 2D regulates interleukin-10 production in microglia to protect neuronal cells from inflammation-induced death.
Autorzy:
Yang S; Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China. .
Gao L; Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China. .
Lu F; Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China. .
Wang B; Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China. .
Gao F; Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China. .
Zhu G; Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China. .
Cai Z; Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China. .
Lai J; Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China. laijuan_.
Yang Q; Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China. .
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Źródło:
Journal of neuroinflammation [J Neuroinflammation] 2015 Feb 20; Vol. 12, pp. 33. Date of Electronic Publication: 2015 Feb 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis/*physiology
Interleukin-10/*metabolism
MEF2 Transcription Factors/*metabolism
Microglia/*metabolism
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/pharmacology ; Animals ; Animals, Newborn ; Apoptosis/drug effects ; Brain/cytology ; Calcium-Binding Proteins/metabolism ; Cells, Cultured ; Chromatin Immunoprecipitation ; Electrophoretic Mobility Shift Assay ; Interleukin-10/genetics ; Lipopolysaccharides/toxicity ; MEF2 Transcription Factors/genetics ; Male ; Mice ; Mice, Inbred C57BL ; Microfilament Proteins/metabolism ; Microglia/drug effects ; RNA, Messenger/metabolism ; Time Factors ; Tyrosine 3-Monooxygenase/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Ubr3 E3 ligase regulates apoptosis by controlling the activity of DIAP1 in Drosophila.
Autorzy:
Huang Q; School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Tang X; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Wang G; State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Fan Y; School of Biosciences, University of Birmingham, Birmingham, UK.
Ray L; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Bergmann A; Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA, USA.
Belenkaya TY; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Ling X; School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Yan D; School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Lin Y; School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Ye X; School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Shi W; School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Zhou X; School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Lu F; School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Qu J; School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Lin X; 1] School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, China [2] Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA [3] State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
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Źródło:
Cell death and differentiation [Cell Death Differ] 2014 Dec; Vol. 21 (12), pp. 1961-70. Date of Electronic Publication: 2014 Aug 22.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis*
Drosophila Proteins/*metabolism
Drosophila Proteins/*physiology
Drosophila melanogaster/*enzymology
Inhibitor of Apoptosis Proteins/*metabolism
Ubiquitin-Protein Ligases/*physiology
Amino Acid Sequence ; Animals ; Caspases/metabolism ; Compound Eye, Arthropod/cytology ; Drosophila melanogaster/cytology ; Female ; Imaginal Discs/cytology ; Molecular Sequence Data ; Ubiquitination
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Primary in vitro and in vivo evaluation of norcantharidin-chitosan/poly (vinyl alcohol) for cancer treatment.
Autorzy:
Li M; School of Pharmacy, Shanghai Jiao Tong University , Shanghai , People's Republic of China and.
Xu X
Lu F
Guo S
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Źródło:
Drug delivery [Drug Deliv] 2014 Jun; Vol. 21 (4), pp. 293-301. Date of Electronic Publication: 2013 Oct 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents/*administration & dosage
Apoptosis/*drug effects
Bridged Bicyclo Compounds, Heterocyclic/*administration & dosage
Chitosan/*administration & dosage
Polyvinyl Alcohol/*administration & dosage
Animals ; Antineoplastic Agents/chemistry ; Apoptosis/physiology ; Bridged Bicyclo Compounds, Heterocyclic/chemistry ; Cell Line, Tumor ; Chitosan/chemistry ; Drug Evaluation, Preclinical/methods ; Female ; Humans ; Mice ; Polyvinyl Alcohol/chemistry ; Treatment Outcome ; Xenograft Model Antitumor Assays/methods
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Role of the inflammatory protein serine protease inhibitor Kazal in preventing cytolytic granule granzyme A-mediated apoptosis.
Autorzy:
Lu F; Drexel Institute for Biotechnology and Virology Research, Department of Microbiology and Immunology, College of Medicine, Drexel University, Doylestown, PA 18902, USA.
Lamontagne J
Sun A
Pinkerton M
Block T
Lu X
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Źródło:
Immunology [Immunology] 2011 Dec; Vol. 134 (4), pp. 398-408.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Immunologic Surveillance*
Apoptosis/*immunology
Granzymes/*immunology
Killer Cells, Natural/*immunology
T-Lymphocytes, Cytotoxic/*immunology
Trypsin Inhibitor, Kazal Pancreatic/*immunology
Antibodies, Monoclonal/immunology ; Cell Line ; Granzymes/metabolism ; Humans ; Immunoprecipitation ; Immunotherapy ; Killer Cells, Natural/pathology ; Neoplasms/immunology ; Neoplasms/therapy ; T-Lymphocytes, Cytotoxic/pathology ; Trypsin Inhibitor, Kazal Pancreatic/metabolism ; Tumor Escape/immunology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Calcium-sensing receptors induce apoptosis in rat cardiomyocytes via the endo(sarco)plasmic reticulum pathway during hypoxia/reoxygenation.
Autorzy:
Lu F; Department of Pathophysiology, Harbin Medical University, Harbin, China.
Tian Z
Zhang W
Zhao Y
Bai S
Ren H
Chen H
Yu X
Wang J
Wang L
Li H
Pan Z
Tian Y
Yang B
Wang R
Xu C
Pokaż więcej
Źródło:
Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2010 May; Vol. 106 (5), pp. 396-405. Date of Electronic Publication: 2009 Dec 22.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis/*physiology
Endoplasmic Reticulum/*metabolism
Myocardial Reperfusion Injury/*metabolism
Myocytes, Cardiac/*metabolism
Receptors, Calcium-Sensing/*metabolism
Activating Transcription Factor 6/metabolism ; Animals ; Calcium/metabolism ; Caspase 12/metabolism ; Cell Hypoxia ; In Vitro Techniques ; JNK Mitogen-Activated Protein Kinases/metabolism ; Male ; Microscopy, Confocal ; Rats ; Rats, Wistar
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Radiation-induced apoptosis of oligodendrocytes and its association with increased ceramide and down-regulated protein kinase B/Akt activity.
Autorzy:
Lu FG; Department of Radiation Oncology, Sunnybrook and Women's College Health Sciences Center, University of Toronto, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada.
Wong CS
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Źródło:
International journal of radiation biology [Int J Radiat Biol] 2004 Jan; Vol. 80 (1), pp. 39-51.
Typ publikacji:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Dose-Response Relationship, Radiation*
Protein Serine-Threonine Kinases*
Apoptosis/*radiation effects
Ceramides/*metabolism
Oligodendroglia/*metabolism
Oligodendroglia/*radiation effects
Proto-Oncogene Proteins/*metabolism
Animals ; Animals, Newborn ; Astrocytes/cytology ; Astrocytes/drug effects ; Astrocytes/metabolism ; Astrocytes/radiation effects ; Cells, Cultured ; Cerebral Cortex/cytology ; Cerebral Cortex/drug effects ; Cerebral Cortex/metabolism ; Cerebral Cortex/radiation effects ; Down-Regulation/drug effects ; Down-Regulation/radiation effects ; Fumonisins/pharmacology ; Gamma Rays ; Monensin/pharmacology ; Oligodendroglia/cytology ; Oligodendroglia/drug effects ; Proto-Oncogene Proteins c-akt ; Radiation Dosage ; Radiation Tolerance/drug effects ; Rats ; Rats, Inbred F344
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Baicalein, a novel apoptotic agent for hepatoma cell lines: a potential medicine for hepatoma.
Autorzy:
Chen CH; Department of Biochemistry, College of Medicine, National Taiwan University, Taipei, Republic of China.
Huang LL
Huang CC
Lin CC
Lee Y
Lu FJ
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Źródło:
Nutrition and cancer [Nutr Cancer] 2000; Vol. 38 (2), pp. 287-95.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Flavanones*
Apoptosis/*drug effects
Carcinoma, Hepatocellular/*pathology
Flavonoids/*pharmacology
Liver Neoplasms/*pathology
Carcinoma, Hepatocellular/drug therapy ; Cell Division/drug effects ; Cell Membrane/drug effects ; Cell Survival/drug effects ; DNA Fragmentation ; DNA, Neoplasm/drug effects ; Dose-Response Relationship, Drug ; Flavonoids/therapeutic use ; Flow Cytometry ; Humans ; Liver Neoplasms/drug therapy ; Membrane Potentials/drug effects ; Mitochondria/drug effects ; Mitochondria/physiology ; S Phase/drug effects ; Tumor Cells, Cultured/drug effects ; Tumor Cells, Cultured/metabolism ; Tumor Cells, Cultured/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Enchancing effect of patented whey protein isolate (Immunocal) on cytotoxicity of an anticancer drug.
Autorzy:
Tsai WY; Department of Biochemistry, College of Medicine National Taiwan University, Taipei, ROC.
Chang WH
Chen CH
Lu FJ
Pokaż więcej
Źródło:
Nutrition and cancer [Nutr Cancer] 2000; Vol. 38 (2), pp. 200-8.
Typ publikacji:
Journal Article
MeSH Terms:
Flavanones*
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Flavonoids/*pharmacology
Milk Proteins/*pharmacology
Tumor Cells, Cultured/*drug effects
Antioxidants/pharmacology ; Cell Survival/drug effects ; Chemotherapy, Adjuvant ; Culture Media ; Drug Synergism ; Flow Cytometry ; Glutathione/drug effects ; Humans ; Kinetics ; Membrane Potentials/drug effects ; Whey Proteins
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Quercetin Alleviates Osteoarthritis Progression in Rats by Suppressing Inflammation and Apoptosis via Inhibition of IRAK1/NLRP3 Signaling
Autorzy:
Li W
Wang Y
Tang Y
Lu H
Qi Y
Li G
He H
Lu F
Yang Y
Sun H
Pokaż więcej
Temat:
quercetin
osteoarthritis
irak1
nlrp3
inflammation
apoptosis
Pathology
RB1-214
Therapeutics. Pharmacology
RM1-950
Źródło:
Journal of Inflammation Research, Vol Volume 14, Pp 3393-3403 (2021)
Opis pliku:
electronic resource
Relacje:
https://www.dovepress.com/quercetin-alleviates-osteoarthritis-progression-in-rats-by-suppressing-peer-reviewed-fulltext-article-JIR; https://doaj.org/toc/1178-7031
Dostęp URL:
https://doaj.org/article/4ae8583861a148279c6a029990ea5c17  Link otwiera się w nowym oknie
Czasopismo naukowe
Szczegóły
Wyświetlanie 1-20 z 83

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